• Biomolecules & Therapeutics
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• v.18 no.4
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• pp.351-362
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• 2010

Nitric oxide (NO), synthesized from L-arginine by three isoforms of NO synthase (NOS), is a gaseous signaling molecule with an astonishingly wide range of biological and pathophysiological activities, including vasorelaxation, angiogenesis, anti-inflammation, and anti-apoptosis in mammalian cells. Recent studies have shown that NO donors and inhaled NO convert to biologically active NO under biological conditions and act as a signaling molecule in pathophysiological conditions. This review will discuss the roles of NO and its potential therapeutic implication in various human diseases, such as tumor, vascular regeneration, hypertension, wound healing, and ischemia-reperfusion injury.

• Journal of Trauma and Injury
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• v.32 no.4
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• pp.243-247
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• 2019

Subclavian vein injuries occasionally occur as a sequela of penetrating trauma or vascular access, but have rarely been reported to occur after clavicle fracture. The subclavian vessels are mainly enclosed by the subclavius muscle, the first rib, and the costocoracoid ligament. Therefore, in such cases, subclavian vein injury is rare because of the strcutures surrounding the subclavian vessels. Nevertheless, subclavian vein injuries occasionally show thrombotic manifestations, and thrombosis of the upper limbs constitutes 1-4% of cases of total deep vein thrombosis. Furthermore, to the best of the authors' knowledge, although vessel injuries have been reported after clavicle or rib fractures and nerve injuries to regions such as the brachial plexus, no case involving delayed presentation of isolated subclavian vein stenosis after clavicle fracture due to blunt trauma has yet been reported.

• YAKHAK HOEJI
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• v.56 no.3
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• pp.180-185
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• 2012

The aim of present study was to investigate the possible influence and related mechanism of alcohol on the arterial contraction. Vascular contraction involves the activation of thick or thin filament pathway. However, there are no reports addressing the question whether this pathway is involved in alcohol-induced regulation. We hypothesized that alcohol plays a role in vascular contraction evoked by a vasoconstrictor in rat aortae regardless of endothelial function. Denuded arterial rings from male rats were used and isometric contractions were recorded using a computerized data acquisition system. Interestingly, alcohol at a low concentration (3% v/v) inhibited thromboxane $A_2$ or phorbol ester-induced contraction with endothelial function but at a high concentration (10%) didn't inhibit and rather increased the contraction in the denuded muscle. Therefore, alcohol at a low concentration decreases the contraction and alcohol at a high concentration increases the contraction suggesting that additional pathways different from endothelial nitric oxide synthesis might be involved in the regulation of contractility. In conclusion, alcohol has some effect on the regulation of contractility regardless of endothelial function.

• Journal of Korean Neurosurgical Society
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• v.59 no.4
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• pp.420-424
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• 2016

The spinal dural arteriovenous fistula (SDAVF) is rare, presenting with progressive, insidious symptoms, and inducing spinal cord ischemia and myelopathy, resulting in severe neurological deficits. If physicians have accurate and enough information about vascular anatomy and hemodynamics, they achieve the good results though the surgery or endovascular embolization. However, when selective spinal angiography is unsuccessful due to neurological deficits, surgery and endovascular embolization might be failed because of inadequate information. We describe a patient with a history of vasospasm during spinal angiography, who was successfully treated by spinal stereotactic radiosurgery using Novalis system.

• Journal of Trauma and Injury
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• v.27 no.4
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• pp.219-223
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• 2014

Traumatic injuries of the inferior vena cava (IVC) are the most challenging lesions in abdominal vascular injuries and are associated with a high mortality rate. Although endovascular treatment has been addressed in the management of vascular trauma, surgery is the mainstay in the treatment for IVC injury as an endovascular technique for the venous system has not been developed. We report a case of successful surgical repair of an extensive IVC laceration following a fall.

• Proceedings of the KOSOMBE Conference
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• v.1996 no.05
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• pp.195-198
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• 1996

This paper is studid the flow analysis of cardio vascular assist device. The experimental study is carried out to measure velocity profiles, Shear stress distributions and Velocity Vector for the flowrare of 4l/min, the frequency of 0.5Hz, the stroke volume of 60ml, the inlet and outlet pressure of 100mmHg by the L.D.V and P.I.V system. These results are agreed with the numerical simulations.

• Journal of Chest Surgery
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• v.18 no.4
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• pp.806-811
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• 1985

Pulmonary arteriovenous fistula is a rare congenital vascular malformation in the lung, resulting from erroneous capillary development, with incomplete formation or disintegration of the vascular septa that would normally divide the primitive connection between the venous and arterial plexus. The pathogenesis of its symptom is that unoxygenated and desaturated arterial blood enter into the pulmonary venous system directly. Recently we have experienced a case of multiple pulmonary arteriovenous fistula in a 15 year old male patient, who presented the symptom of cyanosis and dyspnea on exertion. The operation revealed well circumscribed and multilobulated aneurysmal lesion in left lower lobe with its subpleural and posterolateral basal location, and another aneurysmal lesion in inferior lingular segment of left lung. There was no abnormal connection between the fistula and systemic circulation. The left lower lobectomy was performed along with local extirpation of the inferior lingular segment of left lung. Both lesions showed angiomatous dilatation of the various sized vessels embedded in the parenchyma microscopically. Postoperative clinical course disclosed much improvement in symptoms and in the value of blood gas analysis. The patient was discharged without any complication.

• Biomedical Science Letters
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• v.29 no.1
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• pp.34-40
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• 2023

Smoking is one of the three major risk factors for vascular disease along with hypertension and hyperlipidemia. It is true that smoking has a negative effect on the circulatory system, and the frequency of coronary artery disease and peripheral vascular disease is significantly increased in smokers. Many epidemiological studies report that smokers have an approximately two-fold increased risk of coronary artery disease compared to non-smokers. This study was designed to investigate the relationship between cerebral blood flow change and depression index after acute smoking. Cerebral blood flow tests were performed before and after smoking in 8 subjects. Changes in blood flow after smoking were correlated with the depression score and negatively correlated with the depression score. In particular, there was a strong correlation with changes in blood flow in anterior cerebral artery. It is well known that changes in blood flow after smoking have a negative effect. In addition, considering the study that smoking aggravates the symptoms of depression, it was found that smoking and depression are factors that negatively affect each other.

• Journal of the korean veterinary medical association
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• v.6 no.1
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• pp.11-14
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• 1962

The influence of pentobarbital sodium on the central nervous system has been studied extensively, but its effects on other systems have not received as much atention. In spite of the fact that vast amount of cardio-vascular research has been conducted on

• Proceedings of the Korean Magnestics Society Conference
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• 2011.12a
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• pp.126-128
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• 2011