• 고려인삼학회:학술대회논문집
• /
• 고려인삼학회 1998년도 Advances in Ginseng Research - Proceedings of the 7th International Symposium on Ginseng -
• /
• pp.1-11
• /
• 1998

Ameliorating mechanisms of red ginseng on learning deficits were investigated in the following 3 experiments; its effects on 1) place learning deficits in aged rats and in young rats with selective hippocampal lesions (behavioral study), 2) long-term potentiation in the hippocampal formation (neuro- physiological study), and 3) ChAT (choline acetyl transferase) activity in various brain regions of aged rats (pharmacological study). In the behavioral study, first, performance in the place learning tasks were compared among 3 groups of young and aged rats; control young intact rats (10-12 week old) treated with water, aged rats (28-32 month old) treated with water, and aged rats (28-32 month old) treated with red ginseng (100 mghglday) suspended in water. Second, performance in the place learning tasks was compared among 3 groups of young rats; control intact rats treated with water, rats with bilateral hippocampal lesions treated with water, and rats with bilateral hippocampal lesions treated with red ginseng (100 mg/kg/day). Each rat in these 2 behavioral experiments was tested with the 3 types of the place learning tasks in a circular open field using intracranial self-stimulation (ICSS) as reward. The ICSS reward was delivered if the rat (1) moved distance of 100-160 cm (DMT): (2) entered an experiment-determined reward place within the open field, and this place was randomly varied in sequential trials (RRPST); or (3) entered 2 specific places, and did a shuttle behavior between the 2 places (PLT). Performance of the aged rats in the ginseng group was not significantly different from that of control young rats in ICSS (current intensity, bar press rates), DMT and RRPST. However, treatment with red ginseng significantly ameliorated place-navigation learning deficits in aged rats in the PLT. Similarly, red ginseng ameliorated learning and memory deficits in young rats with hippocampal lesions in the same tasks. In the neurophysiological study using young rats, perfusion of hippocampal slices with non-sapon in fraction of red ginseng significantly enhanced magnitudes of the long-term potentiation (LfP) in the CA3 subfield. In the pharmacological study, treatment with red ginseng did not affect ChAT activity in aged rat brain including the hippocampal formation. These results strongly suggest that red ginseng ameliorates learning and memory deficits in aged rats through actions on the CA3 subfield of the hippocampal formation, which were independent of the presynaptic components of the cholinergic system

• 한국자원식물학회지
• /
• 제33권6호
• /
• pp.624-637
• /
• 2020

High-quality and high-phytonutrient watermelon fruits have strong market opportunities besides their health related benefits. Hence, investigating quality and nutritional related traits of watermelon genetic resources could provide important baseline data in breeding for increased lycopene content thereby increasing the marketability of watermelon. To this end, we have examined some fruit morphological traits and lycopene content of 105 genetic resources. Seeds, originally obtained from 22+ countries, were obtained from the National Agrobiodiversity Center, Jeonju, South Korea, grown in an experimental field and harvested at a fully mature stage. The size of pistil scar (SPS), the width of stripes (WS), weight of fruit (WF), length of fruit (LF), width of fruit (WIF), the thickness of pericarp (TP), soluble solids content (SSC), fruit shape in longitudinal section, ground color of skin, the intensity of the green color of skin, fruit shape at the apical part, grooving distribution, conspicuousness of stripes, and main color of the flesh were recorded on the field and inside laboratory and the lycopene was measured using spectrophotometric and HPLC methods. Watermelon fruits have shown a diverse morphological characters. Red and pink fleshed fruits dominated in the entire collections. Fruits with higher thickness of rind were found to exhibit less soluble solid content (SSC). Korean origin fruits were characterized by intermediate SSC while the United States of America (USA), Russia (RUS), Tajikistan (TJK), Turkmenistan (TKM), Taiwan (TWN), and Uruguay (URY) originated fruits had the highest SSC. The lycopene content varied between 41.37 and 182.82 ㎍/g, 2.81 and 163.72 ㎍/g, and 3.54 and 255.47 ㎍/g using HPLC, UV-Vis spectrophotometer, and microplate reader spectrophotometer, respectively. Red- and pink-fleshed fruits had the highest levels of lycopene content compared to the yellow- and orange-fleshed. Lycopene content had a significant positive correlation with SSC, however, no correlations were detected between lycopene and other quantitative fruit morphological characters. Our study demonstrated high diversity exists in fruit morphological traits and lycopene content of the germplasm collections which provide beneficial baseline data for a future breeding program and utilization of watermelon germplasm collections in gene banks for the maintenance and improvement of the current levels of production, marketability, and health-related benefit of watermelon fruits.

• 대한전자공학회논문지SD
• /
• 제49권7호
• /
• pp.1-9
• /
• 2012

기존의 LED 패키지가 갖는 온도에 따른 광 특성 변화 문제를 해결하기 위하여 온도센서가 집적된 LED 패키지 시스템을 제안하였다. 패키지의 온도를 실시간으로 측정하기 위하여 정확도가 우수하며 온도에 따른 저항의 변화가 선형적인 특징을 갖는 온도센서(RTD 형)를 설계하였으며, 장기간의 안정성을 보장하기 위하여 안정된 박막의 증착조건을 결정하고 이를 바탕으로 $1.560{\Omega}/^{\circ}C$의 민감도를 갖는 온도센서를 패키지 내부에 제작하였다. 제작된 패키지를 이용하여 온도에 무관하게 일정한 광량을 나타내는 시스템의 구현을 위하여 변환 회로부와 제어 회로부를 제작하고 이들을 결합함으로써, 패키지의 온도 변화에 따라 PWM duty ratio의 변화를 통해 광 출력을 보상해 주는 시스템을 제안하고 제작하였다. LED의 동작온도인 $0^{\circ}C$에서 $140^{\circ}C$ 범위에서 PWM duty ratio를 관측한 결과 제안했던 일정한 광량을 위한 PWM duty ratio에 매우 근접한 출력 신호를 발생시키는 것을 확인할 수 있었다.

• 접착 및 계면
• /
• 제4권3호
• /
• pp.33-40
• /
• 2003

본 연구에서는 이관능성 에폭시 (diglycidyl ether of bisphenol A. DGEBA)와 Polyetherimide(PEI) 블랜드를 Amime계 경화제인 DDM을 이용하여 경화를 시켰으며, PEI의 함량 변화가 순수 에폭시 수지의 열적특성과 파괴인성에 미치는 영향에 대해 고찰하였다. 경화된 시편의 열적특성은 DSC에 의한 열분석을 통해 Kissinger 식을 이용하여 경화 활성화 에너지 ($E_a$)를 구하였고, 파괴인성은 크랙성장의 저항을 나타내는 임계응력세기 인자 ($K_{IC}$)을 측정하여 알아보았다. 시편의 파단특성은 주사전자현미경 (SEM)을 통해 조사하였으며, 기계적 계면특성을 알아보기 위해 contact angle로 표면자유에너지를 측정하였다. 실험 결과 DGEBA/PEI 블랜드계의 $E_a$, $K_{IC}$는 PEI 함량이 7.5 phr에서 최대값을 보였다. 이는 PEI 도입에 따른 치밀한 네트워크 구조가 증가했기 때문으로 판단되어 진다. 또한 DGEBA/PEI 블랜드계의 표면자유에너지는 $K_{IC}$와 유사한 경향을 보였으며, 이는 에폭시의 하이드록실기와 PEI의 imide 그룹 사이의 수소결합에 의해 극성요소가 증가되었기 때문으로 판단되어진다.

• 대한교통학회지
• /
• 제26권4호
• /
• pp.99-110
• /
• 2008

교차로는 단일로에 비해 많은 상충점을 가지고 있어 사고의 잠재성이 더욱 높다고 볼 수 있다. 2006년 경찰청 자료에 의하면 교차로 부근의 교통사고가 단일로 교통사고에 비해 크게 증가하고 있는 것으로 나타났다. 그 중 신호교차로의 경우는 비신호교차로에 비해 교통사고 영향요인이 다양하고 개선의 여지가 많아 사고가 일어나는 원인을 예측하고, 교차로 위험요소에 따른 적절한 대비책을 사전에 마련할 수 있다면 안전측면에서 큰 효과를 얻을 것으로 기대된다. 본 연구에서는 도시부 4지 신호교차로를 대상으로 과거 사고이력자료와 교차로 현장 조사를 활용하여 사고예측 모형 및 사고심각도 모형을 개발하였다. 본 연구는 크게 4단계로 나누어 진행되었다. 첫째, 기존 연구된 사고모형을 분석하였으며 둘째, 교통사고에 영향을 미치는 변수를 선정하였고 셋째, 통계적 방법론을 활용한 사고예측모형을 개발, 넷째, 모형의 검증을 실시하였다. 본 연구에서 개발된 신호교차로 교통사고 모형은 계획 및 운영단계에서 신호교차로의 안전성을 측정하는데 활용될 수 있으며, 궁극적으로 신호교차로의 교통사고를 줄이는데 기여할 수 있을 것으로 판단된다.

• 대한한방소아과학회지
• /
• 제31권1호
• /
• pp.52-62
• /
• 2017

Objectives The purpose of this study is to review pre-existing clinical practice guidelines for autism spectrum disorders, and refer those in developing a new practice guideline. Methods A total of 9 existing clinical practice guidelines for autism spectrum disorder developed from 2010 to 2016 were searched by Google scholar and Pubmed, and were reviewed those literatures in three parts: general, diagnosis & evaluation, and intervention. Results There were no consistency in the recommendation methods of 9 clinical care guidelines (such as the method of rating and recommendation intensity for diagnosis, evaluation, and treatment). However, in the diagnosis and evaluation section, frequently used evaluation and diagnostic tools are mentioned in most clinical practice guidelines, and the types of pharmacologic and non-pharmacological treatments that are mainly recommended in treatment are equally mentioned in most clinical practice guidelines could confirm. Conclusions 1. Some guideline recommendations are graded according to each criterion. Recommendations presented in various databases were based on systematic reviews or other literatures. The most utilized database were PsycINFO, CINAHL, Cochrane. 2. DSM-5 and ICD-10 were the most common used diagnostic criteria, and DSM-IV was used as a diagnostic standard in the guideline published before 2013. The tools used for diagnosis and evaluation were also varied. However, most recommended ones were ADI-R, ADOS-G, and DISCO. 3. Treatment was largely divided into pharmacological intervention and non-pharmacological intervention. In some guideline, the interventions were divided into pediatric and adult. Most of the pharmacological interventions were not recommended due to lack of evidence, but in cases in which specific symptoms were aimed, they recommended to seek professional help. 4. In addition to interventions, each guideline referred to supportive interventions that may be helpful in the daily life of patients with ASD, which may need to be addressed in future clinical guidelines.

• 한국버섯학회지
• /
• 제19권3호
• /
• pp.216-224
• /
• 2021

국내산 표고의 식품성분 특성 및 항산화 활성을 알아보기 위해 시판되고 있는 표고 5종을 경남 진주, 전남 광양 및 순천 지역의 농산물 시장 또는 대형 마트에서 구입하여 분석하였다. 수분 함량은 79.17~82.90 g/100 g으로 시료 간의 차이가 적었으나, 조단백질 함량에서 유의적인 차이를 보였다. 무기질 총량은 시료 간의 유의적인 차이를 보였으며, 특히 칼륨(K)의 함량이 가장 많았다. 총 아미노산 및 필수아미노산의 함량은 표고 "A"에서 월등히 높았으나, 총 아미노산에서 필수아미노산 및 aspartic acid와 glutamic acid의 함량 비율은 시료 간에 비슷한 수준이었다. β-Glucan 함량은 10.28~15.68 g/100 g으로 시료 간의 유의적인 차이를 보였다. 시판 표고의 색도와 전반적인 조직감에서는 시료 간의 두드러진 차이가 없었다. 총 페놀 함량은 19.92~30.77 mg/100 g, 플라보노이드 함량은 6.95~10.39 mg/100 g이었으며, 총 페놀 함량에 대한 플라보노이드 함량의 비율은 31.53~38.21%였다. DPPH 라디칼 소거활성은 74.92~79.04%, ABTS 라디칼 소거활성은 80.47~84.97%로 시료 간의 큰 차이를 보이지 않았으나, 환원력은 195.23~317.85 μM로 시료 간의 유의차를 보였다. 본 연구 결과, 공시한 표고 5종의 식품성분이나 항산화 활성에서 두드러진 차이는 보이지 않았다.

• 한국방사선학회논문지
• /
• 제13권3호
• /
• pp.473-479
• /
• 2019

다양한 촬영 조건의 CT 감쇠 지도가 PET 영상에 영향을 미치는지 알아보기 위하여 다양한 kVp와 mA조건에서 Uniformity phantom 영상의 신호 강도(SI; Signal Intensity)와 표준 섭취율 계수(SUV; Standardized Uptake Value)를 측정하고, CTDI (Computed Tomography Dose Index)를 통해 각 조건에 따른 피폭선량을 측정하였다. 또한 동일한 조건에서 Resolution phantom의 반치폭(FWHM; Full Width at Half Maximum)을 측정하여 CT의 kVp와 mA에 따른 PET 영상의 화질 변화에 대하여 정량적으로 알아보고자 하였다. 연구 결과, CT의 촬영 조건은 PET 영상에는 영향을 주지 않는 것으로 나타났으나, CT의 촬영 조건이 감소하게 되면 방사선 피폭이 감소하게 되지만 영상에 영향을 미치게 되므로 향후 진단이 가능한 CT 화질을 유지하면서 방사선 피폭을 최소화할 수 있는 양전자 방출 단층 촬영(PET/CT; Positron Emission Tomography / Computed Tomography)의 촬영 조건에 대한 연구가 지속적으로 되어야 할 것이다.

• 보건행정학회지
• /
• 제4권1호
• /
• pp.49-76
• /
• 1994

Small area variations in health care utilization have long been studied as an important issue related to boto cost containment and quality assurance. This study was conducted to investigate if variations in hospital services across small geographic areas in Korea existed. The claims data of the fiscal year 1992 obtained from the regional health insurance societies were used for the study. Main findings of the research can be summarized as follows : 1. Extremal Quotients(EQ) of hospital expenditure per capita and hospital days per capita varied among diagnosis types. The EQ ranged from 2.05(cataract) to 41.67(pneumonia) in hospital expenditure per capita and from 1.86(cataract) to 45.89(pneumonia) in hospital days per capita. The diagnosis groups which showed high variation were pneumonia, cephalo-pelvic disproportion, gastritis and duodenitis, fracture of rib, and acute bronchitis. Those which showed low variation were acute appendicitis and cataract. 2. The EQ level of admission rate was different in terms of diagnosis types, ranging from 2.57(catarct) to 44.45(pneumonia). The variations were high in medical disorders such as pneumonia, oephalo-pelvic disproportion, gastritis and duodenitis and acute bronchitis, while relatively low in surgical conditions such as acute appendicitis and cataract. 3. As an indicator of service intensity, the EQ of expenditure per admission ranged from 1.67(acute appendicitis) to 31.27(essential hypertension). The diagnoses which had high variation were essential hypertension, gastric ulcer, whereas those which had low variation were cephalopelvic disproportion and acute appendicitis. With regard to hospital days per admission, the EQ ranged from 1.55(acute appendicitis) to 28.13(gastric ulcer) by diagnosis types. The diagnosis groups with showed high variation were gastric ulcer, essential hypertension, and acute bronchitis, whereas those with low variation were cephalo-pelvic disproportion, intervertebral disc disorders, and acute appendicitis. Both the expenditure and hospital days per admission showed lewwer variations than the expenditure per capita, hospital days per capita and admission rate. 4. Comparing patterns of variation in utilization indices, diagnoses such as essential hypertension, gastric ulcer, fracture of rib showed higher variations in expenditure per admission than in admission rates, whereas diagnoses such as pneumonia, cephalo-pelvic disproportion and gastric ulcer showed higher variations in admission rate than expenditure per admission. These findings suggest that wide variations existed in several diagnoses groups across small areas in Korea. Further research should be performed to investigate factors related to small area variations including provider behavior.

• Parasites, Hosts and Diseases
• /
• 제61권3호
• /
• pp.272-281
• /
• 2023

Chigger mites are the vector of scrub typhus. This study estimates the infestation status and ecological characteristics of chiggers on the chestnut white-bellied rat Niviventer fulvescens in Southwest China between 2001 and 2019. Chiggers were identified under the microscope, and infestation indices were calculated. The Preston's log-normal model was used to fit the curve of species abundance distribution. A total of 6,557 chiggers were collected in 136 of 342 N. fulvescens rats, showing high overall infestation indices (prevalence=39.8%, mean abundance=19.2, mean intensity=48.2) and high species diversity (S=100, H'=3.0). Leptotrombidium cangjiangense, Neotrombicula japonica, and Ascoschoengastia sifanga were the three dominant chigger species (constituent ratio=42.9%; 2,736/6,384) and exhibited an aggregated distribution among different rat individuals. We identified 100 chigger species, with 3 of them (Leptotrombidium scutellare, Leptotrombidium wenense, and Leptotrombidium deliense) as the main vectors of scrub typhus in China and nine species as potential vectors of this disease. Disease vector occurrence on N. fulvescens may increase the risk of spreading scrub typhus from rats to humans. Chigger infestation on N. fulvescens varied significantly in different environments. The species abundance distribution showed a log-normal distribution pattern. The estimated number of chigger species on N. fulvescens was 126 species.