• Title/Summary/Keyword: triglyceride.

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Effects of Astragali Radix on the Diet-induced Hyperlipidemia in Rats (황기가 흰쥐의 식이성 고지혈증에 미치는 영향)

  • Kim, Hak-Joon;Kim, Jeung-Beum
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.22 no.3
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    • pp.575-579
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    • 2008
  • The purpose of this study was to investigate the effects of Astragali Radix on the diet-induced hyperlipidemia in rats. Hyperlipedemia was induced in rats with high fat diet. Rats were divided into 4 groups, normal group(supplied enough water and feeds only), high fat diet administered group(supplied high fat diet for 4 weeks, Control group) and Astragali Radix administered group(supplied high fat diet and Astragali Radix lyophilization extract for 4 weeks, 178.6 mg/kg(rat) in sample A, 297.8 mg/kg(rat) in sample B). Body weight, liver weight and serum lipid levels were evaluated. The water extract of Astragali Radix decreased body weight, liver weight, total cholesterol, LDL-cholesterol, triglyceride and phospolipid in high fat diet induced hyperlipidemia in rats, and increased HDL-cholesterol.

Effect of (-)-epigallocatechin-3-gallate on lipogenesis in 3T3-L1 Cell

  • Kang, Shin-Seok;Park, Jae-Myung;Choi, Hae-Yeon;Cho, Woo-Young;Lee, Jong-In
    • Korean Journal of Veterinary Service
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    • v.26 no.4
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    • pp.339-343
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    • 2003
  • We studied the effect of epigallocatechin-3-gallate(EGCG) on the adipose conversion of 3T3-L1 cells by insulin. In the 10 days of culture with insulin, the fat cells exhibited the increased and larger intracytoplasmic lipid droplets. In contrast, the levels of triglyceride(TG), a marker of adipose conversion, were decreased. However, the levels of glucose were decreased in the adipose conversion. In addition, levels of cholesterol were decreased in the differentiated 3T3-L1 cells.

Effect of a Pholiota adiposa Extract on Fat Mass in Hyperlipidemic Mice

  • Cho, Soo-Muk;Lee, Young-Min;Lee, Dae-Hyoung;Chun, Hye-Kyung;Lee, Jong-Soo
    • Mycobiology
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    • v.34 no.4
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    • pp.236-239
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    • 2006
  • The purpose of this study was to investigate the effect of a Pholiota adiposa extract on fat mass in hyperlipidemic mice fed on a high-fat diet. The water extracts from P. adiposa (ASI 24018) were not affected in the total triglyceride contents and epididymal fat mass in mice fed on a high-fat diet, but the retroperitoneal fat mass decreased significantly. This result suggests that the P. adiposa extract may be a potential candidate for use as a functional food that can act as a prophylactic against hyperlipidemia. However, the P. adiposa extract showed no effect in the total triglyceride contents and epididymal fat mass.

Effect of Corn Peptide on the Lipid Metabolism in Rats (옥수수 펩타이드가 흰쥐의 지질 대사에 미치는 영향)

  • Lee, Hai-Mi;Chang, Un-Jae
    • Journal of the Korean Society of Food Culture
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    • v.16 no.5
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    • pp.416-422
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    • 2001
  • This study was conducted to investigate the effects of corn peptide(CP) on lipid metabolism. Sprague-Dawley(S.D) male rats were assigned to three dietary groups {control diet(CD), high fat diet (HFD) & high fat com peptide diet(FCD)} and fed 4 weeks to examine the effects of CP. There were no significantly different in cholesterol concentrations in the liver among the groups. However, triglyceride(TG) concentrations of the FCD & CD significantly lower than the HFD. Fecal excretion of neutral steroids & bile acids of the FCD significantly higher than the CD & HFD. Serum total cholesterol TG & LDL-cholesterol concentrations of the FCD & CD significantly lower than the HFD. These results suggest the improvement of lipid composition in serum by CP might be inhibit of lipid absorption in intestine & increment of neutral steroids & bile acids excretion in feces.

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Effects of T-2 Toxin on Lipid Concentration in Rat Serum (T-2 toxin이 흰쥐 혈철 중 지질농도에 미치는 영향)

  • 강성조;박선자;이웅수;박정현;정덕화
    • Journal of Food Hygiene and Safety
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    • v.14 no.2
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    • pp.129-133
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    • 1999
  • This study was designed to observe the effects of T-2 toxin on total cholesterol and lipid concentration in rat serum. T-2 toxin is a secondary metabolite produced by Fusarium sp. which is often found on agricultural products including cereals, and it is a causal material of liver injuries in cattle and humans. When we fed rats with standard diet treated with T-2 toxin, the body weight and feed consumption of rats treated T-2 toxin were decreased. As the results of lipid analysis, the concentrations of total cholesterol and free cholesterol in serum of treated rats were increased compared to non-fed control group, On the other hand, the levels of triglyceride and phospholipid in the serum of T-2 toxin treated experimental groups were declined. In conclusion, T-2 toxin largely influenced on the total cholesterol and lipid levels in rat serum.

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Effect of Glutinous Barley Intake on Lipid Metabolism in Middle-Aged Rats Fed a High-Fat Diet

  • Sohn, Jung-Sook;Hong, So-Young;Kim, Mi-Kyung
    • Food Science and Biotechnology
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    • v.16 no.6
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    • pp.1023-1028
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    • 2007
  • This study was designed to determine whether dietary glutinous barley (GB) affects lipid metabolism in middle-aged rats previously fed a high-fat diet. To induce obesity, 20 male 9-month-old Sprague Dawley rats were raised for 1 month on a diet containing 20%(w/w) lipid. The rats were allocated to 1 of 2 groups of 10 rats each and for the subsequent 2 months were fed an 8%(w/w) lipid diet containing well-milled rice (WMR) or GB powder. Rats fed the GB diet had significantly lower concentrations of plasma triglyceride, plasma total cholesterol, and liver cholesterol than rats fed the WMR diet. Fecal excretions of triglyceride and bile acids were significantly greater for the GB group than for the WMR group. In conclusion, dietary GB has positive effects on lipid metabolism: it decreases plasma cholesterol concentration by increasing fecal excretion of bile acids.

Antihyperlipidemic Effects of Fried Beancurd Containing Powdered Green Tea in Rats (녹차유부 섭취가 실험쥐의 혈청지질에 미치는 영향)

  • Yum Yoon-Ki;Lee Mi-Young
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.5 no.6
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    • pp.546-551
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    • 2004
  • Effect of fried beancurd containing powered green tea on the serum lipid metabolism in rats were investigated. HPLC analysis of green tea-fried beancurd showed that epigallocatechin, epicatechin, epicatechin gallate and epigallocatechin gallate were intact without degradation during manufacturing process. Serum HDL-cholesterol, LDL-cholesterol, triglyceride and glucose concentrations were measured in rats fed experimental diet containing green tea-fried beancurd. Serum LDL-cholesterol contents and blood glucose were significantly decreased with treatment of green tea-fried beancurd comparing to control.

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Cholesterol Lowering Effect of Enzymatic Hydrolysates of Squid in Rats

  • Park, Ju-Hyun;Lee, Jung-Eun;Kim, Sang-Moo;Kwak, Hae-Soo
    • Food Science and Biotechnology
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    • v.18 no.6
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    • pp.1541-1544
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    • 2009
  • This study evaluated effects of enzymatic hydrolysates of squid on cholesterol lowering in rats. Thirty male rats were blocked into 3 groups [high cholesterol diet (control), 5% normal squid, and 5% enzymatic hydrolysates of squid] and were raised for 10 weeks. Triglyceride level in enzymatic hydrolysates of squid-fed rats was lower than that in the control. Serum low density lipoprotein-cholesterol level followed in the order of control>normal squid>enzymatic hydrolysates. Serum high density lipoprotein-cholesterol level in enzymatic hydrolysates of squid-fed rats was higher than that in control rats. Liver cholesterol level in enzymatic hydrolysates of squid-fed rats was lower than that in control rats.

Antidiabetic and Lipid Metabolism Effect of Paediomyces Japonica in Streptozotocin-Induced Diabetic Rats (눈꽃동충하초(paecilomyces japonica)추출물의 지질대사 및 당대사에 미치는 영향)

  • Kim, Ok-Kyung
    • Journal of the Korean Applied Science and Technology
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    • v.27 no.4
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    • pp.494-500
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    • 2010
  • This study was carried to investigate the antidiabetic and lipid metabolism of water extract paecilomyces japonica(PJ) in Streptozotocin (STZ) induced diabetic rats. Diabetes were induced by intravenous injection of STZ at a dose of 42mg/kg dissolved in citrate buffer. The water extract of paecilomyces japonica were orally administrated once a day for 7 days at a dose of 500mg/kg or 1,000mg/kg. The contents of serum glucose, triglyceride(TG), total cholesterol were significantly decreased in PJ treated group compared to the those of STZ-control group. The content of hepatic glycogen and activities of glucose-6-phosphate dehydrogenase(G-6-PDH), glucokinase(GK) were significantly increased, but activity of glucose-6-phoshatase(G-6-Pase) was significantly decreased in PJ treated group compared to the those of STZ-control group. These results indicated that water extract of paecilomyces japonica would have antidiabetic and lipid metabolism effect in STZ-induced diabetic rats.

The Effect of Mushroom Extracts on Carbon Tetrachloride-Induced Hepatotoxicity in Rats (버섯 추출물이 사염화탄소 유발 간손상에 미치는 영향)

  • 김건희;한혜경
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.27 no.2
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    • pp.326-332
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    • 1998
  • The effect of mushroom extracts from Pleurotus ostreatus and Lentinus edodes on carbon tetrachloride(CCl4)-induced hepatotoxicity was investigated. Rats were administered orally each mushroom extract at the dose of 150mg/kg, foolwed by treatment with CCl4. Liver damage was produced in male Sprague-Dawley rats, after 21hrs from dosing with CCl4(0.25ml/kg) which were given intraperitoneally. Liver damage without renal injury was confirmed by measuring plasma enzyme, creatinine and blood analysis and liver analysis. Plasma aminotransferase activity, and levels of cholesterol and triglyceride were analyzed. Plasma alanine aminotransferase and aspartate aminotransferase activities were decreased by 34% and 61.5% in pretreatment group of Lentinus edodes compared with CCl4 treated group, respectively. The adminstration of all mushroom extracts led the plasma cholesterol and triglyceride levels decrease more than the CCl4-treated rats. These results suggest that Lentinus edodes extract protect liver from damage induced by CCl4.

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