Maxillofacial Plastic and Reconstructive Surgery

Korean Association of Maxillofacial Plastic and Reconstructive Surgeons (대한악안면성형재건외과학회)
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A STUDY ABOUT EARLY OSTEOCONDUCTIVITY OF POROUS ALLOPLASTIC CARBONAPATITE AND ANORGANIC BOVINE XENOGRAFT IN CANINE MAIXLLIARY AUGMENTATION MODEL

탄산아파타이트로 된 인공골과 소뼈에서 유래한 무기질 골의 초기 골전도에 대한 연구

  • Kim, Do-Kyun (Dept. of Oral & Maxillofacial Surgery, School of Dentistry, Seoul National University) ;
  • Cho, Tae-Hyung (Dental Research Institute, Brain Korea 21 for Dental Life Science, Seoul National University) ;
  • Song, Yun-Mi (Dental Research Institute, Brain Korea 21 for Dental Life Science, Seoul National University) ;
  • Pan, Hui (Dept. of Oral & Maxillofacial Surgery, School of Dentistry, Seoul National University) ;
  • Lee, Su-Yeon (Dept. of Oral & Maxillofacial Surgery, School of Dentistry, Seoul National University) ;
  • Jin, Im-Geon (Dept. of Oral & Maxillofacial Surgery, School of Dentistry, Seoul National University) ;
  • Kim, In-Sook (Dental Research Institute, Brain Korea 21 for Dental Life Science, Seoul National University) ;
  • Hong, Kug-Sun (School of Materials Science & Engineering, Seoul National University) ;
  • Hwang, Soon-Jung (Dept. of Oral & Maxillofacial Surgery, School of Dentistry, Seoul National University)
  • 김도균 (서울대학교 치과대학 구강악안면외과학교실) ;
  • 조태형 (서울대학교 치학연구소, BK21 치의학생명과학사업단) ;
  • 송윤미 (서울대학교 치학연구소, BK21 치의학생명과학사업단) ;
  • 판휘 (서울대학교 치과대학 구강악안면외과학교실) ;
  • 이수연 (서울대학교 치과대학 구강악안면외과학교실) ;
  • 진임건 (서울대학교 치과대학 구강악안면외과학교실) ;
  • 김인숙 (서울대학교 치학연구소, BK21 치의학생명과학사업단) ;
  • 홍국선 (서울대학교 공과대학 재료공학부) ;
  • 황순정 (서울대학교 치과대학 구강악안면외과학교실)
  • Published : 2007.11.30
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Abstract

Introduction: Although several types of calcium-phosphate coumpound have been frequently applied to osseous defects at maxillofacial area for many years, there is a controversy about its efficiency on bone conductivity comprared to xenograft bone substitute. Alloplastic carbonapatite has been introduced to improve disadvantages of hydroxyapatite and to mimic natural bone containing carbon elements. However, a preclinical study about its efficiency of osteoconductivity has not been reported. This study was performed to evaluate the early osteoconductive potential of synthetic carbonapatite with multiple pores relative to anorganic bovine xenograft. Materials and methods: Total 5 beagle dogs were used for maxillary augmentation model. The control (anorganic bovine xenograft) and experimental groups (synthetic carbonapatite) were randomly distributed in the mouth split design. After bone graft, all animals were sacrificed 4 weeks after surgery. Histological specimens with Masson Trichrome staining were made and histomorphometrically analysed with image analyser. The statistical analysis was performed using paired t-test. Results: In both groups, all animals had no complications. The experimental group showed relatively much new bone formation around and along the bone substitutes, whereas it was clearly reduced in the control group. The ratios of new bone area to total area, to material area and to the residual area excluding materials were higher in the experimental group ($0.13{\pm}0.03,\;0.40{\pm}0.13,\;0.20{\pm}0.06$ respectively) than in the control group ($0.01{\pm}0.01,\;0.03{\pm}0.02,\;0.03{\pm}0.03$, respectively). And the differences between both groups were statistically significant (p<0.001, <0.01, <0.01, respectively), while the ratio of material area to total area in two groups was not significant. Conclusion: Carbonapatite showed a high osteoconductivity in the early stage of bone healing compared to bovine derived anorganic bone substitute. This study suggests that this bone materials can be applied as a reliable bone substitute in the clinical treatment.

Keywords

References

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