• Title/Summary/Keyword: two-stage experimental design

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A STUDY ABOUT EARLY OSTEOCONDUCTIVITY OF POROUS ALLOPLASTIC CARBONAPATITE AND ANORGANIC BOVINE XENOGRAFT IN CANINE MAIXLLIARY AUGMENTATION MODEL (탄산아파타이트로 된 인공골과 소뼈에서 유래한 무기질 골의 초기 골전도에 대한 연구)

  • Kim, Do-Kyun;Cho, Tae-Hyung;Song, Yun-Mi;Pan, Hui;Lee, Su-Yeon;Jin, Im-Geon;Kim, In-Sook;Hong, Kug-Sun;Hwang, Soon-Jung
    • Maxillofacial Plastic and Reconstructive Surgery
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    • v.29 no.6
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    • pp.485-493
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    • 2007
  • Introduction: Although several types of calcium-phosphate coumpound have been frequently applied to osseous defects at maxillofacial area for many years, there is a controversy about its efficiency on bone conductivity comprared to xenograft bone substitute. Alloplastic carbonapatite has been introduced to improve disadvantages of hydroxyapatite and to mimic natural bone containing carbon elements. However, a preclinical study about its efficiency of osteoconductivity has not been reported. This study was performed to evaluate the early osteoconductive potential of synthetic carbonapatite with multiple pores relative to anorganic bovine xenograft. Materials and methods: Total 5 beagle dogs were used for maxillary augmentation model. The control (anorganic bovine xenograft) and experimental groups (synthetic carbonapatite) were randomly distributed in the mouth split design. After bone graft, all animals were sacrificed 4 weeks after surgery. Histological specimens with Masson Trichrome staining were made and histomorphometrically analysed with image analyser. The statistical analysis was performed using paired t-test. Results: In both groups, all animals had no complications. The experimental group showed relatively much new bone formation around and along the bone substitutes, whereas it was clearly reduced in the control group. The ratios of new bone area to total area, to material area and to the residual area excluding materials were higher in the experimental group ($0.13{\pm}0.03,\;0.40{\pm}0.13,\;0.20{\pm}0.06$ respectively) than in the control group ($0.01{\pm}0.01,\;0.03{\pm}0.02,\;0.03{\pm}0.03$, respectively). And the differences between both groups were statistically significant (p<0.001, <0.01, <0.01, respectively), while the ratio of material area to total area in two groups was not significant. Conclusion: Carbonapatite showed a high osteoconductivity in the early stage of bone healing compared to bovine derived anorganic bone substitute. This study suggests that this bone materials can be applied as a reliable bone substitute in the clinical treatment.

The influence of iatrogenic mobilization in the initial stage of implant installation on final osteointegration (임플란트 식립 초기 의원성 동요가 최종 골결합에 미치는 영향)

  • Kwak, Myeong-Bae;Cho, Jin-Hyun;Lee, Du-Heong;Lee, Cheong-Hee
    • The Journal of Korean Academy of Prosthodontics
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    • v.52 no.2
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    • pp.105-112
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    • 2014
  • Purpose: The aim of present investigation was to find out the influence of several times iatrogenic mobilization in the initial stage of implant installation on bone-implant osteointegration. Materials and methods: The experimental implants (3.75 mm in diameter, 8.0 mm in length) were made of commercially pure (Grade IV) titanium, and were treated with RBM ($MegaGen^{(R)}$: Ca-P) on lower 4.0 mm part. Only lower part of implant was inserted to bone and the implants were nonsubmerged. The 130 implants (two in each tibia) were inserted into the monocortical tibias of 33 rabbits which each weighed more than 3.5 kg (Female, New Zealand White). According to the removal torque interval, the groups were divided into 13 groups, group I (1 day), group II (1 day + 2 days), group III (1 day + 2 days + 3 days), group IV (1 day + 2 days + 3 days + 4 days), group V (2 days), group VI (2 days + 4 days), group VII (2 days + 4 days + 6 days), group VIII (2 days + 4 days + 6 days + 8 days), group IX (4 days), group X (4 days + 7 days), group XI (4 days + 7 days + 10 days), group XII (4 days + 7 days + 10 days + 14 days) and control group. In the control group, the removal torque was measured at 8 weeks with a digital torque gauge (Mark-10, USA). In the experimental groups, the removal torque was given once, twice, three times or four times by experiment design before the final removal torque and the value was measured each time. The implants were then screwed back to their original positions. All the experimental groups were given a final healing time of 8 weeks after placement, in which values were compared with the control groups and the 1st, 2nd, 3rd or 4th removal torque values in each experimental group. Results: In comparison of the final removal torque tests among experimental groups, the removal torque value of experimental groups except group XII were not statistically different that of control group. And the values of group I and II were significantly higher than the values of group VI, VIII, X, XI, and XII. In addition, the values of group III, IV, and V were significantly higher than group XI and XII. In comparison of the removal torque in the each experimental group, the final removal torque were significantly higher in all groups except group VIII, X, XI, and XII. Conclusion: If sufficient healing time was allowed, a few mobilization of fixture at the very early stage after the implant placement in the rabbits didn't interrupt the final bone to implant osseointegration.

The Effect of Crisis Intervention by the Visiting Nurse with Patients with Cancer (방문간호를 통한 암환자의 위기중재 효과에 관한 연구)

  • 김조자;유지수;박지원
    • Journal of Korean Academy of Nursing
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    • v.19 no.1
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    • pp.63-80
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    • 1989
  • This study was undertaken at Yonsei University Medical Center to identify the crisis responses and nursing problems of patients who had been diagnosed with cancer, and changing patterns of grieving over time periods, and to analyse the effectiveness of follow up care through home visiting nursing. This study was carried out in three stages. The 1st study data were collected from a total of 205 patients who had been diagnosed with cancer from Sept.1 to Dec. 31, 1987 using a cross-sectional method. The 2nd study data were collected three times from 30 patients with cancer at 4 weeks intervals from March 1 to June 31, 1988 using a longitudinal method. The 3rd study data were collected from two different groups from March 1 to June 31, 1988. One was an experimental group who was visited by nurses and the other one was a control group not visited by nurses. The subjects of the 3rd study consisted of 60 patients with cancer and a Quasi-experimental research design was used. The results were as follows ; 1. The patients did not experience one stage at a time among the five stages of grieing, denial anger, bargaining, depression and acceptance, as identified by Kubler Ross. They experienced a combination of stages, especially of the bargaining and the depression stages. This stages did not change with the passing of time. 2. The patients expressed more physical and socioecounomical problems than emotional problems. And they used more problem coping methods than emotional coping methods. 3. Follow up care through home visiting nursing positively influenced the patient's quality of life, especially their physical well-being and symptom control The patients responded positively to the home visiting nursing, stating that it was helpful In them. It was concluded that the development of a home visiting nursing program is needed for the effective home care of patients with cancer.

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Effects of a Tilting Training Program on Lower Extremities Function, Depression, and Self-efficacy among Stroke Inpatients (기대기 훈련프로그램이 뇌졸중 입원환자의 하지 기능, 우울 및 자기효능감에 미치는 효과)

  • Seo Nam-Sook;Han Mi-Sook;Lee Jeong-Soon
    • Journal of Korean Academy of Nursing
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    • v.36 no.3
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    • pp.514-522
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    • 2006
  • Purpose: The purpose of this study was to identify effects of a tilting training program on lower extremities function, depression, and self-efficacy among stroke inpatients. Method: The subjects were 60'stroke patients hospitalized in an oriental medical hospital; 31 in the experimental group and 29 in the control group. A nonequivalent control group pretest-posttest design was used. The tilting training program consisted of 3 sessions and was implemented for 30 minutes daily during 3 weeks. Data was collected from Feb to July 2003, and analyzed by percentage, Fisher's exact probability, $\chi^2-test$, and t-test using the SPSS/Win 10.0 computerized program. Result: After treatment with the tilting training program, the experimental group was significantly increased in the mean score for function of lower extremities (t=2.72, p=.009) compared to the control group, especially for keeping standing balance (t=2.78, p=.007) and standing by oneself (t=3.32, p=.002). However, in the mean scores of depression and self-efficacy, there were no significant differences between the two groups. Conclusion: The tilting training program was effective for increasing the function of lower extremities and to improve walking ability earlier among stroke inpatients. Therefore, the tilting training program is applicable to increase the balance level in standing and walking ability at the early rehabilitation stage for stroke patients.

An integrated development methodology of low noise accessory drive system in internal combustion engines (내연기관의 저소음 보기류구동 시스템을 위한 통합 개발 방법론)

  • Park, Keychun;Kong, Jinhyung;Lee, Byunghyun
    • The Journal of the Acoustical Society of Korea
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    • v.35 no.3
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    • pp.183-191
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    • 2016
  • A systematic development process for the low noise FEAD (Front End Accessory Drive) system is presented by combining CAE (Computer Aided Engineering) and the experimental rig test. In the estimation of the belt drive noise, two main difficulties arise from the high non-linearity due to the stick-slip contacts on the interfaces of the belt and pulleys, and the interaction of the belt drive system with the powertrain rotational parts. In this work, a recently developed analysis method of the belt drive has been employed considering powertrain rotational dynamics. As results, it shows good correlation with the vehicle tests in various operational modes. The established model has been employed to validate the new design improving the stick-slip noise of the problematic FEAD system. Furthermore, the best proposal of FEAD system in terms of functionality [NVH (Noise, Vibration and Harshness), fuel economy, cost. etc.] has been suggested in the concept design stage of new engine through this presented methodology.

Prediction of load transfer depth for cost-effective design of ground anchors using FBG sensors embedded tendon and numerical analysis

  • Do, Tan Manh;Kim, Young-Sang
    • Geomechanics and Engineering
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    • v.10 no.6
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    • pp.737-755
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    • 2016
  • The load transfer depth of a ground anchor is the minimum length required to transfer the initial prestressing to the grout column through the bonded part. A thorough understanding of the mechanism of load transfer as well as accurate prediction of the load transfer depth are essential for designing an anchorage that has an adequate factor of safety and satisfies implicit economic criteria. In the current research, experimental and numerical studies were conducted to investigate the load transfer mechanism of ground anchors based on a series of laboratory and field load tests. Optical FBG sensors embedded in the central king cable of a seven-wire strand were successfully employed to monitor the changes in tensile force and its distribution along the tendons. Moreover, results from laboratory and in-situ pullout tests were compared with those from equivalent case studies simulated using the finite difference method in the FLAC 3D program. All the results obtained from the two proposed methods were remarkably consistent with respect to the load increments. They were similar not only in trend but also in magnitude and showed more consistency at higher pullout loading stages, especially the final loading stage. Furthermore, the estimated load transfer depth demonstrated a pronounced dependency on the surrounding ground condition, being shorter in hard ground conditions and longer in weaker ones. Finally, considering the safety factor and cost-effective design, the required bonded length of a ground anchor was formulated in terms of the load transfer depth.

ZVS Phase Shift Full Bridge Converter Design with 2kW Output (2 kW 출력을 갖는 영전압 스위칭 위상 천이 풀 브리지 컨버터 설계)

  • Hwang, Kyu-Il;Kim, Il-Song
    • Asia-pacific Journal of Multimedia Services Convergent with Art, Humanities, and Sociology
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    • v.8 no.11
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    • pp.523-530
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    • 2018
  • It has been studied over the long time for the high efficiency and high power density of the power converter. It is possible to obtain higher power conversion efficiency and small volume by increasing switching frequency, however, the switching loss is also increased. The soft switching technique can overcome of the above deficiency. The design and analysis method for ZVS(Zero Voltage Switching) Phase Shifte Full bridge converter is presented in this paper. The power transfer depends on the phase difference between two legs of the power stage and the maximum power conversion efficiency is achieved by the optimum leakage inductance value. The waveform of the current and voltage of the operational mode is analysed and the corresponding switch status is plotted as on/off status. A ZVS full bridge converter for a communication rectifier with 2kW output power is implemented and its performance are verified through PSIM software simulation and experimental results.

Actual Condition and Characteristics of Residents' Participation of Intentional Communities in Korea (국내 계획공동체 마을의 주민참여의 실태 및 특성)

  • Choi, Jung-Shin
    • Journal of the Korean housing association
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    • v.19 no.5
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    • pp.93-102
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    • 2008
  • In Korea, a movement for forming intentional communities is gathering people's interests to improve individualistic living environment, and to create a humanistic lifestyle. However, it is difficult to say if its management is successful or not, because intentional community is just in the experimental stage in Korea. The purpose of this study is to identify actual condition of residents' participation in forming process, shared activities in their daily lives, residents' regulation, common facilities and its management in order to offer basic information for revitalization of intentional communities in Korea. 7 intentional communities including eco-friendly villages, religious communities and a cooperative housing community were collected as the study objects. Upon analysis, those communities were divided into two groups according to their purpose of establishment; "HC (Housing-life focused Community includes cooperative housing community and eco-friendly community)" and "IC (Ideology focused Community includes ideology community and religious community)" in order to identify difference in residents' participation between the two groups. In-dept interviews with representatives of 7 intentional communities by a structured questionnaire were used as study method. The findings of this study are as follows; In general, more active residents' participation is identified in ICs than in HCs. There is no common house, which is considered as essential in intentional community, in HCs, while it was facilitated in all ICs. Role of leader seems more important in ICs than in HCs. About the ownership of housing and land, private owned is common in HCs, while community owned is common in ICs. Shared activities and residents' regulations are evidently less in most HCs than in ICs. Furthermore, in order to run a community sustainable, it is crucial to encourage sense of community among residents, and developing common house and activity programs. Common house design, which can promote proactive residents' participation in shared activity should be studied fitted to Korean circumstances. Above all, proactive participation in the shared activities is one of the most important factors in intentional community.

Statistical analysis of NTNU test results to predict rock TBM performance (TBM 굴진성능 예측을 위한 NTNU 시험결과의 분석)

  • Choi, Soon-Wook;Chang, Soo-Ho;Lee, Gyu-Phil;Bae, Gyu-Jin
    • Journal of Korean Tunnelling and Underground Space Association
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    • v.13 no.3
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    • pp.243-260
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    • 2011
  • To predict TBM performance in design stage is indispensable for its successful application. The NTNU model, one of the representative TBM performance prediction models uses two distinct parameters such as DRI and CLI obtained from three different tests on bored rock cores. Based on DRI and CLI, it is possible to predict TBM advance rate and cutter life in the NTNU model. In this study, NTNU testing methods and their related testing equipments were introduced to measure DRl and CLI for the NTNU model. Then, in order to derive their relationships, the two key parameters measured for 39 domestic rocks were compared with physico-mechanical properties of rock such as uniaxial compressive strength and quartz content. Lastly, the experimental results were also compared with NTNU database to verify their reliability.

Studies on the Seed Production of Festuca arundinacea Schreb I. Effect of nitrogen Fertilization level and method of its application on the seed production of level and method of its application on the seed production of Festuca arundinacea (톨 페스큐의 종자생산에 관한 연구. I. 질소비료의 시비수준 및 분시방법이 톨 페스큐 ( Festuca arundinacea S. ) 의 종자생산에 미치는 영향)

  • 박근제;권두종;이종열;양종성
    • Journal of The Korean Society of Grassland and Forage Science
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    • v.5 no.2
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    • pp.100-105
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    • 1985
  • To find out the optimum level of nitrogen fertilization and better distribution of application time for seed production of Festuca arundianacea S. (var. Alta), this filed experiment was performed at Livestock Experiment Station in Suweon, during 1979 to 1981. The treatments used in this study were three nitrogen fertilizing levels (120, 180 and 240kg/ha) and four different methods of nitrogen distribution (i. single application of whole amount in early Spring, ii. 50 percent each in Autumn and early Spring, iii. 50 percent each in early Spring and at begin of heading stage and iv. 50 percent in Autumn and 25 percent in early Spring and at begin of heading stage respectively). The experiment was arranged as a split-plot design with 4 replications and performed at the experimental field of the Livestock Experiment Station in Suweon, during 1979 to 1981. The results obtained are summarized as follows: 1. Date of heading stage of Festuca arundinacea was about May 21 and that of flowering stage was June 1 to 3. The optimum stage for the seed harvesting of Festuca arundinacea (var. Alta) was June 25 about 22 to 23 days after full flowering stage. Average plant height was about 127cm and the panicle length, 24cm. 2. 1000 grain weight was 2.72g and the number of panicles were 85 to 107 per square meter. 3. The mean seed wield for two years was 678.8kg/ha with the average of whole treatments and 781.9kg/ha with the best treatment (50 percent in Autumn and 25 percent in early Spring and at begin of heading stage with 240kg/ha respectively). 4. The average germination rate of harvesting seeds was 87.0 percent and it was increasing trend according to frequent application of fertilizer. 5. The average DM yield of aftermath seed harvesting was 6155kg/ha with two cut, and it was the largest DM yield from the higher nitrogen level and also from the single application in early Spring.

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