• 대한수학회보
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• 제44권4호
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• pp.731-742
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• 2007

Let X be a Banach space, $A:D(A){\subset}X{\rightarrow}X$ the generator of a compact $C_0-semigroup\;S(t):X{\rightarrow}X,\;t{\geq}0$, D a locally closed subset in X, and $f:(a,b){\times}C([-q,0];X){\rightarrow}X$ a function of Caratheodory type. The main result of this paper is that a necessary and sufficient condition in order that D be a viable domain of the semi linear differential equation of retarded type $$u#(t)=Au(t)+f(t,u_t),\;t{\in}[t_0,\;t_0+T],{u_t}_0={\phi}{\in}C([-q,0];X)$$ is the tangency condition $$\limits_{h{\downarrow}0}^{lim\;inf\;h^{-1}d(S(h)v(0)+hf(t,v);D)=0}$$ for almost every $t{\in}(a,b)$ and every $v{\in}C([-q,0];X)\;with\;v(0){\in}D$.

• 한국IT서비스학회:학술대회논문집
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• 한국IT서비스학회 2002년도 추계학술대회
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• pp.425-430
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• 2002

Over the years, several different approaches have been proposed to enhance the practice of software reuse. These approaches vary in reuse abstraction levels or application domains they focus on. However, it seems that they do not adequately meet the needs of software designers in planning and managing reuse. One reason may be the lack of conceptually well-established framework supporting work domain analysis and modeling. As a new viable solution to this problem, Sutcliffe and his colleagues developed Domain Theory , which is introduced in this paper. Utilizing multidisciplinary perspective, such as cognitive psychology, management science, human-computer interaction, and software engineering. it provides a schematic framework that defines a comprehensive library of generic and reusable models of domain knowledge in terms of generic tasks and meta-domains. It also provides useful methods and guidelines for software reuse, emphasizing the concept of abstraction process in a designer s mind. This paper firstly gives a brief overview of fundamentals of software reuse. Next, it explains the foundation of domain theory and discusses its applicability to software reuse. In particular, the taxonomy of meta-domains and the types of generic tasks are described in more detail. Finally, the future research framework, which primarily addresses the problem of how to apply the domain theory to various work domains, is proposed.

• The Korean Journal of Ceramics
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• 제1권4호
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• pp.197-203
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• 1995

Nearly fully dense PZT samples both with tetragonal and with morphotropic phase boundary compositions were prepared by the conventional powder processing and sintering. A micro-indentation technique was used to evaluate the dependence of fracture toughness on remanent polarization, crack length and the direction of crack propagation. The result shows that the toughness increases with the remanent polarization along the poling direction and decreases in the transverse direction. The dependence of toughness on the remanent polarization is neither symmetric nor linear but rather shown to be saturated quickly with the increase in remanent polariztion. R-curve behaviors are observed in both poled and unpoled samples. Sequential SEM and XRD studies on annealed, poled, ground, fractured and etched samples show that domain switching is evident as a viable toughening mechanism but might depend upon the rate of crack propagation. Grain bridging is also observed as one of the active toughening mechanisms.

• International Journal of Computer Science & Network Security
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• 제21권7호
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• pp.365-373
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• 2021

Covid-19 posed a serious threat to public health worldwide, especially in the absence of vaccines or medicines. The only viable strategies to combat a virus with a high infection rate were to apply lock-down strategies, transport ban, social and physical distancing. In this work, we provide a domain-specific component model for crisis management. The model allows for building a plan for managing Covid-19 crisis and use the plan as a template to generate a system specific for managing that crisis. The crisis component model is derived from X-MAN II, a generic component model that we have developed for the aircraft industry

• 한국지진공학회논문집
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• 제7권6호
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• pp.1-7
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• 2003

이 논문에서는 비선형 지반-구조물 상호작용해석을 위한 새로운 시간-주파수영역 복합법을 제시하였다. 제안한 방법은 등가선형 지반-구조물 상호작용해석 프로그램과 범용 비선형 유한요소해석 프로그램을 동시에 사용하는 실용적인 방법이다. 이 방법에서는 먼저 주파수영역에서 등가선형 지반-구조물 상호작용해석을 수행하여 유한요소 영역의 경계면에서 응답을 구한 다음, 이를 범용 비선형 유한요소해석 프로그램에 의한 비선형 동적해석의 시간의존 경계조건으로 입력한다. 제안된 방법의 검증을 위하여 2차원 지하철 정거장 구조물에 대한 지진해석을 수행하였다. 이를 위하여 등가선형 지반-구조물 상호작용해석 프로그램 KIESSI-2D와 비선형 유한요소해석 프로그램 ANSYS를 사용하였다 수치적인 해석결과로부터 이 연구에서 제안한 방법의 타당성을 확인할 수 있었다.

• 한국수자원학회논문집
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• 제32권3호
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• pp.215-223
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• 1999

최근, 국내외에서 TDR(Time Domain Reflectometry)기법을 이용한 토양 함수량 측정이 유용한 기술로써 받아들여져 오고 있다. Topp 등, (1980)에 의하여 최초로 제안된 경험식이 TDR에 의해 측정된 유전상수로부터 토양 함수량을 결정하는 데에 폭넓게 적용되어져 왔다. 그러나, 이 방법의 적용범위는 중간 입자 조성의 토양(Medium-testured soils)에 한해서 제한되어져 왔다. 본 연구에서는 Topp 모델이 사력토(Sandy-gravelly soils)에서도 적용가능한 지를 알아보고자 한다. 검정실험은 토양시료내에 설치된 2선 TDR 탐침을 따라 전송되는 광전자파의 전송시간 측정과 중력법에 따른 토양 함수량 결정의 두 부분으로 구성되었다. 실험에 사용된 토양시료는 2개의 다른 TDR 탐침길이에 대하여 중복시료로서 각 시료당 자갈의 질량 퍼센티지가 다른 7개의 입도 분포로 구성되었다. 계산 결과 Topp이 제안한 식은 주어진 유전상수에 대하여 3내지 8%정도 함수량을 과대 추정하고 있음을 알 수 있었으며, 본 연구에서 사력토에 대한 새로운 경험식을 제안하였다.

• Journal of Microbiology and Biotechnology
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• 제33권7호
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• pp.964-972
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• 2023

Bacteriophage endolysins are peptidoglycan hydrolases composed of cell binding domain (CBD) and an enzymatically active domain. A phage endolysin CBD can be used for detecting bacteria owing to its high specificity and sensitivity toward the bacterial cell wall. We aimed to develop a method for detection of Enterococcus faecalis using an endolysin CBD. The gene encoding the CBD of ECP3 phage endolysin was cloned into the Escherichia coli expression vector pET21a. A recombinant protein with a C-terminal 6-His-tag (CBD) was expressed and purified using a His-trap column. CBD was adsorbed onto epoxy magnetic beads (eMBs). The bacterial species specificity and sensitivity of bacterial binding to CBD-eMB complexes were determined using the bacterial colony counting from the magnetic separations after the binding reaction between bacteria and CBD-eMB complexes. E. faecalis could bind to CBD-eMB complexes, but other bacteria (such as Enterococcus faecium, Staphylococcus aureus, Escherichia coli, Acinetobacter baumannii, Streptococcus mutans, and Porphyromonas gingivalis) could not. E. faecalis cells were fixed onto CBD-eMB complexes within 1 h, and >78% of viable E. faecalis cells were recovered. The E. faecalis recovery ratio was not affected by the other bacterial species. The detection limit of the CBD-eMB complex for E. faecalis was >17 CFU/ml. We developed a simple method for the specific detection of E. faecalis using bacteriophage endolysin CBD and MBs. This is the first study to determine that the C-terminal region of ECP3 phage endolysin is a highly specific binding site for E. faecalis among other bacterial species.

• Current Applied Physics
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• 제18권11호
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• pp.1327-1337
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• 2018

This paper investigates the vibration behavior of pristine and defected triangular graphene sheets; which has recently attracted the attention of researchers and compare these two types in natural frequencies and sensitivity. Here, the molecular dynamics method has been employed to establish a virtual laboratory for this purpose. After measuring the different parameters obtained by the molecular dynamics approach, these data have been analyzed by using the frequency domain decomposition (FDD) method, and the dominant frequencies and mode shapes of the system have been extracted. By analyzing the vibration behaviors of pristine triangular graphene sheets in four cases (right angle of 45-90-45 configuration, right angle of 60-90-30 configuration, equilateral triangle and isosceles triangle), it has been demonstrated that the natural frequencies of these sheets are higher than the natural frequency of a square sheet, with the same number of atoms, by a minimum of 7.6% and maximum of 26.6%. Therefore, for increasing the resonance range of sensors based on 2D materials, nonrectangular structures, and especially the triangular structure, can be considered as viable candidates. Although the pristine and defective equilateral triangular sheets have the highest values of resonance, the sensitivity of defective (45,90,45) triangular sheet is more than other configurations and then, defective (45,90,45) sheet is the worst choice for sensor applications.

• Asian Pacific Journal of Cancer Prevention
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• 제13권12호
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• pp.6155-6157
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• 2012

Background: Mutations in the MAPK (Mitogen Activated Protein Kinase) signaling pathway - EGFR/Ras/RAF/MEK have been associated with the development of several carcinomas. ERK2, a downstream target of the MAPK pathway and a founding member of the MAPK family is activated by cellular signals emanating at the cell membrane. Activated ERK2 translocates into the nucleus to transactivate genes that promote cell proliferation. MKP - a dual specific phosphatase - interacts with activated ERK2 via the common docking (CD) domain of the later to inactivate (dephosphorylate) and effectively terminate further cell proliferation. A constitutively active form of ERK2 carrying a single point mutation - E322K in its CD domain, was earlier reported by our laboratory. In the present study, we investigated the prevalence of this CD domain E322K mutation in 88 well differentiated OSCC tissue samples. Materials and Method: Genomic DNA specimens isolated from 88 oral squamous cell carcinoma tissue samples were amplified with primers flanking the CD domain of the ERK2 gene. Subsequently, PCR amplicons were gel purified and subjected to direct sequencing to screen for mutations. Results: Direct sequencing of eighty eight OSCC samples identified an E322K CD domain mutation in only one (1.1%) OSCC sample. Conclusions: Our result indicates that mutation in the CD domain of ERK2 is rare in OSCC patients, which suggests the role of genetic alterations in other mitogenic genes in the development of carcinoma in the rest of the patients. Nevertheless, the finding is clinically significant, as the relatively rare prevalence of the E322K mutation in OSCC suggests that ERK2, being a common end point signal in the multi-hierarchical mitogen activated signaling pathway may be explored as a viable drug target in the treatment of OSCC.

• 전자통신동향분석
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• 제33권3호
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• pp.59-69
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• 2018

Terahertz (THz) imaging and spectroscopy have been developed as non-destructive testing methods for various industrial applications. However, they have not been widely adopted in real applications owing to a high system price and the large size of conventional THz time-domain spectroscopy systems, which are based on ultrashort optical pulse lasers. Recently, various types of compact THz emitters and detectors have become available. As a result, THz non-destructive test (NDT) systems have become viable solutions. Herein, we briefly review the recent advances in THz NDT techniques adopting continuous-wave THz systems, including our recent results of a THz-based waterproof test system and an electrical connection inspection system for car manufacturing.