• Korean Journal of Fisheries and Aquatic Sciences
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• v.48 no.4
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• pp.403-410
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• 2015

Viral nervous necrosis (VNN) is a serious disease of sevenband grouper Epinephelus septemfasciatus in Korean aquaculture farms. However, we suggest the following preventative methods for hatcheries: 1) disinfecting rearing water, 2) selecting spawners via ELISA and PCR, 3) selecting eggs via PCR, 4) disinfecting fertilized eggs, and 5) proper facilities management. When these methods are implemented, nervous necrosis virus (NNV)-free fish are produced because vertical and horizontal transmission is prevented. However, horizontal transmission of NNV through rearing seawater sourced from the environment during grow-out stages in sea cages can still occur. Live NNV vaccines with a low rearing temperature or Poly(I:C) immunization are very effective at preventing horizontal transmission of NNV in rearing farms. Furthermore, even after VNN is contracted, fish mortality can be reduced by administering Poly(I:C).

• Structural Engineering and Mechanics
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• v.64 no.6
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• pp.683-693
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• 2017

According to a generalized nonlocal strain gradient theory (NSGT), dynamic modeling and free vibrational analysis of nanoporous inhomogeneous nanoplates is presented. The present model incorporates two scale coefficients to examine vibration behavior of nanoplates much accurately. Porosity-dependent material properties of the nanoplate are defined via a modified power-law function. The nanoplate is resting on a viscoelastic substrate and is subjected to hygro-thermal environment and in-plane linearly varying mechanical loads. The governing equations and related classical and non-classical boundary conditions are derived based on Hamilton's principle. These equations are solved for hinged nanoplates via Galerkin's method. Obtained results show the importance of hygro-thermal loading, viscoelastic medium, in-plane bending load, gradient index, nonlocal parameter, strain gradient parameter and porosities on vibrational characteristics of size-dependent FG nanoplates.

• THE INTERNATIONAL COMMERCE & LAW REVIEW
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• v.31
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• pp.59-78
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• 2006

The purpose of this research is to discuss the excepted perils of carriers, to expose moot points arising from the applications of the excepted perils of the carriers, and then to suggests improvements them. The methodology of this research depended largely upon a combination of the related precedents, international treaties related to the excepted perils of carriers. The excepted perils of carriers in marine carriage begin with extremely limited perils based on the receptum liabilities and the absolute liability principle in English common law. Proceed via the intemperate expansion of the excepted perils by the widespread diffusion of the principle of free contract. but via the American Harter Act, The Hague Rules, The Hague Visby Rules, and The Hamburg Rules Came contracted. This study conducted an analysis of the excepted perils for the carriers and suggests improvements in them but it remains regrettable that we are not in a position to sustain them since we are lacking is precedents connected with The Hamburg rules.

• Journal of the Korean Society of Manufacturing Technology Engineers
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• v.25 no.6
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• pp.421-425
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• 2016

Micro-EDM is one of the recent fine-machining technologies. Micro-EDM is widely used in precision processes because products manufactured via EDM are free from workpiece hardness. However, the debris produced during the process cause many problems such as reduced precision of the process. The first solution of this problem involves using the milling hole process. Micro-EDM hole process involves an electrode moving rapidly in the vertical direction via a servo system to disperse debris. However, this process can cause reduced work efficiency owing to contact between the electrode and workpiece. In this study, ultrasonic vibration is added to micro-EDM channel machining. Ultrasonic vibration removes the debris during machining and enables precision machining. Consequently, a clean work environment for the subsequent processes is maintained.

• Proceedings of the Korea Institute of Applied Superconductivity and Cryogenics Conference
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• 2003.02a
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• pp.95-97
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• 2003

Y$_2$O$_3$ buffer layers have been fabricated on Ni tapes via MOD process. Films were annealed either in reductive or oxidative condition Successfully (200) orientated buffer layers were grown. The out-of-plane orientation of film were characterized by Δ$\theta$ is about 5.4$^{\circ}$. Although films prepared with acetic acid contains a large amount of microcrack, those prepared with 2-MOE(2-methoxy ethanol) exhibit a crack-free surface.

• Smart Structures and Systems
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• v.16 no.3
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• pp.401-414
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• 2015

A developed hybrid method for crack identification of beams is presented. Based on the Euler-Bernouli beam theory and concepts of fracture mechanics, governing equation of the cracked beams is reformulated. Finite element (FE) method as a powerful numerical tool is used to discritize the equation in space domain. After transferring the equations from time domain to frequency domain, frequencies and mode shapes of the beam are obtained. Efficiency of the governed equation for free vibration analysis of the beams is shown by comparing the results with those available in literature and via ANSYS software. The used equation yields to move the influence of cracks from the stiffness matrix to the mass matrix. For crack identification measured data are produced by applying random error to the calculated frequencies and mode shapes. An objective function is prepared as root mean square error between measured and calculated data. To minimize the function, hybrid genetic algorithms (GAs) and particle swarm optimization (PSO) technique is introduced. Efficiency, Robustness, applicability and usefulness of the mixed optimization numerical tool in conjunction with the finite element method for identification of cracks locations and depths are shown via solving different examples.

• Journal of Plant Biology
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• v.37 no.3
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• pp.333-341
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• 1994

Effective plant regeneration from immature cotyledons of soybean [Glycine max (L.) Merr.] cultivars was achieved via somatic embryogenesis. Somatic embryogenesis was performed with the cotyledons of immature embryos 14-20 d after flowering. Immature cotyledons of cv. Whangkeum were placed abaxial or adaxial side down on modified MS medium containing 20mg/L 2,4-D. The greatest number of somatic embryos, 1.2 per cotyledon, was produced from those of 4.0-4.9 mm in length which had been placed abaxial side down. Among cvs. Pecking, Whangkeum and Baekwoon, Pecking had the highest embryo induction efficiency with 4.3 somatic embryos per cotyledon in 20mg/L 2,4-D treatment and with 1.0 embryo per cotyledon in 8mg/L NAA treatment. Germinable globular somatic embryos were induced with the highest efficiency, 27.6%, in 20mg/L 2,4-D and were proliferated efficiently on liquid medium containing 10mg/L 2,4-D. The globular somatic embryos developed into germinable mature somatic embryos on medium containing 10 $\mu$M CoCl2, 9% sucrose, and 0.5% activated charcoal. These mature somatic embryos germinated on hormone-free mediu. After transfer to the soil, regenerated plants with seeds were obtained.

• Bulletin of the Korean Chemical Society
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• v.24 no.10
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• pp.1490-1494
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• 2003

Noncovalently linked electron donor-acceptor dyad consisting of zinc tetratolylporphyrin and pyridine appended ruthenium trisbipyridine comlex was prepared, via axial coordination of pyridine moiety in ruthenium trisbipyridine complex on zinc tetratolylporphyrin. For the purpose of comparison, axial coordination of pyridine-appended 2,2'-bipyridine on zinc tetratolylporphyrin was also investigated. The Kvalues were detemined based on absorption of fluorescence studies. The fluorescence of zinc teratolylporphrin was efficiently quenched upon axial coordination of pyridine moiety, prbably due to the photoinduced electron transfer from zinc tetrtolylporphyrin to ruthenium trisbipyridine, supported by free enegy estimation.

• Nuclear Engineering and Technology
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• v.49 no.6
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• pp.1181-1188
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• 2017

This paper proposes the adoption of Monte Carlo perturbation theory to approximate the Jacobian matrix of coupled neutronics/thermal-hydraulics problems. The projected Jacobian is obtained from the eigenvalue decomposition of the fission matrix, and it is adopted to solve the coupled problem via the Newton method. This avoids numerical differentiations commonly adopted in Jacobian-free Newton-Krylov methods that tend to become expensive and inaccurate in the presence of Monte Carlo statistical errors in the residual. The proposed approach is presented and preliminarily demonstrated for a simple two-dimensional pressurized water reactor case study.

• Journal of Cancer Prevention
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• v.23 no.4
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• pp.153-161
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• 2018

Imbalance of protein homeostasis (proteostasis) is known to cause cellular malfunction, cell death, and diseases. Elaborate regulation of protein synthesis and degradation is one of the important processes in maintaining normal cellular functions. Protein degradation pathways in eukaryotes are largely divided into proteasome-mediated degradation and lysosome-mediated degradation. Proteasome is a multisubunit complex that selectively degrades 80% to 90% of cellular proteins. Proteasome-mediated degradation can be divided into 26S proteasome (20S proteasome + 19S regulatory particle) and free 20S proteasome degradation. In 1980, it was discovered that during ubiquitination process, wherein ubiquitin binds to a substrate protein in an ATP-dependent manner, ubiquitin acts as a degrading signal to degrade the substrate protein via proteasome. Conversely, 20S proteasome degrades the substrate protein without using ATP or ubiquitin because it recognizes the oxidized and structurally modified hydrophobic patch of the substrate protein. To date, most studies have focused on protein degradation via 26S proteasome. This review describes the 26S/20S proteasomal pathway of protein degradation and discusses the potential of proteasome as therapeutic targets for cancer treatment as well as against diseases caused by abnormalities in the proteolytic system.