• PNF and Movement
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• 제11권1호
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• pp.63-68
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• 2013

Purpose : The purpose of this study was to examine changes in spatiotemporal gait parameters(STGPs) in healthy adults before and after a immediate intervention of a Mulligan taping program(MTP). Methods : A total of 12 healthy adults(mean age, 20.82 years; age range, 19-24 years) participated in the study. performance was assessed by recording changes in the STGPs using GaitRite. comparisons of changes in the STGPs at pre-intervention and at dischange were analyzed using the Wilcox signed rank test and Mann-Whithney U test. Results : There was a significant improvement in the outcome measures of STGPs(stride length, velocity) after immediate of MTP(p<0.05). However, no significant different pre-test and post-test step width, toe angle(p>0.05). Conclusion : Participants in a MTP improves STGPs, thereby increasing the ability of healthy adults to maintain gait. MTP appears to be a safe and efficacious, noninvasive treatment modality for patients with knee joint disease.

• Molecules and Cells
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• 제45권7호
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• pp.479-494
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• 2022

Human mesenchymal stem cells (MSCs) are multipotent stem cells that have been intensively studied as therapeutic tools for a variety of disorders. To enhance the efficacy of MSCs, therapeutic genes are introduced using retroviral and lentiviral vectors. However, serious adverse events (SAEs) such as tumorigenesis can be induced by insertional mutagenesis. We generated lentiviral vectors encoding the wild-type herpes simplex virus thymidine kinase (HSV-TK) gene and a gene containing a point mutation that results in an alanine to histidine substitution at residue 168 (TK(A168H)) and transduced expression in MSCs (MSC-TK and MSC-TK(A168H)). Transduction of lentiviral vectors encoding the TK(A168H) mutant did not alter the proliferation capacity, mesodermal differentiation potential, or surface antigenicity of MSCs. The MSC-TK(A168H) cells were genetically stable, as shown by karyotyping. MSC-TK(A168H) responded to ganciclovir (GCV) with an half maximal inhibitory concentration (IC₅₀) value 10-fold less than that of MSC-TK. Because MSC-TK(A168H) cells were found to be non-tumorigenic, a U87-TK(A168H) subcutaneous tumor was used as a SAE-like condition and we evaluated the effect of valganciclovir (vGCV), an oral prodrug for GCV. U87-TK(A168H) tumors were more efficiently ablated by 200 mg/kg vGCV than U87-TK tumors. These results indicate that MSC-TK(A168H) cells appear to be pre-clinically safe for therapeutic use. We propose that genetic modification with HSV-TK(A168H) makes allogeneic MSC-based ex vivo therapy safer by eliminating transplanted cells during SAEs such as uncontrolled cell proliferation.

• 한국주거학회:학술대회논문집
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• 한국주거학회 2009년 춘계학술발표대회 논문집
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• pp.155-160
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• 2009

Safety of residents could be considered and then increased when we plan, design, and operate a city. In Korea, CPTED (Crime Prevention through Environmental Design) is currently being applied to new towns. However, it is not systemized and neither efficient, for there are no constraint provisions, and the foreign cases are not specifically customized to the current situation of the country. This means, the introduction of CPTED is an indispensable fact, but there are limits to the budget aids and actual application, for there is no legal base to support it. This study, therefore, aims to find the limits from analyzing related laws and regimes, administrative regulations, and applied cases, and to deduct improvement plans based on examined foreign cases. In this Study, the supporting system of foreign CPTED related laws and regulations was analyzed around the cases of England and U.S.A, and based on that information, the present condition and limits of CPTED related laws and regulations of Korea were deducted. As a result of this study, there were no constraint provisions to apply the design guidelines to actual planning, and there were limits on backup aid and actual application due to the lacking of analyzing the relevant area. Also, an acceptable framework must be arranged by the revision of laws and ordinances to compel the system, and link it with the CPTED certification system which will revitalize the whole system.

• 한국안전학회지
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• 제33권4호
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• pp.111-118
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• 2018

Korea is facing a surge in the aging population, showing that population aged 65 and above will be accounted for 42.5% of the total population in 2065 with the emphasis on the over-80 population consisting of 19.2%. In response to this abrupt change in population structure, the number of traffic fatality accident referring to older driver as aged 65+ years had been increasing from 605 fatalities in 2011 to 815 fatalities in 2015 resulting in increases in 34.7% in oppose to happening to decreases in 17.2% about non-older driver. With Logit analysis based on Newton-Raphson algorithm utilizing older driver's traffic fatality data for the 2011-2015 years, it was found that the likelihood of an accident resulting in a fatality for super older driver aged 80 years and above considerably increased compared to other older driver with aging classification: 2.24 times for violation of traffic lane, 2.04 times for violation of U-turn, 1.48 times for violation of safety distance, 1.35 times for violation of obstacle of passing; also average annual increase of traffic accident cost related to super older driver was fairly increased rather than other older driver groups. Hence, this study proposes that improving and amending transport safety system and Road Traffic Act for super older driver needs to be urgently in action about license management, safe driving education, etc. when considering the increase of over-80 population in the near future. Also, implementing a social agreement with all ages and social groups to apply with advanced driver assistance system for older driver groups will be able to become a critical factor to enhance safe driving over the face of the country.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2007년도 제38회 하계학술대회
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• pp.1185-1186
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• 2007

The UTM-01 developed in 1998 was the first maglev vehicle in Korea for the urban transit maglev (UTM) system. Through the improvement of UTM-01 and development of UTM02, the commercialization of the UTM system is being prepared now. In order to prepare for the commercialization of maglev, it is necessary that an optimal design of the levitation magnet should be provided for the safe operation of the vehicle. The levitation force is formed through the function of magnetic flux density on the top of magnet poles and gap between magnet pole and guide rail. To generate a magnetic field that is high enough to levitate the vehicle, ferromagnetic materials, such as pure iron for magnet pole and SS400 for guide rail, were used. The heat generated by $I^2R$ loss of magnet conductor makes the thermal convection on the surface of magnet including coil and poles. As these two characteristics are nonlinear phenomena, this paper deals with the nonlinear analysis on the magnetic and thermal properties of the U-type levitation magnet by using 3-D finite element method (FEM). Base on the analysis results, a small scale U-type magnet was designed, manufactured, and tested and it was verified that the magnet manufactured was satisfactory to all the design specifications.

• 한국식품저장유통학회지
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• 제22권2호
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• pp.251-255
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• 2015

산업적 유산균 배양의 가격대비 효율성을 높이기 위하여 질소원, 탄소원 및 무기염물을 기본량으로 기본배지를 제조하고, 효율적인 고농도 유산균체를 수득하기 위하여 pH 조절제로서 따로 첨가되어지는 합성 화학물질을 대신하여 미역을 실험에 사용하였다. 미역의 최적의 첨가 방법을 찾고자 추출, 착즙, 분말의 형태로 배지를 제조하여 유산균증식능 평가한 결과, 착즙의 형태에서 유산균 증식능이 가장 큰 것으로 확인되었다. 이러한 실험 결과를 통해, 폐기되어 환경오염의 원인이 되는 가식부 외 미역을 유산균 배양배지에 착즙형태로 첨가함으로서 종래 pH 조절을 위해 완충액으로 첨가되는 합성 화학물질을 대체하여 활용될 수 있음을 확인하였다. 또한 미역첨가 기본배지 선정에 따른 배지 단가를 절감하면서 높은 균체 수율을 얻는 등 충분한 경제적 장점을 기대할 수 있다. 이러한 연구결과는 미역을 이용함으로써 배양 시 해조류의 식이섬유 등이 정장작용에 유산균의 시너지 효과뿐만 아니라 폐기되는 천연 식물자원을 활용함으로써 새로운 부가가치 창출과 환경오염을 예방하는 효과를 기대할 수 있을 것이다.

• Archives of Plastic Surgery
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• 제32권1호
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• pp.24-28
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• 2005

Skull or facial bone defect causes cosmetic and functional problems. On going efforts were taken to reconstruct the craniofacial bone defect with autogenous bone or alloplastic materials. Between 2001 and 2003, we reconstructed 15 cases with small to large craniofacial bone defect using Hydroxyapatite paste($BoneSource^{(R)}$, Leibinger Corp., Dallas, TX, U.S.A) and calvarial bone graft. All patients were followed up by clinical examination and periodic radiographic studies for an average of 1.6 years (range, 6 months to 2 years and 6 months). One complication case was noted with $BoneSource^{(R)}$ exposure. Otherwise, there was no evidence of adverse healing, wound infection, foreign body reaction and seroma collection in other patients. Adequate 3-dimensional aesthetic restoration of calvarial contour was noted in each case. In conclusion, $Bonesource^{(R)}$ is relatively safe and rigid material for craniofacial bone defect and reasonable method for the reconstruction of craniofacial bone defects.

• Archives of Pharmacal Research
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• 제27권2호
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• pp.194-198
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• 2004

Reactive oxygen species (ROS) play an important role in the pathogenesis of many human degenerative diseases such as cancer, aging, arteriosclerosis, and rheumatism. Much attention has been focused on the development of safe and effective antioxidants. To discover sources of antioxidative activity in marine algae, extracts from 17 kinds of seaweed were screened for their inhibitory effect on total ROS generation in kidney homogenate using 2',7'-dichlorofluorescein diacetate (DCFH-DA). ROS inhibition was seen in three species: UIva pertusa, Symphyocladia latiuscula, and Ecklonia stolonifera. At a final concentration of 25 $\mu\textrm{g}$/mL, U. pertusa inhibited 85.65$\pm$20.28％ of total ROS generation, S. latiscula caused 50.63$\pm$0.09％ inhibitory, and the Ecklonia species was 44.30$\pm$7.33％ inhibition. E. stolonifera OKAMURA (Lam-inariaceae), which belongs to the brown algae, has been further investigated because it is commonly used as a foodstuff in Korea. Five compounds, phloroglucinol (1), eckstolonol (2), eckol (3), phlorofucofuroeckol A (4), and dieckol (5), isolated from the ethyl acetate soluble fraction of the methanolic extrclct of E. stolonifera inhibited total ROS generation.

• 한국실내디자인학회논문집
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• 제26권5호
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• pp.42-51
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• 2017

The purpose of this study was to analyze the information about the disaster temporary shelter space planning guidance described in the U.S. shelter guidelines in terms of the habitability for disaster victims and to address the implications and potential impacts of its findings for the improvement of the shelter design standards and guidelines in Korea. The researchers reviewed four federal and non-governmental organization shelter field and design guidelines and attributes regarding the shelter space planning were classified in accordance with four habitability categories: Safety, Health, Convenience, and Comfort. Three major findings emerged from this study: 1)A total of 72 items about the shelter space planning were extracted from guidelines, and the majority of items are concerned with dormitory areas and sanitary spaces. Other items were about accessibility, children respite care area, signage, health service areas, food preparation and serving areas, parking and drop-off areas, registration and waiting areas, shelter manager and staff areas, lounge and storage areas, and household pets area. 2)Most of these items are strongly related to the convenience category(66.7%), followed by comfort(40.3%), safety(30.6%), and health(25.0%). 3)The habitability of the disaster temporary shelter can be established with considerations on the needs of disaster victims and vulnerable people, minimum occupancy space per person, separate sanitary spaces for the privacy, safe and convenient access routes to the shelter, and the provision of children areas for safety and comfort. The study findings will contribute to the development of the disaster shelter guidelines in Korea by suggesting shelter space planning indicators related to the habitability for the governmental and non-governmental organizations' immediate and systematic responses to the disaster.

• 방사성폐기물학회지
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• 제11권3호
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• pp.213-227
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• 2013

원자로시설 해체계획서 작성은 원자로시설의 안전한 해체, 해체폐기물의 발생 최소화, 사람과 환경 보호 등을 위해 원자로시설 해체에 앞서 반드시 필요하다. 우리나라는 고리 1호기, 월성 1호기가 머지않은 시기에 해체를 맞이하게 되지만, 해체계획서를 작성하는데 필요한 관련 세부 지침이 미비한 상황이다. 이에 따라 본 논문에서는 IAEA의 원자력 국제 안전기준과 원자로시설 해체경험과 선진화된 규제체계를 보유하고 있는 미국, 영국, 프랑스의 해체계획서 작성 지침을 비교분석하고 국내 상황을 감안하여 원자로시설 해체계획서 세부 작성지침(안)을 개발하였다. 본 논문에서 개발한 작성지침(안)은 국내 원자로시설 해체 관련 법령을 정비하고 해체사업자가 원자로시설을 해체하고자 할 때 미리 준비사항을 알려주는 역할을 할 것으로 기대되고 있다.