• Title/Summary/Keyword: vIL-10

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Volumetrical changes of liver associated with breathing and its impact to normal tissue complication probability (호흡에 따른 간장용적의 변화와 정상조직손상확율에 미치는 영향에 관한 연구)

  • Cho Jung Hee;Kim Joo Ho;Lee Suk;Park Je Il
    • The Journal of Korean Society for Radiation Therapy
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    • v.13 no.1
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    • pp.14-22
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    • 2001
  • Purpose: The aim of this study is to investigate geometrical and volumetrical changes of liver due to breathing and its impact to NTCP. In order to attain better treatment results it should be considered deliberately during planning session. Mehtods and Materials : Seven patients were examined in this study who have done TACE for accurate tumor margin drawing. After contrast media injection, C-T scan data were obtained in supine position during breathing free, inhalation and exhalation, respectively. For all patients C-T scan were done with same scanning parameters- 5 mm index, 5 mm thickness and pitch 1. Based on C-T data we have measured differences of each variables between breathing status such as changes of total and remained liver volumes, GTV, beam path length and superior to inferior shift. NTCP were calculated using Lyman's effective volume DVH reduction scheme and for this NTCP calculation, the V50 was computed from DVH and each m, n value were referred from Burmans data. Results : The measured total tilter volume and the remained liver volume changed between inspiration and expiration about $1.2-7.7\%(mean+2.7\%)$ and $2.5-13.23\%(mean=5.8\%)$ respectively, and these results were statistically significant(p>0.1). The GTV difference in each patient varied widely from $1.17\%\;to\;30.69\%$, but this result was not statistically significant. Depending on the breathing status, the beam path length was changed from 0.5 cm to 1.1 cm with the average of 0.7 cm, and it was statistically significant(p=0.006). The measured superior to inferior shifts were ranged from 0.5 cm to 3.74 cm. The NTCPs were changed relatively small in each patient, but the variation was large between the patients. The mean NTCP difference was $10.5\%$, with the variation ranged from $7\%\;to\;23.5\%$. Conclusion : Variations of liver volume and of beam path length were changed significantly depending on the breathing statues and the range of variation itself was very different between the patients. Since this variance could seriously affect the clinical outcomes of radiation treatments, the breathing of patients need to be accounted when a final treatment planning is derided.

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Optical Properties of Sputtered Ta2O5 Thin Films Using Spectroscopic Ellipsometty (분광타원법을 이용한 스퍼터된 Ta2O5 박막의 광학적 특성)

  • Kim, Sun-Hee;Lee, Eui-Hyun;Jung, In-Woo;Hyun, Jang-Hoon;Lee, Sung-Young;Kang, Man-Il;Ryu, Ji-Wook
    • Journal of the Korean Vacuum Society
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    • v.18 no.2
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    • pp.133-140
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    • 2009
  • $Ta_{2}O_{5}$ thin films were deposited by RF magnetron sputtering method under various RF power, substrates and oxygen partial pressure. Elliptic constants were measured by using a phase modulated spectroscopic ellipsometer and analyzed with the Tauc-Lorentz dispersion formula and best fit method in the range of 310$\sim$1239 nm. Also, transmittance spectra of the films were measured by UV -Vis spectrophotometer in the range of 300$\sim$1000 nm. From these data, thickness of $Ta_{2}O_{5}$ and surface layer were analyzed and changes of magnitude and shape of dispersion of optical constants according to fabricated conditions were measured. Also, to evaluate thickness and optical constants data analyzed by Tauc-Lorentz dispersion formula, the measured and analyzed transmittance spectra were compared. In result of the comparison, two spectra were in good agreement each other. Accordingly, it indicates that our ellipsometric analysis is valid.

A Effect of Heavy Metal to Toxicity of Triclosan Focused on Vibrio fischeri Assay (Triclosan의 독성에 중금속이 미치는 영향 - V. fischeri Assay 관련 내용 중심으로 -)

  • Kim, Ji-Sung;Kim, Il-Ho;Lee, Woo-Mi;Lee, Hye-In;Kim, Seok-Gu
    • Journal of Korean Society of Environmental Engineers
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    • v.36 no.3
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    • pp.153-161
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    • 2014
  • The purpose of this study is to evaluate effect of heavy metals (i.e., $Cu^{2+}$, $Zn^{2+}$, $Cr^{6+}$, $Cd^{2+}$, $Hg^{2+}$, and $Pb^{2+}$) to toxicity of Triclosan as binary mixture. The individual toxicity and combined toxic effects of Triclosan with heavy metals were evaluated by Vibrio fischeri assay. In individual toxicity, the $Hg^{2+}$ was found to be most toxic followed by Triclosan, $Pb^{2+}$, $Cr^{6+}$, $Cu^{2+}$, $Zn^{2+}$, and $Cd^{2+}$, respectively. To evaluate combined toxic effect, correlation analysis of 'predicted value' calculated by Concentration addition (CA) model and Independent action (IA) model with 'experimental value' were performed based on the toxicity of individual compound. As a result, all of the combinations showed that IA model were more correlated with experimental value than CA model. On the basis of the median effect concentration of combination ($EC_{50mix}$) predicted by IA model, experimental $EC_{50mix}$ of Triclosan + Cu, Triclosan + Zn, Triclosan + Pb, Triclosan + Hg, Triclosan + Cd, and Triclosan + Cr were 191%, 226%, 138%, 137%, 209%, and 138% of $EC_{50mix}$ predicted by IA model, respectively, indicating that all of the combinations produced antagonistic effect.

Effect of Fluoride-based Plasma Treatment on the Performance of AlGaN/GaN MISHFET

  • Ahn, Ho-Kyun;Kim, Hae-Cheon;Kang, Dong-Min;Kim, Sung-Il;Lee, Jong-Min;Lee, Sang-Heung;Min, Byoung-Gue;Yoon, Hyoung-Sup;Kim, Dong-Young;Lim, Jong-Won;Kwon, Yong-Hwan;Nam, Eun-Soo;Park, Hyoung-Moo;Lee, Jung-Hee
    • ETRI Journal
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    • v.38 no.4
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    • pp.675-684
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    • 2016
  • This paper demonstrates the effect of fluoride-based plasma treatment on the performance of $Al_2O_3/AlGaN/GaN$ metal-insulator-semiconductor heterostructure field effect transistors (MISHFETs) with a T-shaped gate length of $0.20{\mu}m$. For the fabrication of the MISHFET, an $Al_2O_3$ layer as a gate dielectric was deposited using atomic layer deposition, which greatly decreases the gate leakage current, followed by the deposition of the silicon nitride layer. The silicon nitride layer on the gate foot region was then selectively removed through a reactive ion etching technique using $CF_4$ plasma. The etching process was continued for a longer period of time even after the complete removal of the silicon nitride layer to expose the $Al_2O_3$ gate dielectric layer to the plasma environment. The thickness of the $Al_2O_3$ gate dielectric layer was slowly reduced during the plasma exposure. Through this plasma treatment, the device exhibited a threshold voltage shift of 3.1 V in the positive direction, an increase of 50 mS/mm in trans conductance, a degraded off-state performance and a larger gate leakage current compared with that of the reference device without a plasma treatment.

Optimization of flow performance by designing orifice shape of outdoor unit of air-conditioner (에어컨 실외기 냉각팬 시스템의 오리피스 형상 설계를 통한 유량 성능 최적화)

  • Ryu, Seo-Yoon;Kim, Sanghyeon;Cheong, Cheolung;Kim, Jong-Uk;Park, Byeong Il;Park, Se Min
    • The Journal of the Acoustical Society of Korea
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    • v.36 no.6
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    • pp.371-377
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    • 2017
  • The performance of an air conditioner is closely related to the cooling performance of a split-type outdoor unit so that, in most of the relevant preceding studies, the independent performance of an axial fan in an outdoor unit has been studied. However, there is a lack of research on the effects of other components in an outdoor units was rarely investigated. Therefore, in this paper, the effects of the fan orifice among other parts on the flow performance of the outdoor unit was numerically investigated. A virtual fan tester consisting of 18 million grids was developed for highly resolved flow simulation. The unsteady RANS (Reynolds-averaged Navier-Stokes) equations are numerically solved by using finite-volume CFD (Computational Fluid Dynamics) techniques. In order to verify the validity of the numerical methods, the predicted P-Q curve of the cooling fan in a full outdoor unit is compared with the measured one. Optimization of orifice shape was carried out for maximum flow performance of the outdoor unit using the validated numerical method.

Low-cost Assessment of Canopy Light Interception and Leaf Area in Soybean Canopy Cover using RGB Color Images (RGB 컬러 이미지를 이용한 콩의 군락 피복과 엽면적에 대한 저비용 평가)

  • Lee, Yun-Ho;Sang, Wan-Gyu;Baek, Jae-Kyeong;Kim, Jun-Hwan;Cho, Jung-Il;Seo, Myung-Chul
    • Korean Journal of Agricultural and Forest Meteorology
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    • v.22 no.1
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    • pp.13-19
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    • 2020
  • This study compared RGB color images with canopy light interception (LI) and leaf area index (LAI) measurements for low cost and low labor. LAI and LI were measured from vertical gap fraction derived from top of digital image in soybean canopy cover (cv Daewonkong, Deapongkong and Pungsannamulkong). RGB color images, LAI, and LI were collected from V4.5 stage to R5stage. Image segmentation was based on excess green minus excess red index (ExG-ExR). There was a linear relationship between LAI measured with LI (r2=0.84). There was alinear relation ship between LI measured with canopy cover on image (CCI) (r2=0.94). There was a significant positive relationship(r2=0.74) between LAI and CCI at all grow ingseason. Therefore, it is expected that in the future, the RGB color image could be able to easily measure the LAI and the LI at low cost and low labor.

Development of a Measuring Instrument for the Coefficient of Luminous Intensity of Retro-Reflection of Miniature Telecentric Cameras (소형 텔레센트릭 카메라 광학계의 재귀반사 측정 방법 연구 및 측정 장치 개발)

  • Yeo, TaeWoon;Karasik, V.E.;Kim, Young Il
    • Korean Journal of Optics and Photonics
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    • v.25 no.6
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    • pp.334-339
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    • 2014
  • In this paper, the optical properties of a miniature telecentric camera are studied analytically and experimentally. By means of optical properties, the luminous intensity of retro-reflection of a miniature telecentric optical system is investigated. First, from a simulation the theoretical value of the coefficient of luminous intensity of retro-reflection of a miniature telecentric system is estimated. Second, a miniature telecentric camera device is designed, and the value of the coefficient of luminous intensity of retro-reflection of the actual device is measured through experiment. From simulation and experiment, we found that both the estimated and observed values of the coefficient of luminous intensity of retro-reflection range from 0.002 to $0.03m^2/sr$ (P384200CPH: $0.0042-0.018m^2/sr$, P285200CPH: $0.0045-0.0297m^2/sr$, P321450S: $0.0021-0.00963m^2/sr$) at 1.4 to 4.9 arcminute. The results prove the significance of the mechanisms used to design the miniature telecentric camera, and the experimental method. Accordingly, with these significant results, this study contributes to the development of theory and practice in optical engineering science.

Oral Administration of KTNG0345 Prepared from Red Ginseng Extracts Reduces UVB-induced Skin Wrinkle Formation in Hairless Mice

  • Lee, Min-Jung;Won, Chong-Hyun;Lee, Se-Rah;Kim, Ji-Sook;Oh, Inn-Gyung;Hwang, Eui-Il;Kim, Na-mi;Kang, Byeong-Choel;Chung, Jin-Ho
    • Journal of Ginseng Research
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    • v.32 no.1
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    • pp.48-56
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    • 2008
  • Chronic ultraviolet (UV) exposure is the major cause of photoaging that causes skin wrinkling, roughness, dryness, laxity, and pigmentation. Recently, increasing efforts are being made to understand the relationship between foods and skin health. Ginsenosides are present in ginseng (Ginseng Radix Rubra) extract, and are known to have biomedical properties, such as, anti-oxidant and anti-inflammatory effects. In this study, we investigated whether KTNG0345 prepared from red ginseng extracts delivered orally reduces skin wrinkling and ultraviolet B (UVB)-induced wrinkle formation in hairless mouse skin. KTNG0345 was administrated orally to the mice (5 times a week) during the period of UVB-irradiation (3 times a week) for 8 weeks at three different doses of 300 mg/kg, 500 mg/kg and 1000 mg/kg (w/v). UV doses were increased weekly by 1 MED (1MED = 75 $mJ/cm^2)$ up to 4 MED and then maintained at this level. After the 8-week administration period, it was found that orally administered KTNG0345 significantly inhibited UVB-induced wrinkle formation in a dose-dependent manner. Increases in skin thickness caused by UVB were prevented by KTNG0345. Moreover, it also significantly inhibited matrix metalloproteinases (MMP) -13 and MMP-9 expressional inductions by UVB. In addition, KTNG0345 was observed to prevent UVB-induced water loss of epidermis in hairless mouse skin. Our results demonstrate that orally administered KTNG0345 has anti-wrinkling effects in hairless mouse skin, and suggest that dietary red ginseng and herbal mixture may be considered a functional beauty food for preventing UVB-induced skin wrinkles.

Improving Dyeability of Safflower Yellow Colorants on Cellulose Fibers (홍화 황색소의 셀룰로오스 섬유에 대한 염착성 증진)

  • Shin, Youn-Sook;Cho, A-Rang;Yoo, Dong-Il
    • Journal of the Korean Society of Clothing and Textiles
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    • v.31 no.12
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    • pp.1754-1760
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    • 2007
  • To improve poor dye uptake of safflower yellow colorants, cellulose fibers were pretreated with chitosan. The effect of chitosan pretreatment on the dyeability of safflower yellow colorants to cotton, ramie, and rayon was investigated in terms of dye uptake, color, and colorfastness. Irrespective of fiber types, dye uptake increased continuously with increase in chitosan concentration. Chitosan pretreatment improved dye uptake up to 5.6 times for cotton, 7.2 times for ramie, and 3.7 times for rayon. For cotton and ramie, the shade of dyed fabric changed YR color to Y color with increase in chitosan concentration. Dyed rayon fabrics showed Y color irrespective of chitosan concentration. Shades got darker and deeper with increasing chitosan concentration. Shades of chitosan pretreated fabrics were shifted differently depending on dyeing temperature within same fabrics. In common, the color of all dyed fabrics changed to YR at 50 and $70^{\circ}C$ while Y color at 30 and $90^{\circ}C$. V and C value decreased with increase in dyeing temperature and resulted in darker and duller color, in general. Light fastness was fair while washing fastness was poor. It was confirmed that ultrasonic dyeing method enhanced dye uptake more than 30% for cotton and ramie fabrics compared to the conventional automatic machine dyeing method. However, no difference in dye uptake between two dyeing methods was found for rayon.

The Usefulness of Transcutaneous Tissue Oxygen Pressure ($TcpO_2$) for Determination of the Point of Time at Venous Revascularization (적절한 정맥 재혈류 시점의 판단을 위한 조직산소분압의 유효성)

  • Lee, Eun-Sang;Choung, Jong-Pil;Park, Seung-Ha;Lee, Byung-Il
    • Archives of Plastic Surgery
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    • v.37 no.5
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    • pp.547-554
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    • 2010
  • Purpose: The purpose of this study is to delineate the optimal time of venous revascularization for preventing the flap necrosis due to venous occlusion, and to clarify the usefulness of tissue oxygen pressure ($TcpO_2$) in the determination of the point of time for venous revascularization. Methods: Thirty-six, $3{\times}3\;cm$ sized epigastric island flap was elevated in left abdomen of male Sprague-Dawley rat weighing 250 gram. Flaps were randomly assigned to six groups of six flaps according to the duration of venous occlusion with microvascular clamp; 10 minutes in the group I as the control, 60 minutes in the group II, 2 hours in the group III, 3 hours in the group IV, 4 hours in the group V, and 6 hours in the group VI, respectively. Just before removal of clamp after flap was reposed in situ, the ratio of $TcpO_2$ (tissue oxygen pressure) of the island flap to that of right abdomen was calculated in each group, and tissue specimen was harvested from the distal area of the flap for histological evaluation of vascular change. Five days later, survival area of the flap was estimated, and evaluated the correlation between the tissue oxygen pressure and the rate of flap survival. Results: The $TcpO_2$ and the survival rate of flap were decreased proportionally with the duration of venous occlusion. The ratio of the $TcpO_2$ of the flap is decreased abruptly to below sixty percentile compared to the $TcpO_2$ of normal tissue, and the survived area of the flap is decreased to nine-tenth of the designed size after three hours of total venous occlusion. Histologically, the number of congested vessels was increased according to venous occluded time, and proportionally increased after 3-hours of occlusion significantly. Conclusion: There is a close correlation between the $TcpO_2$ and the survival rate of flaps according to the duration of venous occlusion. Therefore, the $TcpO_2$ represents the hemodynamic changes within the flap, and thought to be an alternative effective tool in the flap monitoring for venous revascularization.