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http://dx.doi.org/10.4163/kjn.2010.43.4.351

Effect of Calcium Source using Tilapia Mossambica Scales on the Bone Metabolic Biomarkers and Bone Mineral Density in Rats  

Yoon, Gun-Ae (Department of Food and Nutrition, Dong-Eui University)
Kim, Kwang-Hyeon (Department of Life Science and Biotechnology, Dong-Eui University)
Publication Information
Journal of Nutrition and Health / v.43, no.4, 2010 , pp. 351-356 More about this Journal
Abstract
This study was done to evaluate the effect of Ca source using fish (Tilapia mossambica) scales on the bone metabolism. Male Sprague-Dawley rats, 4 weeks of age, were fed low-calcium diet (0.15% Ca) for 2 weeks. The rats on the low-calcium diet were further assigned to one of following three groups for an additional 4 weeks: 1) Ca-depletion group (LoCa) given 0.15% Ca diet ($CaCO_3$), 2) Ca-repletion group (AdCa) given 0.5% Ca diet ($CaCO_3$), 3) Ca-repletion diet (AdFa) received 0.5% Ca diet (Ca source from Tilapia mossambica scales). Serum parathyroid (PTH) and calcitonin showed no differences among experimental groups. Whereas LoCa group elevated the turnover markers, serum ALP and osteocalcin, and urinary deoxypyridinoline (DPD), AdCa and AdFa groups reduced their values. Elevation in the femoral weight, ash and Ca contents was observed in AdCa and AdFa groups. Bone mineral density was increased in AdCa and AdFa groups by 25-26% compared with LoCa group. These data demonstrate that Ca repletion with either Ca source from Tilapia mossambica scales or $CaCO_3$ is similarly effective in the improvement of bone turnover markers and BMD, suggesting the usefulness of Tilapia mossambica scales in the prevention of bone loss compared with $CaCO_3$.
Keywords
bone mineral density; bone metabolic biomarkers; Ca-depletion; Ca-repletion;
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연도 인용수 순위
1 Yoon GA, Hwang HJ. Effect of soy protein/animal protein ratio on calcium metabolism of the rat. Nutrition 2006; 22: 414-418   DOI   ScienceOn
2 Moon SJ, Kim JH, Lim SK. Investigation of risk of low serum 25-hydroxyvitamin D levels in Korean menopausal women. Korean J Nutr 1996; 29: 981-990
3 Kodama Y, Miyakoshi N, Linkhart TA, Wergedal J, Srivastava A, Beamer W, Donahue LR, Rosen C, Baylink DJ, Farley J. Effects of dietary calcium depletion and repletion on dynamic determinants of tibial bone volume in two inbred strains of mice. Bone 2000; 27: 445-452   DOI   ScienceOn
4 Delmas PD, Hardy P, Garnero P, Dain M. Monitoring individual response to hormone replacement therapy with bone marker. Bone 2000; 26: 553-560   DOI   ScienceOn
5 Foley MK. Influence of dietary calcium and cholecalciferol on composition of plasma lipids in young pig. J Nutr 1990; 120: 45- 51   DOI
6 Bone Health and Osteoporosis: A surgeon General's Report. Washington DC: US Dept of Health and Human Service; 2004
7 Lee JH, Moon SJ, Huh GB. Influence of phytate and low dietary calcium on calcium, phosphate and zinc metabolism by growing rats. Korean J Nutr 1993; 26: 145-155
8 Han J, Kim E, Cheong M, Chee S, Chee K. Bioavailablity and digestibility of organic calcium source by bone health index. Korean J Nutr 2010; 43: 12-25   과학기술학회마을   DOI
9 Heaney RP, Dowell SD Bierman J. Absorbability and cost effectiveness in calcium supplementation. J Am Coll Nutr 2001; 20: 239-246   DOI
10 Austin LA., Health H. Calcitonin: physiology and pathophysiology. N Eng J Med 1981; 29: 269-278
11 Aloia JF Cohr SH, Vaswani A, Yeh JK, Yuen K, Ellis K. Risk factors for postmenopausal osteoporosis. Am J Med 1985; 78: 95- 100
12 Price PA, Pathermore JG, Doftos LJ. New biochemical marker for bone metabolism. J Clin Invest 1980; 66: 878-883   DOI   ScienceOn
13 Lee SH, Chang SO. Comparison of the bioavailability of calcium from anchovy, tofu and nonfat dry milk in growing male rats. Korean J Nutr 1994; 27: 473-482
14 Weisman SM. Matkovic V. Potential use of biochemical markers of bone turnover for assessing the effect of calcium supplementation and predicting fracture risk. Clin Therapeutics 2005; 27: 299-308   DOI   ScienceOn
15 Lee YS, Oh JH. Effects of bovine bone ash and calcium phosphate on calcium metabolism in postmenopausal osteoporosis model rats. Korean J Nutr 1995; 28: 434-441
16 Siebel M, Woitge HW. Biochemical markers of bone metabolism- update 1999. Clin Lab 1999; 45: 237-256
17 Hannon RA, Eastell R. Biochemical markers of bone turnover and fracture prediction. J Br Menopause Soc 2003; 9:10-15   DOI   ScienceOn
18 Kim YM, Yoon GA, Hwang HJ, Chi GY, Son BY, Bae SY, Kim IY, Chung JY. Effect of bluefin tuna bone on calcium metabolism of the rats. J Korean Soc Food Sci Nutr 2004; 33: 101-106   DOI
19 Cummings SR, Rubin SM, Black D. The future of hip fractures in the United States: number, cost and potential effects of postmenopausal estrogen. Clin Orthop Relat Res 1990; 252: 163-166
20 Ministry of Health and Wellfare. 2005 National Nutrition Survey Report; 2006
21 Ohishi T, TakaHashi M, Kawana K Aoshima H, Hoshino H. Agerelated changes of urinary pyridinoline and deoxypyridinoline in Japanese subjects. Clin Invest Med 1993; 16: 319-325
22 Kato S, Mano T, Kobayashi T, Yamazaki H, Himeno Y YamamotoK, Itoh M, Harada N, Nagasaka A. A calcium-deficient diet caused decreased bone mineral density and secondary elevation of estrogen in aged male rats-Effect of manatetrenone and elcatonin. Metabolism 2002; 51: 1230-1234   DOI   ScienceOn
23 Shen V, Birchman R, Xu R, Lindsay R, Demster DW. Shortterm changes in histomorphometric and biochemical turnover markers and bone mineral density in estrogen-and/or dietary calcium-deficient fats. Bone 1995; 16: 149-156   DOI