• The Korean Journal of Physiology and Pharmacology
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• 제20권5호
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• pp.525-531
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• 2016

The analgesic mechanism of opioids is known to decrease the excitability of substantia gelatinosa (SG) neurons receiving the synaptic inputs from primary nociceptive afferent fiber by increasing inwardly rectifying $K^+$ current. In this study, we examined whether a ${\mu}$-opioid agonist, [D-Ala2,N-Me-Phe4, Gly5-ol]-enkephalin (DAMGO), affects the two-pore domain $K^+$ channel (K2P) current in rat SG neurons using a slice whole-cell patch clamp technique. Also we confirmed which subtypes of K2P channels were associated with DAMGO-induced currents, measuring the expression of K2P channel in whole spinal cord and SG region. DAMGO caused a robust hyperpolarization and outward current in the SG neurons, which developed almost instantaneously and did not show any time-dependent inactivation. Half of the SG neurons exhibited a linear I~V relationship of the DAMGO-induced current, whereas rest of the neurons displayed inward rectification. In SG neurons with a linear I~V relationship of DAMGO-induced current, the reversal potential was close to the $K^+$ equilibrium potentials. The mRNA expression of TWIK (tandem of pore domains in a weak inwardly rectifying $K^+$ channel) related acid-sensitive $K^+$ channel (TASK) 1 and 3 was found in the SG region and a low pH (6.4) significantly blocked the DAMGO-induced $K^+$ current. Taken together, the DAMGO-induced hyperpolarization at resting membrane potential and subsequent decrease in excitability of SG neurons can be carried by the two-pore domain $K^+$ channel (TASK1 and 3) in addition to inwardly rectifying $K^+$ channel.

• 한국전자통신학회논문지
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• 제18권1호
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• pp.115-126
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• 2023

무작위 및 주기적인 변동하는 재생에너지 발전 전력 품질 교란으로 인해 발전 변환 송전 및 배전에서 더 자주 발생하게 된다. 전력 품질 교란은 장비 손상 또는 정전으로 이어질 수 있다. 따라서 서로 다른 전력 품질 외란을 실시간으로 자동감지하고 분류하는 것이 필요하다. 전통적인 PQD 식별 방법은 특징 추출 특징 선택 및 분류의 세 단계로 구성된다. 그러나 수동으로 생성한 특징은 선택 단계에서 정확성을 보장하기 힘들어서 분류 정확도를 향상하는 데에는 한계가 있다. 본 논문에서는 16가지 종류의 전력 품질 신호를 인식하기 위해 CNN(Convolution Neural Networ)과 LSTM(Long Short Term Memory)을 기반으로 시간 영역과 주파수 영역의 특징을 결합한 심층 신경망 구조를 제안하였다. 주파수 영역 데이터는 주파수 영역 특징을 효율적으로 추출할 수 있는 FFT(Fast Fourier Transform)로 얻었다. 합성 데이터와 실제 6kV 전력 시스템 데이터의 성능은 본 연구에서 제안한 방법이 다른 딥러닝 방법보다 일반화되었음을 보여주었다.

• 한국전산유체공학회:학술대회논문집
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• 한국전산유체공학회 2005년도 추계 학술대회논문집
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• pp.45-47
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• 2005

We have investigated the mixing behavior of a tubular heat exchanger reactor using CFD and compared its mixing performance with different type of reactors such as jet mixer and continuous stirred tank reactor (CSTR). The mixedness in each reactor was quantified introducing a statistical average value, the coefficient of variation (CoV), which is a normalized standard deviation of concentration of a component over the whole fluid domain. Through the analysis of the flow pattern and turbulent energy distribution, we suggested a simple but effective way to improve the mixing performance of the tubular heat-exchanger reactor, which include the addition of the internals and/or the increase of the recycle flow rate. It was found that the CoV value of the tubular reactor could be nearly equivalent to that of CSTR by applying those two alternatives suggested here.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2005년도 ICCAS
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• pp.1637-1640
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• 2005

This paper presents a technique for electromagnetic field analysis on surge response due to Mid-span back-flashovers effects in lightning protection system of 500 kV EHV single circuit transmission tower by the neural networks method. These analyses are based on modeling lightning return stroke as well as on coupling the electromagnetic fields of the stroke channel to the line. The ground conductivity influences both the electric field as well as the coupling mechanism and hence the magnitude and wave shape of the induced voltage. The technique can be used to analyzed the corona voltage effect, the effective of stroke to the span tower, the surge impedance of transmission lines. The maximum voltage from flashovers effects in the lines. The model is compatible with general electromagnetic transients programs such as the ATP-EMTP. The simulation results show that this study analyses for time-domain with those produced by a cascade multi-section model, the surge impedance of a full-sized tower hit directly by a lightning stroke is discussed.

• 전자공학회논문지C
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• 제34C권12호
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• pp.20-27
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• 1997

In this paper, a multiplying digital-to-analog converter (MDAC) circuit for low-power high-resolution CMOS algorithmic A/D converters (ADC's) is proposed. The proposed MDAC is designed to operte properly at a supply at a supply voltge between 3 V and 5 V and employs an analog0domain power reduction technique based on a bias switching circuit so that the total power consumption can be optimized. As metal-to-metal capacitors are implemented as frequency compensation capacitors, opamps' performance can be varied by imperfect process control. The MDAC minimizes the effects by the circuit performance variations with on-chip tuning circuits. The proposed low-power MDAC is implementd as a sub-block of a 10-bit 200kHz algorithmic ADC using a 0.6 um single-poly double-metal n-well CMOS technology. With the power-reduction technique enabled, the power consumption of the experimental ADC is reduced from 11mW to 7mW at a 3.3V supply voltage and the power reduction ratio of 36% is achieved.

• 대한수학회지
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• 제58권3호
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• pp.703-722
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• 2021

Let G = (V, E) be a connected locally finite and weighted graph, ∆_p be the p-th graph Laplacian. Consider the p-th nonlinear equation -∆_pu + h|u|^p-2u = f(x, u) on G, where p > 2, h, f satisfy certain assumptions. Grigor'yan-Lin-Yang [24] proved the existence of the solution to the above nonlinear equation in a bounded domain Ω ⊂ V. In this paper, we show that there exists a strictly positive solution on the infinite set V to the above nonlinear equation by modifying some conditions in [24]. To the m-order differential operator 𝓛_m,p, we also prove the existence of the nontrivial solution to the analogous nonlinear equation.

• 대한수학회지
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• 제56권4호
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• pp.857-867
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• 2019

Suppose that G = (V, E) is a connected locally finite graph with the vertex set V and the edge set E. Let ${\Omega}{\subset}V$ be a bounded domain. Consider the following quasilinear elliptic equation on graph G $$\{-{\Delta}_{pu}={\lambda}K(x){\mid}u{\mid}^{p-2}u+f(x,u),\;x{\in}{\Omega}^{\circ},\\u=0,\;x{\in}{\partial}{\Omega},$$ where ${\Omega}^{\circ}$ and ${\partial}{\Omega}$ denote the interior and the boundary of ${\Omega}$, respectively, ${\Delta}_p$ is the discrete p-Laplacian, K(x) is a given function which may change sign, ${\lambda}$ is the eigenvalue parameter and f(x, u) has exponential growth. We prove the existence and monotonicity of the principal eigenvalue of the corresponding eigenvalue problem. Furthermore, we also obtain the existence of a positive solution by using variational methods.

• Journal of Information Technology Applications and Management
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• 제25권3호
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• pp.29-41
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• 2018

The purpose of constructing university information system is for improvement in diversification and throughput of information, streamlines business processes, rapid exchange of information, sharing of information, decision-making information, and securing educational facilities. Similar to business information technology system, university information system does not have a review system for sharing and overlapping investment of information. Due to the lack of project management for outsourcing and vulnerability of system suitability, system audit is absolutely needed for the university information system. This paper especially focuses on an operational phase in the audit of university information system. Additionally, we proposed operating model and checklists of the university information system based on Management Guidelines of ITIL V3 Operational and Information System. We derived the checklists of operation audit by each domain of service strategy, service design, service transition, service operation, and continual service improvement. As the result, this study appear to have more than average satisfaction the suitability results were.

• 생명과학회지
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• 제15권3호
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• pp.479-485
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• 2005

2002년 2월부터 2005년 2월까지 성인 및 소아 호홉기질환자 994명의 상기도 도말물에서 M. pneumoniae 균주를 분리하고, 분리 균주의 ciprofloxacin, ofloxacin, minecline, tetracycline, sparfloxacin, josamycin, erythromycin에 대한 감수성 검사를 실시하였으며, 분리된 균주의 235 rRNA domain II와 V에서 erythromycin저항성 변이가 일어났는가를 PCR과 유전자 염기서열분석으로 erythromycin에 감수성인 M. pneumonine균주의 염기서열과 비교분석하여 확인하였다. 호흡기질환자에서 M. pneumoniae의 분리율은 123/994$(12.4\%)$이었으며, 분리된 M. pneumoniae 균주의 minocycline, sparfloxacin, tetracycline, ciprofloxacin, ofloxacin, josamycin, erythromycin MIC 범위는 각각 $0.015\~0.25,\;0.06\~0.5,\;0.06\~0.5,\;0.25\~0.5,\;0.25\~0.5,\;0.015\~8.0,\;0.015\~8.0{\mu}m$이었다. 분리 동정된 M. pneumoniae 균주 중에서 erythromycin에 저항성인 균주가 60주$(48.8\%)$였으며, 모두가 ribosomal protein L4 영역과 23S rRNA domain V에 내성변이가 일어났으며, 이 중 2균주는 23S rRNA domain II에도 변이가 일어난 균주도 있었다. 국내에서 분리되는 M. pneumoniae균주의 $48\%$가 erytomycin에 저항성인 균주이므로 앞으로 이 균에 의한 폐렴의 치료에 주의가 요구된다.

• BMB Reports
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• 제32권2호
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• pp.196-202
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• 1999

The existence of the Ras-independent signal transduction pathway of insulin leading to DNA synthesis was investigated in Rat-1 fibroblasts overexpressing human insulin receptor (HIRc-B) using the single-cell microinjection technique. Microinjection of a dominant-negative mutant $Ras^{N17}$ protein into quiescent HIRc-B cells inhibited the DNA synthesis stimulated by insulin. Microinjection of oncogenic H-$Ras^{V12}$ protein ($H-Ras^{V12}$) (0.1 mg/ml) induced DNA synthesis by 35%, whereas that of control-injected IgG was induced by 20%. When the marginal amount of oncogenic H-$Ras^{V12}$ protein was coinjected with a dominant-negative mutant of the H-Ras protein ($Ras^{N17}$), DNA synthesis was 35% and 74% in the absence and presence of insulin, respectively. This full recovery of DNA synthesis by insulin suggests the existence of the Ras-independent pathway. The same recovery was observed in the cells coinjected with either H-$Ras^{V12}$ plus H-$Ras^{N17}$ plus SH2 domain of the p85 subunit of PI3-kinase ($p85^{SH2-N}$) or H-$Ras^{V12}$ plus H-$Ras^{N17}$ plus interfering anti-Shc antibody. When co-injected with a dominant-negative H-$Ras^{N17}$, the DNA synthesis induced by the Ras-independent pathway was blocked. These results indicate that the Ras-independent pathway of insulin leading to DNA synthesis exists, bypassing the p85 of PI3-kinase and Shc protein, and requires Rac1 protein.