• Journal of Life Science
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• v.27 no.4
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• pp.398-407
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• 2017

BTG 1 (B-cell translocation gene 1) gene was first identified as a translocation gene in a case of B-cell chronic lympocytic leukemia. BTG1 is a member of the BTG/TOB family with sharing a conserved N-terminal region, which shows anti-proliferation properties and is able to stimulate cell differentiation. In this study, we identified and characterized the pacific oyster Crassostrea gigas BTG1 (cg-BTG1) gene from the gill cDNA library by an Expressed Sequence Tag (EST) analysis and its nucleotide sequence was determined. The cg-BTG1 gene encodes a predicted protein of 182 amino acids with 57% 56% identities to its zebrafish and human counterparts, and is an intron-less gene, which was confirmed by PCR analysis of genomic DNA. Maximal homologies were shown in conserved Box A and B. The deduced amino acid sequence shares high identity with other BTG1 genes of human, rat, mouse and zebrafish. The phylogenic analysis and sequence comparison of cg-BTG1 with other BTG1 were found to be closely related to the BTG1 gene structure. In addition, the predicted promoter region and the different transcription-factor binding site like an activator protein-1 (AP-1) response element involved in negative regulation and serum response element (SRE) were able to be identified by the genomic DNA walking experiment. The quantitative real-time PCR analysis showed that the mRNA of cg-BTG1 gene was expressed in gill, heart, digestive gland, intestine, stomach and mantle. The cg-BTG1 gene was expressed mainly in heart and mantle.

• The Journal of the Korea Contents Association
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• v.13 no.7
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• pp.406-416
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• 2013

This investigation aims to examine whether there is currently the proper use of pedestrian malls created in the Land Development Project areas and to come up with some suggestions for the upcoming plan to build them. The Project areas were designated as the subject of a case study to this end and, on the basis of the findings on the pedestrian movement, Stepwise Regression Analysis was performed. These can be summed up as follows. Firstly, the most important factor which had a decisive effect on the activation of pedestrian malls turned out to be the directions of the exits to the buildings adjoining the pedestrian walkways. Hence, careful consideration should be given to the facade of buildings and the obligation to install the exits to the pedestrian malls for the activation of the pedestrian walkways. Secondly, according to the findings, the use of the buildings adjoining the pedestrian malls could be a second-most-important variable. The introduction of the facilities that encourage walking and the location restriction on the facilities(accommodation facilities) that do not encourage walking should be done aggressively. Thirdly, securing the continuity between the pedestrian malls could affect the reinvigoration of the pedestrian malls. To achieve this, the crosswalks should be actively built in the early stage of development.

• Korean Journal of Environment and Ecology
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• v.33 no.1
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• pp.107-115
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• 2019

The purpose of this study is to examine the effect of forest healing programs with walking, sightseeing, and forest scent among six healing forest treatments using forest environment on the cognitive function, depression, and quality of life of elderly living alone. The subjects of the study were 17 senior citizens living in Samcheok and complaining of severe depression and forgetfulness. They were divided into two groups, and each group participated in the six sessions of the weekly forest healing program. All of them were surveyed of a Korean version of the MMSE-K, BDI (Beck Depression Inventory Korean Version), and SF-36 (Short Form 36 health survey questionnaire) with the questionnaire designed for the one-group pre-post test to examine changes in cognitive function, depression, and quality of life. The results showed that the mental status, depression level, and quality of life of respondents were significantly higher after healing programs. These results suggest that participation in healing program activities using forest environment can improve cognitive function, relieve depression and improve quality of life for senior citizens living alone. Therefore, inducing older adults who live alone and avoid outside activities to participate in the regular forest healing program will contribute to the prevention of dementia due to age and environment.

• Journal of People, Plants, and Environment
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• v.24 no.4
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• pp.403-413
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• 2021

Background and objective: There is growing concern about the effects of modern society on mental health, coming with Covid-19-related caveats on depression, anxiety, and stress (DAS). This can be a subject to provide alternative methods which alleviate DAS. In line with this context, sensory gardens are widely acknowledged to stimulate the five major senses (sight, sound, taste, touch, and smell) and can have a significant (positive) impact on mental health. However, there is limited empirical evidence on the effect of these gardens with regard to alleviating DAS - particularly with respect to urban society This is a gab in knowledge how such limits can be addressed. Accordingly, this present study is clearly needed in order to verify if there are any correlations between sensory gardens and (positive) effects on DAS. The aim of this study was therefore to understand current levels of DAS in a high density building with a sensory garden in a courtyard and determine correlations between experiences in the sensory courtyard and levels of DAS. Methods: The Depression Anxiety and Stress Scale (DASS-21) was employed to test the level of DAS. Results: Additionally, 13 different factors associated with experiences in the building, including the stimulation of the five major senses in the sensory courtyard, were measured to reveal their contribution to mitigating depression, anxiety, and stress. It is noted that the average levels of DAS were 7.91, 7.77 and 9.01 respectively indicating that the mental health of participants requires mental health management. However, results show that factors associated with the sensory courtyard could improve mental health. For example, new social relationships, walking with colleagues, and the stimulation of each of the five major senses in the sensory garden could improve DAS. Conclusion: This illustrates that external experiences are more effective at mitigating depression, anxiety, and stress than internal ones. Factor analysis revealed four components: stimulating the five senses; internal and external facilities; internet-based device use; and new social relationships. There was a strong positive correlation between new social relationships and walking with colleagues. There were also strong positive correlations among the stimulation of each of the five senses. In conclusion, there are strong indications that sensory courtyards can help alleviate DAS and should therefore be promoted, particularly in the current Covid-19 situation wherein the physical and mental health of the public at large are threatened. Accordingly, courtyard design should be rethought in light of the relationship between the positive impact of sensory gardens and mental health.

• Journal of Families and Better Life
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• v.27 no.4
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• pp.31-39
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• 2009

The purpose of this study is to how the music therapy effects to older person's self-esteem feeling and a emotional mood improvement after reminiscence therapy through songs. The object of this research were 10 old men and women, age of 67 to 90 with dementia, and mental and physical dysfunction, but can be self-walking and the stool was made up in social welfare center in the Yuseong-gu, Daejeon-city, The experiment of the research was done from June 18th until July 18th, week 2 each 50 minutes the total 12 times. This study was an experiment, the treatment of a same group before and after treatment. Before the first session I check the self-esteem and emotional mood. And after the final 12th session, post-therapy examination was conducted the same tests. The tools of Self-esteem test is the self-esteem scale developed by Rosenberg(1965) and Jun Byung-se(1974), which was translated. Emotional state check tools developed by MoNair(1992), which was translated by Yun Jae-ryang, and it can also apply to the Korean older person has been modified by Shin yon-hee. The results of changing mood state to 3 factors are as follows: The score of anxiety-depression factor changes from 50.42($\pm$14.15) to 35.10($\pm$10.60), and this is statistically significant.(p<.05). The score of anger factor changes from 11.20($\pm$4.39) to 6.90($\pm$2.51), and this is statistically significant.(p<.01). The score of vitality factor Changes from 30.00($\pm$4.27) to 23.90($\pm$5.09), and this is Statistically significant.(p<.05). For this research, I selected older person's favorite songs which have a positive lyrics and bright melody. And This has significance in terms give positive effects to older person's emotion which influence on their self-esteem and better mood positively. In the clinical treatment for the elderly to improve the positive sentiment and give practical assistance on the basis of this research is done to the future, And I look forward to the future development of a variety of music therapy.

• Journal of Korean Public Health Nursing
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• v.15 no.1
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• pp.157-171
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• 2001

The study was designed to provide the fundamental information for understanding discomfort of bone marrow donors and for promoting an individual comfort by comparing the difference on discomfort between unrelated donors and related donors. The subject of the study was fifty related donors and thirty unrelated donors who was in the C University Hospital. This survey had been carried out and collected from October, 1998 to March, 1999. The scale of discomfort of donors associated with bone marrow donation were assessed by the questionnaire deviced by Kim Sang Dol and amended by the researcher. Data was analyzed by $x^2-test$, t-test, two-way ANOVA, and Pearson Correlation Coefficients. The results were as follows. 1. Considering the general characteristics of bone marrow donors according to gender, male was consisted of $60\%$ and female was consisted of $40\%$. Of those related donors are consisted for $62.5\%$ and accounted for $37.5\%$ of those unrelated donors. Considering the classification to the job, employee of company were major donors which was $35\%$, and next order was student, individual businessman, and housewife. Considering the education level. college students were $48.7\%$ and students who have less than high school level were $42.5\%$. 2. According to the above the results regarding discomfort of bone marrow donation, it is especially shown that the major cause for discomfort of bone marrow donors is on physical factor. The concrete examples for physical factor are pain in the region of bone marrow harvest and pain in the injection part by fluid therapy and blood-sampling, an immovability of the body after bone marrow harvest, and difficulties on walking. Considering physiological factor, there are an uneasiness about leading to injure their health, vague fear about the hospital. and a tedium at hospital. Environmental factors for discomfort of bone marrow donors are insufficient explanation for needle gauge and procedure of bone marrow donation and difficulty on following medical schedule. Therefore. it is necessary to establish more effective and systematically organized program for nursing intervention based on the research results. An effective program is only useful in getting rid of discomfort of bone marrow donors.

• The Journal of the Korea Contents Association
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• v.14 no.7
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• pp.518-528
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• 2014

The purpose of this study is to observe the effects of road facilities that have adopted digital media such as total road facility called L.E.D media pole installed on U-street, Gangnam-gu on the pedestrians' satisfaction. Through the study, we would like to improve the brand competitiveness, increase the revisiting decision factors and suggest the fundamental development direction for the digital media road facilities on the typical pedestrian road, Gangnam street. The three factors from the studies came out to be spatial component, design component, and functional component. In order to analyze the factors, the pedestrians' behaviors were observed through a direct survey which provided 35 reserved factors. Also, the preliminary factors derived through survey questionnaires were revised by experts which compressed the result into 20 factors. The result of the regression analisis states that the 'Factor of the spatial component' is the statistically significant factor among the five elicited factors of the effect of the media pole on the pedestrian satisfaction. U-street's media pole provides the comfortable and various contents and application methods and will provide the new perspective on the purpose of pedestrians by new experience that is based on digital technology.

• The Journal of the Korean bone and joint tumor society
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• v.7 no.4
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• pp.139-143
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• 2001

Purpose : Limb salvage for osteosarcoma of proximal tibia is challenging problem due to difficulties in mobilizing or retracting the main neurovascular structure, inadequate soft tissue coverage, and unsolved problem of patellar tendon reattachment to endoprosthesis. The authors analyzed the functional result of limb salvage using tumor prosthesis with medial gastrocnemius rotation plasty for osteosarcama of the proximal tibia. Materials and Methods : Eleven patients with histologically proven osteosarcoma of the proximal tibia, treated with adjuvant and neoadjuvant chemotherapy and limb salvage operation with tumor prosthesis between January 1992 and December 1998 at our Medical Center, were selected. There were 6 male and 5 female. Age ranged from 15 years to 23.7 years with an average of 23.7 years. Follow-up period ranged from 1 year to 4.5 years with an average of 2.5 years. The final functional result was evaluated using the method by ISOLS, 1993. The factors include pain, functional activities, emotional acceptance, use of external supports, walking ability and gait. Each of the factors has been scored from 0 to 5 depending on the appropriate description or data. The rating score is determined by dividing the individual factor scores into the total score and indicates percentage of normal function. Results : The overall functional result ranged from 53,3% to 86.7% with an average of 68.3% of normal function. In details, the averages were 82.5% for pain, 62.5% for functional activities, 67.5% for emotional acceptance, 77.5% for use of external supports, 62.5% for walking ability, and 57.5% for gait. The average range of motion of the knee joint was $5^{\circ}$ extension and $85^{\circ}$ flexion. Five patients have extension lag ranged from $5^{\circ}$ to $15^{\circ}$ with an average of $10^{\circ}$. Two patients suffered postoperative infection. One was treated with antibiotics injection only, but the other needed removal of the prosthesis and knee fusion. Both of them showed unsatisfactory result. C o n c l u s i o n : The overall functional result after limb salvage using tumor prosthesis with medial gastrocnemius rotational flap for osteosarcoma of the proximal tibia was relatively satisfactory in case of no postoperative infection. The patients were less satisfactory in functional activities, emotional acceptance and gait than pain, use of external supports due to limitation of motion and extension lag. More aggressive postoperative physical therapy and protection with brace for 6~9 months as well as surgical technique is mandatory for more satisfactory result.

• Journal of the Korean Institute of Landscape Architecture
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• v.42 no.6
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• pp.72-88
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• 2014

This study was conducted in order to analyze user behavior and preference factors in the outdoor spaces of mental hospitals. Among hospitals with 250 or more beds, 5 hospitals were selected in consideration of size of garden and diversity of garden elements. The subject of the study was restricted to mild cases of schizophrenia while 30~50 patients were selected on the recommendation of their doctor from 5 hospitals, respectively. The physical environment was analyzed, focusing on space components, after visiting the sites of study. A face to face interview method was selected in consideration of patients' cognitive abilities, a total of 230 questionnaires were used for the analysis. The results of the study can be summarized as follows. Rest facilities occupy the largest numbers in the components of garden, and those are followed by landscape facilities, walking/exercise facilities, and experience facilities. Outdoor walking/exercise programs are classified into group walks and free walks with most patients taking group walks. Most of the patients visit these outdoor spaces every day but some of them rarely use the outdoor areas. In order to increase the efficiency of using these outdoor spaces, the percentage of space for ensuring a sense of control should properly harmonize with the percentage of space to facilitate patients in having social contact. With regard to the reasons for preferring the most widely-used outdoor spaces, landscape/environment property was the most important, followed by functionality and then accessibility. Major activities in the preferred space are mainly composed of walking/exercise and rest. The preferred facilities are waterscape facilities such as ponds, waterfalls and fountains, rest facilities such as pergolas and shade trees, and lawn. It was understood that naturalness should be considered to be the most important factor in constructing a new healing garden, followed by aesthetics and amenities. Single facilities rated by preference for introduction were flower beds, trails, and lawn. According to type, waterscape facilities such as fountains, ponds, waterfalls and waterwheels were most preferred. Space for natural distraction and programs for the cultivation of flower beds were also preferred. The ideal image of a healing garden should be bright, familiar, and orderly as a whole, having plenty of introduced facilities. Open spaces were preferred to enclosed spaces. Finally, the image of a garden that helps patients feel calm was thought to be that of the most ideal garden.

• Journal of the Ergonomics Society of Korea
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• v.26 no.1
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• pp.71-77
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• 2007

Shoe's size and shape are determined by the last that takes shape of foot because last is the mold of shoe in development and manufacturing process. Then adaptation between foot and shoe is dependent on the last. In mass shoe production, model size is developed in the first place, other sized lasts are made through the grading process based on model size. The most important factor in grading system is grading deviation that must be same amount induced from foot measuring database. At present, most of the last manufacturing companies in korea using 260mm as a standard foot model size. When length grading deviation is 5mm, the ball girth grading deviation is 3.7mm and the ball width grading deviation is 1.2mm. I verified existing grading system by comparing grading results with foot measuring data. Also, I proposed reasonable grading deviation and application method of grading system. From the analysis of foot measuring database, reasonable grading deviations are 1.22mm in ball width and 0.84mm in ankle height in case of length grading deviation is 5mm. I confirmed that the current grading system is very accurate. When we grade last from 230mm to 290mm by current grading system based on model size 260mm, there is grading error over 1mm in the front outside area of foot. This error level of 1mm is no problem in normal walking shoe's last, but it induces adaptation problems in sports and special purposed shoe's last. Therefore using of three standard model size is recommended in grading men's last for reducing grading deviation error under the level of 1mm. It is specifically described as 235mm in 225-245mm, 260mm in 250-270mm, 285mm in 275-295mm. According to the above recommended grading system, it is enough to measure only three foot sizes in case of foot measuring project for men's last development.