• Journal of Plant Biotechnology
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• v.33 no.3
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• pp.195-207
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• 2006

Stem cells are the primordial, initial cells which usually divide asymmetrically giving rise to on the one hand self-renewals and on the other hand progenitor cells with potential for differentiation. Zygote (fertilized egg), with totipotency, deserves the top-ranking stem cell - he totipotent stem cell (TSC). Both the ICM (inner cell mass) taken from the 6 days-old human blastocyst and ESC (embryonic stem cell) derived from the in vitro cultured ICM have slightly less potency for differentiation than the zygote, and are termed pluripotent stem cells. Stem cells in the tissues and organs of fetus, infant, and adult have highly reduced potency and committed to produce only progenitor cells for particular tissues. These tissue-specific stem cells are called multipotent stem cells. These tissue-specific/committed multipotent stem cells, when placed in altered environment other than their original niche, can yield cells characteristic of the altered environment. These findings are certainly of potential interest from the clinical, therapeutic perspective. The controversial terminology 'somatic stem cell plasticity' coined by the stem cell community seems to have been proved true. Followings are some of the recent knowledges related to the stem cell. Just as the tissues of our body have their own multipotent stem cells, cancerous tumor has undifferentiated cells known as cancer stem cell (CSC). Each time CSC cleaves, it makes two daughter cells with different fate. One is endowed with immortality, the remarkable ability to divide indefinitely, while the other progeny cell divides occasionally but lives forever. In the cancer tumor, CSC is minority being as few as 3-5% of the tumor mass but it is the culprit behind the tumor-malignancy, metastasis, and recurrence of cancer. CSC is like a master print. As long as the original exists, copies can be made and the disease can persist. If the CSC is destroyed, cancer tumor can't grow. In the decades-long cancer therapy, efforts were focused on the reducing of the bulk of cancerous growth. How cancer therapy is changing to destroy the origin of tumor, the CSC. The next generation of treatments should be to recognize and target the root cause of cancerous growth, the CSC, rather than the reducing of the bulk of tumor, Now the strategy is to find a way to identify and isolate the stem cells. The surfaces of normal as well as the cancer stem cells are studded with proteins. In leukaemia stem cell, for example, protein CD 34 is identified. In the new treatment of cancer disease it is needed to look for protein unique to the CSC. Blocking the stem cell's source of nutrients might be another effective strategy. The mystery of sternness of stem cells has begun to be deciphered. ESC can replicate indefinitely and yet retains the potential to turn into any kind of differentiated cells. Polycomb group protein such as Suz 12 repress most of the regulatory genes which, activated, are turned to be developmental genes. These protein molecules keep the ESC in an undifferentiated state. Many of the regulator genes silenced by polycomb proteins are also occupied by such ESC transcription factors as Oct 4, Sox 2, and Nanog. Both polycomb and transcription factor proteins seem to cooperate to keep the ESC in an undifferentiated state, pluripotent, and self-renewable. A normal prion protein (PrP) is found throughout the body from blood to the brain. Prion diseases such as mad cow disease (bovine spongiform encephalopathy) are caused when a normal prion protein misfolds to give rise to PrP$^{SC}$ and assault brain tissue. Why has human body kept such a deadly and enigmatic protein? Although our body has preserved the prion protein, prion diseases are of rare occurrence. Deadly prion diseases have been intensively studied, but normal prion problems are not. Very few facts on the benefit of prion proteins have been known so far. It was found that PrP was hugely expressed on the stem cell surface of bone marrow and on the cells of neural progenitor, PrP seems to have some function in cell maturation and facilitate the division of stem cells and their self-renewal. PrP also might help guide the decision of neural progenitor cell to become a neuron.

• Journal of KIISE:Information Networking
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• v.29 no.5
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• pp.573-582
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• 2002

We propose centralized server based QoS routing schemes, where a route server is responsible for determining QoS paths on behalf of all the routers in a routing domain. In the proposed server based schemes, the dynamic link QoS state information, which is required for a QoS path computation, is implicitly maintained at route server as it assigns or gets back QoS paths. By maintaining the network state information this way, we may not only eliminate the overhead to exchange network state update message but also achieve higher routing performance by utilizing accurate network state information in path computation. We discuss path caching techniques for reducing the amount of path computation overhead at the route server, and evaluate the performance of the proposed schemes using simulation. The simulation results show that the path caching schemes may significantly reduce the route server load. The proposed schemes are also compared to the distributed QoS routing schemes proposed in the literature. It has been shown that the proposed server based schemes not only enhance the routing performance, but they are also competitive with respect to routing overheads.

• Journal of Yeungnam Medical Science
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• v.11 no.2
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• pp.270-276
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• 1994

To evaluate the effect of a new topical anesthetic cream (EMLA: Eutectic mixture of local anesthetics) on reducing pain associated with DPT vaccination, we conducted a clinical observation on eighty infants who were brought to well baby clinic of Yeungnam University Hospital for DPT vaccination. 80 Infants, who were between 2 months and 8 months in age, were divided into two groups. EMLA treated group and control group. Male to femle sex ratio was 1.4 to 1. EMLA cream was applied 60 minutes before DPT vaccination, the effect of reducing pain was assessed by using McGrath's face scale, Oucher pain scale and modified behavioral pain scale (MBPS) and also evaluated by measuring the duration and time of crying (the time of the first crying after injection, duration of the first crying, total duration of crying). The scores of those scales were lower in EMLA treated group than in control group significantly (P(0.01 in McGrath's face scale, MBPS and p<0.05 in Oucher pain scale). There was no difference in the time of the first crying after vaccination in both groups. The duration of the first crying was shorter in EMLA treated group than control group of crying was also shorter in EMLA treated group (EMLA treated group $9.0{\pm}6.0$ sec, control group $21.9{\pm}12.5$ sec, p<0.05). Transient skin erythema was noted in 5 infants after EMLA application, but no other adverse effects were observed. We conclude that the application of EMLA cream before vaccination seems to be an effective and safe way to reduce the pain from vaccination, but it takes usually 60 minutes to get the anesthetic effect of EMLA and it is expensive, so EMLA cream can not be recommended in routine vaccination in infants now.

• Restorative Dentistry and Endodontics
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• v.31 no.6
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• pp.477-484
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• 2006

The purposes of this study were to compare the apical terminus width of simulated curved root canal prepared with three NiTi file systems used by undergraduates for evaluation the effects of flute angle and pitch or radial land on reducing screw-in effect and to determine more safe NiTi file system for inexperienced operators. Fifty inexperienced undergraduate students prepared 150 simulated curved root canals in resin blocks with three NiTi file systems ; ProFile$^{(R)}$, Hero Shaper$^{(R)}$, K3$^{TM}$. The electric motor set at a speed of 300 rpm and torque of 30 in a 16 : 1 reduction handpiece was used. The simulated root canal was prepared to ISO #25 sizes with each file system. The scanned images of pre- and post-instrumented canal of resin block were superimposed. To evaluate the screw-in effect of three NiTi file systems, apical terminus width of root canal was measured from superimposed images and statistical analysis was performed. There were significant differences in three NiTi flle systems. ProFile$^{(R)}$ had significantly smaller width than Hero Shaper$^{(R)}$ and K3$^{TM}$"" (P < 0.05), but no significant difference was observed between K3$^{TM}$ and Hero Shaper$^{(R)}$. Under the condition of this study, active file system (Hero SHaper$^{(R)}$, K3$^{TM}$) with variable pitch and helical angle had more screw-in effect than passive file system (ProFile$^{(R)}$) with constant pitch and helical angle. It seems that the radial lands play more important role in reducing screw-in effect.

• Journal of The Korean Association of Information Education
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• v.24 no.2
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• pp.177-188
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• 2020

The purpose of this study was to examine the relationship between techno-stress perceived by elementary school teachers and related variables in a flipped learning environment. To achieve the purpose, the following research question have been established: First, what is the difference between techno-stress perceived by elementary school teachers? Second, what is the difference between techno-stress related variables perceived by elementary school teachers? Third, how do the TPACK, teacher effectiveness, and school environment support, perceived by elementary school teachers, affect technostress? 207 teachers at elementary school responded on a questionnaire to measure their perceived techno-stress, TPACK, teacher efficacy, and school environment support. Data were analyzed with using independent two-sample t-test, one-way ANOVA, and multiple regression analysis. The results were as follows: First, the elementary school teachers working on a leading school perceived higher techno-overload and techno-complexity more than those in ordinary school. Second, the elementary school teachers showed differences in the perception of TPACK, teacher efficacy, and school environment support according to the teacher's career, and leading school. Third, the elementary schools teachers perceived in TK, TCK, TPACK, educational support, and technology have a positive affect with techno-stress. The results are significant in that they provided data for reducing techno-stress of elementary school teachers in a flipped learning environment.

• Journal of KIISE:Databases
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• v.31 no.6
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• pp.567-584
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• 2004

As XML becomes popular as the way of presenting information on the web, how to secure XML data becomes an important issue. So far study on XML security has focused on security of data communications by using digital sign or encryption technology. But, it now requires not just to communicate secure XML data on communication but also to manage query process to access XML data since XML data becomes more complicated and bigger. We can manage XML data queries by access control technique. Right now current XML data access control only deals with read operation. This approach has no option to process update XML queries. In this paper, we present XML access control model and technique that can support both read and update operations. In this paper, we will propose the operation for XML document update. Also, We will define action type as a new concept to manage authorization information and process update queries. It results in both minimizing access control steps and reducing memory cost. In addition, we can filter queries that have no access rights at the XML data, which it can reduce unnecessary tasks for processing unauthorized query. As a result of the performance evaluation, we show our access control model is proved to be better than other access control model in update query. But it has a little overhead to decide action type in select query.

• The KIPS Transactions:PartC
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• v.15C no.1
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• pp.37-44
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• 2008

In order to minimize the signaling delay for a resource reservation on the new routing path after the handover of Mobile Node(MN) is completed, it is important to discover the crossover node where the old and new routing paths meet. With the 크로스오버 노드 being found, the signaling messages only need to be transferred on the changed part of the end-to-end path. The crossover node is generally discovered using the end-to-end Session ID(SID) of the established session between MN and Correspondent Node(CN). However, in the Hierarchical Mobile IPv6(HMIPv6) network, if the Mobile Anchor Point (MAP) reserves the resource by aggregate with the Home Agent(HA), the crossover node discovery cannot be performed in the general way since the aggregate SID that has established between the previous MAP and HA is different from the that of the current MAP and HA after MN's handover. In this paper, we propose a mechanism to discover the crossover node within the tunnel between the MAP and the HA in an HMIPv6 network, assuming that the Next Steps in Signaling(NSIS) is deployed for the resource reservation and the aggregate reservation is applied over the MAP and HA tunnel. The local repair required for the change of path is performed upon the crossover node discovery. The simulation results show that the proposed scheme reduces the signaling delay for the reservation and outperforms the existing scheme with respect to throughput during the handover.

• The KIPS Transactions:PartB
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• v.14B no.2
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• pp.65-70
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• 2007

Red tide is becoming hot issue of environmental problem worldwide since the 1990. Advanced nations, are progressing study that detect red tide area on early time using satellite for sea. But, our country most seashores bends serious. Also because there are a lot of turbid method streams on coast, hard to detect small red tide area by satellite for sea that is low resolution. Also, method by sea color that use one feature of satellite image for sea of existent red tide area detection was most. In this way, have a few feature in image with sea color and it can cause false negative mistake that detect red tide area. Therefore, in this paper, acquired texture information to use GLCM(Gray Level Co occurrence Matrix)'s texture 6 information about high definition land satellite south Coast image. Removed needless component reducing dimension through principal component analysis from this information. And changed into 2 principal component accumulation images, Experiment result 2 principal component conversion accumulation image's eigenvalues were 94.6%. When component with red tide area that uses only sea color image and all principal component image. displayed more correct result. And divided as quantitative,, it compares with turbid stream and the sea that red tide does not exist using statistical feature analysis about texture.

• KIPS Transactions on Computer and Communication Systems
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• v.6 no.9
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• pp.377-384
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• 2017

The performance improvement of a single core processor has reached its limit since the circuit density cannot be increased any longer due to overheating. Therefore, the multicore and manycore architectures have emerged as viable approaches and parallel programming becomes more important. Haskell, a purely functional language, is getting popular in this situation since it naturally supports parallel programming owing to its beneficial features including the implicit parallelism in evaluating expressions and the monadic tools supporting parallel constructs. However, the performance of Haskell parallel programs is strongly influenced by the performance of the run-time system including the garbage collector. Though a memory profiling tool namely GC-tune has been suggested, we need a more systematic way to use this tool. Since GC-tune finds the optimal memory size by executing the target program with all the different possible GC options, the GC-tuning time takes too long. This paper suggests a basic divide-and-conquer method to reduce the number of GC-tune executions by reducing the search area by one-quarter for every searching step. Applying this method to two parallel programs, a maximally independent set and a K-means programs, the memory tuning time is reduced by 7.78 times with accuracy 98% on average.

• Journal of Distribution Research
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• v.6 no.2
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• pp.1-17
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• 2002

The recent dot-com craze has been one of the main causes that accelerated the growth of internet-related companies in diversity as well as in size. Meanwhile, the domestic market of supplies and equipment for internet businesses has been dominated by major foreign companies. To regain their market positions, the domestic manufacturers had to find the way to build up their competitive advantages, such as meeting their customers needs and reducing overall costs. In this study, one domestic PC server manufacturer, which competes fiercely with foreign manufacturers for the top place, has been chosen as a model to evaluate its current supply chain and to find an area that can be improved for a better performance. System Dynamics is used throughout the study. The central concept to system dynamics is understanding how all the objects in a system interact with one another. It focuses on feedback and secondary effects to think through how a strategy might or might not work, depending on how organizational changes are received, and what kinds of consequences emerge. Then, computerized models were built for simulations, each with different conditions, and, finally, the results were evaluated based on some criteria which are considered to be important and meaningful. The inefficiency that exists in the supply chain was proved to be a thirty-day long purchasing order leadtime, and it was expected that more effective supply chain could be formed if the leadtme were reduced to 14 days or 7 days. The results of simulations showed that the overall expected costs in supply chain was the least with the purchasing leadtime being 7 days. The lower average number of parts held as inventory, along with the reduced lost sales, acted as the factor reducing the expected overall costs. Although there was a slight increase in the average number of final products held as inventory and the total ordering cost, the benefits from lower parts inventory and reduced lost sales were large enough to justify the overall cost reduction.