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Effects of Endothelium on ${\alpha}_1$-and ${\alpha}_2$-adrenoceptor Agonist-induced Contraction in the Rat Isolated Aorta (흰쥐 적출 대동맥에서 ${\alpha}_1$-수용체 효능약과 ${\alpha}_2$-수용체 효능약의 혈관수축반응에 대한 내피세포의 영향)

  • Chung, Joon-Ki;Hong, Sung-Cheul;Choi, Su-Kyung;Kang, Maeng-Hee;Ku, Mi-Geong;Park, Sang-Il;Yun, Il
    • YAKHAK HOEJI
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    • v.34 no.3
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    • pp.180-191
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    • 1990
  • A comparison was made of the effects of selective ${\alpha_1}-adrenoceptor$ agonist phenylephrine and selective ${\alpha_2}-adrenoceptor$ agonist clonidine on endothelium-containing and endothelium-denuded rings of the rat aorta. In the case of phenylephrine, removal of endothelium increased sensitivity 2.5 fold at $EC_{50}$ level and maximum contractive response 1.4 fold. In the case of clonidine, which gave only 15% of maximum contractive response given to phenylephrine on endothelium-containing rings, removal of the endothelium increased sensitivity 5.6 fold at $EC_{50}$ level and maximum contractive response 5 fold, which was about 55% of that given by phenylephrine. In endothelium-denuded ring, phenylephrine-induced contraction tended to be more increased in tonic contraction than in phasic contraction as compared to that in endothelium-containing ring, while clonidine-induced contraction was monophasic and was increased only in tonic contraction. In the calcium-free solution or in the presence, of verapamil, contraction stimulated by clonidine was almost abolished while that stimulated by phenylephrine produced only phasic contraction. The depression of sensitivity to these agonists in rings with endothelium appeared to be due to the vasodepressor action of endothelium derived relaxing factor (EDRF), because hemoglobin, a specific blocking agent of EDRF, abolished this depression. It is unlikely that the endothelium-dependent relaxation was due to stimulation of release of EDRF, because clonidine did not produce endothelium-dependent relaxation in 5-hydroxytryptamine-precontracted ring even when its contractile action was blocked by the ${\alpha_1}-adrenoceptor$ antagonist, prazosin. When the efficacy of phenylephrine was reduced to about the initial efficacy of clonidine by pretreatment with dibenamine, the contraction-response curves for phenylephrine became very similar to the corresponding curves obtained for clonidine before receptor inactivation. In the dibenamine-treated rings, contraction of phenylephrine was abolished in calcium-free solution or in the presence of verapamil like that obtained for clonidine before receptor inactivation. These results suggest that EDRF spontaneously released from endothelium depress contraction more profoundly in a case of an agonist with low efficacy and the phenylephrine-induced contraction was totally dependent on extracellular calcium as was that obtained for clonidine when the efficacy of phenylephrine was reduced to that of clonidine by irreversible inactivation of ${\alpha_1}-adrenoceptor$ with dibenamine.

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The Late Cretaceous Emplacement Age of Masan Hornblende-Biotite Granite (마산 각섬석-흑운모 화강암의 연령: 후기 백악기 정치연령)

  • Lee, Tae-Ho;Park, Kye-Hun;Kim, Jeongmin;Kim, Myoung Jung
    • The Journal of the Petrological Society of Korea
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    • v.26 no.1
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    • pp.1-11
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    • 2017
  • We have dated the K-Ar, Ar-Ar and U-Pb ages of the Masan hornblende-biotite granite in the southern Cretaceous Gyeongsang basin to constrain its emplacement age. The ~108 Ma hornblende K-Ar age obtained in the study is similar to the previously reported Rb-Sr age. However, the single grain total fusion $^{40}Ar/^{39}Ar$ dating on hornblende failed to yield statistically meaningful ages because the isotopic system was open during its alteration. Thus the hornblende K-Ar age in the study is also unlikely to be reliable. The single grain total fusion $^{40}Ar/^{39}Ar$ dating on biotite yielded an average age of $75.8{\pm}3.0Ma$. Apart from scattered data in the range of ~45-75 Ma, the average age increased to ~80 Ma. The SHRIMP and LA-MC-ICPMS U-Pb isotopic compositions of zircon from the Masan hornblende-biotite granite yielded its emplacement age as $87.6{\pm}2.7Ma$ and $86.8{\pm}0.4Ma$, respectively. It is thus likely that the ~80 Ma $^{40}Ar/^{39}Ar$ age of biotite might reflect the cooling age of Masan hornblende-biotite granite or the thermal influences from later intense igneous activities in the Gyeongsang basin.

Capacity of Distribution Science and the Energy Distribution Role for Visegrád Group Cooperation (비셰그라드 그룹의 협력에 따른 유통과학의 역량과 에너지유통의 역할)

  • Seo, Daesung
    • Journal of Distribution Science
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    • v.13 no.12
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    • pp.95-103
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    • 2015
  • Purpose - The Visegrád Group cooperation of the past 14 years and that of V4 for the past 20 years has very important significance in the 21st century that must be maintained. This cooperation is valuable because of the trade routes that connect northern Poland to the Balkans in southern Croatia, which forman important basis for the resuscitation of Central European development. Currently, because of the European manufacturing base and industrial development, an energy supply and stable energy distribution networks have been introduced to secure cooperation and not competition within the Visegrád Group. This paper's research emphasizes the supply chain hub in neighboring countries. Although Central and Eastern European countries are small, they can provide a competitive response to Western Europe if they collaborate with the V4 group and other countries. Research design, data, and methodology - The subjects of this study in the Visegrád Group area are related to the development of Marketing and Distribution Sciences in the integrated European Union. In relation to the existing energy infrastructure, construction companies and financial institutions benefit from large-scale construction projects. Existing or new infrastructure facilities among the V4 must comply with the preconditions of regional energy markets. The network of emerging markets is changing into a European-logistics hub of new markets. This hub is closely associated with the economic development of European self-sustainment given that energy for distribution and consumption is imported from Russia. Therefore, this paper indirectly provides data on the regional distribution of energy as alternative bases in Europe for market expansion to Asia. Results - As a result, it appeared unlikely that V4 failed to implement homogeneity following the standards of Western Europe, as proposed by the EU. Throughout European history, individuals have gathered in Central Europe as an innovation hub. Currently, the region is being established independently for energy industrial development and not for tourism development, and is expected to play a central role in innovation and distribution consumption. Therefore, similar to Western and Northern Europe, V4 only appears to engage in distribution consumption on the basis of the identity that it formed for itself. This area is expected to either create a regional platform or a voice over a single economic policy. Conclusions - To this end, regarding the distribution of consumer groups within and outside the region, the V4 group is expected to be established for various policy areas and as a Eurasian outpost of trade and distribution logistics. In addition, given its purpose of engaging in the distribution of energy cooperation and trade clusters, the Visegrád Group will be in charge of the center axis of the bridge for distribution logistics trading partners from the Western Balkans to Caucasus and Eastern Europe. Thus, the Visegrád Group is entering this region as a platform for market share by enabling all or any investor can gain greater industrial benefits.

The Exploitation of World Fishery Resources for 10 Years under the New Regime in the Sea (신해양질서 10년후 세계어업자원 이용동향)

  • 이장욱;허영희
    • The Journal of Fisheries Business Administration
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    • v.23 no.1
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    • pp.43-87
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    • 1992
  • In this paper, state of exploitation of world fishery resources after 10 years under the new regime in the sea, called the era of exclusive economic zone (EEZ) expending up to a 200 nautical miles from coastal line, was reviewed to determine effect from establishing EEZ in the world fishery production and its export/import volume based on the fishery statistics annually published by the Food and Agriculture Organization (FAO) of United Nation. The world total production from marine living resources had a trend showing a waned increase during 1970's when most of coastal states were translated into the reality of EEZ. From mid-1980's onwards, it increased rapidly, reaching about 85 million tons . Such increase in production was basically from the Pacific Ocean, accounting for more than 60% of the world total production. Fishing areas where showed increase in the production after the new regime in the sea were the southwestern Atlantic (FAO area 41) , the eastern Indian (FAO area 57) and the whole fishing areas in the Pacific except the eastern central Pacific (FAO area 77). Increase in the production from distant-water fishing countries came from the regions of the southwest Atlantic (FAO area 41) and the southwest Pacific (FAO area 81) . The production from coastal states was up from the regions of the eastern Indian (FAO area 57) , the northwest and northeast Pacific (FAO areas 61 and 67) and the southeast Pacific (FAO area 87) . It was likely that the exploitation of the fishable stocks was well monitored in the areas of the northwest Atlantic (FAO area 21) , the eastern central Atlantic (FAO area 34) and the northeast Pacific (FAO area 67) through appropriate management measures such as annual harvest level, establishment of total allowable catch etc. The marine fisheries resources that have made contribution to the world production, despite expansion of 200 EEZ by coastal states, were sardinellas, Atlantic cod, blue whiting and squids in the Atlantic Ocean : tunas which mainly include skipjack, yellowfin and bigeye tuna, croakers and pony fishes in the Indian Ocean : and sardine, Chilean pilchard, Alaska pollock, tunas (skipjack and yellowfin tuna) , blue grenadier and blue whiting including anchoveta in the Pacific Ocean. It was identified that both fishery production and its export since introduction of the new regime in the sea were dominated by such coastal states as USA, Canada, Indonesia, Thailand, Mexico, South Africa and Newzealand. But difficulties have been experienced in the European countries including Norway, Spain, Japan and Rep. of Korea. Therefore, majority of coastal states are unlikely to have yet undertaken proper utilization as well as rational management of marine living resources in their jurisdiction during the last two decades. The main target species groups which led the world fishery production to go up were Alaska pollock, cods, tunas, sardinellas, chub and jack mackerel and anchoveta. These stocks are largely expected to continue to contribute to the production. The fisheries resources which are unexploited, underexploited and/or lightly exploited at present and which will be contributed to the world production in future are identified with cephalopods, Pacific jack mackerel and Atlantic mackerel, silver hake including anchovies. These resources mainly distribute in the Pacific regions, especially FAO statistical fishing areas 67, 77 and 87. It was likely to premature to conclude that the new regime in the sea was only in favour of coastal states in fishey production.

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A Semiotic Approach on the Political UCC Contents Focused on Video UCC, (정치적 UCC 콘텐츠에 대한 기호학적 연구 동영상 UCC, 을 중심으로)

  • Mha, Joung-Mee;Kang, Ki-Ho
    • Korean journal of communication and information
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    • v.46
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    • pp.245-279
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    • 2009
  • UCC, an abbreviation for User Created Contents, is not only a symbol of desire but also a product of creativity that a producer contains his or her subjective disposition. More and more UCC tend to have significantly increased in Web 2.0 environment. However, the research on the contents as a creative product has rarely been processed. It may be fairly said that this results in the indifference of researchers in the special field like the political contents since UCC is usually produced by amateurs. Producers' various desire is unlikely revealed, which leads to the flow of users into open media such as the Internet. It could also be available to represent the property, of plural visual language signs in a field. Moreover, UCC has the attribute of re-mediation in effective communication, so the differences between the semiotic properties in the Internet contents could be a significant material for researches. This could contribute to establish a theoretical system for the visual communication. Therefore, this study aims to analyse the signification of the political video UCC, . To develop this analysis, I apply Greimas' Generative Trajectory of Signification Theory to the text, or the UCC. He classifies it as three structures: deep structure, superficial structure, and discourse structure. As a result, the text shows meaningful contents delivering core political messages. In addition, this approach could exam that 'Obama Syndrome' in American recent presidential campaigns is caused by web 2.0 based on Internet campaigns including video UCC.

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A STUDY ON THE SIZE OF THE DECIDUOUS TEETH (유치의 치아크기에 관한 연구)

  • Baik, Byeong-Ju;Jeon, So-Hee;Kim, Jae-Gon;Kim, Young-Sin
    • Journal of the korean academy of Pediatric Dentistry
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    • v.29 no.3
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    • pp.382-388
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    • 2002
  • In the present study, crown diameters and their sexual differences in deciduous teeth were investigated in children of Chon-ju city, Korea. Plaster casts of the deciduous dentitions obtained from 50 boys and 50 girls were examined. Mesiodistal and buccolingual crown diameters were measured using a digital caliper(0.01mm) according to the definitions of Seipel and Moorees et al. These measurements were performed three times, and intra-observer measurement errors were calculated by the single determination method. The crown index, module and area were calculated in order to provide a comparison of crown proportions. The results obtained were summarized as follows; 1. The mean values of intra-observer measurement errors were 0.255mm and are unlikely to have influenced the statistical analysis. 2. The mean values of mesiodistal and buccolingual crown diameters examined were larger in boys than girls. 3. The mean coefficient of variation was 5.6 in the deciduous dentition. There were a trend for the primary second molar to be the least variable in size of all teeth both in boys and girls. 4. Fluctuating asymmetry is the difference between left and right antimeres in individuals. Primary second molars were less asymmetrical than primary first molars in both dimensions. 5. In maxillary teeth, Crown index is larger in boys than in girls. In contrast, in mandibular teeth, except primary canine, it is larger in girls than in boys. Crown module is larger in boys than in girls and increased progressively from primary first incisor to primary second molar. Crown area is consistently larger in boys than in girls. The minimum crown area is mandibular primary incisor and maximum crown area is maxillary primary second molar.

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THERAPEUTIC APPROACHES FOR TREATMENT RESISTANT OBSESSIVE-COMPULSIVE DISORDER IN CHILDREN AND ADOLESCENTS (소아청소년기 치료저항성 강박장애의 치료적 접근)

  • Suh, Hyun-Ju;Kim, Boong-Nyun
    • Journal of the Korean Academy of Child and Adolescent Psychiatry
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    • v.14 no.1
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    • pp.64-80
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    • 2003
  • Although obsessive-compulsive disorder(OCD) affects children, adolescents, and adults whether its juvenile(dhild and adolescent) and adult forms are different subtype of a disorder remains unknown. But there are increasing findings that suggest that juvenile OCD may be unique subtype of the disorder. One proposed subtype is the childhood OCD associated with high comorbidity of tic disorder and increased familial loading for OCD or tic disorder. The other proposed subtype is the childhood OCD and/or tic disorder occuring in association with streptococcal infection(PANDAS). These two subtypes of OCD are unlikely to respond to SSRI due to possible different pathphysiological mechanism. So this paper reviews the characteristics of OCD and therapeutic approaches for treatment resistant OCD in childhood and adolescence. Considering the likely heterogeneity of OCD, the possibility that juvenild OCD may be a variant of the disorder can have important clinical and scientific implications because it may further our understanding of this disorder, its etiology, and perhaps its treatment.

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An Experimental Analysis of Hydrate Production using Multi-Well, Plate-Type Cell Apparatus (다중공 평판형 셀기기에서 하이드레이트 생산실험 분석연구)

  • Bae, Jaeyu;Sung, Wonmo;Kwon, Sunil
    • Korean Chemical Engineering Research
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    • v.45 no.3
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    • pp.304-309
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    • 2007
  • In this study, the "Multi Well Plate-type cell Apparatus" was designed and setup for performing the producing experiments of methane hydrate by depressurization, heat stimulating methods. In order to characterizing the producing mechanism of hydrate through porous materials, the experiments for various producing methods have been conducted with the aid of the apparatus which has high permeability. In the experimental result of depressurization method, the pressure is temporarily increased unlikely conventional gas reservoir due to the sourcing effect of hydrate dissociation in the pore. Meanwhile, the temperature is decreased because of the endothermic reaction while hydrate is dissociated. In the experimental results of heat stimulating method, the dissociation in depressurization method is more slowly processed than that in thermal method, and hence, its gas production is lower. In the case of production right after heating, hydrate is dissociated only near injecting point and the permeability becomes greater at that area only. It infers that the more gas is produced during relatively earlier producing period. Since then, the hydrate is more slowly dissociated than the case of production after heating and soaking. This time, the performances of pressure and production obtained by thermal method have been analyzed in order to investigate the effect of soaking time on gas recovery. As a result, the gas recoveries in the case of 2 min and 4 min soaking are higher than case in 6 min soaking. This is reason that hydrate is reformed due to the decrease of temperature. It is expected that the experimental results obtained in this work may be more clearly explained by utilizing the lower permeable porous system with the greater hydrate saturation.

Dental Treatment of a Patient with Cerebral Palsy under General Anesthesia (뇌성마비 환자의 전신마취 하 치과치료)

  • Chung, Jun-Min;Seo, Kwang-Suk;Yi, Young-Eun;Han, Hee-Jung;Han, Jin-Hee;Kim, Hye-Jung;Shin, Teo-Jeon;Kim, Hyun-Jeong;Yum, Kwang-Won;Chang, Ju-He
    • Journal of The Korean Dental Society of Anesthesiology
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    • v.8 no.1
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    • pp.22-28
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    • 2008
  • Background: Cerebral palsy (CP) is non-progressive disorder of motion and posture. In CP patient, there are difficulties in dental treatment because of uncontrolled movement of limb and head, and conjoined disabilities such as cognitive impairment, sensory loss, seizures, communication and behavioral disturbances. It is reported that CP patients have high incidence in caries and a higher prevalence of periodontal disease. But, despite the need for oro-dental care, these patients often are unlikely to receive adequate treatment without sedation or general anesthesia because of uncontrolled movements of the trunk or head. Methods: We reviewed the 58 cases of 56 patients with CP who underwent outpatient general anesthesia for dental treatment at the clinic for the disabled in Seoul National University Dental Hospital. Results: The mean age was 19 (2-54) years. The number of male patient was 40 and that of female was 18. They all had severe spastic cerebral palsy and 22 had sever mental retardation, 15 epilepsy, 8 organic brain disorder, 1 blindness, 2 deafness and cleft palate. For anesthesia induction, 14 cases was needed physical restriction who had sever mental retardation and cooperation difficulty, but 44 cases showed good or moderate cooperation. Drugs used for anesthesia induction were thiopental (37 cases), sevoflurane (14 cases), ketamine (3 cases ) and propofol (4 cases). All patients except one were done nasotracheal intubation for airway management and 4 cases were needed difficult airway management and 1 patient already had tracheostomy tube. Mean total anesthetic time was $174{\pm}56$ min and staying time at PACU was $88{\pm}39$ min. There was no death or long term hospitalization because of severe complications. Conclusion: If general anesthesia is needed, pertinent diagnostic tests and workup about anomaly, and appropriate anesthetic planning are essential for safety.

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The Analysis of Geothermal Gradient at Icheon Hot Spa Area (이천 온천원보호지구의 지온경사 해석)

  • Lee, Chol-Woo;Moon, Sang-Ho
    • The Journal of Engineering Geology
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    • v.18 no.2
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    • pp.185-190
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    • 2008
  • Nine wells have been developed for uses of thermal waters at the Icheon hot spa area. Drilling depths of those hot spring wells range from 166 to 294 m and their piezometric heads are located at about 50 m below the surface. Using the differences between the surface and bottom temperatures within all boreholes, we can simply estimate geothermal gradient in this area. Thus, we obtained the highest, lowest and average gradient values as $64^{\circ}C/km$ from SB-2 well, $45^{\circ}C/km$ from SB-1 well and approximately $54.28^{\circ}C/km$, respectively. However, observing the MRD-2 well additionally drilled into the depth of 996 m, we found out that this study area has widely experienced the temperature disturbance due to thermal groundwater penetration through the fracture systems within the depth of 720 m. Unlikely this phenomenon, we can conclude that the groundwater flow below the depth of 720 m does not exist. Therefore, using only those temperature data below the 720 m depth, we can estimate reasonable geo-thermal gradient values as $33^{\circ}C/km$ in this study area. Pumping test shows that outflowing temperature is $36^{\circ}C$ corresponding to the temperature logging data at 720 m depth.