• Journal of the Korean Wood Science and Technology
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• v.45 no.1
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• pp.72-84
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• 2017

This study aimed to suggest a method to establish vessel-lumen-area chronologies in domestic Quercus spp. from Mt. Songni and to verify their potential as a climate proxy. In order to establish vessel-lumen-area chronologies, three options were applied to filter vessels. Options 1 and 2 use vessels having lumina larger than or equal to $6,000{\mu}m^2$ (MVA-60) and $7,500{\mu}m^2$ (MVA-75), respectively, to establish the chronologies by their mean values in each year, and option 3 uses the largest one (MAX) in each tree ring. MVA-60 and MVA-75 had mostly significant relationships with the winter precipitation between November in the previous year and January in the current year, however, MAX had only significant relationship with November precipitation in the previous year. Based on these results, it was verified that the potential of vessel lumina in domestic Quercus spp. could be a climate proxy in dendroclimatology.

• ETRI Journal
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• v.39 no.5
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• pp.662-671
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• 2017

Coronary artery disease (CAD) is a major cause of death in the world. As a non-invasive imaging modality, computed tomography angiography (CTA) is now usually used in clinical practice for CAD diagnosis. Precise quantification of coronary stenosis is of great interest for diagnosis and treatment planning. In this paper, a novel cluster method based on a Modified Student's t-Mixture Model is applied to separate the region of vessel lumen from other tissues. Then, the area of the vessel lumen in each slice is computed and the estimated value of it is fitted with a curve. Finally, the location and the level of the most stenoses are captured by comparing the calculated and fitted areas of the vessel. The proposed method has been applied to 17 clinical CTA datasets and the results have been compared with reference standard degrees of stenosis defined by an expert. The results of the experiment indicate that the proposed method can accurately quantify the stenosis of the coronary artery in CTA.

• Journal of the Korea Furniture Society
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• v.28 no.3
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• pp.248-258
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• 2017

A study was carried out to observe the 1% aqueous safranine solution flow speed in longitudinal and radial directions of softwood Thuja orientalis L., diffuse-porous wood Gmelina arborea Roxb., and ring-porous wood Phellodendron amurense Rupr., Longitudinal flow was considered from bottom to top while the radial flow was considered from bark to pith directions. In radial direction, ray cells and in longitudinal direction tracheids, vessel and wood fiber were considered for the measurement of liquid penetration speed at less than 12% moisture contents(MC). The variation of penetration speed for different species was observed and the reasons behind for this variation were explored. The highest radial penetration depth was found in ray parenchyma of T. orientalis but the lowest one was found in ray parenchyma of P. amurense. The average liquid penetration depth in longitudinal trachied of T. orientalis was found the highest among all the other cells. The penetration depth in fiber of G. arborea was found the lowest among the other longitudinal cells. It was found that cell dimension and also meniscus angle of safranine solution with cell walls were the prime factors for the variation of liquid flow speed in wood. Vessel was found to facilitate prime role in longitudinal penetration for hardwood species. The penetration depth in vessel of G. arborea was found highest among all vessels. Anatomical features like ray parenchyma cell length and diameter, end-wall pits number were found also responsible fluid flow differences. Initially liquid penetration speed was high and the nit gradually decreased in an uneven rate. Liquid flow was captured via video and the penetration depths in those cells were measured. It was found that even in presence of abundant rays in hardwood species, penetration depth of liquid in radial direction of softwood species was found high. Herein the ray length, lumen area, end wall pit diameter determined the radial permeability. On the other hand, vessel and fiber structure affected the longitudinal flow of liquids. Following a go-stop-go cycle, the penetration speed of a liquid decreased over time.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.31 no.4
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• pp.300-305
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• 2005

Purpose: For the reconstruction of maxillofacial defect created by trauma, infection, or tumor etc, the role of microvascular anastomosis or vessel graft has been increased. Many methods has been tried to increase the success rate of microvascular anastomosis. Various anticoagulants and thrombolytic agents have been used to reduce the failure rate of microvascular anastomosis and avoid re-operation. Many drugs, however, have been used in the limited cases because most of these drugs may cause complications, such as allergy, fever or systemic bleeding. This study was performed to evaluate the influence of the Argatroban on patency and thrombosis in microvascular anastomosis when it is used for local irrigation or general administration. Materials & methods: Eight mature rabbits, weighing 2kg, were used. After exposing both femoral veins, the artificial thrombotic model was made by crushing injury using a smooth needle holder, and the transverse incision were made on femoral vein. The animals were divided into 4 groups according to Argatroban administration methods; control group (n=4), topical irrigation of lumen with saline solution; experimental group 1 (n=4), topical irrigation of lumen with Argatroban saline solution; experimental group 2 (n=4), topical irrigation of lumen with heparin followed by intravenous injection of Argatroban; experimental group 3 (n=4), topical irrigation of lumen with Argatroban followed by IV of Argatroban. Microvascular anastomosis was done with 10-0 Ethilon. The patency was evaluated by empty-and-refill test 30 minutes and 3 days after microanastomosis. The thrombus formation was examined 3 days after microanastomosis by surgical microscope. The histologic findings were also examined. Results: 1. Thirty minutes after microvascular anastomosis, the patency of all experimental groups was better than that of control group, but there was no significant difference among groups. 2. Three days after microvascular anastomosis, the patency of all experimental groups was more improved than that of control group (p<0.05). There was no significant difference among experimental groups. 3. Three days after microvascular anastomosis, the amount of thrombus in all experimental groups was less than that of control group (p<0.05). There was no significant difference among experimental groups. 4. Histologically, a lot of luminal thrombus was observed around sutured area in control group. Few luminal thrombus was observed in all experimental groups. The necrotic changes were observed on the sutured vein wall in all specimens. Conclusion: These results indicate that topical irrigation and/or intravenous administration of Argatroban is effective in improving patency and preventing thrombus formation after microvascular anastomosis.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.29 no.4
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• pp.232-238
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• 2003

This study was performed to evaluate the effect of topical and intravenous heparin on thrombosis and patency in the microvascular anastomosis of the traumatized veins. Nine white rabbits weighing about 2 kg were used. After exposure of both femoral veins, the veins were crushed by the jaws of smooth needle holder in order to create a thrombosis model. Transectional incision was made in the vein. The animals were then divided into 3 groups based on the administration method of heparin: 1) Experimental Group I, topical irrigation of lumen with heparin saline solution (n=6); 2) Experimental Group 2, topical irrigation of lumen with heparin saline solution and intravenous injection of heparin (0.75 mg/kg) via the marginal ear vein for 3 days; 3) Control Group, topical irrigation of lumen with saline solution (n=6). The patency was evaluated with empty-and-refill test and thrombus formation was judged by surgical microscope. The results were as follows: 1. Thirty minutes after microvascular anastomosis, the patency of all Experimental Groups was better than Control group. However, there was no significant difference among groups. 2. Three days after anastomosis, the patency of all Experimental Groups was much more improved than that of Control Group (P<0.05). There was no significant difference between Experimental Group 1 and 2. 3. Three days after anastomosis, the amount of thrombus in all Experimental Groups was much less than that of Control Group (P<0.05). 4. In histologic findings a lot of luminal thrombus were observed around sutured area in Control Groups. Few luminal thrombus was observed in all Experimental Groups. Mild necrosis in the vessel wall was observed around sutured area in all specimens. These results indicate that topical irrigation of heparin may improve the patency and inhibit the formation thrombus in the microvascular anastomosis of the traumatized veins.

• 대한핵의학회:학술대회논문집
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• 1999.05a
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• pp.205-208
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• 1999

Percutaneous Transluminal Coronary Angioplasty (PTCA) remains limited by restenosis that occurs in 30 to 50% of patients with coronary artery disease. During the last decade, numerous agents have been used to prevent restenosis. Despite positive results in animal models, no pharmacological therapy has been found to significantly decrease the risk of restenosis in humans. These discrepancies between animal models and clinical situation were probably related to an incomplete understanding of the mechanism of restenosis. Neointimal thickening occurs in response to experimental arterial injury with a balloon catheter. Neointimal formation involves different steps: smooth muscle cell activation, proliferation and migration, and the production of extracellular matrix. The factors that control neointimal hyperplasia include growth factors, humoral factors and mechanical factors. Arterial remodeling also plays a major role in the restenosis process. Studies performed in animal and human subjects have established the potentials for "constrictive remodeling" to reduce the post-angioplasty vessel area, thereby indirectly narrowing the vessel lumen and thus contributing to restenosis. The reduction of restenosis rate in patients with intracoronary stent implantation has been attributed to the preventive effect of stent itself for this negative remodeling. In addition to these mochanisms for restenosis, intraluminal or intra-plaque thrombus formation, reendothelialization and apoptosis theories have been introduced and confirmed at least in part.

• Journal of the Korean Society of Radiology
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• v.15 no.5
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• pp.621-628
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• 2021

Prior studies on frequency-related image quality analysis of intravascular ultrasound catheters are lacking both in Korea and abroad. Therefore, this study was conducted to prepare a standard for measuring the image quality using the program and to suggest a measuring method to researchers related to the quality analysis of intravascular ultrasound images. For the target, the vessel lumen size is 3.0 - 4.0 mm. Before using intravascular ultrasound, thoroughly clean the ultrasound catheter so that no air or foreign substances enter it. Normal vascular images and lesion vascular images of sufficiently dilated images were used. As a standard image acquisition method, the image of the end-systolic section, which has the best evaluation of vascular lesions when using intravascular ultrasound, was acquired retrospectively through the DCAS PACS program to set the standard. When setting the measurement method criteria, we proposed a standard setting method that corresponds to the concentric and eccentric circles of normal and lesion vessels. By applying this criterion, we proposed a method for measuring the lumen and lateral cavities of normal and lesion vessels of interest and background area. In conclusion, if the image quality of intravascular ultrasonography is measured through the method devised by these researchers, consistent quality measurement is possible regardless of the type of intravascular ultrasound catheter. Therefore, it is thought that it can be applied as a guideline for the actual image quality measurement method in the study related to intravascular ultrasound image quality.

• Journal of Nutrition and Health
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• v.1 no.3_4
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• pp.201-205
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• 1968

The authors has observed the histopathologically and histochemically on the effect of the garlic and garlic oil to the liver and kidney of rats. In order to confirm the histochemical changes of the metabolism of polysaccarides, the periodic acid Schiff reaction was applied. The 30 albino adult male rats weighing about 150 grames from the National Institute of Health were housed individualy and devide into 3 experimental groups: Group C: stock diet group Group B: stock diet-garlic group Group A: stock diet-garlic oil group Group C was fed with stock diet only through out this experimental period, Group B was fed with stock diet supplemented with garlic homogenator to be 1%, and Group A was fed with stock diet supplemented with the garlic oil to 0.05%. The garlic oil used in this experiments was extracted by author. And all rats was fed during 10 weeks. The histopathological and histochemical results were shown in each figure. According to the all results, the following concIusions were drawn. 1) In the garlic oil administrated groups, congestion of the sinusoid was subsided and the liberation of the Kupffer's cells were observed. 2) In garlic administrated groups, fatty metamorphosis in hepatic cells, and slight liberation of Kupffer's cells in sinusoidal walls were observed. Connective tissue proliferation and collagen bundle were observed. 3) The connective tissue and blood vessel wall in portal area Were reacted intensely with PAS stain. The hepatic cells Were reacted intensely with PAS stain in control group and moderately or slightly in garlic and garlic oil administrated group. 4) There were no significant differences in collecting and Henle's loops in each groups, but narrowing of lumen of the distal tubules were observed in garlic oil administrated group. 5) The basement membrane of the tubules and the connective tissues of the vessel wall in Kideny were reacted intensely with PAS stain in each groups. In control and garlic administrated groups. the brush border of the proximal tubules were reacted intensely with PAS stain, but epithelium of the Heine's loop, proximal, distal and collecting tubules were reacted moderately. In garlic oil administrated-group, there were tendency of decreasing of PAS stain in each tubules.