• Asian Pacific Journal of Cancer Prevention
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• v.13 no.10
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• pp.4909-4914
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• 2012

Objective: The aim of this Human Genome Epidemiology (HuGE) review and meta-analysis was to derive a more precise estimation of the association between p53 codon 72 polymorphism (Arg72Pro, rs1042522 G>C) and cervical cancer risk among Asians. Methods: A literature search of Pubmed, Embase, Web of Science and CBM databases from inception through June 2012 was conducted. The meta-analysis was performed using STATA 12.0 software. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of any association. Twenty-eight case-control studies were included with a total of 3,580 cervical cancer cases and 3,827 healthy controls. When all the eligible studies were pooled into the meta-analysis, the results showed that the Pro/Pro genotype was associated with increased risk of cervical cancer under the heterozygous model (Pro/Pro vs. Arg/Pro: OR = 1.25, 95%CI: 1.02-1.53, P= 0.005). However, no statistically significant associations were found under four other genetic models (Pro vs. Arg: OR = 0.97, 95%CI: 0.85-1.10, P= 0.624; Pro/Pro + Arg/Pro vs. Arg/Arg: OR = 0.84, 95%CI: 0.70-1.01, P= 0.058; Pro/Pro vs. Arg/Arg + Arg/Pro: OR = 1.13, 95%CI: 0.92-1.39, P= 0.242; Pro/Pro vs. Arg/Arg: OR = 0.97, 95%CI: 0.76-1.22, P= 0.765; respectively). In the subgroup analysis based on country, the Pro/Pro genotype and Pro carrier showed significant associations with increased risk of cervical cancer among Indian populations, but not among Chinese, Japanese and Korean populations. Conclusion: Results from the current meta-analysis suggests that p53 codon 72 polymorphism might be associated with increased risk of cervical cancer, especially among Indians.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.2
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• pp.803-805
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• 2014

The IL-16 rs4778889 T/C polymorphism is associated with cancer risk. However, the results are conflicting. We performed this meta-analysis to derive a more precise estimation of the relationship. A comprehensive literature search was performed using PubMed, Embase and Web of Science databases. Odds ratio (OR) and 95% confidence interval (CI) were used to assess the strength of association. A total of 6 studies including 1,603 cases and 2,342 controls were identified. With all studies involved, results showed no statistically significant association between IL-16 rs4778889 T/C polymorphism and cancer risk (CC vs. CT+TT: OR=0.74, 95%CI:0.55-1.02, $P_h=0.15$; CC+CT vs. TT: OR=0.89, 95%CI: 0.72-1.10, $P_h=0.03$; CC vs. TT: OR=0.73, 95%CI: 0.53-1.00, $P_h=0.08$; CT vs. TT: OR=0.91, 95%CI: 0.79-1.05, $P_h=0.08$; C vs. T: OR=0.89, 95%CI: 0.74-1.07, $P_h=0.02$). In addition, the results were not changed when studies were stratified by cancer type. However, to verify our findings, it is essential to perform more well-designed studies with larger sample sizes in the future.

• Journal of The Korean Association of Information Education
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• v.7 no.3
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• pp.341-352
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• 2003

While most researches for cyber counseling until now have been about counseling methods and the effects that teenagers utilize cyber counseling, there have been no efforts that store counseling contents, analyze them using features and technologies of web and use them effectively to guide students. Therefore, we propose a cyber counseling system that provides counseling information so that teacher may grasp students various interests and problems and thus helps to guide students. For this, we used XML. Since XML document can systematically create a structured information and represent a structure with meaningful information unit than the existing file-based information, it can be effectively used to manage, search and store documents. Thus, we implement a cyber counseling system using XML, which can effectively manage and represent the various analysis information of counseling.

• The KIPS Transactions:PartC
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• v.10C no.1
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• pp.87-94
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• 2003

As the number of the Internet users increases explosively, a solution for this problem is web caching. So, many techniques on improving cache server performance have been suggested. In this paper, we analyze the cause of the bottleneck in cache servers, and propose an arbitral thread and delayed caching mechanism as a solution. We use an arbitral thread in order to provide a quick service to user requests through eliminating the ready multi-thread search problem in case of disk writing operation. We also use delayed caching in order to provide stable system operation through avoiding overloaded disk operation and queue threshold. Proposed cache server is implemented through modification on SQUlD cache server, and we compare its performance with the original SQUID cache server.

• Journal of KIISE
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• v.44 no.11
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• pp.1165-1177
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• 2017

Many developers utilize specific APIs to develop software, and to identify the use of a particular API, a developer can refer to a website that provides the API or can retrieve the API from the web. However, the site that provides the API does not necessarily provide guidance on how to use it while it can be partially provided in many other cases. In this paper, we propose a novel system JACE (Java AST collocation-pattern extractor) as a method to reuse commonly-used code as a supplement. The JACE extracts the API call nodes, collocation patterns and analyzes the relations between the collocations to extract significant API patterns from the source code. The following experiment was performed to verify the accuracy of a defined pattern: 794 open source projects were analyzed to extract about 15M API call nodes. Then, the Eclipse plug-in test program was utilized to retrieve the pattern using the top 10 classes of API call nodes. Finally, the code search results from reference pages of the API classes and the Searchcode [1] were compared with the test program results.

• Journal of the Korean Society for information Management
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• v.25 no.4
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• pp.43-66
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• 2008

Currently be proceeded a lot of researchers for 'user information demand description' for interface of an information retrieval system or Web search engines, but user information demand description for a natural language form is a difficult situation. These reasons are as they cannot provide the semantic similarity that an information retrieval model can be completely satisfied with variety regarding an information demand expression and semantic relevance for user information description. Therefore, this study using the description logic that is a knowledge representation base of OWL and a vector model-based weight between concept, and to be able to satisfy variety regarding an information demand expression and semantic relevance proposes a decision way for perfect assistances of user information demand description. The experiment results by proposed method, semantic similarity of a polyseme and a synonym showed with excellent performance in decision.

• Proceedings of the KOSOMBE Conference
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• v.1998 no.11
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• pp.104-105
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• 1998

To minimize the Y2K (year 2000) date aware problem of medical devices, we are developing a database that keeps the data such as equipment type, specification, serial number, model number, acquisition date, vendor, manufacturer of the device as well as the names of departments that installed and that is currently responsible for the management of the medical device. The database also keeps the information as to whether the device awares the date, whether it is affected by the Y2K problem or not, how to solve the problem, reference home page address, and so on. The data was collected via internet search of the FDA web site and related of manufacturers homepages. To manage the Y2K problem effectively, the database should be updated regularly to include recent information.

• Journal of Oriental Neuropsychiatry
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• v.21 no.4
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• pp.151-161
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• 2010

Objectives : This study aimed to evaluate any clinical studies regarding the herbal medicine for dementia focusing on Korean literature for future rigorous clinical research. Methods: Every article relevant to dementia was initially obtained from oriental medical related journals by electronic search at journal web sites or manual searches. Journals were limited to those registered with the Korea Research Foundation. From initial findings. two independent reviewers selected clinical articles and these articles were further analyzed separately by predefined criteria according to prospective and retrospective studies. For randomized controlled trial and non randomized controlled trial. quality assessment was also conducted. Results: From ninety seven patients initially obtained articles. twenty three patients were finally analyzed. One article was randomized controlled study. Four articles were prospective whereas eighteen patients were retrospective. In the qualitative evaluation of prospective articles. there was deduction regarding pre-calculated study size and prospective data collecting. Assessment measurement most frequently used was Mini Mental State Examination. The order of frequency of use herbs were identified. Conclusions : According to our study. the herbal medicine for dementia in general showed a positive effect in the cognitive aspects of dementia patients. Further well-designed randomized controlled studies should be conducted.

• Journal of Korea Society of Industrial Information Systems
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• v.13 no.5
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• pp.22-28
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• 2008

This paper aims to offer a solution based on semantic document classification to improve e-Government utilization and efficiency for people using their own information retrieval system and linguistic expression. Generally, semantic document classification method is an approach that classifies documents based on the diverse relationships between keywords in a document without fully describing hierarchial concepts between keywords. Our approach considers the deep meanings within the context of the document and radically enhances the information retrieval performance. Concept Weight Document Classification(CoWDC) method, which goes beyond using existing keyword and simple thesaurus/ontology methods by fully considering the concept hierarchy of various concepts is proposed, experimented, and evaluated. With the recognition that in order to verify the superiority of the semantic retrieval technology through test results of the CoWDC and efficiently integrate it into the e-Government, creation of a thesaurus, management of the operating system, expansion of the knowledge base and improvements in search service and accuracy at the national level were needed.

• Journal of Pharmacopuncture
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• v.20 no.3
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• pp.173-178
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• 2017

Objectives: Medicinal plants are vital sources of bioactive compounds that are useful for the treatment of patients with snake bites or are indirectly applicable for boosting the effects of conventional serum therapy. These plants are being used traditionally by local healers and tribes for the treatment of patients with snake bites and therefore can be used as an alternative against snake envenomation. Scientifically, using the secondary metabolites of plants to neutralize venom enzymes has an extra benefit of being based on traditional knowledge; also, the use of such metabolites for the treatment of patients with snake bites is cheaper and the treatment can be started sooner. Methods: All the available information on various secondary metabolites exhibiting venom neutralizing ability were collected via electronic search (using Google books, Pubmed, SciFinder, Scirus, Google Scholar, and Web of Science) and articles of peer-reviewed journals. Results:Recent interest in different plant has focused on isolating and identifying of different phytoconstituents that exhibit Phospholipase A2 activity and other venom enzyme neutralizing ability. In this support convincing evidence in experimental animal models are available. Conclusion: Secondary metabolites are naturally present, have no side effect, are stable for a long time, can be easily stored, and can neutralize a wide range of snake enzymes, such as phospholipase A2, hyaluronidase, protease, L-amino acid oxidase, 5'nucleotidase, etc. The current review presents a compilation of important plant secondary metabolites that are effective against snake venom due to enzyme neutralization.