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http://dx.doi.org/10.4014/jmb.1512.12018

Triglyceride-Lowering Effects of Two Probiotics, Lactobacillus plantarum KY1032 and Lactobacillus curvatus HY7601, in a Rat Model of High-Fat Diet-Induced Hypertriglyceridemia  

Choi, Il-Dong (Korea Yakult Co., Ltd.)
Kim, Sung-Hwan (Korea Yakult Co., Ltd.)
Jeong, Ji-Woong (Korea Yakult Co., Ltd.)
Lee, Dong Eun (Korea Yakult Co., Ltd.)
Huh, Chul-Sung (Graduate School of International Agricultural Technology, Institute of Green Bio Science & Technology, Seoul National University)
Hong, Seong Soo (Division of Gastroenterology, Vievis NAMUH Hospital)
Sim, Jae-Hun (Korea Yakult Co., Ltd.)
Ahn, Young-Tae (Korea Yakult Co., Ltd.)
Publication Information
Journal of Microbiology and Biotechnology / v.26, no.3, 2016 , pp. 483-487 More about this Journal
Abstract
The triglyceride-lowering effect of probiotics Lactobacillus plantarum KY1032 and Lactobacillus curvatus HY7601 were investigated. Male SD Wistar rats were randomly divided into three groups and fed high-fat diet (HFD), HFD and probiotics (5 × 109 CFU/day of L. plantarum KY1032 and 5 × 109 CFU/day of L. curvatus HY7601), or normal diet for 6 weeks. Probiotic treatment significantly lowered the elevated plasma triglyceride and increased plasma free fatty acid, glycerol, and plasma apolipoprotein A-V (ApoA-V) levels. The probiotic-treated group showed elevated hepatic mRNA expression of PPARα, bile acid receptor (FXR), and ApoA-V. These results demonstrate that L. plantarum KY1032 and L. curvatus HY7601 lower triglycerides in hypertriglyceridemic rats by upregulating ApoA-V, PPARα, and FXR.
Keywords
Triglyceride; probiotics; Lactobacillus plantarum; Lactobacillus curvatus; apolipoprotein A-V;
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