• 한국독성학회:학술대회논문집
• /
• 한국독성학회 2002년도 Current Trends in Toxicological Sciences
• /
• pp.76-77
• /
• 2002

Ras expression has been suggested as a marker for tumor aggressiveness of breast cancer including the degrees of invasion and tumor recurrence. Expression of H-, K-, and N-ras is regulated in a tissue-specific manner and during development, indicating that ras proteins may have different cellular functions.(omitted)

• 한국독성학회:학술대회논문집
• /
• 한국독성학회 2003년도 춘계학술대회 논문집
• /
• pp.39-40
• /
• 2003

Ochratoxin A (OA), a potent nephrotoxin in several species, is knownto be a renal carcinogen in animals and is implicated in the etiology of Balkan endemic nephropathy (BEN). The NTP (National Toxicology Program) classified Ochratoxin A as having clear evidence of carcinogenic activity, based on uncommon tubular adenomas and tubular cell carcinomas of the kidney and multiple fibroadenomas of the mammary gland, seen in the rat.(omitted)

• Asian Pacific Journal of Cancer Prevention
• /
• 제14권2호
• /
• pp.609-617
• /
• 2013

Renal cell carcinomas make up 3% of all cancers and one in four patients is metastatic at time of diagnosis. This cancer is one of the most resistant to cytotoxic chemotherapy. Studies have shown that the efficiency of interferon-alpha and/or interleukin-2 based immune therapies is limited in patients with metastatic renal cell carcinoma but latest advances in molecular biology and genetic science have resulted in better understanding of its biology. Tumor angiogenesis, tumor proliferation and metastasis develop by the activation of signal message pathways playing a role in the development of renal cell carcinomas. Better definition of these pathways has caused an increase in preclinic and clinical studies into target directed treatment of renal cell carcinoma. Many recent studies have shown that numerous anti-angiogenic agents have marked clinical activity. In this article, the focus is on general characteristics of molecular pathways playing a major role in renal cell carcinoma, reviewing clinical information onagents used in the target directed treatment of metastatic lesions.

• 대한의용생체공학회:학술대회논문집
• /
• 대한의용생체공학회 1998년도 추계학술대회
• /
• pp.319-320
• /
• 1998

We have developed algorithm for calculating tumor dose from transmission dose in radiation therapy. Using data acquisition card and LabVIEW programming language, we acquired the signal from 9 ion chambers, processed and displayed it in real time. And we also developed GUI(Graphic User Interface) for system operation.

• Journal of Chest Surgery
• /
• 제16권4호
• /
• pp.470-475
• /
• 1983

Myxoma of the heart can now be successfully treated but the success is obviously dependent upon the correct diagnosis and treatment prior to development of catastrophic complications such as sudden death, embolism or cardiac failure. The right ventricular myxoma is very rare, and we treated successfully a case of giant right ventricular myxoma, sessile tumor originated from ventricular apex, weighed 175 gm. The tumor base was broad, about 3 cm x 3cm, and it was hardly adhesed to the tricuspid valvular structures, but could remove with the preservation of adequate residual ventricular chamber size and the maintenance of functional tricuspid valve anatomy. The postoperative course was excellent and uneventful.

• 한국발생생물학회:학술대회논문집
• /
• 한국발생생물학회 2001년도 후기 제12차 학술대회 논문집
• /
• pp.45-47
• /
• 2001

생쥐 착상전 초기배아에서 insulin과 tumor necrosis factor $\alpha$ (TNF$\alpha$)에 의한 배아의 형태 발생, 세포증식, apoptosis 및 MAPK활성의 변화를 조사하였다. Insulin에 의해 형태발생 및 포배당 세포수가 증가되었으며 TNF $\alpha$ 처리시 유의하게 감소하였다. TNT$\alpha$ 전처리시 insulin에 의한 발생 및 세포수 증가 촉진효과가 상쇄되었으며 TNF$\alpha$는 배아내 caspase-3의 활성을 증가시켰다. Insulin은 단시간내에 포배에서 mitogen activated protein kinase (MAPK or Erk1/2)의 활성을 증가시켰다. TNF$\alpha$는 포배내 MAPK의 활성을 감소시켰다. Insulin 처리 전 TNF $\alpha$를 전처리한 경우 insulin에 의한 MAPK 활성의 증가가 상쇄되었다. 배발생을 촉진하는 인슐린 신호전달 과정은 MAPK cascade를 경유하며 TNF $\alpha$를 경유한 신호전달과 Crosstalk이 존재하는 것으로 사료된다.

• Journal of electromagnetic engineering and science
• /
• 제10권4호
• /
• pp.199-205
• /
• 2010

This paper presents a tumor detection system for breast cancer that utilizes two-dimensional (2D) image reconstruction with microwave tomographic imaging. The breast cancer detection system under development consists of 16 transmit/receive antennas, and the microwave tomography system operates at 900 MHz. To solve a 2D inverse scattering problem, the method of moments (MoM) is employed for forward problem solving, and the simplex method employed as an optimization algorithm. The results of the reconstructed image show that the method accurately shows the position of a breast tumor.

• Molecules and Cells
• /
• 제41권2호
• /
• pp.83-92
• /
• 2018

The biological significance and deregulation of the Hippo pathway during organ growth and tumorigenesis have received a surge of interest in the past decade. The Hippo pathway core kinases, MST1/2 and LATS1/2, are tumor suppressors that inhibit the oncogenic nuclear function of YAP/TAZ and TEAD. In addition to earlier studies that highlight the role of Hippo pathway in organ size control, cell proliferation, and tumor development, recent evidence demonstrates its critical role in cancer stem cell biology, including EMT, drug resistance, and self-renewal. Here we provide a brief overview of the regulatory mechanisms of the Hippo pathway, its role in cancer stem cell biology, and promising therapeutic interventions.

• Investigative Magnetic Resonance Imaging
• /
• 제23권1호
• /
• pp.17-25
• /
• 2019

We discuss recent advances in Gd-based $T_1$-weighted MR contrast agents for the mapping of cellular pH. The pH plays a critical role in various biological processes. During the past two decades, several MR contrast agents of strategic importance for pH-mapping have been developed. Some of these agents shed light on the pH fluctuation in the tumor microenvironment. A pH-responsive self-assembled contrast agent facilitates the visualization of tumor size as small as $3mm^3$. Optimization of various parameters is crucial for the development of pH-responsive contrast agents. In due course, the new contrast agents may provide significant insight into pH fluctuations in the human body.

• Journal of Medicine and Life Science
• /
• 제15권1호
• /
• pp.27-30
• /
• 2018

Osteoid osteoma is a benign bone tumor composed of osteoid and atypical bone. The most commonly known sites of following tumor are long tubular bones, especially femur and tibia. Yet, development of osteoid osteoma in the foot is unusual, and there aren't much reported literatures of metatarsal osteoid osteoma. In this article, we report a case of the osteoid osteoma in the 3rd metatarsal bone of a 14-year-old male patient.