• Korean Journal of Plant Taxonomy
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• v.40 no.1
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• pp.16-26
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• 2010

The petiole anatomy of three sections (sects. Calospira, Chamaedryon, and Spiraria) in the genus Spiraea (Rosaceae), which are distributed/cultivated in Korea, was studied and described in details. The vascular bundle system of the distal, medial, and proximal parts of the petiole were studied using LM with the aim of documenting any differences in vascular anatomy. Significant variation of anatomical characters was found in petiole shape (dichotomy, lens or subcircular in outline), presence of two distinct lateral wings, the thickness of epidermis, number of vascular bundles, length of ventral axis, length of dorsiventral axis, width of median vascular bundle, and length of median vascular bundle. All features were compared and we concluded that petiole anatomical characters can be useful for providing diagnostic features to distinguish the studied taxa. A key for identifying the Spiraea taxa in Korea based on their petiole anatomical characters is also provided.

• Archives of Plastic Surgery
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• v.34 no.1
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• pp.13-17
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• 2007

Purpose: To understand the pathogenesis of the disease that presents abnormally proliferated vascular endothelial cells, a model of DMH(1,2-dimethylhydrazine)-induced abnormal proliferation of HUVECs(Human Umbilical Vein Endothelial Cells) was made. We indirectly determined that Protein Kinase C(PKC) restricts the cellular proliferation and inhibits the manifestation of growth factor by using several inhibiting substances of the transmitter through our previous studies. Thereupon, we attempted to observe direct enzymatic activities of PKC and its correlation with the abnormal proliferation of vascular endothelial cells. Methods: $10^5$ HUVECs cells were applied to 6 individual well plates in three different groups; A control group cultured without treatment, a group concentrated with $0.75{\times}10^{-8}M$ DMH only, and a group treated with DMH & $5{\times}10^{-9}M$ Calphostin C, inhibitor of PKC. In analyzing the formation of intracellular PKC enzyme, protein separation was performed, and separated protein was quantitatively measured. PKC enzyme reaction was analyzed through Protein Kinase C Assay System (Promega, USA), and the results were analyzed according to Beer's law. Results: Enzymatic activity of PKC presented the highest in all reaction time of a group concentrated only with DMH, and the lowest in the control group. The group treated with DMH and the inhibitor revealed statistically lower enzymatic activity than group only with DMH in all reaction time, although higher than the control group. Conclusion: From the enzymatic aspect, most active and immediate reaction of the PKC was observed in the group concentrated with DMH only. The group treated with DMH & PKC inhibitor showed meaningful decrease. Accordingly, PKC holds a significant role in DMH-induced abnormal proliferation of vascular endothelial cells.

• Journal of Industrial Convergence
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• v.20 no.7
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• pp.131-137
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• 2022

In the study, we endeavored to assess the convergence effect of Silybum marianum-derived silymarin and epidemiologically-correlated alcohol intake on vascular contractility and to determine the mechanism involved. There were few reports addressing the question whether thin or thick filament modulation is included in ethanol and silymarin-induced regulation. We hypothesized that ethanol at a low concentration and silymarin play a role in agonist-dependent regulation of vascular contractility. Denuded arterial muscles of Sprague-Dawley male rats were suspended in organ baths and isometric tensions were transduced and recorded using isometric transducers and an automatic data acquisition system. Interestingly, both silymarin and ethanol didn't encourage silymarin alone-induced inhibition in agonists-induced contraction suggesting that endothelial nitric oxide synthesis might be involved in ethanol or silymarin-induced modulation of vascular contractility and additional pathways besides endothelial nitric oxide synthesis such as ROCK inactivation might be involved in the silymarin-induced modulation of vascular contractility.

• Proceedings of the KSME Conference
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• 2007.05b
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• pp.2935-2940
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• 2007

To diagnose circulatory diseases in the viewpoint of hemodynamics, we need to get quantitative hemodynamic information of blood flows related with the vascular diseases with high spatial resolution of tens micrometer and high temporal resolution in the order of millisecond. For investigating in-vivo hemodynamic phenomena, a new diagnosing technique combining medical radiography and PIV method was newly proposed and developed. This angiographic PIV technique consists of a medical X-ray tube, an X-ray CCD camera, a shutter module for double pulses of X-ray, and a synchronizer. The feasibility of the angiographic PIV technique was tested and quantitative flow velocity field distribution of a flow inside an opaque conduit was acquired by the developed system. It can be used for measuring flow phenomena of nontransparent fluids inside opaque conduits.

• Korean Journal of Veterinary Research
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• v.6 no.1
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• pp.76-81
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• 1966

This study was conducted to observe the condition of the ramification of the bronchus and pulmonary blood vascular system by injection of vinylite into the bronchial tree and pulmonary blood vessels in normal adult swines. The results obtained were summarized as follows. 1. Lungs of swine were composed of the same pulmonary territories as in lungs of human and dog. 2. Bronchial tree of swine also were axial divergency in the patterns. 3. Ramification of the left and right apical lobes are especially complex patterns but cardiac and diaphragmatic lobes are a little monotonous. 4. Intermediate lobe corresponding to mediobasalis branch of human lungs formed only one lobe in swine lung. 5. Pulmonary artery of right apical lobe was mono branch form in all case by authors observation. 6. $B._2$ streched into the seg. dorsalis of the right apical lobe was especially developed compare to $B._1$, $B._3$ of the seg, apicalis and seg, ventralis.

• Toxicological Research
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• v.11 no.2
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• pp.169-173
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• 1995

The effects of tumor necrosis factor alpha $(TNF-{\alpha})$ on growth and tubular formation of bovine aortic endothelial cells were examined using an in vitro angiogenesis model system. The growth of endothelial cells was enhanced in a dose-dependent manner when the cells were cultured with $TNF-{\alpha}$ for 3 days, but $TNF-{\alpha}$, at the concentration of 1 nM or higher, produced a growth inhibition of endothelial cells when the cells were cultured for 8 days. The endothelial cells incubated with $TNF-{\alpha}$ for 48-h exhibited a typical morphologic change. Then, they showed a fibroblastoid organization of overlapping, elongated, and spindle-shaped cells. $TNF-{\alpha}$, at the concentration of O. 1 nM or higher, inhibited the tubular formation of vascular endothelial cells in an in vitro anglogenesis model using a 3-dimensional culture system.

• BMB Reports
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• v.49 no.5
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• pp.255-262
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• 2016

The disease known as cerebral cavernous malformations mostly occurs in the central nervous system, and their typical histological presentations are multiple lumen formation and vascular leakage at the brain capillary level, resulting in disruption of the blood-brain barrier. These abnormalities result in severe neurological symptoms such as seizures, focal neurological deficits and hemorrhagic strokes. CCM research has identified 'loss of function' mutations of three ccm genes responsible for the disease and also complex regulation of multiple signaling pathways including the WNT/β-catenin pathway, TGF-β and Notch signaling by the ccm genes. Although CCM research is a relatively new and small scientific field, as CCM research has the potential to regulate systemic blood vessel permeability and angiogenesis including that of the blood-brain barrier, this field is growing rapidly. In this review, I will provide a brief overview of CCM pathogenesis and function of ccm genes based on recent progress in CCM research.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2017.05a
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• pp.179-182
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• 2017

Cerebral nervous system intervention procedures have been reported frequently due to radiation exposure such as skin baldness, hair loss, and redness due to prolonged procedures. Therefore, the bismuth shield designed to reduce the radiation exposure of the target organ located in the anterior part of the human body sensitive to skin and radiation sensitivity during CT (computed tomography) scan is applied to the cerebral vascular system intervention by ergonomic design, To reduce the radiation dose of sensitive scalp, we propose a study.

• Journal of Mechanical Science and Technology
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• v.19 no.spc1
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• pp.343-349
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• 2005

There are many things in common between hemodynamics in arterial systems and multibody dynamics in mechanical systems. Hemodynamics is concerned with the forces generated by the heart and the resulting motion of blood through the multi-branched vascular system. The conventional hemodynamics model has been intended to show the general behavior of the body arterial system with the frequency domain based linear model. The need for detailed models to analyze the local part like coronary arterial tree and cerebral arterial tree has been required recently. Non-linear analysis techniques are well-developed in multibody dynamics. In this paper, the studies of hemodynamics are summarized from the view of multibody dynamics. Computational algorithms of arterial tree analysis is derived, and proved by experiments on animals. The flow and pressure of each branch are calculated from the measured flow data at the ascending aorta. The simulated results of the carotid artery and the iliac artery show in good accordance with the measured results.

• Clinical Endoscopy
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• v.51 no.6
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• pp.563-569
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• 2018

Background/Aims: To evaluate patients with portal hypertension (PH) of varied etiologies for portal hypertensive enteropathy (PHE) using the PillCam SB3 capsule endoscopy (CE) system. Methods: Consecutive patients with PH presenting with unexplained anemia and/or occult gastrointestinal bleeding were evaluated using the PillCam SB3 CE system. Abnormal findings were categorized as vascular or non-vascular. The patients with ongoing bleeding caused by PHE were treated. The correlation of the CE scores of PHE with the clinical, laboratory, and endoscopic features was determined. Results: Of the 43 patients included in the study, 41 (95.3%) showed PHE findings. These included varices (67.4%), red spots (60.5%), erythema (44.2%), villous edema (46.5%), telangiectasia (16.3%), and polyps (16.3%). The CE scores varied from 0 to 8 ($mean{\pm}standard$ deviation, $4.09{\pm}1.8$). Five patients (11.6%) showed evidence of ongoing or recent bleeding due to PHE. Three of these five patients underwent endotherapy, and one patient underwent radiological coil placement. Conclusions: The PillCam SB3 CE system revealed a high prevalence of PHE in the patients with PH. Using this system, evidence of bleeding due to PHE was found in a small but definite proportion of the patients.