• Journal of Nutrition and Health
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• 제26권2호
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• pp.145-155
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• 1993

A factorial experiment was conducted to determine the influence of phytate(0 or 10g/kg diet) and calcium (Ca)(3 or 10g/kg diet) intakes on Ca, P and Zn metabolism by growing female rats. Food intake and weight were similar for the all groups, however, phytate ingestion for six weeks depressed femur growth. The low Ca plus phytate group showed the lowest Ca content of total femur and this was related to a significant decrease of Ca retention. Phytate intake depressed zinc(Zn) absorption in the first metabolic collection. This inhibitory effect of phytate on Zn absorption was improved in the low Ca plus phytate group after several weeks. Impared Zn absorption however remained in the high Ca plus phytate group which was reflected in the lowest Zn content of femur, phytate intake with high Ca also depressed phosphorous(P) absorption and serum and urinary P. These adverse effects of phytate on Zn and P absorption when the dietary Ca was high could explain reduced femur weight despite the highest concentration of femur Ca(mg/g ash) in this group. Results suggest that phytate can adversely affect not only Ca metabolism but Zn and P utilization. Thus, for the normal bone growth when phytate intake is high, the ingesion of Ca, P, Zn and other minerals should be enhanced.

• 한국식품영양과학회지
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• 제28권5호
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• pp.1124-1130
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• 1999

The purpose of this study was to investigate the effect of copper supplementation on mineral utilizations in rats. Intakes, excretions, and tissue levels of Fe, Zn, Cu, Ca, Mg, Na, K were compared in rats fed diet with 100, 200, 400% of copper requirement(1Cu, 2Cu and 4Cu, respectively) for 6 weeks. The feed intake was significantly higher in 2Cu compared to 1Cu group, however, body weight gain was not significantly different among the three groups. While the serum level of Fe was significantly decreased, that of Cu was significantly elevated by Cu supplementation. The liver and kidney levels of Mg and Na, intakes of all the minerals, urinary excretions of Fe, Cu, Ca and Mg were significantly higher in 2Cu and/or 4Cu compared to 1Cu. The fecal excretions, retentions and absorptions of all the minerals were not affected by Cu supple mentation. In summary, these results suggest that dietary Cu supplementation has no effect on mineral utilizations, but effect on distribution in tissues of rats.

• Journal of Nutrition and Health
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• 제37권2호
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• pp.100-107
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• 2004

This study was performed to evaluate the effect of dietary protein source and sulfur amino acid content on bone metabolism in ra. Thirty male rats (body weight 145$\pm$2g) were divided into three groups. The rats in the first group were fed on casein 20% diet as animal protein source and those in the second group were fed on soy 20% diet as plant protein source. Sulfur amino acid ratio of these group was 1.07:1. The rats in the third group were fed on soy 20% diet and the sulfur amino acid were supplemented with the amount contained as much in the soy 20% diet. All rats were fed on experimental diet and deionized water ad libitum for 9 weeks, The total body, spine, femur bone mineral density and bone mineral content were measured using Dual Energy X-ray Absorptiometry Calcium, phosphate, pyridinoline, creatinine in urine and calcium, phosphate, alkaline phosphatase, osteocalcin in serum were measured. During the experimental period, plant protein (soy protein) group had a lower urinary Ca excretion, urine pyridinoline ＆ crosslinks value and had a higher Ca efficiency in total bone and femur bone mineral density than animal protein (casein) group. There were no significant differences in serum calcium, phosphate, alkaline phosphatase and osteocalcin among the three groups of the rats. The findings from this study demonstrated that plant protein (soy protein) is beneficial of bone mineral density because it had a higher Ca efficiency in total bone and femur bone mineral density than animal protein (casein). However, the supplementation of sulfur amino acid on soy results were consistent with prior studies that dietary sulfur amino acid load had a negative effect on calcium balance. The rats fed sulfur amino acid supplementation diet increased urinary calcium excretion and decreased calcium efficiency for total and femur mineral density. Therefore, dietary protein source and sulfur amino acid content influence bone metabolism. (Korean J Nutrition 37(2): 100-107, 2004)

• 고려인삼학회:학술대회논문집
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• 고려인삼학회 1990년도 Proceedings of International Symposium on Korean Ginseng, 1990, Seoul, Korea
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• pp.132-136
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• 1990

The metabolic disturbance and nephrotoxicity induced by sodium dichromate (20 mg/kg, SC) have been diminished by the administration of Korean red ginseng extract (100 mg/kg, PO). Red ginseng has a powerful potency on the blood urea nitrogen (BUN) increment shown in the early 2h after dichromate intoxication. It normalized the dichromate induced hepatic glycogenolysis. The effect of red ginseng on dichromate induced nephrotoxicity was investigated by hematological analysis, and urinalysis. Ginseng treatment significantly reduced the increases in the urinary excretion of protein and glucose. These effects were dose dependent. Ginseng protected the accumulation of BUN and cretonne in the blood, caused by dichromate intoxication. Unlike CaEDTA, ginseng did not change the urinary excretion chromium. And it could not convert htxavalent chromium to trivalent chromium. These results suggest that ginseng treatment is effective in decreasing the metabolic disturbance, one of the earliest signs of dichromate toxicity, resulting in the protective effect of dichromate induced renal damage.

• Journal of Ginseng Research
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• 제14권2호
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• pp.274-278
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• 1990

The metabolic disturbance and nephrotoxicity induced by sodium dichromate (20 mg/kg, SC) have been diminished by the administration of Korean red ginseng extract (100 mg/kg, PO). Red ginseng has a powerful potency on the blood urea nitrogen (BUN) increment shown in the early 2h after dichromate intoxication. It normalized the dichromate induced hepatic glycogenolysis. The effect of red ginseng on dichroamte induced nephrotoxicity was investigated by hematological analysis, and urinalysis. Ginseng treatment significantly reduced the increases in the urinary excretion of protein and glucose. These effects were dose dependent. Ginseng protected the accumulation of BUN and creatinine in the blood, caused by dichromate intoxication. Unlike CaEDTA, ginseng did not change the urinary excretion of chromiilm and it could not convert hexavalent chronlium to trialvalent chromium. These results suggest that ginseng treatment is effective in decreasing the metabolic disturbance, one of the earliest signs of dichromate toxicity, resulting in the protective effect of dichromate induced renal damage.

• 대한지역사회영양학회지
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• 제5권2호
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• pp.243-252
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• 2000

This study examined the effects of excess intake of calcium(Ca) and iron(Fe) supplements on iron bioavailability, liver and kidney functions in anemic model rats. Seven-week-old female rats were first fed and Fe-deficient diet for ten weeks, and then fed one of nine experimental diets for an additional eight weeks, containing three levels of Ca, normal (0.5%) or high(1.5%) or excess (2.5%) and three levels of Fe, normal(35ppm) or high(210 ppm) or excess(350ppm). In anemic model rats, serum Fe, total iron binding capacity(TIBC), hemogolin(Hb), hematocrit(Hct) and liver Fe contents were significantly decreased. Apparent Fe absorption significantly increased with increasing dietary Fe levels, and decreased with increasing dietary Ca levels. serum Fe concentration significantly increased in rats fed a high- and excess-Fe diet, and decreased in rats fed a excess-Ca diet. TIBC was decreawed in rats fed a excess-Ca diet, and transferrin saturation(%) increased in rats fed ahigh- and excess-Fe diet. Hb and Hct were decreased in rats fed an excess-Ca diet regardless of dietary Fe levels. Fe and thiobarbituric acid reactin gsubstance(TBARS) Contents of liver significantly increased in rats fed a high- and excess0-Fe diet, and decreased in rats fed a high- and excess-Ca diet. Fe content of the spleen showed similar results. Urinary creatinine and GFR increased in rats fed an excess-Ca diet regardless of dietary Fe levels. GOT, GPT and LDH were not significantly affected by dietary Ca and Fe levels. These results suggest that excess intake of Fe may increase liver Fe deposits and TBARS, and excess intake of Ca may decrease Fe bioavailability and kidney function leading to potential health problems in anemic model rats.

• Journal of Nutrition and Health
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• 제43권4호
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• pp.351-356
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• 2010

본 연구는 칼슘고갈식이와 칼슘회복식이를 급여한 SD 종 흰쥐에서 골격대사 지표와 골밀도를 측정함으로써 어린소재 Ca (Tilapia mossambica 비늘을 이용한 칼슘소재)의 유용성을 $CaCO_3$와 비교 평가하였다. 1) 칼슘고갈식이인 LoCa군에 비해 칼슘회복식이를 먹인 AdCa군과 AdFa군에서 체중증가, 사료섭취량이 유의하게 높았고, 이는 어린소재 Ca의 식이효율이 적정수준에 있다고 할 수 있다. 2) 혈청 PTH와 칼시토닌은 실험군 사이에 차이가 없었다. 3) 혈청 ALP와 오스테오칼신은 LoCa군에서 유의하게 증가하였고, AdCa와 AdFa군에서 저하되었다. 뇨의 DPD는 LoCa군에서 현저히 높은 수치를 보인 반면, AdCa와 Ad-Fa군에서 낮은 수치를 보임으로써 뼈의 형성지표와 흡수지표는 칼슘회복식이에 의해 개선되었다. 4) 대퇴골의 습윤무게, 건조무게, 체중 100g 단위당 중량이 모두 AdFa > AdCa > LoCa 순으로 높았고, 대퇴골의 회분함량과 칼슘함량도 모두 같은 순서를 보임으로써 뼈의 형성과 칼슘 축적에 AdCa군과 마찬가지로 AdFa군에서도 효과적이었음을 시사한다. 5) 대퇴골의 골밀도는 AdCa군과 AdFa군에서 LoCa군에 비해 25~26%의 유의하게 높은 수치를 보였다. 이상에서와 같이 칼슘회복식이 (AdCA와 AdFa)는 ALP, 오스테오칼신, DPD의 지표를 개선하였고, 대퇴골의 중량과 회분함량의 증가와 함께 골밀도를 향상시키는 것으로 나타났다. 따라서 어린소재 칼슘은 대조 칼슘급원으로 많이 사용되는 $CaCO_3$에 비교하여 뼈 건강에 대등한 효과를 보이므로, 칼슘 소재로서 개발될 가치가 있을 것으로 평가된다.

• 한국식품영양과학회지
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• 제36권1호
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• pp.51-57
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• 2007

본 연구에서는 레반의 경구 투여가 혈중 지질 및 체내 칼슘대사에 미치는 영향을 검토하고자 0.1% 칼슘제한식이를 섭취하는 흰쥐를 대상으로 각각 식이무게의 2.5%와 5% 수준의 레반을 8주간 투여하면서 대사실험을 수행하였으며 그 결과는 다음과 같다. 체중 증가량은 대조군(C)에 비하여 5% 레반을 섭취한 군에서 감소하였으며 신장의 무게는 대조군에 비하여 레반 섭취군에서 유의적으로 높았으나 간무게는 차이가 없었다. 레반의 섭취는 맹장 내용물을 유의적으로 증가시켰으며 5%레반 섭취시 맹장조직의 무게가 유의적으로 증가하였다. 혈장 triacylglycerol과 LDL-cholesterol은 대조군에 비하여 5% 레반 섭취군에서 유의적으로 감소하였으나 AI에는 차이가 없었다. 혈장 alkaline phosphatase (ALP)와 뇨중 hydroxnproline(HP) 배설량, 혈장 칼슘 농도, 체중에 대한 대퇴골 무게 비는 레반 섭취로 변화되지 않았다. 그러나 5% 레반 섭취군의 변 중 칼슘 배설량은 대조군에 비하여 유의적으로 적었으며 칼슘 흡수율은 높았다. 레반섭취군의 뇨 칼슘 배설량과 칼슘 보유량(Ca retention)은 대조군과 차이가 없었다. 본 연구의 결과로 보아 수용성 식이섬유인 레반은 혈장 지질 개선효과와 칼슘 흡수율 증가 등의 유익한 생리적 특성을 보이므로 다이어트와 정장 기능성 소재로 뿐만 아니라 심순환계 질환의 예방과 골 대사 개선용 기능성식품 소재로의 활용도 가능할 것으로 보인다.

• Journal of Nutrition and Health
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• 제23권1호
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• pp.25-36
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• 1990

This study was carried out to investigate Mg status and the relationship between dietary Mg the blood pressure in 30 healthy women, 26 to 57 year of age, living in rural area of Korea. Dietary intake of the subjects on self-selected diet were recorded. Duplicated food sample and 24-hour urine samples were collected for 3 days. Mean daily dietary Mg intake levels were determined by chemical analysis of duplicated food samples and mean daily urinary Mg excretion was measured from urine samples. Fasting serum Mg levels of each subjects was measured on the 3rd day of the survey. The results were as following: 1) The mean daily intakes of energy, protein were 1770.36㎉ and 55.55g, respectively. Carbohydrare, fat and protein supplied 77.1%, 10.4% and 12.5% of total energy intake. 2) The dietary Mg showed positive correlations with carbohydrate(P<0.05), vitamin A and vitamin B2(P<0.01), energy, Ca, P, fiber, vitamin B1 and niacin(P<0.001), but negative correlation with SBP(P<0.05). 3) The daily mean intake of Mg was 259.07$\pm$74.54mg and the urinary excretion of Mg was 75.48$\pm$33.14mg which was 29.5% of the dietary intake of Mg. And there was no significance between the dietary intake and the urinary excretion of Mg. 4) The dietary fiber showed negative correlations with SBP and DBP(P<0.05). 5) The serum and urinary concentrations of Mg were normal range and the serum Mg showed negative correlation with dietary vitamin C(P<0.05, r=-0.3655). It was concluded that the dietary Mg level of Korean rural women consuming self-selected diets was lower than that of RDA of American women but higher than that of RDA of Canadian. And the dietary intake levels of Mg and fiber, which are contained mostly in cereals and vegetables are useful to prevent hypertention.

• 한국동물생명공학회지
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• 제36권3호
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• pp.129-136
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• 2021

This study identified single nucleotide polymorphisms (SNPs) that affect the body weight of chickens. Analysis of body weight showed that the Cornish breed had the highest body weight, and the Korean native chicken (Gray Brown) had the lowest body weight. TSH is composed of an α-subunit and a β-subunit, and the TSH-β gene encoding the β-subunit has been reported to be associated with obesity. In chickens, it is located on chromosome 26 and is reported to be associated with growth. The calcium-sensing receptor gene (CaSR) plays a role in the regulation of extracellular calcium homeostasis and is responsible for calcium absorption in the urinary tract, which affects the eggshell quality in poultry. It was shown that TSH-β was strongly correlated with weight in Cornish and Korean native (Gray Brown) chickens, particularly in those with the CC trait. However, CaSR showed no association with body weight in poultry; it was associated with calcium and the eggshell. Thus, selection for TSH-β can be used to produce individuals with more favorable traits in terms of body weight.