• Tuberculosis and Respiratory Diseases
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• v.70 no.4
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• pp.323-329
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• 2011

Background: Although patients with tuberculous-destroyed lung (TDL) account for a significant proportion of those with chronic airflow obstruction, it is difficult to distinguish patients with airway obstruction due to TDL from patients with pure chronic obstructive pulmonary disease (COPD) on initial presentation with dyspnea. We investigated clinical features differing between (i) patients with TDL and airway obstruction and (ii) those with COPD admitted to the intensive care unit (ICU) due to dyspnea. Methods: We reviewed the medical records of patients with TDL who had a forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC) of <70% on a pulmonary function test (PFT; best value closest to admission) and patients with COPD without a history of pulmonary tuberculosis (TB) who were admitted to the ICU. Ultimately, 16 patients with TDL and 16 with COPD were compared, excluding patients with co-morbidities. Results: The mean ages of the patients with TDL and COPD were 63.7 and 71.2 years, respectively. Mean FVC% (50.4% vs. 71.9%; p<0.01) and mean FEV1% (39.1% vs. 58.4%; p<0.01) were significantly lower in the TDL group than in the COPD group. More frequent consolidation with TB (68.8% vs. 31.3%; p=0.03) and more tracheostomies (50.0% vs. 0.0%; p=0.02) were observed in the TDL than in the COPD group. Conclusion: Upon ICU admission, patients with TDL had TB pneumonia more frequently, more diminished PFT results, and more tracheostomies than patients with COPD.

• Journal of the Korean Society of Clothing and Textiles
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• v.27 no.3_4
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• pp.407-417
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• 2003

The purpose of this study is to develop designs and patterns of a functional brassiere. For this purpose, women who have protruding and drooping breasts with 75B for their brassiere size were sampled. The fitting test for the fitness and function of test brassiere and control brassiere were carried out twice and compared the results from the both in terms of front, rear and side looks. The results of this study can be summarized as follows; 1. The results from measuring the level of sag and spread, and volume and protrusion of breasts shows that there are some distinctive differences in the measurements before and after wearing the test brassiere and the test brassiere is proved to be very effective in correcting breasts' shapes. 2. Front look: Since the two front cutting lines of the test brassiere served to have the curved main part pressing against the breasts, it could support breasts to more than satisfactory level. In addition, upperline panel and side panels of the test brassiere were found to have the upperline of the upper cup pressed against the breasts and at the same time it pressed and gathered the flab around upper part of the breasts and armpits that helped to rearrange the shape of the breasts. It is also proved that the two-pieced test brassier was found to be more functional in supporting the lower cup of the breasts. 3. Rear look: The test brassier was made up of two wide U-shaped wings with 2.5cm tape on its lower sides. Each wing has 4 lines and 3 hems (5.5cm). For this reason, the test brassiere was tighter and better fitted on its back. 4. Side look and entire look: The wings of the test brassiere might look wider than that of the control brassier which has conventional straight-shaped wings, but it was analyzed that the test brassiere held the upper and lower sides of the wings more effectively to be more pressed against the breast. Therefore, the test brassiere scored higher in terms of adjusting to body movements, while the control brassiere looked better in overall terms. 5. The functional brassier fur protruding and drooping breasts developed from the experiments of this study is a full side stretch brassiere which covers the entire breasts satisfactorily. The pattern drafting methods are suggested in to .

• Journal of the Korea Academia-Industrial cooperation Society
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• v.15 no.2
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• pp.1109-1117
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• 2014

We study free vibration analysis of sigmoid functionally graded materials(S-FGM) nano-scale plates, using a nonlocal elasticity theory of Eringen in this paper. This theory has ability to capture the both small scale effects and sigmoid function in terms of the volume fraction of the constituents for material properties through the plate thickness. Numerical solutions of S-FGM nano-scale plate are presented using this theory to illustrate the effect of nonlocal theory on natural frequency of the S-FGM nano-scale plates. The relations between nonlocal and local theories are discussed by numerical results. Further, effects of (i) power law index (ii) nonlocal parameters, (iii) elastic modulus ratio and (iv) thickness and aspect ratios on nondimensional frequencies are investigated. In order to validate the present solutions, the reference solutions are compared and discussed. The results of S-FGM nano-scale plates using the nonlocal theory may be the benchmark test for the free vibration analysis.

• Journal of Wetlands Research
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• v.20 no.3
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• pp.235-242
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• 2018

The function of vertical subsurface flow wetlands can potentially be reduced with time due to clogging and are often assumed to be occurring when ponding and overflow is observed during rainfall. To investigate their clogging potential, three pilot-scale vertical subsurface flow (VSF) wetland systems were constructed employing woodchip, pumice, and volcanic gravel as main media. The systems received stormwater runoff from a highway bridge for seven months, after which the media were taken out and divided into layers to determine the amount and characteristics of the accumulated clogging matters. Findings revealed that the main clogging mechanism was the deposition of suspended solids. This is followed by the growth of biofilm in the media which is more evident in the wetland employing woodchip. Up to more than 30% of the clogging matter were found in the upper 20 cm of the media suggesting that this layer will need replacement once clogging occurs. Moreover, no signs of clogging were observed in all the wetlands during the operation period even though an estimation of at least 2 months without clogging was calculated. This was attributed to the intermittent loading mode of operation that gave way for the decomposition of organic matters during the resting period and potentially restored the pore volume.

• Proceedings of the Korea Water Resources Association Conference
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• 2019.05a
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• pp.258-258
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• 2019

계산 격자에 기반하여 천수 흐름을 모의할 때, 그 격자에 담긴 물의 양을 정확하게 파악할 필요가 있다. 예를 들어, 초기조건으로 수위가 부여된다면 계산격자의 기하 특성에 맞추어 흐름 변수인 수심이나 흐름 단면적으로 바꾸어야하기 때문이다. 필요에 따라서는 모의 결과를 수위로 보이거나 격자 속 수심을 계산에 사용할 수도 있으므로 그 역변환도 고려되어야 한다. 2차원의 삼각형 계산격자에 대해서는 물의 부피와 수위 관계(volume/free-surface relationship)가 이미 정확(exact)하게 구명되어 있다(Hwang, 2017, J. KWRA). 그런데 1차원 문제의 횡단면에서 흐름 단면적과 수위의 관계(area/free-surface relationship)는 수위로부터 면적 환산에 대해서는 정확하나 그 역변환은 그렇지 않다. 매 시간 단계에서 갱신된 흐름 단면적으로부터 수위를 환산하기 위해 미리 작성된 면적-수위 자료를 이용한 선형 보간이 적용된다(Goodell, 2011, The RAS Solution). 이때, 환산 정확도는 자료의 해상도에 의존된다. 다행히 하천 횡단면 대부분을 채워 흐르는 홍수모의에서는 이 문제가 그리 심각하지는 않다. 심지어 수위가 복단면 저수로 턱에 걸쳐있어 흐름단면적이 급변하는 경우에도 환산 수위의 정확도는 크게 훼손되지 않는다. 그러나 미미한 환산 오차일지라도 그로 인해 수위가 저수로 턱을 넘거나 그보다 작을 수 있다. 이 경우, 홍수터의 잠김여부에 따라 수면폭(top width)이 실제 계산 결과에 비해 크게 달라질 수밖에 없다. 수면폭 오차는 그것을 이용하여 결정되는 수리 수심(hydraulic depth)이나 평균 하상고(mean bed level)의 산정에도 전파된다. 이 연구에서는 하천 횡단면에서 수위와 흐름 단면적 사이의 환산 정확도를 크게 높일 수 있는 기법을 제시하였다. 먼저 하천 횡단면에서 주어진 수위에 대해 흐름 단면적을 산정할 수 있는 알고리듬을 보였다. 또한, 횡단면에서 수위와 흐름 단면적의 관계가 단조 증가 함수(monotonically increasing function)임에 착안하여 그 역변환에 대해 해 찾기(root finding) 방법의 하나인 Brent 기법을 적용하였다. 이 기법은 주어진 구간에서 도함수가 알려져 있지 않은 경우에 대해서도 효과적으로 해를 찾을 수 있는 것으로 알려져 있다(Press et al., 2002, Numerical Recipes in C, 2nd Ed.). 내성천 하류 수계의 333개 단면에서 수면폭에 대한 상대 오차를 살펴보면, 선형 보간에 의한 기존 방법으로는 면적-수위 자료의 수가 1,000개가 되어도 그 최대치가 1% 이내에 들지 않은 반면, 이 연구에서 제시한 기법으로 면적-수위 자료 없이도 1% 이내로 줄어드는 것을 확인하였다. 다만, 반복 계산에 의한 계산 시간의 증대를 피할 수 없다. 미리 작성된 면적-수위 자료를 이용하면 계산 비용을 줄일 수 있으며, 약 35개의 구간으로 나누었을 때 비용 대비오차가 적절하였다. 이 연구는 한국건설기술연구원(주요사업 과제번호: 20190116-001)의 지원에 의한 것이다.

• Elastomers and Composites
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• v.39 no.3
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• pp.179-185
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• 2004

Frequency dependency or electrical property stabilization during vulcanization of modified NR/IR composite materials was studied using in-situ electrical property measuring technique. Volume resistivity(p) before and after vulcanization reaction of the sample was measured as the function or frequency in the range or 1Hz to 10kHz at reaction temperatures of 130, 140, 150, and $160^{\circ}C$, respectively. A double stabilization mode of frequency dependency was observed, in which a slow stabilization process of p to a value of ca. $1.0{\times}10^7\;{\Omega}-cm$ occurred after a drastic initial decrease from ca. $9.0{\times}10^7\;{\Omega}-cm$. In addition, notable temperature dependencies of p values were also observed before and after vulcanization reaction, that is, p values at 130 and $140^{\circ}C$ after vulcanization were observed as about 1/3 of those values before vulcanization. All the observed facts were considered as the results from the interaction between the electrode and the bulk sample materials, i.e., electronic charge-discharge, and from the structure change of samples including CB rearrangement by the vulcanization.

• Laboraroty Animal Research
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• v.34 no.4
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• pp.302-310
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• 2018

CD47 (integrin-associated protein), a multi-spanning transmembrane protein expressed in all cells including red blood cells (RBCs) and leukocytes, interacts with signal regulatory protein ${\alpha}$ ($SIRP{\alpha}$) on macrophages and thereby inhibits phagocytosis of RBCs. Recently, we generated a novel C57BL/6J CD47 knockout ($CD47^{-/-}$ hereafter) mouse line by employing a CRISPR/Cas9 system at Center for Mouse Models of Human Disease, and here report their hematological phenotypes. On monitoring their birth and development, $CD47^{-/-}$ mice were born viable with a natural male-to-female sex ratio and normally developed from birth through puberty to adulthood without noticeable changes in growth, food/water intake compared to their age and sex-matched wild-type littermates up to 26 weeks. Hematological analysis revealed a mild but significant reduction of RBC counts and hemoglobin in 16 week-old male $CD47^{-/-}$ mice which were aggravated at the age of 26 weeks with increased reticulocyte counts and mean corpuscular volume (MCV), suggesting hemolytic anemia. Interestingly, anemia in female $CD47^{-/-}$ mice became evident at 26 weeks, but splenomegaly was identified in both genders of $CD47^{-/-}$ mice from the age of 16 weeks, consistent with development of hemolytic anemia. Additionally, helper and cytotoxic T cell populations were considerably reduced in the spleen, but not in thymus, of $CD47^{-/-}$ mice, suggesting a crucial role of CD47 in proliferation of T cells. Collectively, these findings indicate that our $CD47^{-/-}$ mice have progressive hemolytic anemia and splenic depletion of mature T cell populations and therefore may be useful as an in vivo model to study the function of CD47.

• The Korean journal of internal medicine
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• v.33 no.6
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• pp.1093-1102
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• 2018

Background/Aims: The aim of this study was to investigate parameters that predict radiation-induced liver disease (RILD) following stereotactic body radiotherapy (SBRT) in patients with hepatocellular carcinoma (HCC) and to identify the clinical significance of RILD. Methods: We retrospectively reviewed the medical records of 117 HCC patients who were treated by SBRT from March 2011 to February 2015. RILD was defined as elevated liver transaminases more than five times the upper normal limit or a worsening of Child-Pugh (CP) score by 2 within 3 months after SBRT. All patients were assessed at 1 month and every 3 months after SBRT. Results: Median follow-up was 22.5 months (range, 3 to 56) after SBRT. RILD was developed in 29 of the 117 patients (24.7%). On univariate analysis, significant predictive factors of RILD were pretreatment CP score (p < 0.001) and normal liver volume (p = 0.002). Multivariate analysis showed that CP score was a significant predictor of RILD (p < 0.001). The incidence of RILD increased above a CP score of 6 remarkably. The rate of recovery from RILD decreased significantly above a CP score of 8. Survival analysis showed that CP score was an independent prognostic factor of overall survival (p = 0.001). Conclusions: CP score is a significant factor to predict RILD in patients with chronic liver disease. RILD can be tolerated by patients with a CP score ${\leq}7$. However, careful monitoring of liver function is needed for patients with a CP score 7 after SBRT.

• Journal of Navigation and Port Research
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• v.42 no.6
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• pp.546-554
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• 2018

The Bulk market, unlike the line market, is characterized by stiff competition where certain ship or freight owners have no influence on freight rates. However, freights are subject to macroeconomic variables and economic external shock which should be considered in determining management or chartering decisions. According to the results analyzed by use of ARIMA Inventiom model, the impact of the financial crisis was found to have a very strong bearing on the BDI index. First, according to the results of the VEC model, the libor rate affects the BDI index negatively (-) while exchange rate affects the BDI index by positively (+). Secondly, according to the results of the VEC model's J ohanson test, the order ship volume affects the BDI index by negatively (-) while China's economic growth rate affects the BDI index by positively (+). This shows that the shipping company has moved away from the simple carrier and responded appropriately to changes in macroeconomic variables (economic fluctuations, interest rates and exchange rates). It is believed that the shipping companies should be more aggressive in its "trading" management strategy in order to prevent any unfortunate situation such as the Hanjin Shipping incident.

• Journal of the Korean Society of Marine Environment & Safety
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• v.25 no.5
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• pp.527-534
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• 2019

Several types of mathematical analysis methods are used for port waterway risk assessment based on marine traffic volume. In Korea, a marine traffic congestion model that standardizes the size of the vessels passing through the port waterway is applied to evaluate the risk of the waterway. For example, when marine traffic congestion is high, risk situations such as collisions are likely to occur. However, a scientific review is required to determine if there is a correlation between high density of maritime traffic and a high risk of waterway incidents. In this study, IWRAP Mk2(IALA official recommendation evaluation model) and a marine traffic congestion model were used to analyze the correlation between port waterway risk and marine traffic congestion in the same area. As a result, the linear function of R2 was calculated as 0.943 and it was determined to be significant. The Pearson correlation coefficient was calculated as 0.971, indicating a strong positive correlation. It was confirmed that the port waterway risk and the marine traffic congestion have a strong correlation due to the influence of the common input variables of each model. It is expected that these results will be used in the development of advanced models for the prediction of port waterway risk assessment.