• 제목/요약/키워드: vIL-10

검색결과 1,174건 처리시간 0.032초

Triglyceride-Lowering Effects of Two Probiotics, Lactobacillus plantarum KY1032 and Lactobacillus curvatus HY7601, in a Rat Model of High-Fat Diet-Induced Hypertriglyceridemia

  • Choi, Il-Dong;Kim, Sung-Hwan;Jeong, Ji-Woong;Lee, Dong Eun;Huh, Chul-Sung;Hong, Seong Soo;Sim, Jae-Hun;Ahn, Young-Tae
    • Journal of Microbiology and Biotechnology
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    • 제26권3호
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    • pp.483-487
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    • 2016
  • The triglyceride-lowering effect of probiotics Lactobacillus plantarum KY1032 and Lactobacillus curvatus HY7601 were investigated. Male SD Wistar rats were randomly divided into three groups and fed high-fat diet (HFD), HFD and probiotics (5 × 109 CFU/day of L. plantarum KY1032 and 5 × 109 CFU/day of L. curvatus HY7601), or normal diet for 6 weeks. Probiotic treatment significantly lowered the elevated plasma triglyceride and increased plasma free fatty acid, glycerol, and plasma apolipoprotein A-V (ApoA-V) levels. The probiotic-treated group showed elevated hepatic mRNA expression of PPARα, bile acid receptor (FXR), and ApoA-V. These results demonstrate that L. plantarum KY1032 and L. curvatus HY7601 lower triglycerides in hypertriglyceridemic rats by upregulating ApoA-V, PPARα, and FXR.

OLED 소자의 효율 개선을 위한 소재 및 구조의 변화에 따른 특성 평가

  • 배일지;홍영규;윤당모;신진국
    • 한국진공학회:학술대회논문집
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    • 한국진공학회 2014년도 제46회 동계 정기학술대회 초록집
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    • pp.227-227
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    • 2014
  • OLED 소자에 사용되는 유기물들은 대부분 전자에 비해 정공의 이동속도가 매우 빨라 소자 효율의 손실이 일어난다. 본 연구에서는 이러한 전하 이동도의 불균형에 의한 OLED 소자 성능의 감소를 개선하기 위해 HBL (hole blocking layer) 물질로 BCP (HOMO : 6.5 eV, LUMO : 2.83 eV)를 도입하였다. 그러나 BCP의 LUMO 값이 약 3 eV를 가지기 때문에 전자의 이동에 영향을 미치는 것으로 예상되어 더 높은 효율을 가지는 소자를 제작하기 위해 host 물질을 상용물질(PGH02)로 교체하였다. PGH02의 HOMO 값은 약 5.86 eV로 소자에 사용된 HTL (hole transport layer)의 HOMO 값(5.54 eV)에 비해 높은 값을 가지기 때문에 HBL의 역할 역시 가능하여 소자의 성능이 상당히 개선되는 것을 확인할 수 있었다. 또한 전하 이동도의 균형을 맞추기 위해 ETL 물질로는 기존에 많이 사용되고 있는 Alq3 (${\mu}{\sim}10-5cm2/Vs$)에 비해 이동도가 10배 이상 빠른 Bebq2 (${\mu}{\sim}10-4cm2/Vs$)를 사용하였다. HTL (hole transport layer) 물질로는 상용물질(LHT 259)를 사용하였고, LHT 259의 전하 이동도는 FET (field effect transistor)를 제작하여 측정하였다. 이를 기반으로 하여 ETL과 HTL의 두께를 조절하여 전하 이동도가 균형을 이루는 OLED 소자를 제작하기 위해 실험을 진행하였다.

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ON SPATIAL DISTRIBUTION OF SHORT GAMMA-RAY BURSTS FROM EXTRAGALACTIC MAGNETAR FLARES

  • Chang, Heon-Young;Kim, Hee-Il
    • Journal of Astronomy and Space Sciences
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    • 제19권1호
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    • pp.1-6
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    • 2002
  • Recently, one interesting possibility is proposed that a magnetar can be a progenitor of short and hard gamma-ray bursts (GRBs). If this is true, one may expect that the short and hard GRBs, at least some of GRBs in this class, are distributed in the Euclidean space and that the angular position of these GRBs is correlated with galaxy clusters. Even though it is reported that the correlation is statistically marginal, the observed value of < $V/V_{max}$ > deviates from the Euclidean value. The latter fact is often used as evidence against a local extragalactic origin for short GRB class. We demonstrate that GRB sample of which the value of < $V/V_{max}$ > deviates from the Euclidean value can be spatially confined within the low value of z. We select very short bursts (TgO < 0.3 sec) from the BATSE 4B catalog. The value of < $V/V_{max}$ > of the short bursts is 0.4459. Considering a conic-beam and a cylindrical beam for the luminosity function, we deduce the corresponding spatial distribution of the GRB sources. We also calculate the fraction of bursts whose redshifts are larger than a certain redshift z', i.e. f>z'. We find that GRBs may be distributed near to us, despite the non-Euclidean value of < $V/V_{max}$ >. A broad and uniform beam pattern seems compatible with the magnetar model in that the magnetar model requires a small $z_{max}$.

220V, 440V 3상 계통전압 혼용이 가능한 용접 전원장치용 위상천이 풀브리지 컨버터 (Phase-Shifted Full-Bridge Converter for Welding Power Supply Capable of Using 220 V, 440 V 3-Phase Grid Voltages)

  • 윤덕현;이우석;이준영;이일운
    • 전력전자학회논문지
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    • 제26권5호
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    • pp.372-375
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    • 2021
  • A three-leg inverter-type isolated DC-DC Converter that can use 220 and 440 V grid input voltages is introduced. The secondary circuit structure of the proposed topology is center-tap, which is the same as the conventional phase-shifted full-bridge converter. However, the primary circuit structure is composed of a three-leg inverter structure and a transformer, in which two primary windings are connected in series. The proposed circuit structure has a wider input voltage range than the conventional phase-shifted full-bridge converter, and the circulating-current on the primary-side is reduced. In addition, the voltage stress at the secondary rectifier is greatly improved, and high efficiency can be achieved at a high input voltage by removing the snubber circuit added to the conventional converter. Prototype converters with input DC of 311 V, output of 622 V, and 50 V and 6 kW class specifications were designed and manufactured to verify the validity of the proposed topology; the experimental results are presented.

다양한 제조방법으로 제조된 V2O5-TiO2 촉매를 이용한 제련공정에서 발생한 황화수소 제거능 비교 (Performance of V2O5-TiO2 Catalyst Prepared by Various Methods for Removal of Hydrogen Sulfide Emitted from Steel Smelting Process)

  • 김문일
    • 한국환경과학회지
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    • 제30권6호
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    • pp.501-505
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    • 2021
  • V2O5-TiO2 catalysts were prepared by various methods. V2O5-TiO2 were prepared by sol-gel method with different drying conditions (aerogel and xerogel), and V2O5 supported on TiO2 obtained by sol-gel method with precipitation-deposition method and impregnation method. The performance of the V2O5-TiO2 catalysts was investigated for the selective oxidation of hydrogen sulfide in the stream containing both ammonia and excess water. All the catalysts showed good dispersion of vanadium and they had high H2S conversion with no or little production of sulfur dioxide. The V2O5-TiO2 aerogel catalyst prepared by sol-gel method with drying under super critical condition had the highest surface area which led to better catalytic activity compared to those by other synthesis methods.

금강 하구의 Vibrio cholerae non-O1과 Vibrio mimicus의 선택 (Ecology of Vibrio cholerae non-O1 and Vibrio mimicus in Estuary of Kum River, Korea)

  • 장수현;송대진;양송주;신일식;김영만
    • 한국수산과학회지
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    • 제28권1호
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    • pp.15-22
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    • 1995
  • 새로운 식중독 원인균으로 알려지고 있는 V cholerae non-O1과 V mimicus의 분포와 서식 조건을 밝히고자 금강 하구에서 1993년 3월 26일부터 1994년 2월 22일까지 수질 환경과 V cholerae non-O1 및 V mimicus의 분포를 조사한 결과는 다음과 같다. 1. V cholerae non-O1은 해수 54개 시료에서 $16.7\%$, 뻘 49개 시료에서 $6.1\%$, 전체 $11.7\%$가 검출되었으며 V mimicus는 해수 54개 시료에서 $11.1\%$, 뻘 49개 시료에서 $10.2\%$, 전체 $10.7\%$가 검출되었다. 2. V cholerae non-O1과 V. mimicus는 수온 $24^{\circ}C$이상, 염도 $10\%o$ 이하의 기수에서 주로 검출되었으나, 수온이 $3.5^{\circ}C$인 1월에 뻘에서 검출되었다. 3. V cholerae non-O1과 V. mimicus의 서식에 영향을 주는 주요 인자는 온도, 염도 및 유기물질의 오염이며, V. cholerae non-O1은 V. mimicus보다 염도 변화에 대한 적응력이 더 높았다.

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기둥의 단면 확대보강을 위한 V-타이 보조 띠철근의 형상 제시 (Proposals of Reliable Shapes of Supplementary V-ties for Section Jacketing Method of Columns)

  • 권혁진;양근혁;심재일
    • 한국건축시공학회지
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    • 제18권2호
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    • pp.99-107
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    • 2018
  • 이 연구의 목적은 기존 철근콘크리트 기둥의 내진보강을 위한 단면 확대보강공법에서 보조 띠철근으로써 배근할 수 있는 V-타이의 상세를 제시하는 것이다. 모두 24개의 직접 인발실험체에서 V-타이의 역학적 거동을 고려한 부착강도 관점에서 선택한 주요 변수는 V-타이의 형상, 묻힘길이 및 콘크리트 강도이다. 다양한 상세를 갖는 V-타이의 부착강도는 일반 V-타이의 부착강도 및 CEB-FIP 제안식과 비교하였다. 그 결과 보강단면의 두께가 기존 V-타이의 묻힘 길이[= max(75mm, $6d_b$)]보다 적은 기둥의 경우 단부 압착형의 V-타이가 보조 띠철근로 추천될 수 있었는데, 여기서 $d_b$는 V-타이로 사용된 철근의 직경이다.

Tetramethylpyrazine이 LPS의 뇌실주입에 따른 생쥐 뇌조직의 Pro-Inflammatory Cytokines 발현에 미치는 영향 (Effect of Tetramethylpyrazine on Pro-Inflammatory Cytokine Expressions in Mouse Brain Tissue following Intracerebroventricular Lipopolysaccharide Treatment)

  • 최용석;원종우;유인우;신정원;김성준;손낙원
    • 대한본초학회지
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    • 제28권1호
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    • pp.83-90
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    • 2013
  • Objectives : Tetramethylpyrazine (TMP) is an active ingredient in Ligusticum wallichii and has a wide range of neuroprotection effects. This study investigated anti-neuroinflammatory effect of TMP on brain regions in intracerebroventricular (i.c.v.) lipopolysaccharide (LPS)-treated C57BL/6 mice. Methods : TMP was administered intraperitoneally at doses of 10, 20, and 30 mg/kg at 1 h prior to LPS (3 mg/kg) i.c.v. injection. mRNA level of pro-inflammatory cytokines, including tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$), interleukin (IL)-$1{\beta}$ and IL-6, was measured in the cerebral cortex, hippocampus, and hypothalamus tissue using real-time polymerase chain reaction at 24 h after the LPS injection. Cyclooxygenase-2 (COX-2) positive cells in the hypothalamus was also observed using immunohistochemistry at 24 h after the LPS injection. Results : At a dose of 30 mg/kg TMP significantly attenuated up-regulation of TNF-${\alpha}$ and IL-$1{\beta}$ mRNA in the cerebral cortex and IL-$1{\beta}$ mRNA in the hippocampus. In the hypothalamus, doses of 20 mg/kg and 30 mg/kg TMP significantly attenuated up-regulation of TNF-${\alpha}$, IL-$1{\beta}$, and IL-6 mRNA induced by the LPS injection. In addition, TMP (30 mg/kg) significantly reduced the number of COX-2 positive cells in the hypothalamus. Conclusion : These results indicate that TMP has an anti-inflammatory effect on neuroinflammation, especially in the hypothalamus, induced by LPS i.c.v. injection and suggest that TMP-containing Ligusticum wallichii may play a modulatory role on the systemic responses following hypothalamic inflammation.

근접장 발파진동에서 진동속도와 진동레벨의 비교 (The Vibration Velocity and Vibration Level of Near-field Blasting Vibration in an Urban Blasting Site)

  • 이연수;장서일
    • 한국소음진동공학회논문집
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    • 제15권8호
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    • pp.918-923
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    • 2005
  • The vibration level (dB(V)) and vibration velocity (cm/sec) on the ground and buildings due to the differences of the measuring sites from the blasting source was investigated. To compare with vibration level and vibration velocity theirs magnitude was not surely directly proportional and vibration velocity 0.1 cm/sec was $45\~50$ dB(V). The difference between the measured vibration level and the calculated vibration level by Ejima's equation using vibration velocity PVS(peak vector sum) showed $21.0\~30.9$ dB(V) on the ground, $15.3\~23.6$ dB(V) on the apartment, respectively. And the correlation of vibration velocity and nitration level at the measuring sites of lower altitude showed higher than that of higher altitude.

금도금 방법으로 제작한 코일을 이용한 초소형 발전기의 저주파 진동 특성분석 (Characterization of a Micro Power Generator using a Fabricated Electroplated Coil Measured at Low Frequency)

  • 이동호;김성일;이윤표;백창욱
    • 신재생에너지
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    • 제2권3호
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    • pp.10-14
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    • 2006
  • We have designed and fabricated coil structures by gold electroplating technique. The thickness, width, and length are $7{\mu}m,\;20{\mu}m$, and 1.6m, respectively. With vibrating a magnet on the surface of a fabricated electroplated coil, the micro power generator produce an alternating voltage. We have changed the vibrational frequency from 0.5Hz to 8Hz. The generated voltage was 106mV at 3Hz and 198mV at 6Hz. We have rectified and stepped up the input voltage using a quadrupler circuit. After using the step up circuit, the measured voltage was 81mV at 3Hz and 235mV at 6Hz.

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