• Journal of KIISE:Information Networking
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• v.32 no.5
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• pp.615-624
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• 2005

In Mobile IP, several types of messages - binding update, binding request and binding acknowledgement - are used to support user mobility. It is necessary to exchange those messages frequently for seamless mobility but it incurs both the increase of network overhead and poor usage of mobile node battery power Thus, we need a mechanism that the server detects users location and also copes with the problems effectively, which is our main concern in this paper Each user records all moving logs locally and periodically makes out profile based on them in HMIPv6. By using profile, estimated resident time can be computed whenever he enters an area and the time is set up as the binding update message lifetime. Of course, the more correct lifetime nay be obtained IP arrival time as well as average resident time Is considered in profile. Through extensive experiments, we measure the bandwidth usage for binding update messages by comparing the proposed schemes with that in HMIPv6. From the results, Gain gets over $80\%$ when mobile node stays more than 13 minutes in a subnet. Namely, we come to know that our schemes improve network usage and energy usage in mobile node by decreasing the number of messages while they also manage users locations like that in HMIPv6.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.17 no.1
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• pp.47-54
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• 1984

From the four tuna purse seiners operating in the western equatorial Pacific waters 370 tuna schools were sampled on attribute of the school, fishing operation of purse seine sit and catch. The data were tabulated and subjected to the statistical tests of independency on the associated object and availability of the school, and catch per set of purse seine fishery as well. The resultant inferences are as follows. 1. Most frequent attributes of the tuna schools found on the surface are associated with sea birds, bait fishes and the flotsams. 2. In fishing operations of purse seine sets on the flotsam-associated schools, the settings were more frequently performed at dawn than in day-time. In fishing operations on the sea-birds-associated schools, the siftings were more frequent in day-time than at dawn. 3. From the flotsam-associated schools the successful sets were significantly more frequent. 4. In the fishing operations of purse seine sets, some of the flotsam-associated schools were subjected to the supplementary sets in success to the initial sets until the schools were consummated. 5. The fish-attracting effect of the flotsam is correlated with structure of the flotsam, but not with length of the flotsam. The flotsams, which tend to attract large tuna schools are the complicated-structure flotsams, i, e. driftwoods with roots or branches or with both of them, otherwise a bunch of uprooted bamboo shrubs, while a log without roots and branches tend to be an attractant inferior to the flotsam of complicated structure.

• Water for future
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• v.14 no.1
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• pp.39-49
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• 1981

The purpose of this study is to examine the meander charactericstics for the rivers in Korea..In this study, the new characteristics factors of meander are proposed, and the relationships among the factors proposed in this study and the existing factors are derived. An attempt is made to find considerable relation among meander characteristics, but width and meander belt did not show any defined trend and considerable scatter of points was observed. Relationships among the meander length, belt and flowrate, etc., which are factors of meander characteristics, are analyzed the 67 rivers above 30km in length. Channel shape factor which is the ratio of the length from the starting point to the end to the channel lenght, tortuosity which is the ratio of the curved channel length against the channel length are suggested for a new characteristics factor of meander. They are well correlated with channel length, Horton's shape facotr and meander gradient, consequently have to be important measures of river meander. The result of the detailed comparison and the analysis of degree of sinuosity, velocity and water surface slop are brought light on the fact show that the curved reach is morestable than the straight one. The ratio of the meander length to the meander belt and its accumulative frequency showed excellent correlationship when plotted on the semi-log paper. The results of regression analysis of meander belt and meander length show linear for the South Han river branches and power curve for the Geum river and the Nakdong river branches.

• Journal of Acupuncture Research
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• v.20 no.2
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• pp.77-84
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• 2003

Objective : In order to study the effects of bee venom(BV) on the pain, edema, and acute inflammatory reactant of rheumatoid arthritis(RA) patients. Methods : Patients with RA who met the ACR(American College of Rheumatology) 1987 revised criteria for the diagnosis of RA were treated with the BV therapy twice a week for 3 months. Tender joint counts, swollen joint counts, Visual analog scale(VAS), morning in stiffness, ESR, C-reactive protein(CRP) were analyzed before and after BV therapy. Results : The results as follows: 1. Tender joint counts in patients after BV therapy were significantly lower than those before BV therapy($9.0{\pm}7.9$ vs $15{\pm}11.4$, p=0.002). 2. Swollen joint counts of the patients after BV therapy were significantly lower than those before BV therapy ($5.0{\pm}6.1$ vs $1.5{\pm}2.3$, p=0.001). 3. VAS in patients after BV therapy was significantly lower than before BV therapy($60.8{\pm}17.6$ vs $38.0{\pm}15.9$, p=0.000). 4. Duration of morning stiffness in patients after BV therapy was significantly reduced compared with that before BV therapy($119.1{\pm}112.6min$ vs $59.0{\pm}89.7min$, p=0.009). 5. ESR and CRP were not significantly changed before and after BV therapy, suggesting BV itself could make inflammatory reaction as well as therapeutic effect. Conclusions: BV therapy improved tender joint counts, swollen joint counts and duration of morning stiffness in this study, and further study is needed in log-term effect of BV therapy.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.7
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• pp.3029-3034
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• 2015

Background: While the perinatal outcomes of active maternal smoking are well documented, results of the effects of environmental tobacco smoke (ETS) exposure during pregnancy are inconsistent. We aimed to examine the effect of ETS exposure, assessed by maternal hair nicotine levels at $35^{th}$ week of gestation, on birth weight and the risk of small for gestational age (SGA) and low birth weight (LBW). Materials and Methods: A total of 871 non-smoking healthy pregnant women were recruited by one Korean hospital between 1 October 2006 and 31 July 2007. Hair samples were collected and anthropometric questionnaires administered at $35^{th}$ week of gestation. The primary outcome was birth weight and secondary outcomes were the risk of babies being SGA and LBW. Results: Log-transformed hair nicotine concentrations were inversely related with birth weight after adjusting for confounding variables (${\beta}=-0.077$, p=0.037). After stratifying hair nicotine levels by tertiles (T1, low [0.0-0.28 ng/mg]; T2, medium [0.29-0.62 ng/mg]; and T3, high [0.63-5.99 ng/mg]), the mean birth weight in each groups were 3,342g (T1) 3,296g (T2) and 3,290 g (T3), respectively. However the difference between groups was not statistically significant by analysis of co-variance (ANCOVA) adjusting for covariates (p=0.062). In logistic regression analysis, the risk of SGA was higher in the T3 (OR=1.59, 95%CI 1.05-2.42) than in the reference group (T1), after controlling for confounding variables. The risk of low birth weight (<2,500g, LBW) was not significantly higher (OR=1.44, 95%CI 0.95-2.19), but the risk of babies being below 3,000g birth weight was increased in the T3 group (OR=1.53, 95%CI 1.00-2.36) compared with that in the T1 group. Conclusions: Maternal ETS exposure during pregnancy was inversely related with birth weight. The risk of SGA increased in the highest ETS exposure group compared with in the low exposure group. To prevent ETS exposure during pregnancy, more comprehensive tobacco control policies are needed.

• Geotechnical Engineering
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• v.1 no.1
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• pp.59-72
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• 1985

This paper deals with the numerical analysis by the (mite element method introducing Biot's theory of consolidation and the modified Cambridge model proposed by Roscoe school of Cambridge University as constitutive equation and using Christian-Boehner's technique. Especially, time interval and division of elements are investigated in vies of stability and economics. In order to check the validity of author's program, the program was tested with one-dimensional consolidation case followed by Terzaghi's exact solution and with the results of the Magnan's analysis for existing banking carried out for study at Cubzac-les-ports in France. The main conclusions obtained are summarized as follows: 1. In the case of one-dimensional consolidation, the more divided the elements are near the surface of the foundation, the higher the accuracy of the numerical analysis is. 2. For the time interval, it is stable to divide 20 times per 1-lg cycle. 3. At the element which has long drain distance, the Mandel-fryer effect appears due to time lag. 4. Lateral displacement at an initial loading stage predicted by author's program, in which the load was assumed as not concentrative. but rather in grid form, is well consistent with the value of observation. 5. The pore water pressure predicted by author's program has a better accordance with the value of observation compared with Magnan's results. 6. Optimum construction control by Matsuo-Kawamura's method is possible with the predicted lateral displacement and settlement by the program.

• Journal of Environmental Health Sciences
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• v.40 no.2
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• pp.88-97
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• 2014

Objectives: The aim of this study was to evaluate the occurrence of microbiological contamination of kitchen utensils and environments of food service operations at university located in Seoul, Korea. Methods: We collected swab samples from the surfaces of knives, chopping boards, floors, and drains, as well as drinking water and airborne bacteria samples from 20 food service operations. Three bacterial indicators and five food poisoning bacteria were measured quantitatively and qualitatively, respectively. We used selective culture media and the PCR assay targeting 16S rRNA gene for the microbiological analysis. Results: We detected bacterial indicators on knives or chopping boards in eight different food service operations and, three food service operations (I, M, and O) showed more than 3 log colony forming units $(CFU)/100cm^2$ on their knives, significantly higher than the others. The levels of bacterial indicators on the floors and drains in the cooking areas were much higher than those on the cooking utensils. S. aureus was detected on 10 floors and 8 drains. Culturable bacteria were identified in 5 drinking water samples, and food service operation B ($431.1CFU/m^3$) and C ($551.2CFU/m^3$) showed more than $400CFU/m^3$ of total airborne bacteria. Conclusions: These results suggest that some of food service operations in this study may require additional investigation to secure the microbial safety of cooking environments. In addition, further actions including hygiene education for employees and proper guidelines to maintain clean cooking environments should be prepared.

• Journal of the Korean Society of Food Science and Nutrition
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• v.42 no.10
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• pp.1533-1538
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• 2013

The objective of this study is to select an effective microbial strain to enhance the sensory qualities and functionalities of fermented ginseng soymilk. For this purpose, soybean were ground with water extracts of ginseng and fermented with five Lactobacillus strains. All strains grew well in ginseng soymilk, and viable cell counts reached greater than 8 log CFU/mL after 18 h of fermentation. The contents of total ginsenosides were higher in soymilk fermented with L. casei ATCC 393 than those in the other strains. The sensory qualities of the fermented soymilk were observed to increase with the intensity of sourness and showed the best sensory acceptability of soymilk fermented with L. kefir ATCC 35411. Moreover, the antioxidant activities, superoxide and hydroxyl radical scavenging activities were significantly enhanced by 2~4 and 4~5 times, respectively, compared to the non-fermented soymilk. In particular, the antioxidant activities of the fermented soymilk by L. kefir ATCC 35411 were the highest among the samples. This result suggests that soymilk fermented by L. kefir ATCC 35411 allowed obtaining a soymilk with enhanced sensory quality and antioxidant activity was able to contribute to the health benefit.

• BMB Reports
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• v.51 no.5
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• pp.255-260
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• 2018

Wntless/GPR177 functions as WNT ligand carrier protein and activator of $WNT/{\beta}$-catenin signaling, however, its molecular role in gastric cancer (GC) has remained elusive. We investigated the role of GPR177 in gastric tumorigenesis and provided the therapeutic potential of a clinical development of anti-GPR177 monoclonal antibodies. GPR177 mRNA expression was assessed in GC transcriptome data sets (GSE15459, n = 184; GSE66229, n = 300); protein expression was assessed in independent patient tumor tissues (Yonsei TMA, n = 909). GPR177 expression were associated with unfavorable prognosis [log-rank test, GSE15459 (P = 0.00736), GSE66229 (P = 0.0142), and Yonsei TMA (P = 0.0334)] and identified as an independent risk predictor of clinical outcomes: GSE15459 [hazard ratio (HR) 1.731 (95% confidence interval; CI; 1.103-2.715), P = 0.017], GSE66229 [HR 1.54 (95% CI, 1.10-2.151), P = 0.011], and Yonsei TMA [HR 1.254 (95% CI, 1.049-1.500), P = 0.013]. Either antibody treatment or GPR177 knockdown suppressed proliferation of GC cells and sensitized cells to apoptosis. And also inhibition of GPR177 suppresses in vitro and in vivo tumorogenesis in GC cells and inhibits $WNT/{\beta}$-catenin signaling. Finally, targeting and inhibition of GPR177 with antibody suppressed tumorigenesis in PDX model. Together, these results suggest GPR177 as a novel candidate for prognostic marker as well as a promising target for treatment of GC patients.

• Journal of Life Science
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• v.27 no.3
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• pp.283-288
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• 2017

Porcine circovirus type 2 (PCV2) is a notorious and ubiquitous virus in the swine industry. The susceptibility of the host to PCV2 infection is considered to be one factor associated with the dynamics of PCV2. The objective of this study was to verify the criteria for host susceptibility to PCV2, using blood parameters of post-weaned pigs naturally infected with the virus. The PCV2 DNA viral load, antibody titer, and leukopenia characteristics were measured in the serum extracted from the pigs at the 10th week. We classified the pigs into high (>5.0), intermediate (3.0 to 5.0), and low (<3.0) groups on the basis of the PCV2 viral load (log copies/ml), or as positive (${\leq}0.50$) and negative (>0.50) groups on the basis of antibody titer (sample-to-negative corrected ratio). Moreover, using these two categorized parameters, we suggested the criteria for classification into the susceptible and resistant groups. Statistical analyses revealed that pigs in the susceptible group had a significantly higher viral load (p<0.001) and negative antibody titer (p<0.001), as well as significantly lower leukocyte counts (p=0.018) and lower amounts of several leukocyte components (p<0.05), than pigs in the resistant group. We concluded that the susceptible group could be considered to have PCV2-induced leukopenia. Therefore, we suggest that the combined classifications of viral loads and anti-PCV2 antibodies can be used to determine PCV2-induced leukopenia in the subclinical PCV2 infection of post-weaned pig populations.