• 약학회지
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• 제43권5호
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• pp.584-590
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• 1999

Bioactivity-directed fractionation from the seeds of Annona cherimolia resulted in the isolation of two known cytotoxic compounds : corrosolin (1) and compound-2 (2). The structures of these compounds were characterized on the basis of chemical and spectral data. Corrosolin has a relative stereochemical relationship of threo/trans/threo for the mono-tetrahydrofuran (THF) ring with two flanking hydroxyls, from C-15 to C-20, which is the annonacin type. Compound-2 has a relative stereochemical relationship of threo/trans/threo/trans/threo for the adjacent bis-THF ring with two flanking hydroxyls, such as in the asimicin type. The absolute configurations of carbinol carbons in corrosolin in corrosolin were determined as 10R, 15R, and 20R by analysis of its Mosher ester derivatives. Corrosolin and compound-2 are known, but are first isolated in this plant.

• Steel and Composite Structures
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• 제33권2호
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• pp.245-259
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• 2019

The present study aims to investigate the ultimate strength and geometric nonlinear behavior of composite plates containing initial imperfection subjected to combined end-shortening strain and lateral pressure loading by using a semi-analytical method. In this study, the first order shear deformation plate theory is considered with the assumption of large deflections. Regarding in-plane boundary conditions, two adjacent edges of the laminates are completely held while the two others can move straightly. The formulations are based on the concept of the principle of minimum potential energy and Newton-Raphson technique is employed to solve the nonlinear set of algebraic equations. In addition, Hashin failure criteria are selected to predict the failures. Further, two distinct models are assumed to reduce the mechanical properties of the failure location, complete ply degradation model, and ply region degradation model. Degrading the material properties is assumed to be instantaneous. Finally, laminates having a wide range of thicknesses and initial geometric imperfections with different intensities of pressure load are analyzed and discuss how the ultimate strength of the plates changes.

• 한국지진공학회논문집
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• 제1권1호
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• pp.79-88
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• 1997

주상복합건물의 강체거동을 보이는 연결층은 인접한 층에 비해 큰 질량과 강성차에 의해서 수치해석상의 문제점을 일으킨다. 강체거동을 보이는 구조물의 정적해석은 상부와 하부구조물을 별개의 구조물로 보고 2단계에 걸쳐서 근사적으로 수행될수 있지만, 동적해석은 구조물을 분리해서 행해질 수 없다. 이러한 주상복합건물의 동적해석을 위한 효율적인 모형화기법이 본 연구에서 제시된다. 자유도수를 줄여서 컴퓨터해석시간을 대폭 감소시키는 행렬의 응축기법과 연결층을 모형화하기 위해서 일반적인 보요소에 강체가 연결된 요소를 도입한다. 제안된 모형화기법의 효율성과 정확성을 입증하기 위해서 몇가지 구조해석을 한다.

• Bulletin of the Korean Chemical Society
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• 제22권9호
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• pp.984-988
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• 2001

Since anti-angiogenesis could lead to the suppression of tumor growth, angiogenesis inhibitors have received particular attention for their therapeutic potential. In this study, two angiogenic inhibitors using the bioactive sequence from the kring le 5, AK1(KLYDY), AK2(KLWDF) were designed and synthesized. We have investigated their solution structures using NMR spectroscopy and their activities as angiogenesis inhibitors. AK2 has an intramolecular hydrogen bon d between the side chain amino proton of Lys1 and the carboxyl oxygen of Asp4 with a N ${\cdot}{\cdot}{\cdot}$O distance of $3.27\AA$, while AK1 shows more flexible structures than AK2. Indole ring in Trp is much bigger than the phenyl ring in Tyr and may have good face-to-edge interaction enforcing more rigid and constrained conformational features of AK2. Because of this relatively stable structure, Trp3 in AK2 may have better hydrophobic interaction with Phe5 than Tyr3 in AK1 if two adjacent aromatic groups are located in hydrophobic pocket of receptor. Since AK2 shows the similar anti-angiogenic activities to AK1, we are also able to confirm that the activity of AK1 is irrelevant to the Tyr phosphorylation. More rigid drug with higher activities can be provided by the mimetic approaches. For the further development of the angiogenesis inhibitors, these conformational studies on our lead peptides will be helpful in design of peptidomimetics.

• Geomechanics and Engineering
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• 제31권6호
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• pp.599-614
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• 2022

One of the methods of stabilizing retaining walls, embankments, and deep excavations is the implementation of plate anchors (like the Geolock wall anchor systems). Back-to-back Mechanically Stabilized Earth (BBMSE) walls are common stabilized earth structures that can be used for bridge ramps. But so far, the analysis of the interactive behavior of two back-to-back anchored walls (BBAW) by double-plates anchors (constructed closely from each other and subjected to the limited-breadth vertical loading) including interference of their failure and sliding surfaces has not been the subject of comprehensive studies. Indeed, in this compound system, the interaction of sliding wedges of these two back-to-back walls considering the shear failure wedge of the foundation, significantly impresses on the foundation bearing capacity, adjacent walls displacements and deformations, and their stability. In this study, the effect of horizontal distance between two walls (W), breadth of loading plate (B), and position of vertical loading was investigated experimentally. In addition, the comparison of using single and equivalent double-plate anchors was evaluated. The loading plate bearing capacity and displacements, and deformations of BBAW were measured and the results are presented. To evaluate the shape, form, and how the critical failure surfaces of the soil behind the walls and beneath the foundation intersect with one another, the Particle Image Velocimetry (PIV) technique was applied. The experimental tests results showed that in this composite system (two adjacent-loaded BBAW) the effective distance of walls is about W = 2.5*H (H: height of walls) and the foundation effective breadth is about B = H, concerning foundation bearing capacity, walls horizontal displacements and their deformations. For more amounts of W and B, the foundation and walls can be designed and analyzed individually. Besides, in this compound system, the foundation bearing capacity is an exponential function of the System Geometry Variable (SGV) whereas walls displacements are a quadratic function of it. Finally, as an important achievement, doubling the plates of anchors can facilitate using concrete walls, which have limitations in tolerating curvature.

• Computers and Concrete
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• 제21권2호
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• pp.219-229
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• 2018

In this paper, a modified rigid body spring model (RBSM) is proposed and used to analyze the damage and failure process of reinforced concrete (RC) structures. In the proposed model, the concrete is represented by an assembly of rigid blocks connected with a uniform distribution of normal and tangential springs to simulate the macroscopic mechanical behavior of concrete. Steel bars are evenly dispersed into rigid blocks as a kind of homogeneous axial material, and an additional uniform distribution of axial and dowel springs is defined to consider the axial stiffness and dowel action of steel bars. Perfect bond between the concrete and steel bars is assumed, and tension stiffening effect of steel bars is modeled by adjusting the constitutive relationship for the tensile reinforcement. Adjacent blocks are allowed to separate at the contact interface, which makes it convenient and easy to simulate the cracking process of concrete. The failure of the springs is determined by the Mohr-Coulomb type criterion with the tension and compression caps. The effectiveness of the proposed method is confirmed by elastic analyses of a cantilever beam under different loading conditions and failure analyses of a RC beam under two-point loading.

• Smart Structures and Systems
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• 제12권5호
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• pp.483-499
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• 2013

A new piezoceramic $d_{15}$ shear-induced torsion actuation mechanism representative benchmark is proposed and its experimentations and corresponding 3D finite element (FE) simulations are conducted. For this purpose, a long and thin smart sandwich cantilever beam is dimensioned and built so that it can be used later for either validating analytical Saint Venant-type solutions or for analyzing arm or blade-based smart structures and systems applications. The sandwich beam core is formed by two adjacent rows of 8 oppositely axially polarized d15 shear piezoceramic patches, and its faces are dimensionally identical and made of the same glass fiber reinforced polymer composite material. Quasi-static and static experimentations were made using a point laser sensor and a scanning laser vibrometer, while the 3D FE simulations were conducted using the commercial software $ABAQUS^{(R)}$. The measured transverse deflection by both sensors showed strong nonlinear and hysteretic (static only) variation with the actuation voltage, which cannot be caught by the linear 3D FE simulations.

• Computers and Concrete
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• 제32권5호
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• pp.527-541
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• 2023

This paper emphasizes the use of CFT columns in frame structures subjected to strong horizontal forces and shows that the efficiency of using CFT columns is increased when the plastic design approach is adopted. Because the plastic design approach is based on redistribution of the force of the internal member, a double node for the rotational degrees of freedom, where the adjacent two rotational degrees of freedom can be connected by a non-dimensional spring element, is designed and implemented into the formulation. In addition, an accompanying criterion is considered in order to make it possible to describe the continuous moment redistribution in members connected to a nodal point up to a complete plastic state. The efficiency of CFT columns is reviewed in comparison with RC columns in terms of the cost and the resistance capacity, as defined by a P-M interaction diagram. Three representative frame structures are considered and the obtained results show that the most efficient and economical design can be expected when the use of CFT columns is considered on the basis of the plastic design, especially when a frame structure is subjected to significant horizontal forces, as in a high-rise building.

• 대한수학회지
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• 제51권4호
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• pp.721-734
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• 2014

Let M be a module over a commutative ring R, and let T(M) be its set of torsion elements. The total torsion element graph of M over R is the graph $T({\Gamma}(M))$ with vertices all elements of M, and two distinct vertices m and n are adjacent if and only if $m+n{\in}T(M)$. In this paper, we study the basic properties and possible structures of two (induced) subgraphs $Tor_0({\Gamma}(M))$ and $T_0({\Gamma}(M))$ of $T({\Gamma}(M))$, with vertices $T(M){\backslash}\{0\}$ and $M{\backslash}\{0\}$, respectively. The main purpose of this paper is to extend the definitions and some results given in [6] to a more general total torsion element graph case.

• 천문학회보
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• 제36권2호
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• pp.58.1-58.1
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• 2011

We present our N-body simulation study on the disk galaxy warp formation via close encounters. Using a publicly available code Gadget2, we investigate morphological and kinematical structures of disk galaxies while the galaxies are undergoing fly-by encounters with adjacent dark matter halos. In this study, we find that warps can be excited by impulsive encounters and sustained for a few billion years. Most of the warps from the simulation show inclination angles that are comparable to the observations. The creation of warps, their inclination and their lifetimes are governed primarily by the following three parameters: the impact parameter (the minimum distance between two halos), the mass ratio between two galaxies, and the incoming angle of the intruder. We discuss pros and cons about our alternative scenario in comparison with existing explanations.