• Proceedings of the Korean Society of Applied Pharmacology
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• 1992.05a
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• pp.39-39
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• 1992

5-Hydroxytryptamine(serotonin, 5-HT)은 중추신경의 신경 전달물질로서 조울병, 불안신경증 등의 정신병태생리에 중요한 역할을 한다. Radioligand 결합실험에 의하여 5-$HT_{1A}$, 5-$HT_{1B}$, 5-$HT_{1C}$, 5-$HT_{1D}$, 5-$HT_{2}$, 5-$HT_3$의 5-HT receptor subtypes의 존재가 확인되어 있고, 그 중에서도 5-$HT_{1A}$ receptor는 중추작용 증 정 도의 조절에 관계가 깊은 raphe nuclei 및 해마에 주로 존재하여 약리학적으로는 체온강하, 혈압 강하, 과식작용, corticosterone 분비 등과 관련되어 있음이 알려져 있다. 따라서 본 수용체 agonist가 항불안약, 항우울약 또는 항고혈압약으로서의 응용이 가능해지면서 5-$HT_{1A}$ 수용체 기능의 해명 및 그 agonist의 개발이 주목받고 있는 가운데, 본 연구에 있어서, 항불안약 개발목적으로 합성된 일련의 화합물 중 1-<3-(3,4-methylene-dioxyphenoxy)propyl> 4-phenyl piperazine (DP-554)이 5-HT 수용체에 특이적이고 선택적으로 높은 친화성을 가지며, rat 해마의 막분획에서 adenylate cyclase 활성을 억제하고, 뇌내 5-HT turnover rate를 감소시키는 둥의 약리학적 작용을 나타내어, 이 화합물이 5-$HT_{1A}$ receptor agonist로서 작용함을 밝혔다. Mouse vas deferens (MVD)를 이용한 실험에서 5-$HT_{1A}$ receptor가 MVD의 교감신경 말단에 존재하여 그 neurotransmission을 억제함이 시사되었으며, 이 조직에서 또한 5-$HT_2$와 5-$HT_3$ 수용체의 존재를 확인하고 각각의 기능을 분명히 했다.

• Korean Journal of Occupational Health Nursing
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• v.18 no.2
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• pp.165-173
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• 2009

Purpose: In Korea, the number of migrant workers is increasing. However, migrant workers have low job satisfaction due to poor working environment, and insufficient social support. This study aimed to investigate the role of social support for job satisfaction of migrant workers. Method: We have analyzed the survey data of 397 migrant workers collected from free clinic for migrant workers located in Seoul, Gyeonggi-do and Chungcheong-do. Result: When the migrant workers received monetary and emotional supports from supervisors and colleagues, their job satisfaction turned out to be significantly high. The factors that influence job satisfaction of migrant workers are as follows: involvement in manufacturing industry, over 9 hours of daily sleep, monetary and emotional support from supervisors. Their job satisfaction strongly influenced by these factors. Conclusion: Social support will increase job satisfaction of migrant workers and it will subsequently decrease job turnover rate and increase productivity as well as quality of life.

• Korean Journal of Occupational Health Nursing
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• v.26 no.1
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• pp.55-64
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• 2017

Purpose: This study was performed for the effective management of nursing organization as surveyed choice motives and job satisfaction about nurses who changed to public hospitals. Methods: This study is a descriptive study. This study surveyed 214 nurses who changed jobs to public hospital in six Gyeonggi-do hospitals from October 23 to November 20, 2015. The collected data were analyzed for descriptive statistics, t-test, one-way ANOVA, sheffe test, multiple linear regression analysis using the SPSS/WIN 21.0 program. Results: Most of the nurses chose public hospitals due to benefits correspond to public officials. They had worked in general hospitals located on provinces and changed jobs due to a heavy workload and low benefits. Of the participants 84.1% were satisfied with changing jobs to public hospitals and the advantages of public hospitals of their choice were job stability and good employee benefits(guaranteed maternity and paternity leave, etc). On the other hand there were complaints about low salaries compared to the workload after changing jobs to public hospitals. Conclusion: Hospitals need to enhance job stability and provide nurses with good employee benefits to reduce turnover rate.

• Journal of the Korean Society of Safety
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• v.26 no.2
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• pp.77-82
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• 2011

Recently, personal characteristics of organizational members arc regarded as an important factor that affects performance of organization. In addition, job stress is attributed to one of main factors that result in poor work ability and high turnover rate. In this study, job stress, work ability and DISC personality types were surveyed targeting 292 of foreman in shipbuilding company. The relationships between job stress and personal characteristics including personality types and correlation between job stress and work ability were analyzed based on the result of survey. As a result of statistical analysis, there were six statistically significant relationships between job stress and age, job tenure, work type, hobbies, exercise, personality types. On the other hand, there was a statistically significant relationship between work ability and exercise. Furthermore, negative correlation between job stress and work ability were found. In accordance with these analysis, this study presented how to improve work ability by managing job stress items and personal characteristics that affect the stress and the stress level.

• Proceedings of the Microbiological Society of Korea Conference
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• 2002.10a
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• pp.76-78
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• 2002

Heat shock proteins (HSPs) are induced in most living cells by mild heat treatment, ethanol, heavy metal ions and hypoxia. In yeast Saccharomyces cerevisiae, mild heat pretreatment strongly induces Hsp104 and thus provide acquired thermotolerance. The ability of hsp104 deleted mutant $({\triangle}hsp104)$ to acquire tolerance to extreme temperature is severely impaired. In providing thermotolerance, two ATP binding domains are indispensible, as demonstrated in ClpA and ClpB proteases of E. coli. The mechanisms by which Hsp104 protects cells from severe heat stress are not yet completely elucidated. We have investigated regulation of mitochondrial metabolic pathways controlled by the functional Hsp104 protein using $^{13}C_NMR$ spectroscopy and observed that the turnover rate of TCA cycle was enhanced in the absence of Hsp104. Production of ROS, which are toxic to kill cells radiply via oxidative stress, was also examined by fluorescence assay. Mitochondrial dysfunction was manifested in increased ROS levels and higher sensitivity for oxidative stress in the absence of Hsp104 protein expressed. Finally, we have identified mitochondrial complex I and Ferritin as binding protein(s) of Hsp104 by yeast two hybrid experiment. Based on these observations, we suggest that Hsp104 protein functions as a protector of oxidative stress via either keeping mitochondrial integrity, direct binding to mitochonrial components or regulating metal-catalyzed redox chemistry.

• Journal of Korean society of Dental Hygiene
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• v.18 no.5
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• pp.717-727
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• 2018

Objectives: This study aimed to provide basic data on ways to facilitate effective communication between patients and dental hygienists, to improve the job satisfaction of dental hygienists, and to reduce the turnover rate among dental hygienists. Therefore, a comparative analysis of the perception of dental hygienists' emotional labor was conducted targeting patients and dental hygienists. Methods: Data were collected from August 1 to September 20, 2018, from 367 participants, including 216 dental hygienists and 151 patients residing in Gwangju, Jeonnam. Using the co-orientation model, their perception of dental hygienists' emotional labor was analyzed through the independent t-test and paired t-test. Results: With reference to objective consistency, patients showed a higher perception of dental hygienists' emotional labor than dental hygienists did, indicating that the former perceived the emotional labor more negatively. Regarding accuracy, there were significant differences in dental hygienists' response to six questions, while the same was observed for 11 questions for patients. Thus, the accuracy of dental hygienists was relatively higher than that of patients. Conclusions: To help dental hygienists perform dental health prevention activities more actively, consistently, and happily, and to establish commitment and professionalism in dental hygienists to enhance national dental health. Additionally, it would be necessary to sustain continuous research interest on measures for understanding the co-oriented relationship between patients and dental hygienists, and to solve the negative elements of dental hygienists' emotional labor.

• Journal of Technology Innovation
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• v.16 no.2
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• pp.201-223
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• 2008

This paper studies the supply and demand of Industrial Technology Labor-force(ITL) and analyzes the determinate of ITL shortage in Korean manufacturing. We classified the industry into four categories-high technology industries, medium-high technology industries, medium-low technology industries and low technology industries-based on its R&D intensity like OECD. For the empirical analyses we use a survey data collected from 5,703 enterprises. The key findings are as follows: Firstly, a large majority of ITL is engaged in more technology-intensive industries but the categories that are exposed to more serious labor-force shortage problem are medium-high technology industries and low technology industries. Secondly, in the terms of supply factor, the ITL shortage problems are mainly due to the avoidance of ITL jobs. And the demand point, the reason is that the most of ITL are not researchers but production managers. Thirdly, the cause of imbalance between supply and demand of ITL are different by the technological categories. For example, in the high technology industries, the supply factors, such as average wage and turnover rate played more important role in the imbalance. But in the low technology industries the demand factors, such as per capita sales and the ratio of ITL in all employees were relatively much more important. Based on the findings, we discovered some political meanings such as the necessity to plan various policies to resolve the shortage problem of ITL according to the technological categories, etc.

• Korean Journal of Organic Agriculture
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• v.9 no.3
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• pp.45-71
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• 2001

The duck-rice forming system is increasingly spread up throughout Korea since 1992. It is discussed the rice field, rice quality, weed and pest management in the duck-rice weeding system compared to conventional farming system. Moreover the optimizing duck population, system management and fertilizer application rate were reported. Energy input and output by duck-rice farming system were carefully compared with those of low input sustainable paddy field and conventional farming paddy field. To find out the environmentally sound function of duck-rice system, the total nitrogen in paddy soil and paddy water, and nitrogen cycle in paddy rice cultivation system were analysed. finally the input and output were calculated, and ecological characteristic were determined in terms of nitrogen balance, labor input, animal input, renewable energy input, turnover of soil organic matter, energy loss, non-renewable indirect and direct energy input. It was concluded duck-rice weeding system could be recommended in terms of net only environmentally sound, but also farmer's income. But there are still some research needs for successful adaption of duck-rice farming to investigate to determine the optimal population of duck in rice paddy field unit, release time of duckling, duck management after release, and strategy for duck marketing and duck processing.

• Journal of Fisheries and Marine Sciences Education
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• v.23 no.3
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• pp.515-525
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• 2011

Due to changes in internal and external environment of coastal & offshore fishery such as decrease in coastal & offshore fishery resources, rising labor costs, rising gas prices, rising turnover rate of seamen, and intensified avoiding 4D types of business, the domestic seamen's avoidance of going to sea is being intensified. In order to solve the problems of domestic seamen shortage, coastal & offshore fishery businesses prefer to employ foreign seamen whose wages are relatively low, so employment of foreign seamen continues to increase. However, the foreign seamen system has the problems in selecting and managing seamen but these problems have been not adequately dealt with, so damages to fishery business continue to occur due to the seamen's deserting. The cases, in which foreigners who entered the country to take the sea in coastal & offshore fishing boats deserted their workplace, recorded 36.4% as of 2010. So in order to achieve the purpose of the foreign seamen system itself through rational management of foreign seamen, the exclusive organization to manage foreign seamen should be established and the system to rationally select foreign seamen who have experiences of fishery should be established. The utilization of foreign seamen during off season needs to be maximized by establishing the employment connection system for the management of foreign seamen and employment stabilization, and the exclusive organization for education of foreign seamen and the organization for nurturing domestic seamen need to be established and operated.

• The Korean Journal of Physiology
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• v.20 no.2
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• pp.157-164
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• 1986

Since it has been reported that vanadate inhibits $Ca^{++}-ATPase$ activity without affecting $Ca^{++}$ uptake, this study was undertaken to investigate the effects of vanadate on $Ca^{++}-ATPase$ activity and $Ca^{++}$ uptake in the sarcoplasmic reticulum of rat skeletal muscle. The following results were obtained. 1) $Ca^{++}$ activated ATPase activity of the intact sarcoplasmic reticulum was significantly inhibited when vanadate was added to the incubation medium at concentration greater than $10^{-6}\;M$. However $Mg^{++}$-ATPase activity of the intact SR was not affected by vanadate at concentrations ranging from $10^{-7}\;to\;10^{-4}\;M.$ Similarly, $Ca^{++}-ATPase$ activity in sonicated sarcoplasmic reticulum was significantly reduced by vanadate at a concentration $10^{-7}$ M or higher. 2) The uptake of $Ca^{++}$ by isolated sarcoplasmic reticulum was also inhibited by vanadate under the conditions where the turnover rate of $Ca^{++}-ATPase$ was made to increase. These results suggest that the inhibition of $Ca^{++}$ uptake by vanadate may be correlated with that of $Ca^{++}-ATPase$ if experimental conditions are properly set.