• Title/Summary/Keyword: variant

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Pressure titration of the monomeric variant of transthyretin

  • Bokyung Kim;Jin Hae Kim
    • Journal of the Korean Magnetic Resonance Society
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    • v.27 no.1
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    • pp.1-4
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    • 2023
  • Transthyretin (TTR) is an indispensable transporter protein of thyroxine and a retinol molecule in humans. TTR has a stable homo-tetrameric structure in its native state, while upon dissociation into monomers, it becomes aggregation-prone and can form an amyloid fibril. Although the amyloidogenic propensity of TTR has been known and investigated since the late 1990s, the structural information regarding TTR's amyloidogenic species is still elusive. Here, we employed high-pressure nuclear magnetic resonance (HP-NMR) approaches on the monomeric variant of TTR (TTR[F87M/L110M]; M-TTR) and observed that it experiences a two-step transition in response to the pressurized condition. Our study demonstrated that M-TTR in an ambient condition has heterogeneous structural features, which is likely related to the amyloidogenic propensity of TTR.

La Variación de /ɾ/ en Posición Posnuclear en el Español Andino del Perú

  • Kim, Kyoung-Lai
    • Iberoamérica
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    • v.21 no.1
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    • pp.127-158
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    • 2019
  • In this paper, the variation in coda /ɾ/ is analyzed in the Spanish of the Tupe district in Peru. The work was carried out on the corpus of 24 semi-structured interviews. Four variants of /-ɾ/ were distinguished and 1920 tokens were analyzed. Praat was used to recognize and describe the variants and two statistical analysis were carried out: descriptive analysis and probabilistic analysis using the statistical program Goldvarb X. The results obtained from the analysis show that the assibilated variant is favored in the prepausal position and before homorganic consonants. The frequency of occurrence was very low before other consonants. Regarding the social factor that contributes to the assimilated variant, the young and middle-aged men (from 20 to 60), those who did not live more than a year on the Peruvian coast and male speakers favor it.

A THIRD-ORDER VARIANT OF NEWTON-SECANT METHOD FINDING A MULTIPLE ZERO

  • Kim, Young Ik;Lee, Sang Deok
    • Journal of the Chungcheong Mathematical Society
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    • v.23 no.4
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    • pp.845-852
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    • 2010
  • A nonlinear algebraic equation f(x) = 0 is considered to find a root with integer multiplicity $m{\geq}1$. A variant of Newton-secant method for a multiple root is proposed below: for n = 0, 1, $2{\cdots}$ $$x_{n+1}=x_n-\frac{f(x_n)^2}{f^{\prime}(x_n)\{f(x_n)-{\lambda}f(x_n-\frac{f(x_n)}{f^{\prime}(x_n)})\}$$, $$\lambda=\{_{1,\;if\;m=1.}^{(\frac{m}{m-1})^{m-1},\;if\;m{\geq}2$$ It is shown that the method has third-order convergence and its asymptotic error constant is expressed in terms of m. Numerical examples successfully verified the proposed scheme with high-precision Mathematica programming.

ON A VARIANT OF VERTEX EDGE DOMINATION

  • S.V. SIVA RAMA RAJU
    • Journal of applied mathematics & informatics
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    • v.41 no.4
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    • pp.741-752
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    • 2023
  • A new variant of vertex edge domination, namely semi total vertex edge domination has been introduced in the present paper. A subset S of the vertex set V of a graph G is said to be a semi total vertex edge dominating set(stved - set), if it is a vertex edge dominating set of G and each vertex in S is within a distance two of another vertex in S. An stved-set of G having minimum cardinality is said to be an γstve(G)- set and its cardinality is denoted by γstve(G). Bounds for γstve(G) - set have been given in terms of various graph theoretic parameters and graphs attaining the bounds have been characterized. In particular, bounds for trees have been obtained and extremal trees have been characterized.

SELF-PAIR HOMOTOPY EQUIVALENCES RELATED TO CO-VARIANT FUNCTORS

  • Ho Won Choi;Kee Young Lee;Hye Seon Shin
    • Journal of the Korean Mathematical Society
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    • v.61 no.3
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    • pp.409-425
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    • 2024
  • The category of pairs is the category whose objects are maps between two based spaces and morphisms are pair-maps from one object to another object. To study the self-homotopy equivalences in the category of pairs, we use covariant functors from the category of pairs to the group category whose objects are groups and morphisms are group homomorphisms. We introduce specific subgroups of groups of self-pair homotopy equivalences and put these groups together into certain sequences. We investigate properties of these sequences, in particular, the exactness and split. We apply the results to two special functors, homotopy and homology functors and determine the suggested several subgroups of groups of self-pair homotopy equivalences.

Case Report : Chronic Cough Treated by Gyejigahubakhaengja-tang (계지가후박행자탕(桂枝加厚朴杏子湯)으로 호전된 만성기침 1례 증례보고)

  • Jae-won Jeong
    • 대한상한금궤의학회지
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    • v.15 no.1
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    • pp.149-160
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    • 2023
  • Objective: To report a chronic cough that has improved after administering the Gyejigahubakhaengja-tang using Shanghanlun DPIDS(disease pattern identification diagnostic system). Methods: Chronic cough patient who occurred after COVID-19 was presumed to be diagnosed with cough variant asthma. After that, it was diagnosed as Taeyang-byung, number 43 provision according to Shanghanlun DPIDS, and the result of taking the Gyejigahubakhaengja-tang for 30 days was evaluated as VAS (visual analogue scale) and LCQ (leicester cough questionnaire). Results: After taking Gyejigahubakhaengja-tang for 30 days, chronic cough decreased from VAS 10 to VAS 1. The LCQ increased from 24 to 122. Conclusions: For chronic cough patients, 喘 at Shanghanlun DPIDS can be considered as the cause.

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