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The Efficacy of P2Y12 Reactive Unit to Predict the Periprocedural Thromboembolic and Hemorrhagic Complications According to Clopidogrel Responsiveness and Safety of Modification of Dual Antiplatelet Therapy : A Meta-Analysis

  • Kim, Hyun Jung;Oh, Jae Sang;Park, Sukh Que;Yoon, Seok Mann;Ahn, Hyeong Sik;Kim, Bum Tae
    • Journal of Korean Neurosurgical Society
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    • v.63 no.5
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    • pp.539-549
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    • 2020
  • The efficacy of P2Y12 reaction unit (PRU) of VerifyNow still remains as a controversial issue in neurointervention. So we investigated the usefulness of PRU of VerifyNow to predict the peri-procedural thromboembolic events (TE) and hemorrhagic events (HE). And we evaluated the safety of modified dual antiplatelet therapy (DAPT) or triple antiplatelet therapy (TAPT) for clopidogrel hyporesponders. We searched MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials, Web of Science and Scopus on August 19 2018. Data was collected the 1) incidence of TE between clopidogrel responder and clopidogrel hypo-responder, 2) incidence of HE between clopidogrel hyper-responder and clopidogrel responder and hypo-responder, and 3) incidence of TE and HE between modified DAPT or TAPT and standard DAPT in clopidogrel hypo-responder. High cut-off value of PRU was defined as PRU >40% or <220. Fifteen studies were enrolled. Clopidogrel responder showed lower incidence of TE than hypo-responder (risk ratio [RR], 0.32; 95% confidence interval [CI], 0.17-0.61; p<0.001). With the high cut-off value of PRU, clopidogrel responder showed more lower incidence of TE than hypo-responder (RR, 0.11; 95% CI, 0.02-0.45; p=0.002). The incidence of periprocedural HE have higher on clopidogrel hyper-responder than clopidogrel responder and hypo-responder (RR, 4.26; 95% CI, 1.10-16.44; p=0.04; I2=66%). The incidence of periprocedural TE after changing regimen of DAPT for clopidogrel hypo-responder have a tendency to reduce, but there was no significant difference between modified DAPT or TAPT group and standard DAPT group (p>0.05). The incidence of periprocedural HE after changing regimen of DAPT for clopidogrel hypo-responder was no significant difference between modified DAPT or TAPT group and standard DAPT group (p>0.05). PRU is a useful tool as a predictor of peri-procedural TE or HE on neurointervention. PRU has a threshold effect of cut-off value to predict the peri-procedural TE. Modified DAPT or TAPT to prevent TE in clopidogrel hypo-responders could not reduce the incidence of TE. We should investigate the further research about modification of regiment on neurointervention.

Comparison of college students' behavior toward nutrition information communication between Korea and the US

  • Kim, Chang-Sik;Bosselman, Robert;Choi, Hyung-Min;Lee, Keum Sil;Kim, Eojina;Moon, Hyeyoung;Jang, Yoon Jung;Ham, Sunny
    • Nutrition Research and Practice
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    • v.14 no.4
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    • pp.401-411
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    • 2020
  • BACKGROUND/OBJECTIVES: The expansion of menu labeling to restaurants has created a need to study customers' behavior toward nutrition information. Therefore, the purpose of this research was to compare college students' behavior toward nutrition information communication between Korea and the US. This study consisted of three objectives: 1) to compare the frequency of usage as well as degree of trust regarding smartphone-based communication channels in the acquisition of nutrition information among college students between Korea and the US, 2) to compare knowledge-sharing behavior related to nutrition information among college students between Korea and the US, and 3) to identify the role of country in the process of knowledge-sharing behavior. SUBJECTS/METHODS: A survey was distributed via the web to college students in Korea and the US. Data were collected in the 2nd week of March 2017. Completed responses were collected from 423 Koreans and 280 Americans. Differences between Koreans and Americans were evaluated for statistical significance using a t-test. In order to verify the effects of knowledge self-efficacy and transactive memory capability on knowledge-sharing behavior related to nutrition information, a regression analysis was performed. RESULTS: Significant differences were found in the frequency of usage as well as degree of trust in communication channels related to nutrition information between Korean and American college students. While knowledge self-efficacy and tractive memory capability had positive effects on knowledge-sharing behavior related to nutrition information, country had a significant effect on the process. CONCLUSIONS: This study is the first to compare customer behavior toward nutrition information acquisition and sharing between Korea and the US. Comparative research on nutrition information revealed differences among the different countries. Therefore, this study contributes to the body of knowledge on the nutrition information research, in particular, by providing a comparison study between countries.

Toward an Evaluation Framework of Library Services: Re-examination of LibQUAL+TM (도서관 서비스 품질평가 도구로서 LibQUAL+TM에 대한 재평가)

  • Park, Ji-Hong
    • Journal of the Korean Society for information Management
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    • v.24 no.2
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    • pp.5-27
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    • 2007
  • While $LibQUAL+^{TM}$ is in the headlines of many articles focusing on library service evaluations, little research has been conducted to study the relationship between the $LibQUAL+^{TM}$ factors and the adoption of library services. It remains unclear whether the factors of $LibQUAL+^{TM}$ have any effect on its adoption. A framework was adapted from Icek Ajzen's theory of planned behavior and proposed to extract factors affecting the adoption of library services. The factors were examined via data collection from a Web-based questionnaire survey with college students in the United States. Factor analyses and multiple regression analysis were conducted. Findings show that the intention to use library services is explained by attitude toward library service quality. The attitudinal factors that are significant are (1) perceived personal control, (2) perceived affect of service, and (3) perceived comprehensiveness of information. The relative importance among the factors is also represented by the numbered sequence. However, perceived timeliness of information access and the perception of library as place do not have a significant effect on the intention. This study extends the research on library service evaluation, and provides a new evaluation framework by applying adoption behaviors.

A study on the operation status and effective management of mixed-age classes in kindergartens (유치원 혼합연령학급 운영 실태 및 개선 방안에 관한 연구)

  • Lee, JinWha;Eom, Ji-Won
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.17 no.12
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    • pp.253-261
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    • 2016
  • This study discusses the effective management of mixed-ages classes in kindergarten. For the study, 300 kindergarten teachers in charge of mixed classes for regular courses completed a self-reported questionnaire through a web survey. The data were analyzed by chi-square test and presented by frequency and percentage. Mixed-ages classes had relatively fewer children than one-age classes and they were prevalent in public kindergartens and rural areas. The results were as follows. First, mixed-ages classes were induced by the small number of young children. Second, teachers managed their classes with difficulty due to the lack of supporting staff and few chances for additional teaching training. Third, teachers needed supporting human resources for their teaching and administration assistances. About 23.0% of kindergartens received assistance such as additional training, financial assistance, and consulting supervision from related institutions. The study results suggested the challenges in regulations of age ratio in mixed-ages class, additional teaching training for teachers in mixed-ages classes and replacement of mixed-ages class to same age class as the long-term plan.

Mediating Effects of Relief from Fatigue through Sleep and Perceived Subjective Health in the Relationship between Perceived Stress and Subjective Happiness in Middle School Who Attempted Suicide (자살시도 중학생의 스트레스와 주관적 행복감 (주관적 건강인지와 잠으로 피로회복정도의 평행다중매개모델))

  • Wi, Ok-Youn;Lee, Ji-Hyun
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.19 no.4
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    • pp.229-238
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    • 2018
  • The purpose of this study is to examine the difference in the mediating effects of relief from fatigue through sleep and perceived subjective health in the relationship between perceived stress and subjective happiness in middle school students who attempted suicide. The analysis was conducted using Path analysis, the Bootstrapping method, Phantom variable and Multiple group analysis by AMOSS using the IBM SPSS 23 and IBM SPSS AMOS 23 programs with 820 middle school students who attempted suicide in the past 12 months using the raw data of the Korea Risk Behavior Web-Based Survey (2016). In the relationship between perceived stress and perceived subjective health, the indirect effect of relief from fatigue through sleep and perceived subjective health (${\beta}=-.12$, p=.003) was statistically significant. The difference in the magnitude of the two indirect effects was found to be greater for the subjective health status than for relief from fatigue through sleep (difference = .02, p=.028) and the effects were greater for the males (${\beta}=.44$, p <.001) than for the females (${\beta}=.23$, p<.001). Based on the findings, it is necessary to develop and apply an educational program that includes the factors that contribute to improving the happiness of middle school students.

Q Analyses of the Structure of Internet Bookstore Users' Subjectivity (인터넷 서점 이용자의 주관성에 관한 Q분석)

  • Jung Huyn-Wook;Kang Hye-Young;Kim Sun-nam
    • Journal of Korean Library and Information Science Society
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    • v.36 no.2
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    • pp.197-220
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    • 2005
  • This paper examined the structure of internet bookstore users' subjectivity by focusing on their beliefs, values and attitudes.0 methodology was utilized for the study. After constituting 36 Q sample and 28 P sample, data were collect from April 15, 2005 to April 22 2005. The analyses showed 3 types of subjectivity structures. The first one was 'the economic benefit-seeking type.' Those in this type were motivated to use internet bookstores to achieve economic benefits. They paid more attention to the Prices discounted than the web site contents provided by internet bookstores. This type was conspicuously found among college students. The second one was the 'information-seeking type.' People in this category made visits to internet bookstores in order to obtain new information or professional materials. This type was dominantly found among women. The third one was the 'convenience-seeking type.' Those in this type were concerned not only with the accessibility and convenience, but also with such practical issues as delivery, price, applicability, payment, and bonus. This type was conspicuously observed among white collar workers. These findings suggests that in order to make internet bookstores more attractive to users, it is demanded to understand various needs held by users and map out sophisticated marketing strategies on the basis of such a knowledge.

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A Study on Spam Document Classification Method using Characteristics of Keyword Repetition (단어 반복 특징을 이용한 스팸 문서 분류 방법에 관한 연구)

  • Lee, Seong-Jin;Baik, Jong-Bum;Han, Chung-Seok;Lee, Soo-Won
    • The KIPS Transactions:PartB
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    • v.18B no.5
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    • pp.315-324
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    • 2011
  • In Web environment, a flood of spam causes serious social problems such as personal information leak, monetary loss from fishing and distribution of harmful contents. Moreover, types and techniques of spam distribution which must be controlled are varying as days go by. The learning based spam classification method using Bag-of-Words model is the most widely used method until now. However, this method is vulnerable to anti-spam avoidance techniques, which recent spams commonly have, because it classifies spam documents utilizing only keyword occurrence information from classification model training process. In this paper, we propose a spam document detection method using a characteristic of repeating words occurring in spam documents as a solution of anti-spam avoidance techniques. Recently, most spam documents have a trend of repeating key phrases that are designed to spread, and this trend can be used as a measure in classifying spam documents. In this paper, we define six variables, which represent a characteristic of word repetition, and use those variables as a feature set for constructing a classification model. The effectiveness of proposed method is evaluated by an experiment with blog posts and E-mail data. The result of experiment shows that the proposed method outperforms other approaches.

A Clinical Analysis of Patients Who Visited Emergency Department due to Chemical Incident Occurred at Industrial Place: A Retrospective Study (산업장 화학 사고로 응급실에 내원한 환자의 임상적 고찰: 일개병원의 후향적 연구)

  • Shin, Hee Jun;Oh, Se Kwang;Yoo, Byeong Dai;Jun, Duck Ho;Lee, Dong Ha;Woo, Kuck Hyeun;Yoon, Seong Yong;Choi, Sung Yong
    • Journal of The Korean Society of Clinical Toxicology
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    • v.13 no.2
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    • pp.78-86
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    • 2015
  • Purpose: The purpose of this study is to understand what kinds of chemical substances have been used annually and to investigate incidents that occurred due to chemical hazard release and to analyze statistically clinically chemical injury patients who visited one regional emergency medical center in Gumi city with documented references review. Methods: Annual chemical waste emission quantity (Kg/Year) (Cwep) was reproduced using national web site data governed by the Ministry of Environment and 5 years (from 1 .Jan. 2010 to 31. Dec. 2014) of medical records of chemical injury patients who visited our emergency department were reviewed retrospectively. By applying exclusion criteria, 446 patients of 460 patients were selected. Results: Dichloromethane, Toluene, Trichloroethylene, and Xylene were always included within Top 5 of Cweq. Six cases of chemical incidents were reported and in 3 of 6 cases involving Hydrogen fluoride were included during the study period. Male gender and twenties were the most prevalent group. Injury evoking chemicals were Hydrogen fluoride, unknown, complex chemicals (over 2 substances) in sequence. The most frequent site of wounds and injuries was the respiratory tract. Gas among status, intoxication among diagnosis, and discharge among disposition was most numerous in each group. Conclusion: There have been no uniform clinical protocols for chemical wounds and injuries due to various kinds of chemicophysical properties and ignorance of antidotes. Therefore conduct of a multicenter cohort study and experiments for ruling out chemicals according to chemicophysical priority as well as development of antidotes and clinical protocols for chemical injury patients is needed.

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Development of Spatial Landslide Information System and Application of Spatial Landslide Information (산사태 공간 정보시스템 개발 및 산사태 공간 정보의 활용)

  • 이사로;김윤종;민경덕
    • Spatial Information Research
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    • v.8 no.1
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    • pp.141-153
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    • 2000
  • The purpose of this study is to develop and apply spatial landslide information system using Geographic information system (GIS) in concerned with spatial data. Landslide locations detected from interpretation of aerial photo and field survey, and topographic , soil , forest , and geological maps of the study area, Yongin were collected and constructed into spatial database using GIS. As landslide occurrence factors, slope, aspect and curvature of topography were calculated from the topographic database. Texture, material, drainage and effective thickness of soil were extracted from the soil database, and type, age, diameter and density of wood were extracted from the forest database. Lithology was extracted from the geological database, and land use was classified from the Landsat TM satellite image. In addition, landslide damageable objects such as building, road, rail and other facility were extracted from the topographic database. Landslide susceptibility was analyzed using the landslide occurrence factors by probability, logistic regression and neural network methods. The spatial landslide information system was developed to retrieve the constructed GIS database and landslide susceptibility . The system was developed using Arc View script language(Avenue), and consisted of pull-down and icon menus for easy use. Also, the constructed database can be retrieved through Internet World Wide Web (WWW) using Internet GIS technology.

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An Empirical Study on the Relationship Between Firm Characteristics, Financial Security Indices, and Financial Profit Indices of Korean Private Venture Capital Firms (창업투자회사의 특성과 재무안정성 및 수익성지표 간의 관계에 대한 실증적 연구)

  • Lee, Joo-Heon;Kim, Sung-Min
    • Korean Business Review
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    • v.19 no.1
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    • pp.157-174
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    • 2006
  • In the past, because Korean private venture capital firms could get government support and subsidies, they could be survived in the market without having required management capabilities, advanced venture investment techniques, and professional supporting agencies and institutions. However, business environments have changed a lot recently. Now, only through identifying the optimal financial structures(the ratio of debt to equity), Korean private venture capital firms can minimize investment risks and ensure higher profits. Since Modigliani and Miller(1958) criticized the existence of the optimal financial structure, there have been numerous studies on the optimal financial structure of firms. However, there is no empirical study investigating the financial structure of venture capital firms. The purpose of this article is to analyze the relationship between firm characteristics, financial security indies, and financial profit indices of korean private venture capital firms. We gathered the data from various sources, including the web pages and the financial statements for 2003 and 2004. By using the student's t-test and the correlation analysis, we showed that there are differences in the current ratio and the ratio of net profit to net sales between new and old korean private venture capital firms. Even though it is known that korean private venture capital firms does not have enough knowledge and investment technique to compete with global venture capital firms, our result show that old korean private venture capital firms have already built some knowledge and understanding of venture capital investing.

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