Browse > Article

Effect of Glutinous Barley Intake on Lipid Metabolism in Middle-Aged Rats Fed a High-Fat Diet  

Sohn, Jung-Sook (Department of Nutritional Science and Food Management, Ewha Womans University)
Hong, So-Young (Department of Nutritional Science and Food Management, Ewha Womans University)
Kim, Mi-Kyung (Department of Nutritional Science and Food Management, Ewha Womans University)
Publication Information
Food Science and Biotechnology / v.16, no.6, 2007 , pp. 1023-1028 More about this Journal
Abstract
This study was designed to determine whether dietary glutinous barley (GB) affects lipid metabolism in middle-aged rats previously fed a high-fat diet. To induce obesity, 20 male 9-month-old Sprague Dawley rats were raised for 1 month on a diet containing 20%(w/w) lipid. The rats were allocated to 1 of 2 groups of 10 rats each and for the subsequent 2 months were fed an 8%(w/w) lipid diet containing well-milled rice (WMR) or GB powder. Rats fed the GB diet had significantly lower concentrations of plasma triglyceride, plasma total cholesterol, and liver cholesterol than rats fed the WMR diet. Fecal excretions of triglyceride and bile acids were significantly greater for the GB group than for the WMR group. In conclusion, dietary GB has positive effects on lipid metabolism: it decreases plasma cholesterol concentration by increasing fecal excretion of bile acids.
Keywords
middle-aged rat; high-fat diet; glutinous barley; cholesterol; bile acid;
Citations & Related Records

Times Cited By Web Of Science : 1  (Related Records In Web of Science)
Times Cited By SCOPUS : 1
연도 인용수 순위
1 Truswell AS. Cereal grains and coronary heart disease. Eur. J. Clin.Nutr. 56: 1-14 (2002)   DOI   ScienceOn
2 Jackson KA, Suter DAI, Topping DL. Oat bran, barley, and malted barley lower plasma cholesterol relative to wheat bran but differ in their effects on liver cholesterol in rats fed diets with and without cholesterol. J. Nutr. 124: 1678-1684 (1994)
3 Reeves PG, Nielsen FH, Fahey GC. AIN-93 purified diets for laboratory rodents : Final report of the American Institute Nutrition Ad Hoc wrighting Committee on the reformulation of the AIN-79A rodent diet. J. Nutr. 123: 1939-1951 (1993)   DOI
4 Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can. J. Biochem. Phys. 67: 911-917 (1959)
5 Hopwood DE, Pethick DW, Pluske JR, Hampson DJ. Addition of pearl barley to a rice-based diet for newly weaned piglets increases the viscosity of the intestinal contents, reduces starch digestibility, and exacerbates post-weaning colibaccillosis. Brit. J. Nutr. 92: 419- 427 (2004)   DOI   ScienceOn
6 Li J, Kaneko T, Qin LQ, Wang J, Wang Y, Sato A. Long-term effects of high fiber intake on glucose tolerance and lipid metabolism in GK rats: Comparison among barley, rice, and cornstarch. Metabolism 52: 1206-1210 (2003)   DOI   ScienceOn
7 Black DM. Therapeutic targets in cardiovascular disease: A case for high-density lipoprotein cholesterol. Am. J. Cardiol. 91: 40E-43E (2003)   DOI   ScienceOn
8 De Schrijver R, Fremaut D, Verheyen A. Cholesterol-lowering effects and utilization of protein, lipid, fiber, and energy in rats fed unprocessed and baked oat bran. J. Nutr. 122: 1318-1324 (1992)   DOI
9 Qureshi AA, Burger WC, Peterson DM, Elson CE. The structure of an inhibitor of cholesterol synthesis isolated from barley. J. Biol. Chem. 261: 10544-10550 (1986)
10 Yang JL, Kim YH, Lee HS, Lee MS, Moon YK. Barley beta-glucan lowers serum cholesterol based on the up-regulation of cholesterol 7 alpha-hydroxylase activity and mRNA abundance in cholesterol-fed rats. J. Nutr. Sci. Vitaminol. 49: 381-387 (2003)   DOI   ScienceOn
11 Rackley CE. Cardiovascular basis for cholesterol therapy. Cardiol. Rev. 8: 124-131 (2000)   DOI   ScienceOn
12 Martinez VM, Newman RK, Newman CW. Barley diets with different fat sources have hypocholesterolemic effects in chicks. J. Nutr. 122: 1070-1076 (1992)   DOI
13 Newman CW, Newman RK. Influence of the waxy starch gene on the carbohydrate composition of covered and hull-less barleys. Cereal Food World 35: 835 (1990)
14 Ministry of Health and Welfare. Report on 2001 National Health and Nutrition Survey: Nutrition survey (I). p. 86. Ministry of Health and Welfare & Korea Institute for Health and Social Affairs, Seoul, Korea (2002)
15 McGowan MW, Artiss JD, Strandbergh DR, Zak B. A peroxidasecoupled method for colorimetric determination of serum triglycerides. Clin. Chem. 29: 538-542 (1983)
16 Sutanam N, Ramachandran S, Parthasarathy S. Oxygen radicals, antioxidants, and lipid peroxidation. Semin. Reprod. Endocr. 16: 275-280 (1998)   DOI
17 Kuller LH. Dietary fat and chronic diseases: Epidemiologic overview. J. Am. Diet Assoc. 97: S9-S15 (1997)
18 Subcommittee on Laboratory Animal Nutrition, Committee on Animal Nutrition, Board on Agriculture, National Research Council. Nutrient Requirements of Laboratory Animals. 4th ed. National Academy Press, Washington DC, USA (1995)
19 Ok HM, Sohn JS, Kim MK. Effect of whole grains intake on glucose metabolism and antithrombogenic capacity in induced obese rats with different levels of dietary lipid. Korean J. Nutr. 38: 613-625 (2005)
20 Dongowski G, Huth M, Gebhardt E. Steroids in the intestinal tract of rats are affected by dietary-fiber-rich barley-based diets. Brit. J. Nutr. 90: 895-906 (2003)   DOI   ScienceOn
21 Frings CS, Dunn RT. A colorimetric method for determination of total serum lipid based on the sulfuric-phospho-vaillin reaction. Am. J. Clin. Pathol. 53: 89-92 (1970)   DOI
22 Croce LD, Bruscalupi G, Trentalance A. Independent behavior of rat liver LDL receptor and HMGCoA reductase under estrogen treatment. Biochem. Bioph. Res. Co. 224: 345-350 (1996)   DOI   ScienceOn
23 Ministry of Health and Welfare. Report on 2001 National Health and Nutrition Survey: Health Examination. p. 57. Ministry of Health and Welfare & Korea Institute for Health and Social Affairs, Seoul, Korea (2002)
24 Coughlan BJ, Sorrentino MJ. Does hypertriglyceridemia increase risk for CAD? Growing evidence suggests it plays a role. Postgrad. Med. 108: 77-84 (2000)
25 Um MY, Rho KA, Kim MK. Age-related changes of lipid metabolism and thrombogenic capacity in rats. Korean J. Nutr. 37: 525-532 (2004)
26 Porter JL, Fordtran JS, Santa Ana CA, Emmett M, Hagey LR, MacDonald EA, Hofmann AF. Accurate enzymatic measurement of fecal bile acids in patients with malabsorption. J. Lab. Clin. Med. 141: 411-418 (2003)   DOI   ScienceOn
27 Wang L, Newman RK, Newman CW, Hofer PJ. Barley $\beta$-glucans alter intestinal viscosity and reduce plasma cholesterol concentrations in chicks. J. Nutr. 122: 2292-2297 (1992)   DOI
28 Abbey M, Triantafilidis C, Topping DL. Dietary nonstarch polysacchrides interact with cholesterol and fish oil in their effects on plasma lipids and hepatic lipoprotein receptor activity in rats. J. Nutr. 123: 900-908 (1993)
29 KREI. Food Balance Sheet. Korea Rural Economic Institute, Seoul, Korea (2003)
30 Kim MK, Paek JE. Effect of dietary fibers in rice barley on lipid and cadmium metabolism in the rat. Korean J. Nutr. 30: 252-265 (1997)
31 Marlett JA, Hosig KB, Vollendorf NW, Shinnick FL, Haack VS, Story JA. Mechanism of serum cholesterol reduction by oat bran. Hepatology 20: 1450-1457 (1994)   DOI   ScienceOn
32 Zhang JX, Lundin E, Andersson H, Bosaeus I, Dahlgren S, Hallmans G, Stenling R, Aman P. Brewer's spent grain, serum lipids, and fecal sterol excretion in human subjects with ileostomies. J. Nutr. 121: 778-784 (1991)   DOI
33 Samuel PC, Geral R, Cooper S, Jay S, Gary LM. Assessment of current National Cholesterol Education Program guidelines for total cholesterol, triglyceride, HDL-cholesterol, and LDL-cholesterol measurements. Clin. Chem. 44: 1650-1658 (1998)
34 Silvia U, Aroon DH, John M, Patrick V. What is the optimal age for starting lipid lowering treatment? A mathematical model. Brit. Med. J. 320: 1134-1140 (2000)   DOI   ScienceOn
35 Warnick GR, Nguyen T, Albers AA. Comparison of improved precipitation method for quantification of high density lipoprotein cholesterol. Clin. Chem. 31: 217-222 (1985)
36 Rimm EB, Sampfer MJ, Giovannucci E, Ascherio A, Spiegelman D, Colditz GA, Willett WC. Body size and fat distribution as predictors of coronary heart disease among middle aged and older US men. Am. J. Epidemiol. 141: 1117-1127 (1995)   DOI
37 McIntosh GH, Whyte J, McArthur T, Nestel PJ. Barley and wheat foods: Influence on plasma cholesterol concentrations in hypercholesterolemic men. Am. J. Clin. Nutr. 53: 1205-1209 (1991)   DOI
38 Li J, Wang J, Kaneko T, Qin LQ, Sato A. Effect of fiber intake on the blood pressure, lipids, and heart rate in Goto Kakizaki rats. Nutrition 20: 1003-1007 (2004)   DOI   ScienceOn