• BMB Reports
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• v.48 no.4
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• pp.223-228
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• 2015

The Drosophila lymph gland is the hematopoietic organ in which stem-like progenitors proliferate and give rise to myeloid-type blood cells. Mechanisms involved in Drosophila hematopoiesis are well established and known to be conserved in the vertebrate system. Recent studies in Drosophila lymph gland have provided novel insights into how external and internal stresses integrate into blood progenitor maintenance mechanisms and the control of blood cell fate decision. In this review, I will introduce a developmental overview of the Drosophila hematopoietic system, and recent understandings of how the system uses developmental signals not only for hematopoiesis but also as sensors for stress and environmental changes to elicit necessary blood responses. [BMB Reports 2015; 48(4): 223-228]

• Journal of Engineering Education Research
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• v.13 no.5
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• pp.61-65
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• 2010

As an activity of one working group for the Good Practice program at Kumamoto University, we proposed a questionnaire survey on the degree in which students understand the uppermost points of importance in their classes in addition to the usual type of class questionnaire. Each class lists three uppermost points of importance which are essential for understanding the class content. The degree of understanding is classified into four levels: full, most, insufficient, and not at all understandings. Through the analysis of questionnaire replies, the degree of understanding for bachelor students in the Department of Engineering was discovered to be meaningfully affected by the degree of difficulty, the effectiveness of audiovisual aids, self-study time, and class attendance.

• Journal of Hospice and Palliative Care
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• v.10 no.3
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• pp.120-127
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• 2007

Bereavement is the state of loss resulting from death. Grief is the emotional response associated with loss, intense and acute sorrow resulting from loss. Complicated grief represent a pathological outcome involving social, physical, emotional, cognitive, spiritual morbidity. The common psychiatric disorders associated complicated grief or abnormal grief responses include clinical depression, anxiety disorders, alcohol abuse or other substance abuse, and dependence, psychotic disorders, and post-traumatic stress disorder (PTSD). Grief tasks involve a series of stage or phases following an important loss that gradually permit adjustment and recovery. Three phases of grief involve phase 1 (walking the edges), phase 2 (entering the depths), and phase 3 (reconnecting the world). For intervention to be effective they need to be individually tailored to abnormal grief reaction or unresolved grief reaction. Clear understandings of complicated grief, abnormal responses, factors increasing risk after bereavement will often enable us to prevent psychiatric disorders in bereaved patients.

• Molecules and Cells
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• v.43 no.10
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• pp.841-847
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• 2020

Histone acetylation and deacetylation play central roles in the regulation of chromatin structure and transcription by RNA polymerase II (RNA Pol II). Although Hda1 histone deacetylase complex (Hda1C) is known to selectively deacetylate histone H3 and H2B to repress transcription, previous studies have suggested its potential roles in histone H4 deacetylation. Recently, we have shown that Hda1C has two distinct functions in histone deacetylation and transcription. Histone H4-specific deacetylation at highly transcribed genes negatively regulates RNA Pol II elongation and H3 deacetylation at inactive genes fine-tunes the kinetics of gene induction upon environmental changes. Here, we review the recent understandings of transcriptional regulation via histone deacetylation by Hda1C. In addition, we discuss the potential mechanisms for histone substrate switching by Hda1C, depending on transcriptional frequency and activity.

• 한국경영정보학회:학술대회논문집
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• 2007.06a
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• pp.339-344
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• 2007

In the cut-throat competitive environment of business, large-scale IS investment is becoming inevitable strategic necessity for gaining competitive advantage. However. it bears great deal of risk over all the associated processes so that the investment decisions need to be taken in a greatly careful manner. Nonetheless, Korean organizations are prominently showing risk taking behaviors regarding major is investment, in terms of system downsizing. Although decision theory argues decision makers' rational choice of options through the assessment of risk and benefit, the notable trend toward system downsizing in Korea defies common understandings on IS project risk. Furthermore, it encourages us to investigate many impenetrable characteristics underlying organizational risk taking decisions with IS investment. We found out that there is Significant effect of IS decision makers' risk propensity when they make system downsizing decisions. Moreover. we Identified that IS decision makers do not get a strong pressure of cost savings and have tendencies to mimic competitor's decisions.

• Proceedings of the KSRS Conference
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• 2002.10a
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• pp.411-416
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• 2002

The emergence of viral diseases transmitted is nowadays a central problem in the world. Problem, which is becoming very critical in developing countries, where the health systems are not yet enough developed to face the bursting of such diseases. Emerging viral diseases constitute one of the major threats to human being that are arising in the modern world. Besides bio-chemical and medical researches, new orientations are developed to understand the environmental dimensions of such emergence. Questions concerning the inter-plays between the environmental and disease dynamics are building up new investigations, both in remote sensing and GIS, for the elaboration of levels of organization of space and environment in relation to incidences, to gain understandings in these issues. Environmental attributes attached to land cover types: area, spatial heterogeneity and physical state, are derived from remote sensing and applied to uncover related dimensions of the Dengue disease.

• Journal of the Korean Society of Safety
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• v.18 no.1
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• pp.28-32
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• 2003

The present study investigates the spray characteristics of water mist nozzle with mid-low pressure for fire suppression. The examined nozzle types are swirl and spiral nozzle. The result shows that K factor of water mist nozzle is much smaller than those of general sprinkler. Spray angle of spiral nozzle is largest and more than $150^{\circ}$. SMD(Sauter Mean Diameter) of water mist nozzles is ranged between 100 and 200$\mu\textrm{m}$through measuring by image processing method. The spray pattern of spiral nozzle represent that water flux of first stream is 2 times larger than that of second stream. This study will contribute better understandings of the water-mist spray characteristics and useful daia for developing the water-mist nozzles.

• Knowledge Management Research
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• v.9 no.4
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• pp.157-178
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• 2008

It is well known in KM (Knowledge Management) literature that a certain amount of knowledge is necessary for KM to contribute to corporate performance to some extent. However, for a company to amass knowledge is very difficult due to limited time and poor understandings from employees. Especially, it becomes harder in public organization where simulating financial motif among members is constrained. In this respect, KORAIL, one of typical and leading public organizations in Korea, shows very unique example in which KORAIL succeeds in catalyzing the knowledge circulation process among members, string the resulted working knowledge, and then sharing it to improve working performance at an individual level as well as team level. This KORAIL case will help understand how important the knowledge circulation speed is to improving the corporate performance.

• Development and Reproduction
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• v.15 no.3
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• pp.187-195
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• 2011

X chromosome inactivation (XCI) is a process that enables mammalian females to ensure the dosage compensation for X-linked genes. Investigating the mechanism of XCI might provide deeper understandings of chromosomal silencing, epigenetic regulation of gene expressions, and even the course of evolution. Studies on mammalian XCI conducted with mice have revealed many fundamental findings on XCI. However, difference of murine and human XCI necessitates the further investigation in human XCI. Recent success in reprogramming of differentiated cells into pluripotent stem cells showed the reversibility of XCI in vitro, X chromosome reactivation (XCR), which provides another tool to study the change in X chromosome status. This review summarizes the current knowledge of XCI during early embryonic development and describes recent achievements in studies of XCI in reprogramming process.

• Clinical and Experimental Pediatrics
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• v.48 no.8
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• pp.806-812
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• 2005

Repair mechanisms in the postnatal and mature central nervous system(CNS) have long been thought to be very limited. However recent works have shown that the mature CSN contains neural progenitors, precursors, and stem cells that are capable of generating new neurons, astrocytes, and oligodendrocytes especially in germinative areas such as the subventricular zone of the lateral ventricles, the dentate gyrus of the hippocampus. These findings raise the possibilities for the development of novel neural repair strategies via mobilization and replacement for dying neurons of neural stem cells in situ. Indeed recent reports have provided evidences that endogenous stem cells are activated in response to various injuries, and in some injury models, limited neuronal replacement occurs in the CNS. Here, current understandings for endogenous neurogenesis and induction neurogeneis in postnatal CNS including neonatal brain are summarized and discussed.