• Journal of Theoretical and Applied Mechanics
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• 제2권1호
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• pp.31-50
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• 1996

In this paper, a finite element analysis based on the local approach concept to fracture in the continuum damage mechanics is performed to analyze ductile fracture in two dimensional quasi-static state. First an isotropic damage model based on the generalized concept of effective stress is proposed for structural materials in the context of large deformation. In this model, the stiffness degradation is taken as a measure of damage and so, the fracture phenomenon can be explained as the critical deterioration of stiffness at a material point. The modified Riks' continuation technique is used to solve incremental iterative equations. Crack propagation is achieved by removing critically damaged elements. The mesh size sensitivity analysis and the simulation of the well known shearing mode failure in plane strain state are carried out to verify the present formulation. As numerical examples, an edge cracked plate and the specimen with a circular hole under plane stress are taken. Load-displacement curves and successively fractured shapes are shown. From the results, it can be concluded that the proposed model based on the local approach concept in the continuum damage mechanics may be stated as a reasonable tool to explain ductile fracture initiation and crack propagation.

• Imaging Science in Dentistry
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• 제41권4호
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• pp.183-187
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• 2011

Progressive hemifacial atrophy, also known as Parry-Romberg syndrome, is an uncommon degenerative condition which is poorly defined. It is characterized by a slow and progressive atrophy affecting one side of the face. The onset usually occurs during the first two decades of life. Characteristically, the atrophy progresses slowly for several years, and then it becomes stable. Ophthalmic involvement is common, with progressive enophthalmos which is a frequent finding. Cutaneous pigmentation is common in such conditions, however its extension to the conjunctiva is rarely reported. We report a case of Parry Romberg syndrome with characteristic clinical and radiographic presentation accompanied with rare ocular findings. The clinical features, radiological findings, and differential diagnoses to be considered, and the available treatment options are discussed in this report.

• 한국임상수의학회지
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• 제20권3호
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• pp.399-402
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• 2003

A female unknown aged Yorkshire terrier, weighing 3.5 kg with nasal discharge, left facial swelling and severe inflammation was referred to Veterinary Medical Teaching Hospital, Seoul National University. Radiographic findings were lytic change and soft tissue swelling of left zygomatic process and increased radiopacity of nasal cavity. In computed tomography, turbinate bone destruction was observed as well as lytic change of left zygomatic process and left maxilla indicating aggressive lesion. Then 3-dimensional reconstruction was also performed. Biopsy of tissue mass revealed it as squamous cell carcinoma. For this patient, euthanasia was performed guarded prognosis. Generally, tumors of the nasal cavity in dogs account for approximately 1 % to 2% of all neoplasms. The prevalence of these tumors increased with age and exposure to the ultraviolet. About two thirds of all nasal tumors are malignant tumors such as squamous cell carcinoma and adenocarcinoma. As these tumors of nasal cavity are locally invasive, and external beam radiotherapy is the current treatment of choice. Unfortunately, diagnosis of these tumors often occurs late in the course of disease, resulting in a poor prognosis for outcome in many patients. It is considered that computed tomography could be used as an aid modality for the exact evaluation of extend and degree of bone lysis of nasal cavity and metastasis.

• 약학회지
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• 제53권3호
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• pp.145-150
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• 2009

We evaluated cytotoxic effect based on the MTT assay and identified altered proteins in 5-FU(fluorouracil) treated HT29 cells using two-dimensional gel electrophoresis and MALDI-TOF/TOF-MS. As proteins inducing apoptosis, siah binding protein 1 and p47 protein isoform a were up-regulated and tumor protein translationally-controlled 1 was down-regulated by 5-FU treatment. And mannose 6 phosphate receptor binding protein 1 controls DNA mismatch repair system was increased. We suggest 5-FU promotes a cytotoxicity under the action of these proteins in colon cancer cells.

• Membrane and Water Treatment
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• 제2권2호
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• pp.105-119
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• 2011

This study presents the tests of an Immersed Membrane BioReactor (IMBR) equipped with a draft tube and focuses on the influence of hydrodynamic conditions on membrane fouling in a pilot-scale using a hollow fiber membrane module of ZW-10 under ambient conditions. In this system, the cross-flow velocities across the membrane surface were induced by a cylindrical draft-tube. The relationship between cross-flow velocity and aeration strength and the influence of the cross-flow on fouling rate (under various hydrodynamic conditions) were investigated using Multi-Dimension Scaling (MDS) analysis. MDS technique is especially suitable for samples with many variables and has relatively few observations, as the data about Membrane Bio-Reactor (MBR) often is. Observations and variables are analyzed simultaneously. According to the results, a specialized form of MDS, CoPlot enables presentation of the results in a two dimensional space and when plotting variables ratio (output/input) rather than original data the efficient units can be visualized clearly. The results indicate that: (i) aeration plays an important role in IMBR performance; (ii) implementing the MDS approach with reference to the variables ratio is consequently useful to characterize performance changes for data classification.

• Membrane and Water Treatment
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• 제6권6호
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• pp.513-524
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• 2015

In this study, the effects of the angles of spacer filaments and the different feed Reynolds number on the fluid flow behavior have been investigated. Three-dimensional computational fluid dynamics (CFD) study is carried out for fluid flow through rectangular channels within different angles ($30^{\circ}$, $40^{\circ}$, $50^{\circ}$, $60^{\circ}$, $70^{\circ}$, $80^{\circ}$, $90^{\circ}$, $100^{\circ}$, $110^{\circ}$, $120^{\circ}$, respectively) between two filaments of spacer for membrane modules. The results show that the feed Reynolds number and the angles of spacer filaments have an important influence on pressure drop. While the feed Reynolds number is fixed, the optimal angle of spacer should be between $80^{\circ}$ to $90^{\circ}$, because the pressure drop is not only relatively small, but also high flow rate region expanded significantly with the increase of the angles between $80^{\circ}$ to $90^{\circ}$.The Contours of velocities and change of the average shear stress with the different angle of spacer filaments confirm the conclusion.

• 한국재료학회지
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• 제30권11호
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• pp.636-640
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• 2020

Due to the serious air pollution problem, interest in eco-friendly vehicles is increasing. Solving the problem of pollution will necessitate the securing of high energy storage technology for batteries, the driving force of eco-friendly vehicles. The reason for the continuing interest in the transition metal oxide LiMO₂ as a cathode material with a layered structure is that lithium ions reveal high mobility in two-dimensional space. Therefore, it is important to investigate the effective intercalation and deintercalation pathways of Li⁺, which affect battery capacity, to understand the internal structure of the cathode particle and its effect on the electrochemical performance. In this study, for the cathode material, high nickel Ni_0.8Co_0.1Mn_0.1(OH)₂ precursor is synthesized by controlling the ammonia concentration. Thereafter, the shape of the primary particles of the precursor is investigated through SEM analysis; X-ray diffraction analysis is also performed. The electrochemical properties of LiNi_0.8Co_0.1Mn_0.1O₂ are evaluated after heat treatment.

• Reproductive and Developmental Biology
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• 제37권4호
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• pp.255-261
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• 2013

To profile the proteome in porcine plasma, blood samples were collected from adult male barrows and those plasma were retrieved. For the depletion or pre-fractionation of high-abundance proteins, plasma samples were treated with commercial kits. Then, protein profiling was initiated using one and two-dimensional electrophoresis. Proteins were spotted and then identified by MALDI-TOF-TOF and LC-MS-MS. In the results, more than forty six proteins were identified and the reference map was constructed. The pre-treatment for the removal of high-abundance proteins caused the changes in 2-DE images and some of the proteins were newly uncovered after the most of high abundant proteins were removed. However, it is expected for further steps necessary to identify more low-abundance proteins that may contain potential bio-markers.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2005년도 추계학술대회 논문집
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• pp.244-247
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• 2005

Although several artificial disc designs have been developed for the treatment of discogenic low back pain and used clinically, biomechanical change with its implantation seldom studied. To evaluate the effect of artificial disc implantation on the biomechanics of lumbar spinal unit, nonlinear three-dimensional finite element model of L1-L5, S1 was developed and strain and stress of vertebral body and surrounding spinal ligaments were predicted. Intact osteoligamentous L1-L5, S1 model was created with 1-mm CT scan of a volunteer and known material property of each element were applied. This model also includes the effect of local muscles which was modeled with pre-strained spring elements. The intact model was validated with reported biomechanical data. Two models implanted with artificial discs, SB Charite or Prodisc, at L4/5 via anterior approach were also developed. The implanted model predictions were compared with that of intact model. Angular motion of vertebral body, force on spinal ligaments, facet joint contact force with $2\sim12$ Nm flexion-extension moment.

• 한국표면공학회:학술대회논문집
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• 한국표면공학회 2007년도 춘계학술발표회 초록집
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• pp.147-148
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• 2007

In this study, the technology to grow oriented nanotube thin film from dip-coated $TiO_2$ using hydrothermal method has been successfully developed. The effects of preparation parameters, such as reaction temperature, duration and post treatment conditions on the film morphologies and the adherence to the substrate, have been examined. A general formation mechanism of oriented titanate nanotube thin film is proposed in terms of the detailed observation of the products via two dimensional surface FESEM studies and HRTEM images. The overall formation of $TiO_2-based$ nanotube thin film can be summarized with three successive steps: (1) $TiO_2$ dissolving and amorphous $Na_2TiO_3$ deposition process; (2) layered $Na_2Ti_3O_7$ formation via spontaneous crystallization and rapid growth process; (3) formation of nanotube thin film via $Na_2Ti_3O_7$ splitting and multilayer scrolling process of (100) planes around the c axis of $Na_2Ti_3O_7$.