• Asia pacific journal of information systems
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• v.33 no.4
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• pp.1043-1057
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• 2023

The objective of this study is to explore the perceptions of justice regarding the implementation of flexible work arrangements, as well as to analyze the effects of such arrangements on job satisfaction and organizational effectiveness. The present study posits three key aspects, namely distributive justice, procedural justice, and interactional justice, which are hypothesized to influence individuals' impression of justice in relation to flexible work systems. To investigate the influence of job types on an R&D organization, specifically comparing R&D employees and office management employees, a dataset of 190 R&D employees and 50 office management employees was collected. The findings of the investigation provide empirical evidence that distributive justice has a significant impact on the level of job satisfaction among employees in both research and development (R&D) and office administration roles. Moreover, the influence of work satisfaction on organizational performance is noteworthy, particularly with regard to factors such as job dedication, organizational citizenship behavior, and knowledge sharing. The aforementioned findings offer significant insights for research and development (R&D) firms that have incorporated flexible work arrangements. These insights underscore the significance of emphasizing specific justice perceptions in order to augment job satisfaction and overall performance within the organization.

• Animal cells and systems
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• v.6 no.1
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• pp.1-12
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• 2002

A role of Src family protein Tyrosine kinases (SFK) as mediators of receptor-ligand initiated responses is well established. Well documented, but less well understood is the role of SFK in cellular reaction to stresses. Evidence from the wide variety of experimental systems indicates that SFK mediate responses to all major classes of stress, including oxidation, DNA damage, mechanical impacts, and protein denaturing. SFK may be activated by stresses directly or via regulatory circuits whose identity is not yet fully understood. Depending on the cell type and the nature of activating stimulus, SFK may activate known downstream signaling cascades leading to cell survival, proliferation, cytoskeletal rearrangement, and apoptosis; the identity of these cascades is discussed. As in the case of receptor-initiated signaling, roles of individual SFK in various stress response may be redundant or non-redundant. Although signals generated by different stresses are generally transduced via distinct SFK pathways, these pathways may overlap or exhibit crosstalk. In some cell types stress-induced activation of SFK promotes survival and inhibits apoptosis, whereas the opposite may be true for other cell types. Stress responses constitute a new and rapidly developing area of SFK-mediated signaling.

• Toxicological Research
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• v.35 no.4
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• pp.331-341
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• 2019

Cancer is one of the common causes of death with a high degree of mortality, worldwide. In many types of cancers, if not all, sex-biased disparities have been observed. In these cancers, an individual's sex has been shown to be one of the crucial factors underlying the incidence and mortality of cancer. Accumulating evidence suggests that differentially expressed genes and proteins may contribute to sex-biased differences in male and female cancers. Therefore, identification of these molecular differences is important for early diagnosis of cancer, prediction of cancer prognosis, and determination of response to specific therapies. In the present review, we summarize the differentially expressed genes and proteins in several cancers including bladder, colorectal, liver, lung, and nonsmall cell lung cancers as well as renal clear cell carcinoma, and head and neck squamous cell carcinoma. The sex-biased molecular differences were identified via proteomics, genomics, and big data analysis. The identified molecules represent potential candidates as sex-specific cancer biomarkers. Our study provides molecular insights into the impact of sex on cancers, suggesting strategies for sex-biased therapy against certain types of cancers.

• Fashion & Textile Research Journal
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• v.21 no.2
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• pp.209-219
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• 2019

This study analyzed and compared wearer mobility for different types of clothing that also included the potential to develop firefighter station uniforms using range of motion (ROM) and electromyography (EMG). This study focused on a comparison of wearer mobility affected by different materials and shapes of the station uniforms worn under firefighter turnout gear. Japanese standard uniform (UNI), stretch-wear (ST), and compression-wear (CP) were used as station uniforms for the experiment. This study analyzed wearer movements and quantified ROM and EMG. In addition, the subjective evaluation of wearer mobility and comfort were assessed for comparisons. Nine healthy male students participated in the experiment. Wearer mobility was analyzed using ROM and EMG data obtained by measuring five motions; in addition, subjective evaluations were also obtained. As compared with the standard station uniform, ROM increased 6.8 % and 7.2 % due to stretch-wear and compression-wear. The benefits of wearing stretch material or compression material to improve muscle performance (such as reduced percent of maximum voluntary contraction) were not proven. Differences between materials and designs influenced subjective wearer comfort. In particular, the wearing of compression materials was shown best in terms of wearer comfort that may also allow greater wearer mobility.

• Journal of the Ergonomics Society of Korea
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• v.30 no.4
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• pp.473-480
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• 2011

Objective: This paper presents the results of a literature review undertaken to analyze the types and risk factors of unsafe posture in accordance with the crops and the working position and to introduce various ergonomic intervention approaches. Background: There is clear and consistent evidence that agricultural work has been rated as one of the dangerous occupations in the world. A considerable number of adverse health conditions, including musculoskeletal disorders(MSDs) are related to agricultural work. Method: An agricultural work requires squatting, kneeling, and bending(stooping) postures for significant periods of the work day which due to a wide variety of activities such as planting, cultivating and harvesting various agricultural products. Thus, each of these postures is analyzed in detail to recommend the improvement methods. Results: Various unsafe postures in agricultural works are revealed and analyzed. It is proven that ergonomics intervention has the potential benefits to reduce MSDs among agricultural workers. Two types of ergonomic intervention methods were discussed to improve unsafe working postures, engineering controls and administrative controls. Conclusion & Application: As a concluding remark, this article can be used as a reference manual for the agricultural workers and also used to raise the research community's awareness to the risk of unsafe working postures for workers in agriculture.

• Korean Institute of Interior Design Journal
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• v.18 no.5
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• pp.119-127
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• 2009

The main goal of this research was to understand housing environment as well as the living behaviors of Korean people who reside in foreign countries. This study includes examination of dwelling units, especially focusing on dwelling behaviors by space types, arrangement and use of the space, and the according residence patterns of the Koreans in the United States. Focus group interview method and survey method were conducted; photography were taken as a visual evidence; and results were analyzed by researchers. This study strongly indicates that most of Koreans try to keep their own way of living in foreign cultures and rather readjust the housing spaces and living patterns to their own culture. The results from this study have limitations in generalizing all Korean families living in foreign cultures, because a convenience sample was used. Although studies of Korean families in Columbia, MO may not provide information that can be generalized to the entire population of Koreans overseas, we expect that this study provides useful insight in understanding and estimating the future trends in residential planning for Koreans.

• The Journal of Asian Finance, Economics and Business
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• v.8 no.2
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• pp.387-399
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• 2021

This study mainly aims to examine the effect of intangible assets on the value relevance of the Gulf Cooperation Council (GCC)-listed non-financial firms. This study tested three types of models by using a large sample of non-financial firms listed in GCC countries as emerging markets from 2008 to 2016. The types of models are accounting information (earnings per share and book value of share) without intangible assets model, intangible assets model, and accounting information (earnings per share and book value of share) with intangible assets model. Ordinary least square (OLS) shows mixed results as intangible assets improve the value relevance of accounting information positively in UAE and negatively in Kuwait but not in other countries. The study documents a robust positive relationship between intangible assets and earnings quality in terms of value relevance in KSA and Qatar. The findings provide implications for policymakers, investors, and managers. The results suggest that intangible assets can improve the value relevance in emerging markets, such as GCC, as the need to organize the requirements of information disclosures on intangible assets and provide great transparency and additional disclosure of information about intangible assets and their components.

• Biomolecules & Therapeutics
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• v.31 no.5
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• pp.473-483
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• 2023

Many cancers arise from sites of chronic inflammation, which creates an inflammatory microenvironment surrounding the tumor. Inflammatory substances secreted by cells in the inflammatory environment can induce the proliferation and survival of cancer cells, thereby promoting cancer metastasis and angiogenesis. Therefore, it is important to identify the role of inflammatory factors in cancer progression. This review summarizes the signaling pathways and roles of C-reactive protein (CRP) in various cancer types, including breast, liver, renal, and pancreatic cancer, and the tumor microenvironment. Mounting evidence suggests the role of CRP in breast cancer, particularly in triple-negative breast cancer (TNBC), which is typically associated with a worse prognosis. Increased CRP in the inflammatory environment contributes to enhanced invasiveness and tumor formation in TNBC cells. CRP promotes endothelial cell formation and angiogenesis and contributes to the initiation and progression of atherosclerosis. In pancreatic and kidney cancers, CRP contributes to tumor progression. In liver cancer, CRP regulates inflammatory responses and lipid metabolism. CRP modulates the activity of various signaling molecules in macrophages and monocytes present in the tumor microenvironment, contributing to tumor development, the immune response, and inflammation. In the present review, we overviewed the role of CRP signaling pathways and the association between inflammation and cancer in various types of cancer. Identifying the interactions between CRP signaling pathways and other inflammatory mediators in cancer progression is crucial for understanding the complex relationship between inflammation and cancer.

• IMMUNE NETWORK
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• v.22 no.1
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• pp.5.1-5.22
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• 2022

The approval of immunotherapies such as checkpoint inhibitors (CPIs), adoptive cell therapies and cancer vaccines has revolutionized the way cancer treatment is approached. While immunotherapies have improved clinical outcome in a variety of tumor types, some cancers have proven harder to combat using single agents, underscoring the need for multi-targeted immunotherapy approaches. Efficacy of CPIs and cancer vaccines requires patients to have a competent immune system with adequate cell numbers while the efficacy of adoptive cellular therapy is limited by the expansion and persistence of cells after infusion. A promising strategy to overcome these challenges is combination treatment with common gamma-chain cytokines. Gamma-chain cytokines play a critical role in the survival, proliferation, differentiation and function of multiple immune cell types, including CD8 T-cells and NK cells, which are at the center of the anti-tumor response. While the short halflife of recombinant cytokines initially limited their application in the clinic, advancements in protein engineering have led to the development of several next-generation drug candidates with dramatically increased half-life and bioactivity. When combining these cytokines with other immunotherapies, strong evidence of synergy has been observed in preclinical and clinical cancer settings. This promising data has led to the initiation of 70 ongoing clinical trials including IL-2, IL-7, IL-15 and IL-21. This review summarizes the recent advancements of common gamma-chain cytokines and their potential as a cancer immunotherapy.

• Phonetics and Speech Sciences
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• v.4 no.2
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• pp.127-134
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• 2012

The purpose of this study is to present evidence for a particular processing approach based on the language-specific characteristics of Korean. To compare individuals' sentence-comprehension abilities, this study measured the accuracy and reaction times (RT) of 12 aphasic patients (AP) and 12 normal controls (NC) during a sentence-picture matching task. Four versions of a sentence were constructed with the two types of voice (active/passive) and two types of word order (agent-first/patient-first). To examine the effects of increased processing demand, picture stimuli were manipulated in such a way that they appeared immediately after the sentence was presented. As expected, the AP group showed higher error rates and longer RT for all conditions than the NC group. Furthermore, Korean speakers with aphasia performed above a chance level in sentence comprehension, even with passive sentences. Aphasics understood sentences more quickly and accurately when they were given in the active voice and with agent-first order. The patterns of the NC group were similar. These results confirm that Korean adults with aphasia do not completely lose their knowledge of sentence comprehension. When the processing demand was increased by delaying the picture stimulus onset, the effect of increased processing demands on RT was more pronounced in the AP than in the NC group. These findings fit well with the idea that the computational system for interpreting sentences is intact in aphasics, but its ability is compromised when processing demands increase.