• 자원환경지질
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• 제56권3호
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• pp.259-275
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• 2023

Pan African granitoids of Kaiama is comprised of K-feldspar rich granites, porphyritic granites, and granitic gneiss that are intruded by quartz veins and aplitic veins and dykes which trend NE-SW. In order to establish the geochemical signatures, petrogenesis, and tectonic settings of the lithological units, petrological, petrographical, and geochemical studies was carried out. Petrographic analysis reveals that the granitoids are dominantly composed of quartz, plagioclase feldspar, biotite, and k-feldspar with occasional muscovites, sericite, and opaque minerals that constitute very low proportion. Major, trace, and rare earth elements geochemical data reveal that the rocks have moderate to high silica (SiO₂=63-79.7%) and alumina (Al₂O₃=11.85-16.15) contents that correlate with the abundance of quartz, feldspars, and biotite. The rocks are calc-alkaline, peraluminous (ASI=1.0-<1.2), and S-type granitoids sourced by melting of pre-existing metasedimentary or sedimentary rocks containing Al, Na, and K oxides. They plot dominantly in the WPG and VAG fields suggesting emplacement in a post-collisional tectonic setting. On a multi-element variation diagram, the granitoids show depletion in Ba, K, P, Rb, and Ti while enrichment was observed for Th, U, Nd, Pb and Sm. Their rare-earth elements pattern is characterized by moderate fractionation ((La/Yb)_N=0.52-38.24) and pronounced negative Eu-anomaly (Eu/Eu^*=0.02-1.22) that points to the preservation of plagioclase from the source magma. Generally, the geochemical features of the granitoids show that they were derived by the partial melting of crustal rocks with some input from greywacke and pelitic materials in a typical post-collisional tectonic setting.

• 인터넷정보학회논문지
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• 제22권6호
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• pp.83-89
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• 2021

RMF(사이버보안 위험관리 프레임워크)는 지금 현재 국방영역을 넘어 미 연방정부 전체에 통용되는 보다 강화된 미 국방 사이버보안 프레임워크이다. 최근 십여년 간 미국이 접한 비정규전에 있어 사이버전이 차지하는 비율, 특히 중국과 북한으로부터 유발된 사이버공격 비중은 점점 더 증대되고 있다. 결국 미국은 범정부 차원의 보다 강화된 사이버보안 정책을 마련하고자 RMF체계를 새롭게 구축중이며, 미 국방부는 연방정부차원을 넘어 동맹국 간에도 미 국방 RMF평가 정책을 확대해 나가고자 한다. 이미 한국군도 F-35A 획득 시 RMF 적용방침을 통보한 미측 요구로 RMF를 적용한 바 있다. 한국군의 RMF적용은 더 이상 피할 수 없는 대세이다. 이제 우리군은 성공적인 한국형 RMF체계 조기 구축을 위해 무엇을 준비해야 하는지 진지하게 고민해야 할 시점이다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권6호
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• pp.2251-2256
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• 2015

To study effects of cellular FLICE (FADD-like IL-$1{\beta}$-converting enzyme)-inhibitory protein (c-FLIP) inhibition by RNA interference (RNAi) on sensitivity of U2OS cells to tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced apoptosis, plasmid pSUPER-c-FLIP-siRNA was constructed and then transfected into U2OS cells. A stable transfection cell clone U2OS/pSUPER-c-FLIP-siRNA was screened from the c-FLIP-siRNA transfected cells. RT-PCR and Western blotting were applied to measure the expression of c-FLIP at the levels of mRNA and protein. The results indicated that the expression of c-FLIP was significantly suppressed by the c-FLIP-siRNA in the cloned U2OS/pSUPER-c-FLIP-siRNA as compared with the control cells of U2OS/pSUPER. The cloned cell line of U2OS/pSUPER-c-FLIP-siRNA was further examined for TRAILinduced cell death and apoptosis in the presence of a pan-antagonist of inhibitor of apoptosis proteins (IAPs) AT406, with or without 4 hrs pretreatment with rocaglamide, an inhibitor of c-FLIP biosynthesis, for 24 hrs. Cell death effects and apoptosis were measured by the methods of MTT assay with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and flow cytometry, respectively. The results indicated that TRAIL-induced cell death in U2OS/pSUPER-c-FLIP-siRNA was increased compared with control cells U2OS/pSUPER in the presence or absence of AT406. Flow cytometry indicated that TRAIL-induced cell death effects proceeded through cell apoptosis pathway. However, in the presence of rocaglamide, cell death or apoptotic effects of TRAIL were similar and profound in both cell lines, suggesting that the mechanism of action for both c-FLIP-siRNA and rocaglamide was identical. We conclude that the inhibition of c-FLIP by either c-FLIP-siRNA or rocaglamide can enhance the sensitivity of U2OS to TRAIL-induced apopotosis, suggesting that inhibition of c-FLIP is a good target for anti-cancer therapy.

• 한국정보과학회논문지:컴퓨팅의 실제 및 레터
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• 제14권9호
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• pp.916-920
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• 2008

개인 컴퓨팅 환경은 사용자에 특화된 응용프로그램 및 설정, 사용자 데이타 등을 총칭하는 개념으로써, 노트북, UMPC 등의 휴대용 컴퓨팅 H/W는, 어떤 곳에서도 항상 개인에게 특화된 컴퓨팅 환경에서 작업 가능하도록 소형화, 경량화가 진행되고 있다. 그러나, 최근 가상화 기술 및 휴대용 스토리지 기술을 이용한 다양한 개인 컴퓨팅 환경 이동성 지원 기술이(c.f. VMWare Pocket ACE[1], Mojopac[2], u-PC[3] 등) 등장함으로써, 공용 PC 상에 자신의 컴퓨팅 환경을 로딩하여 사용할 수 있도록 지원하는 기술이 주목받고 있다. 특히, 본 논문의 이전 연구로써, u-PC[3]에서는 UPnP 및 iSCSI 프로토콜을 이용하여 사용자 영역 네트워크(PAN)상에서 자동 검색 및 구성이 가능한 무선 스토리지 기술과, Windows 운영체제 상에서 구동 가능한 개인 컴퓨팅 환경 이동성지원 기술을 제안하였다. 그러나, 기존의 u-PC 기술에서는, Windows 운영체제 상 Filter Driver 계층에서 IRP(I/O Request Packet) forwarding을 이용하여 개인 컴퓨팅 환경의 이동성 지원 기술을 구현함으로써, 제한적인 응용 프로그램만 구동 가능한 한계점이 있었다. 본 논문에서는 Windows 운영체제 상 System Call Hooking 기법을 이용하여 운영체제 가상화 기술을 구현하고, 개인 컴퓨팅 환경의 이동성을 지원함으로써, 기존 논문에서의 한계성을 극복하였으며, VMWare Pocket ACE, Mojopac 등의 단점인 개인 컴퓨팅 환경의 구동 초기화 오버 헤드를 극복하였다. 또한, Ultra Wide Band (UWB) 기반 고속 무선 네트워크 상 적용 가능한 무선스토리지 기술을 개발하고, 개선된 u-PC 플랫폼을 연동하여 다양한 형태의 개인 컴퓨팅 환경 사용 모델을 제시함으로써 기술의 적용성을 검증하였다.

• 통상정보연구
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• 제12권1호
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• pp.3-33
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• 2010

Paperless trade is a new trade paradigm that has innovated on traditional trade procedures, which relied on manual work in the past, and applied an IT-based e-document standard. To realize paperless trade in Korea, a lot of efforts have been made. Korea has overcome many difficulties, a lack of awareness, trials and errors, etc. at the initial introduction stage and strived to establish a stable infrastructure through the government's policy support and active cooperation with the trade business communities and related organizations. Now, Korea became a well-known leader in IT industry, especially in the paperless trade infrastructure and strategic policies. The one-stop trading system named 'uTradeHub' is operated by a paperless trade service provider, Korea Trade Network(KTNET). uTradeHub includes trade finance and settlement, customs clearance and export and import logistics, improving trading procedures and reducing related expenses. Private-Public joint efforts from Korean government and private sectors which have respectively fulfilled their role and function with market-oriented practical policies and strategies has lead Korea a world leading country in paperless trade. Moreover, Korea expended its efforts to the global areas. Korea has started to activate multi-national paperless trade alliances such as PAA(Pan-Asia e-Commerce Alliance), ASEAL(Asia Europe Alliance for Paperless Trading) as well as established the bilateral cooperative networks with China and Taiwan. The one-stop trading system, uTradeHub should keep close cooperations between nations since trade itself is implemented in a cross-border ways. In the near future, it is expected uTradeHub can achieve best results in the simplification of procedures and cost savings when an international linkage is completely established with international cooperations.

• Asian Pacific Journal of Cancer Prevention
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• 제15권15호
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• pp.6343-6347
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• 2014

Multi-target drug design, in which drugs are designed as single molecules to simultaneously modulate multiple physiological targets, is an important strategy in the field of drug discovery. QT-011, a tamibarotene-furoxan derivative, was here prepared and proposed to exert synergistic effects on antileukemia by releasing nitric oxide and tamibarotene. Compared with tamibarotene itself, QT-011 displayed stronger antiproliferative effects on U937 and HL-60 cells and was more effective evaluated in a nude mice U937 xenograft model in vivo. In addition, QT-011 could release nitric oxide which might contribute to the antiproliferative activity. Autodocking assays showed that QT-011 fits well with the hydrophobic pocket of retinoic acid receptors. Taken together, these results suggest that QT-011 might be a highly effective derivative of tamibarotene and a potential candidate compound as antileukemia agent.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2013년도 춘계학술대회
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• pp.947-949
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• 2013

개인 휴대단말기로부터 측정된 생체정보 데이터가 PHR에 데이터베이스화되기 위해서는 응용 계층 표준 프로토콜인 HL7 CDA 표준에 따라야 한다. 하지만 국제 표준 HL7 CDA는 병원 시스템 간 의료정보 전달을 위한 프로토콜이기 때문에 개인 건강 기기로부터 측정된 생체 정보가 IEEE 11073 PHD 표준에 준하여 전달하더라도 HL7 CDA 프로토콜과 연동될 수 없다. 즉, 모바일 단말기 기반의 u-헬스케어 모니터링 서비스를 위해서는 IEEE 11073 PHD와 HL7 CDA 간 메시지 변환 게이트웨이가 필요하다. 이에 본 논문에서는 개인 휴대단말기를 통해 원격지에 있는 의료진이 사용자의 생체데이터를 실시간 관리하기 위해 ISO/IEEE 11073과 HL7 CDA 간 메시지 변환 게이트웨이 및 HL7 기반 진단지원시스템을 설계하였다.

• Journal of Magnetics
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• 제18권3호
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• pp.235-239
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• 2013

The effect of Dy addition on the microstructure and magnetic properties of the sintered NdFeB magnets was investigated. The results of the microstructure analysis showed that Dy-free and Dy-doped samples are composed of $Nd_2Fe_{14}B$ (P42/mnm) and a trace of Nd-rich phase. Dy addition reduces significantly the pole density factor of (004), (006) and (008) crystal faces as estimated by the Horta formula. Accordingly, the coercivity of the Dy-doped sample increases from 2038 $kA{\cdot}m^{-1}$ up to 2288 $kA{\cdot}m^{-1}$. The $H_{cj}(T)/M_s(T)$ versus $H^{min}_N/M_s(T)$ (Kronm$\ddot{u}$ller-plot) behavior shows that the nucleation is the dominating mechanism for the magnetization reversal in these two kinds of magnets, and two microstructural parameters of ${\alpha}_k$ and $N_{eff}$ are obtained. The Kronm$\ddot{u}$ller-Plot gives evidence for an increase of the ${\alpha}_k$ responsible for an increase of the coercivity as the result of the increase of the magnetic field as the magnetic domain reversed.

• 대한의생명과학회지
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• 제25권1호
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• pp.66-74
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• 2019

Hyperlipidemia is defined as conditions of the accumulation of lipids such as free fatty acids (FFA), triglyceride (TG), cholesterol and/or phospholipid in the bloodstream. Hyperlipidemia can cause lipid accumulation in non-adipose tissue, which is lipid-cytotoxic effects in many tissues and mediates cell dysfunction, inflammation or programmed cell death (PCD). TG is considered to be a major cause of atherosclerosis through inflammatory necrosis of vascular endothelial cells. Recently, TG have also been shown to exhibit lipid-cytotoxicity and induce PCD. Therefore, we investigated the effect of TG on the cytotoxic effect of various cell types. When exposed to TG, the cell viability of U937 monocytes and Jurkat T lymphocytes, as well as the cell viability of MCF-7, a non-immune cell, decreased in time- and dose-dependent manner. In U937 cells and Jurkat cells, caspase-9, an intrinsic apoptotic caspase, and caspase-8, an extrinsic apoptotic caspase, were increased by exposure to TG. However, in TG-treated MCF-7 cells, caspase-8 activity increased only without caspase-9 activity. In addition, the reduction of cell viability by TG was recovered when all three cell lines were treated with pan-caspase inhibitor. These results suggest that activation of apoptotic caspases by TG causes lipotoxic effect and decreases cell viability.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제17권8호
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• pp.1996-2015
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• 2023

High-definition (HD) maps can provide precise road information that enables an autonomous driving system to effectively navigate a vehicle. Recent research has focused on leveraging semantic segmentation to achieve automatic annotation of HD maps. However, the existing methods suffer from low recognition accuracy in automatic driving scenarios, leading to inefficient annotation processes. In this paper, we propose a novel semantic segmentation method for automatic HD map annotation. Our approach introduces a new encoder, known as the convolutional transformer hybrid encoder, to enhance the model's feature extraction capabilities. Additionally, we propose a multi-level fusion module that enables the model to aggregate different levels of detail and semantic information. Furthermore, we present a novel decoupled boundary joint decoder to improve the model's ability to handle the boundary between categories. To evaluate our method, we conducted experiments using the Bird's Eye View point cloud images dataset and Cityscapes dataset. Comparative analysis against stateof-the-art methods demonstrates that our model achieves the highest performance. Specifically, our model achieves an mIoU of 56.26%, surpassing the results of SegFormer with an mIoU of 1.47%. This innovative promises to significantly enhance the efficiency of HD map automatic annotation.