• 한국수자원학회논문집
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• 제50권12호
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• pp.889-896
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• 2017

본 연구에서는 무심천 유역을 대상으로 지표수-지하수 통합해석 모형인 SWAT-MODFLOW를 이용하여 수량이 부족한 하천으로 지하수를 이용한 물공급 방안을 모색하였다. 2011년부터 2015년까지 다양한 모의실험을 수행한 결과 극한가뭄이 도래했던 2015년에 지하수 공급에 의한 월 유출량의 변화는 현 양수시 23%, 최대 양수시에는 68.3%의 증가를 나타냈다. 이를 연간 지하수 함양량으로 산정할 경우 현 이용량을 적용하면 연평균 강수량의 6.2%인 75 mm, 최대 이용량 적용시 연평균 강수량의 24%인 290 mm에 해당하여 연간 안정적인 공급이 가능한 것으로 나타났다. 본 연구는 가뭄에 취약한 지표수자원과 달리 지하수는 하천수 부족시 물공급의 효과적인 대안이 될 수 있을 것으로 판단된다.

• 환경위생공학
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• 제5권1호
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• pp.1.2-6
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• 1990

사탕무우 품종 Mirabo를 공시하여 수경과 포양실험을 통하여 나타는 B결핍증 식물체의 해부학적 및 전현적 관찰을 하였다. B결핍증에 걸린 사탕무우에 있어서는 수경또는 포양에서 다 같이 B함량이 매우 적었다. B결핍증의 증상진행은 우선 엽병의 표면쪽 기부에 흑갈색 줄이 나타나기 시작하였으며, 그 후 유엽록과 생장점 근처가 검게 괴사하였고, 엽신이 심하게 오그라졌으며, 생장이 거의 정지되었다. 나중에는 표면쪽 엽병 기부의 표피와 그 밑의 유조직이 괴사하였다. 그리고 유엽록 조직의 괴사와 붕괴는 점차 확대되어 갔다. B결핍증을 나타낸 사탕무우의 전현적 관찰에서는 그와 같은 식물의 엽록체는 붕괴하기 시작하였으며 다량의 전분과 Osmophilic granules가 보였다. 그리고 특히 어떤 엽록체 안에는 격자를 가진 다면체의 결정체가 발견되었다.

• Toxicological Research
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• 제31권1호
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• pp.17-23
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• 2015

Excessive manganese (Mn) in the brain promotes a variety of abnormal behaviors, including memory deficits, decreased motor skills and psychotic behavior resembling Parkinson's disease. Hereditary hemochromatosis (HH) is a prevalent genetic iron overload disorder worldwide. Dysfunction in HFE gene is the major cause of HH. Our previous study has demonstrated that olfactory Mn uptake is altered by HFE deficiency, suggesting that loss of HFE function could alter manganese-associated neurotoxicity. To test this hypothesis, Hfe-knockout ($Hfe^{-/-}$) and wild-type ($Hfe^{+/+}$) mice were intranasally-instilled with manganese chloride ($MnCl_2$ 5 mg/kg) or water daily for 3 weeks and examined for memory function. Olfactory Mn diminished both short-term recognition and spatial memory in $Hfe^{+/+}$ mice, as examined by novel object recognition task and Barnes maze test, respectively. Interestingly, $Hfe^{-/-}$ mice did not show impaired recognition memory caused by Mn exposure, suggesting a potential protective effect of Hfe deficiency against Mn-induced memory deficits. Since many of the neurotoxic effects of manganese are thought to result from increased oxidative stress, we quantified activities of anti-oxidant enzymes in the prefrontal cortex (PFC). Mn instillation decreased superoxide dismutase 1 (SOD1) activity in $Hfe^{+/+}$ mice, but not in $Hfe^{-/-}$ mice. In addition, Hfe deficiency up-regulated SOD1 and glutathione peroxidase activities. These results suggest a beneficial role of Hfe deficiency in attenuating Mn-induced oxidative stress in the PFC. Furthermore, Mn exposure reduced nicotinic acetylcholine receptor levels in the PFC, indicating that blunted acetylcholine signaling could contribute to impaired memory associated with intranasal manganese. Together, our model suggests that disrupted cholinergic system in the brain is involved in airborne Mn-induced memory deficits and loss of HFE function could in part prevent memory loss via a potential up-regulation of anti-oxidant enzymes in the PFC.

• 한방안이비인후피부과학회지
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• 제22권1호
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• pp.120-132
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• 2009

Objective : Yukmijihwang-tang is one of the important medicines for blood- deficiency and yin-deficiency. Atopic dermatitis usually shows dampness-heat pattern in its acute stage and blood-deficiency or yin-deficiency pattern in its chronic stage. Therefore, I hypothesized that Yukmijihwang-tang is effective on atopic dermatitis and investigated the effects of Yukmijihwang-tang on NC/Nga mice's atopic dermatitis induced by DNCB. Methods : The NC/Nga mice with atopic dermatitis were divided into four groups: three experimental groups and one control group. The experimental groups were respectively put on 2.5g(YM-2.5), 5g(YM-5) and 10g(YM-10) of Yukmijihwang-tang extract per their weight once a day for 10 days while the control group was fed normal saline. After 10 days, I measured TEWL(transepidermal water loss), observed scratching behaviors, conducted a skin biopsy and checked levels of Total IgE, IL-4 and $IFN-\gamma$ on NC/Nga mice. Results : 1. Yukmijihwang-tang significantly suppressed skin dryness. In particular, YM-5 and YM-10 had better skin hydration than YM-2.5. 2. Yukmijihwang-tang significantly suppressed pruritus while there was no significant difference among the experimental groups. 3. Yukmijihwang-tang retained skin structure(epidermis, dermis and subcutaneous fat). 4. Yukmijihwang-tang reduced Total IgE level while there was no significant difference between the control group and the experimental groups. 5. Yukmijihwang-tang did not reduce IL-4(Th2 cytokine) level. 6. Yukmijihwang-tang significantly reduced $IFN-\gamma$(Th1 cytokine) level. In particular, YM-2.5 and YM-5 had lower $IFN-\gamma$ level than YM-10. Conclusion : The results suggest that Yukmijihwang-tang suppresses skin dryness and pruritus, retains skin structure and is effective on chronic atopic dermatitis which is associated with Th1 cytokines in the immune response.

• 대한한의학원전학회지
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• 제35권1호
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• pp.117-136
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• 2022

Objectives : The objective of this paper is to examine the pathology and treatment methods of tinnitus and deafness. Methods : Contents on the ears, pathology and treatment methods of tinnitus and deafness in the Donguibogam were examined. Results & Conclusions : Findings indicate that Kidney jing deficiency and problems of qi metabolism of the Kidney are at the root of tinnitus and deafness pathology. In treatment, once the primary symptoms are managed, the root, which is Kidney deficiency, needs to be improved, together with life style management. In the case of Heart-Kidney disconnection, the Heart must be collected while nurturing jing; in the case of yin deficiency and flaring, ministerial fire must be managed while tonifying jing and blood. If the cause lies in the Lungs and Kidney, they must be tonified, while in cases due to problematic water fluid metabolism, phlegm-fire or exterior pathogens, the Kidney needs to be dealt with even after treating the aforementioned causes.

• Environmental Analysis Health and Toxicology
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• 제11권3_4호
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• pp.45-51
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• 1996

Histopathological changes of gills and caudal fins isolated from fishes, Cyprinus carpio, Carassius auratus, and Hernibarbus labeo, which were killed by oxygen deficiency or toxic chemicals, were studied. The toxic chemicals were HCl, NaOH, chloroform, benzene, heavy metals(Cu, Cr, Zn, Pb, Hg), and o-dichlorobenzene. The exposure level was enough to kill the fishes within 30 minutes. Oxygen deficient water was prepared by aeration of nitrogen gas and the oxygen concentration was less than l ppm. Cryocutting was used for the rapid preparation of tissue slides and the tissues were stained by hematoxylin/eosin. In the fishes killed by hazardous chemicals, congestion and/or hyperplasia of secondary lamella and erosion of fin were found as the major histopathological changes. Whereas, these characteristics were not observed in gills or caudal fins of fishes killed by oxygen deficiency. These different bioindications appeared in the fishes killed by toxic substances or natural causes, can be used for the rapid identification of the causes of fish kills.

• Journal of Nutrition and Health
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• 제26권6호
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• pp.680-691
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• 1993

Rats were fed for an 8-week period a low riboflavin diet(5ug riboflavin/day) or a control diet(30ug/day) supplied either ad libitum or by pair feeding in order to study the effect of riboflavin on the metabolism of lipids and neurotransmitters. Erythrocyte glutathione reductase (EGR) and monomine oxidase(MAO) activity in the liver and brain were assayed. EGR activity coefficient in riboflavin deficient rats was significantly higher than in ad libitum controls whereas MAO activity was decreased in the deficient rats. Fatty acid composition showed a different trend in the serum, liver and brain. In the serum, the concentrations of essential fatty acids and $\omega$-3 fatty acids(eicosapentaenoic acid, docosahexaenoic acid)were decreased about 20-40% in the deficient and pair-fed than in the ad libitum controls. Brain serotonin and 5-HIAA(5-hydroxyindole acetic acid) concentrations were decreased in the riboflavin deficient rats. Learning ability measured by a water maze and exploratory activity using the open field test were not impaired in the deficient rats. These results indicate that brain lipid metabolism was protected in subclinical riboflavin deficiency, however, riboflavin deficiency affected brain serotonin content.

• 대한한의학원전학회지
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• 제33권2호
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• pp.91-108
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• 2020

Objectives : To study the shu points selection of the Four Seas in the 「Hailun」 chapter of 『Lingshu』. Methods : The effects and main indications of each shu point, their anatomical position, characteristics along with similarities of disease patterns according to excessiveness and deficiency of the Four Seas were examined. Results : The selection of shu points of the Four Seas were deeply related to the effects and main indications, and the common similarity among conditions due to excessiveness and deficiency was the presence of psychological aspects. Also, when the Four Seas are connected to the Jing-Qi-Shen and Blood, marrow sea[髓海] is connected to Jing & Shen, qi sea[氣海] is connected to Qi, blood sea[血海] is connected to Blood, and sea of water and grain[水穀之海] replenishes Jing-Qi-Shen and Blood. When connected to the Four Qi Intersections, the marrow sea is connected to 'head qi with intersection', qi sea is connected to 'chest qi with intersection', sea of water and grain or blood sea is connected to 'stomach qi with intersection', otherwise sea of water and grain is connected to 'shin qi with intersection'. Conclusions : The Four Seas are designated to the shu points due to their accumulation of Qi when the main elements of Jing-Qi-Shen and Blood are deficient or excessive, allowing for the most convenient management and manipulation of the condition of these main elements. In clinical practice, the shu points of the Four Seas will likely increase treatment efficacy for conditions that include psychological aspects.

• Ocean and Polar Research
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• 제29권4호
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• pp.349-366
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• 2007

Seasonal variations of various physicochemical components (temperature, salinity, pH, DO, COD, DOC, nutrients-silicate, DIN, DIP) and potential limiting factor for phytoplankton primary production were studied in the surface water of semi-enclosed Masan Bay. Seasonal variations of nutrient concentrations, with lower values in summer and winter, and higher in fall, are probably controlled by freshwater loadings to the bay, benthic flux and magnitude of occurrence of phytoplankton communities. Their spatial distributional patterns are primarily dependent on physical mixing process between freshwater and coastal seawater, which result in a decreasing spatial gradient from inner to outer part of the bay. In the fall season of strong wave action, the major part of nutrient inputs (silicate, ammonium, dissolved inorganic phosphorus) comes from regeneration (benthic flux) at sediment-water interface. During the summer period, high Si:DIN and Si:DIP and low DIN:DIP relative to Redfield ratios suggest a N- and secondarily P-deficiency. During other seasons, however, silicate is the potential limiting factor for primary production, although the Si-deficiency is less pronounced in the outer region of the bay. Indeed, phytoplankton communities in Masan Bay are largely affected by the seasonal variability of limiting nutrients. On the other hand, the severe depletion of DIN (relatively higher silicate level) during summer with high freshwater discharge probably can be explained by N-uptake of temporary nanoflagellate blooms, which responds rapidly to pulsed nutrient loading events. In Masan Bay, this rapid nutrient consumption is considerably important as it can modify the phytoplankton community structures.

• 한국농림기상학회지
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• 제22권3호
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• pp.205-214
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• 2020

본 연구에서는 중량식 라이시미터를 이용하여 토양 및 물관리 방법에 따라 배추와 옥수수 재배기간 동안 물수지를 평가하였으며, 작물 생산성과 물 부족 상황을 고려하여 작물 수분스트레스 계수와 최소 물 필요량을 산정하였다. 2018 년 배추 재배는 정식 2 주 후 빈번한 강우로 인해 관개가 실시되지 않아 무관개구와 적습관개구의 관개량 차이가 없었으며, 생산량 차이 또한 나타나지 않았다. 2018 년 배추 재배를 제외하고 배추와 옥수수 재배에서 적습관개구가 무관개구보다 생산량이 높게 나타났으며 대체적으로 증발산량 또한 높게 나타났다. 생산량과 증발산량은 밀접한 관련이 있으며 바이오매스 증가에 따라 증산작용이 활발해짐을 알 수 있었다. 작물 수분스트레스 계수는 배추 중기 0.8, 후기 0.8, 옥수수 중기 0.8, 후기 0.5 로 산정되었다. 배추와 옥수수의 최소 물 필요량(2017 년 배추 196.2 mm, 2018 년 옥수수 321.0 mm)은 적정 물 필요량(배추 239.4 mm, 2018 년 옥수수 466.9 mm) 대비 각각 82.0%, 68.8% 수준으로 나타났다. 이러한 산정 결과는 물부족 시기에 최소 관수량을 확보하여 작물 재배를 위한 물관리의 기초자료로 활용할 수 있을 것으로 생각된다.