• Journal of the Korean Geophysical Society
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• v.9 no.2
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• pp.135-145
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• 2006

The surface temperature and hydrological budget for the last glacial maximum (LGM) is simulatedwith an atmospheric general circulation model of NCAR CCM3 at spectral truncation of T170, corespondingto a grid cel size of roughly 75 km. LGM simulations were forced with the reconstructed CLIMAP sea surface temperatures, sea ice distribution, ice sheet topography, reduced CO2, and orbital parameters.oC in winter, 5.6oC in sumer,and 6oC annual-mean. The decrease of surface temperature leads to a weakening of the hydrologicalcycle. Global-mean precipitation decreases by about 14% in winter, 17% in summer, and 13% annually.However, some regions such as the U.S., southern Europe, northern and eastern Africa, and the SouthAmerica appear to be weter in the LGM winter and Canada and the Midle East are weter in sumer. model captures detailed climate features over land.

• Applied Microscopy
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• v.51
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• pp.4.1-4.12
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• 2021

Fluorescence in situ hybridization (FISH) is a technique to visualize specific DNA/RNA sequences within the cell nuclei and provide the presence, location and structural integrity of genes on chromosomes. A confocal Whole Slide Imaging (WSI) scanner technology has superior depth resolution compared to wide-field fluorescence imaging. Confocal WSI has the ability to perform serial optical sections with specimen imaging, which is critical for 3D tissue reconstruction for volumetric spatial analysis. The standard clinical manual scoring for FISH is labor-intensive, time-consuming and subjective. Application of multi-gene FISH analysis alongside 3D imaging, significantly increase the level of complexity required for an accurate 3D analysis. Therefore, the purpose of this study is to establish automated 3D FISH scoring for z-stack images from confocal WSI scanner. The algorithm and the application we developed, SHIMARIS PAFQ, successfully employs 3D calculations for clear individual cell nuclei segmentation, gene signals detection and distribution of break-apart probes signal patterns, including standard break-apart, and variant patterns due to truncation, and deletion, etc. The analysis was accurate and precise when compared with ground truth clinical manual counting and scoring reported in ten lymphoma and solid tumors cases. The algorithm and the application we developed, SHIMARIS PAFQ, is objective and more efficient than the conventional procedure. It enables the automated counting of more nuclei, precisely detecting additional abnormal signal variations in nuclei patterns and analyzes gigabyte multi-layer stacking imaging data of tissue samples from patients. Currently, we are developing a deep learning algorithm for automated tumor area detection to be integrated with SHIMARIS PAFQ.

• Journal of Korea Water Resources Association
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• v.40 no.4
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• pp.335-343
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• 2007

Drought characteristics need to be preceded before establishing a drought mitigation plan. In this study, using a Standardized Precipitation Index (SPI), a hydrologic drought was defined as an event during which the SPIs are continuously below a certain truncation level. Then, a methodology of drought frequency analysis was performed to quantitatively characterize droughts considering drought duration and severity simultaneously. The theory of runs was used to model drought recurrence and to determine drought properties like duration and severity. Short historical records usually do not allow reliable bivariate analyses. However, more than hundred years of precipitation data (1770 ${\sim}$ 1907) collected in Chosun Kingdom Age using an old Korean rain gage called Chukwooki can provide valuable information about past events. It is shown that a bivariate gamma distribution well represented the joint probabilistic properties of Korean drought duration and severity. The overall results of this study show that the proposed bivariate drought frequency analysis overcomes the drawbacks of the conventional univariate frequency analysis by providing a consistent representation of the drought recurrent property.

• The Korean Journal of Petroleum Geology
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• v.5 no.1_2 s.6
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• pp.9-15
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• 1997

The study area is located in the Central Bransfield Basin, Antarctica. To analyze the morphology of seafloor, structure of basement, and seismic stratigraphy of the sedimentary layers, we have acquired, processed, and interpreted the multi-channel seismic data. The northwest-southeastern back-arc extension dramatically changes seafloor morphology, volcanic and fault distribution, and basin structure along the spreading ridges. The northern continental shelf shows a narrow, steep topography. In contrast, the continental shelf or slope in the south, which is connected to the Antarctic Peninsula, has a gentle gradient. Volcanic activities resulted in the formation of large volcanos and basement highs near the spreading center, and small-scale volcanic diapirs on the shelf. A very long, continuous normal fault characterizes the northern shelf, whereas several basinward synthetic faults probably detach into the master fault in the south. Four transfer faults, the northwest-southeastern deep-parallel structures, controlled the complex distributions of the volcanos, normal faults, depocenters, and possibly hydrocarbon provinces in the study area. They have also deformed the basement structure and depositional pattern. Even though the Bransfield Basin was believed to be formed in the Late Cenozoic (about 4 Ma), the hydrocarbon potential may be very high due to thick sediment accumulation, high organic contents, high heat flow resulted from the active tectonics, and adequate traps.

• The Korean Journal of Quaternary Research
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• v.20 no.1 s.26
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• pp.51-66
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• 2006

The climate of the last glacial maximum (LGM) in northeast Asia is simulated with an atmospheric general circulation model of NCAR CCM3 at spectral truncation of T170, corresponding to a grid cell size of roughly 75 km. Modern climate is simulated by a prescribed sea surface temperature and sea ice provided from NCAR, and contemporary atmospheric CO2, topography, and orbital parameters, while LGM simulation was forced with the reconstructed CLIMAP sea surface temperatures, sea ice distribution, ice sheet topography, reduced $CO_2$, and orbital parameters. Under LGM conditions, surface temperature is markedly reduced in winter by more than $18^{\circ}C$ in the Korean west sea and continental margin of the Korean east sea, where the ocean exposed to land in the LGM, whereas in these areas surface temperature is warmer than present in summer by up to $2^{\circ}C$. This is due to the difference in heat capacity between ocean and land. Overall, in the LGM surface is cooled by $4{\sim}6^{\circ}C$ in northeast Asia land and by $7.1^{\circ}C$ in the entire area. An analysis of surface heat fluxes show that the surface cooling is due to the increase in outgoing longwave radiation associated with the reduced $CO_2$ concentration. The reduction in surface temperature leads to a weakening of the hydrological cycle. In winter, precipitation decreases largely in the southeastern part of Asia by about $1{\sim}4\;mm/day$, while in summer a larger reduction is found over China. Overall, annual-mean precipitation decreases by about 50% in the LGM. In northeast Asia, evaporation is also overall reduced in the LGM, but the reduction of precipitation is larger, eventually leading to a drier climate. The drier LGM climate simulated in this study is consistent with proxy evidence compiled in other areas. Overall, the high-resolution model captures the climate features reasonably well under global domain.