• Journal of Pharmaceutical Investigation
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• v.36 no.3
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• pp.185-192
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• 2006

The purpose of this study was to determine the effects of iontophoresis on transdermal delivery of procaine hydrochloride in healthy volunteers, as well as to the synergic effect of high voltage current or ultrasound on the efficacy of transdermal delivery of iontophoresis. Forty healthy volunteers were randomly assigned to four groups topical application group (TA), iontophoresis group (IT), pre-treatment of high voltage current stimulation with iontophoresis (HVS + IT), and pre-treatment of ultrasound application with iontophoresis (US + IT). All subjects received procaine iontophoresis on the forearm using direct current with 4 mA f3r 15 minutes. All subject was measured the duration of local anesthesia, pressure pain threshold, pain perception threshold using rectangular wave at 0.2 ms, 1 ms, 50 ms of rectangular current stimulation after procaine iontophoresis. For comparisons of the sensory characteristics and efficacy of iontophoresis between the groups, an one-way ANOVA and Kruskal-Wallis were used. The significant difference the duration of local anesthesia were found between the groups (p<0.001). The local anesthetic duration of IT, HVS+IT were significantly longer than TA. Meanwhile, the local anesthetic duration of US+IT was significantly longer than HVS+IT, IT and TA group (p<0.05). Also, the pressure pain threshold, pain perception threshold at 0.2 ms, 1 ms, 50 ms were significant difference between the groups (p<0.001). All sensory characteristics including pressure pain threshold, pain perception threshold of IT, HVS+IT was significantly increased than TA, whereas, US+1T was significantly increased HVS+1T, IT and TA (p<0.05). This study showed that the procaine iontophoresis have increase the duration of local anesthesia concomitantly pressure pain threshold and pain perception threshold of sensory nerve fibers such as $A-{\beta}$, $A-{\delta}$ and C fiber. This findings suggest that the iontophoresis enhanced the transdermal delivery of drug ions in vivo. The combination of ultrasound application and iontophoresis synergized the transdermal delivery of drug ions. It is suggests that an electric field, mechanical and heating property of ultrasound may contribute to synergic effect due to temporary changes of structure in the stratum corneum.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.5
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• pp.426-431
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• 2018

This study examines exchange rate volatility spillovers that affect the exchange rate volatility of Korean currency. For this study, the Japanese yen, British pound, Euro, and Canadian dollar are used as the currencies of developed countries, and the Thai baht, Indonesian rupiah, Singapore dollar, and Australian dollar are used as the currencies of the areas near Korea. The GARCH(1.1) model is employed for weekly data covering the period from January 2009 to December 2017. This study finds that the volatility spillovers from the Canadian dollar, Singapore dollar, and Australian dollar to the Korean won are significant, while the volatility spillovers from the Japanese yen, British pound, Euro, Thai baht, and Indonesian rupiah to the Korean won are insignificant. In terms of the economic system and structure, Japan, Britain, and European countries are at a higher level than Korea, while Thailand and Indonesia are at a lower level than Korea. Canada, Singapore, and Australia are almost at the same level as Korea. Therefore, these results appear to be derived from the phenomenon of exchange rate spillovers among countries with a similar economic system and structures, and contradict the literature, which has argued that exchange rates volatility spillovers occur among countries that are in the same area geographically.

• Journal of Korean Tunnelling and Underground Space Association
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• v.6 no.4
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• pp.327-343
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• 2004

During tunnel construction, ground failures often occur due to existence of weak zones, such as faults, joints, and cavities, ahead of tunnel face. It is hard to detect effectively weak zones, which can lead underground structure to fail after excavation and before supporting, by using conventional characterization methods. In this study, an enhanced analytical method of predicting weak zones ahead of tunnel face is developed to overcome some problems in the conventional geophysical exploration methods. The analytical method is based on Coulomb's and Gauss' laws with considering the characteristics of electric fields subjected to rock mass. Using the developed method, closed form solutions are obtained to detect a spherical shaped zone and an oriented fault ahead of tunnel face respectively. The analytical results suggest that the presence of weak zones and their sizes, location, and states can be accurately predicted by combining a proper inversion process with resistance measured from several electrodes on the tunnel face. It appears that the skin depth or resistivity in rock mass is affected by the diameter of tunnel face, natural electric potential and noises induced by experimental measurement and spatial distribution of uncertain properties. The developed analytical solution is verified through experimental tests. About 1800 concrete blocks of 5cm by 5cm by 5cm in size are prepared and used to model a joint rock mass around tunnel face. Weak zones are simulated ahead of tunnel face with a material which has relatively higher conductivity than concrete blocks. Experimental results on the model test show a good agreement with analytical results.

• Journal of Korean Tunnelling and Underground Space Association
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• v.18 no.2
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• pp.119-128
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• 2016

In a performance-based design, the structural safety is estimated from pre-defined damage states and corresponding damage indices. Both damage states and damage indices are well defined for above-ground structures, but very limited studies have been performed on underground structures. In this study, we define the damage states and damage indices of a cut-and-cover box tunnel which is one of typical structures used in metro systems, under a seismic excitation from a series of inelastic frame analyses. Three damage states are defined in terms of the number of plastic hinges that develop within the structure. The damage index is defined as the ratio of the elastic moment to the yield moment. Through use of the proposed index, the inelastic behavior and failure mechanism of box tunnels can be simulated and predicted through elastic analysis. In addition, the damage indices are linked to free-field shear strains. Because the free-field shear strain can be easily calculated from a 1D site response analysis, the proposed method can be readily used in practice. Further studies are needed to determine the range of shear strains and associated uncertainties for various types of tunnels and site profiles. However, the inter-linked platform of damage state - damage index - shear wave velocity - shear strain provides a novel approach for estimating the inelastic response of tunnels, and can be widely used in practice for seismic designs.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.26 no.2
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• pp.182-197
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• 1993

Algal community on the subtidal rocky zone of the South Sea of Korea was divided into two or three sequencing zones. The upper subtidal zone was characterized by the wave exposure-tolerant surf wrack(Pachymeniopsis, Gigartina), which formed dense swirling carpet. Its vertical range was from the surface to $3{\sim}5$ meters in depth, and more deeply extended in turbid waters including Sorido, Yokchido, Pijindo, Manjedo. The mid subtidal zone ranging from 5 to 25 meters in depth was characterized by a large brown algal forest (Ecklenia, Sargassum). But it was generally unrecognizable in that turbid waters, in which the vertical limit of vegetation was at most $10{\sim}15$ meters in depth. The low subtidal zone was characterized by a general lack of algal species and was not easily distinguished from the mid or sometimes from the upper zone. There was a distinct difference in abundance of vegetation between turbid waters and clear waters including Munsom, Kwantaldo, Yosodo, Hongdo, Ch'ujado. In turbid waters the vegetation was much poorer because the tubidity caused from the muddy sediment inhibited an algae to settle down and to grow up. On the basis of the phytogeographical methods using UPGMA, the 10 studied islands were classified into two groups, Munsom and the others. This floristic discontinuity between the two groups might be caused from the difference of water temperature.

• Journal of the Korean Geophysical Society
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• v.6 no.3
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• pp.139-153
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• 2003

Subsurface information is one of the most important factors in the archaeological excavation. To obtain the information on the underground, geophysical prospecting is becoming a popular method. This study is on the small rocky islands located 200m away from the shoreline of Gampo, Gyeongju city, Korea. According to the historical records and field surveys, it was revealed as the tomb of King Munmu of Shilla Dynasty. However, the questions and debates, such as whether it is really the tomb of King Moonmu or not, and whether it is a buried place or not, are still remains, in addition to the incompletion of precise surveying and scientific studies. The scope of this study contains the researches on the above problems and debates using the geophysical and geological methods and techniques. The rocky islands around the submerged Tomb of King Moonmu is composed of granite, and sag exists inside of the islands. Sea water enters through the east groove by wave and is drained to the west slot by hydraulic gradient, since west slot is 15cm lower than the east. Sag inside of the islands is believed to be extended and widened from pre-existed sinkage by applying tools like chisel in the joints and cracks. It is concluded that the submerged megalith inside of sag was from the rock block which was developed by joints. Geophysical surveys reveal that there is no artificial structure or stone/china/steel chest, under the m egalith and rocky island. Researches show that the tomb of King Moonmu was constructed in the small rocky island artificially. However, the evidences show that planners and constructors of the tomb made every possible effort to preserve the natural environment and condition. It is strongly believed that the megalith was sort of alter to sprinkle bone-ash rather than buried place.

• Geophysics and Geophysical Exploration
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• v.9 no.1
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• pp.73-85
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• 2006

Array observations of the vertical component of microtremors are frequently conducted to estimate a subsurface layered-earth structure on the assumption that microtremors consist predominantly of the fundamental mode Rayleigh waves. As a useful tool in the data collection, processing and analysis, the spatial autocorrelation (SPAC) method is widely used, which in practice requires a circle array consisting of M circumferential stations and one centre station (called "M-station circle array", where M is the number of stations). The present paper considers the minimum number of stations required for a circle array for efficient data collection in terms of analytical efficacy and field effort. This study first rearranges the theoretical background of the SPAC algorithm, in which the SPAC coefficient for a circle array with M infinite is solely expressed as the Bessel function, $J_0(rk)$ (r is the radius and k the wavenumber). Secondly, the SPAC coefficient including error terms independent of the microtremor energy field for an M-station circle array is analytically derived within a constraint for the wave direction across the array, and is numerically evaluated in respect of these error terms. The main results of the evaluation are: 1) that the 3-station circle array when compared with other 4-, 5-, and 9-station arrays is the most efficient and favourable for observation of microtremors if the SPAC coefficients are used up to a frequency at which the coefficient takes the first minimum value, and 2) that the Nyquist wavenumber is the most influential factor that determines the upper limit of the frequency range up to which the valid SPAC coefficient can be estimated.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.41 no.10
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• pp.109-117
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• 2004

In this paper, a K-band local oscillator composed of a VCDRO(Voltage Controlled Dielectric Resonator Oscillator), GaAs MESFET, and Reflector type frequency doubler has been designed and fabricated. TO obtain a good phase noise performance of a VCDRO, a active device was selected with a low noise figure and a low flicker noise MESFET and a dielectric resonator was used for selecting stable and high oscillation frequency. Especially, to have a higher conversion gain than a conventional doubler as well as a good harmonic suppression performance with circuit size reduced a doubler structure was employed as the Reflector type composed of a reflector and a open stub of quarter wave length for rejecting the unwanted harmonics. The measured results of fabricated oscillator show that the output power was 5.8 dBm at center frequency 12.05 GHz and harmonic suppression -37.98 dBc, Phase noise -114 dBc at 100 KHz offset frequency, respectively, and measured results show of fabricated frequency doubler, the output power at 5.8 dBm of input power is 1.755 dBm conversion gain 1.482 dB, harmonic suppression -33.09 dBc, phase noise -98.23 dBc at 100 KHz offset frequency, respectively. This oscillator could be available to a local oscillator in K-band which used frequency doubler techniques.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.14 no.7
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• pp.750-755
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• 2003

This paper proposes a new three-line balun. The equivalent circuit of the proposed three-line balun is presented, and impedance matrix［Z］of the equivalent circuit is derived from the relationship between the current and voltage at each port. The design equation for a given set of balun impedance at input and output ports is presented using［S］parameters, which is transferred fom impedance matrix,［Z］. To demonstrate the feasibility and validity of design equation, multi-layer ceramic(MLC) chip balun operated in the 2.4 GHz ISM band frequency is designed and fabricated by the use of the low temperature co-fired ceramic(LTCC) technology. By employing both the proposed new three-line balun equivalent circuit and multi-layer configuration provided by LTCC technology, the 2012 size MLC balun is realized. Measured results of the multi-layer LTCC three-line balun match well with the full-wave electromagnetic simulation results, and measured in band-phase and amplitude balances over a wide bandwidth are excellent. This proposed balun is very easily applicable to multi-layer structure using LTCC as shown in the paper, and also can be realized with microstrip lines on PCB. This distinctive performance is very favorable for wireless communication systems such as wireless LAN(Local Area Network) and Bluetooth applications.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.24 no.4
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• pp.366-373
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• 2013

This paper discusses the singly curved phased reflector for reduced RCS pattern, which has minimized RCS level at boresight with a null by phase cancelation and the lowered RCS level of main beam by splitting the main beam into multi directions. Considering the reduced level of boresight and main beam compared to the same sized reference PEC, this proposed multi-beam reflector can be adopted in the mono-static radar and the bi-static radar environment. The proposed reflector is a multi-beam reflector, which has different phase distributions at each row for different steering angle. It is designed through an intermediate stage of a single and dual-beam reflector. The behaviors of the designed reflectors are verified through full-wave simulation and experiment. The reflectors are designed in the frequency of 10 GHz and it has a size $240{\times}180mm^2$($8{\times}6\;{\lambda}^2$) with the curvature k=3.3. From the measured results, the proposed reflectors reduce the reflected power by 17 dB at boresight.