• Journal of Ginseng Research
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• 제38권4호
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• pp.239-243
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• 2014

Background: To investigate the antidiabetic effects of hydrolyzed ginseng extract (HGE) for Korean participants in an 8-wk, randomized, double-blinded, placebo-controlled clinical trial. Methods: Impaired fasting glucose participants [fasting plasma glucose (FPG) ${\geq}5.6mM$ or < 6.9mM who had not been diagnosed with any disease and met the inclusion criteria were recruited for this study. The 23 participants were randomly divided into either the HGE (n = 12, 960 mg/d) or placebo (n = 11) group. Outcomes included measurements of efficacy (FPG, postprandial glucose, fasting plasma insulin, postprandial insulin, homeostatic model assessment-insulin resistance, and homeostatic model assessment-${\beta}$) and safety (adverse events, laboratory tests, electrocardiogram, and vital signs). Results: After 8 wk of HGE supplementation, FPG and postprandial glucose were significantly decreased in the HGE group compared to the placebo group. No clinically significant changes in any safety parameter were observed. Our study revealed that HGE is a potent antidiabetic agent that does not produce noticeable adverse effects. Conclusion: HGE supplementation may be effective for treating impaired fasting glucose individuals.

• 한국안광학회지
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• 제17권4호
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• pp.321-334
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• 2012

목적: 검안렌즈에서 굴절력의 분포와 차이를 알아보고자 하였다. 방법: 4개 제품의 검안렌즈에 대해 광학중심과 주변부에서 굴절력을 측정하여, 굴절력의 분포와 균일성을 조사하고 국제규격과 비교하였다. 결과: 검안렌즈의 제품에 따라서 렌즈의 형상에 차이가 있으며, 국제규격의 굴절력 허용오차를 초과하는 경우가 있었다. 일부 렌즈에서 전 후면의 굴절력에서 차이, 광학중심과 주변부에서 굴절력의 차이가 발생되었으며, 원주렌즈에서 구면굴절력, 구면렌즈에서 원주굴절력이 측정되는 경우도 있었다. 결론: 검안렌즈는 굴절이상을 평가하는데 사용된다. 따라서 정확한 시력검사를 위해 검안렌즈는 좀 더 정밀한 제조가 요구되며, 이를 위해 철저한 품질관리가 필요할 것이다. 또한 검안렌즈를 사용함에 있어서 좀 더 세심한 주의와 관심이 요구된다.

• 한국양식학회지
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• 제12권2호
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• pp.163-165
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• 1999

A production method for scaled and scaleless strain of common carp (Cyprinus carpio) at a breeding trial is developed by test-cross technique. When the fish with scaleless (Israeli strain of common carp) were crossed with scaled strain (hybrid fish between oriental and Israeli strain of the species), we can easily obtain 2 types of common carp with or without scale. The frequency of scaleless fish in this experiment was about 40% in the population, however, their growth rate was slightly higher than scaled fish after 3 months of this experiment.

• Journal of Pharmaceutical Investigation
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• 제35권5호
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• pp.323-328
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• 2005

The purpose of the present study was to evaluate the bioequivalence of two torasemide tablets, Torem tablet (Roche Korea Co., Ltd., Korea, reference drug) and Boryung Torsemide tablet (Boryung Pharmaceutical Co., Ltd., Korea, test drug), according to the guidelines of Korea Food and Drug Administration (KFDA). After adding an internal standard (furosemide) to human serum, serum samples were extracted using 5 mL of ethyl acetate. Compounds were analyzed by reverse-phase HPLC method with UV detection. This method showed linear response over the concentration range of 0.05 ug/mL with correlation coefficient of 0.999. The lower limit of quantitation using 0.5 mL of serum was 0.05 ug/mL which was sensitive enough for pharmacokinetic studies. Twenty-eight healthy male Korean volunteers received each medicine at the torasemide dose of 20 mg in a $2{\times}2$ crossover study. There was a one-week washout period between the doses. Serum concentrations of torasemide were monitored by an HPLC-UV for over a period of 12 hr after the administration. $AUC_{t}$(the area under the serum concentration-time curve from time zero to 12 hr) was calculated by the linear trapezoidal rule method. $C_{max}$ (maximum serum drug concentration) and $T_{max}$ (time to reach $C_{max}$) were compiled from the serum concentration-time data. Analysis of variance was carried out using logarithmically transformed $AUC_{t}$ and $C_{max}$. No significant sequence effect was found for all of the bioavailability parameters indicating that the crossover design was properly performed. The 90% confidence intervals of the $AUC_{t}$ ratio and the $C_{max}$ ratio for Boryung Torsemide/Torem were log 0.97-10g 1.03 and log 0.93log 1.12, respectively. These values were within the acceptable bioequivalence intervals of log 0.80-log 1.25. Thus, the criteria of the KFDA guidelines for the bioequivalence was satisfied, indicating Boryung Torsemide tablet and Torem tablet are bioequivalent.

• 한국양식학회지
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• 제12권3호
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• pp.197-204
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• 1999

Successful produciton of seedlings for marine fish species are highly influenced by the aquisiton of sufficient number of good-quality eggs on required time. human chorionic gonadotropin has been used to induce successful ovulation for the purpose. Rabbitfish, siganus canaliculatus, is inhabited along the coast of Cheju Province and treated valuably for raw fish and fish roasted with seasoning. Female wild-captured rabbitfish (314 to 279 g in body weigth) were injected into intraperitoneal space with human chorionic gonadotropin (HCG) of 5,00,1,000, and 1,500 IU/kg body weight during spawning season of July 14 (trial 1), and July 27 (trial 2). Test fish in trial 1 were injected two times, first on July 14 and second on July 21 with one weekinterval because of no ovulation symptoms, but just one time in trial 2. All females injected both 1,000 and 1,500 IU/kg body weight ovulated in all trials. Among 500 IU/kg injection treatments, just one female ovulated in trial 1 showing 25% of ovulation rate, but none ovulated in trial 2. Ovulation was not occurred in control goups during test period. Time to reach ovulation after injection was 172 to 270 hours in trial 1 and 77 to 132 hours in trial 2, showing shorter as spawning season approached. Generally, ovulation of smaller females were late than that of larger ones. Gonadosomatic index (GSI) and pseudo-gonadosomatic index (Pseudo-GSI) were ranged 22 to 33% and 19 to 28%, respectively. One female spawned 406,200 to 1,032,000 eggs, and obtainable eggs per 100g of body weight were calculated by 130,000 to 190,000. Spawning rates were comparatively high by 96.0 to 98.4%. Rates to reach embryo-formation and hatching were higher in 500 high by 96.0 to 98.4%. Rates to reach embryo-formation and hatching were higher in 500 and 1,000 IU/kg treatments than in 1,500 IU/kg treatment. The result of present study demontrates that HCG treatment during spawning season could become very useful for ovulation of rabbitfish and the suitable dosage was suggested as 1,000 IU/kg of body weight.

• 한방재활의학과학회지
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• 제20권2호
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• pp.63-77
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• 2010

Objectives : It is known that abdominal obesity increases the possibility of cardiovascular diseases, early death, and metabolic syndrome including dyslipidemia and insulin resistance. Clinical trials have been under way to verify the effectiveness of treatment for abdominal obesity. The objective of this study is to set criteria about how effective oriental medicine and acupuncture are in abdominal obesity. Methods : I manually search "www.clinicaltrial.gov", 4 Korean medical databases and 4 Korean medical journals of abdominal obesity. Search terms used were "abdominal obesity" or "visceral obesity". In order to see detail review, searching was performed from 01, 01, 2005 to 11, 31, 2009. And I classified all the searched studies into design, intervention, purpose, end point, diseases, condition and etc. Results : 1. I could search total 67 trials in "www.clinicaltrial.gov". I found 9, 10, 13, 8, 6 clinical trial from 2005 to 2009 every year. 2. Test on both gender and adult or adult and senior have been most frequent. 3. Randomization clinical trial is 51 cases that occupied 96.2%. 38 cases use control group. 4. Body mass index(BMI) and waist circunference(WC) are major criteria of abdominal obesity clincal trial. WC, BMI, abdominal fat mass, body weight are measured at end point of abdominal obesity clincal trial. 5. I could search total 86 cases in domestic study. I found 15, 23, 23, 20, 5 cases from 2005 to 2009 every year. 6. Test on female and adult have been most frequent in domestic study. 7. Randomization clincal trial is only 2 cases that occupied 2.3%. 62 cases use control group in domestic study. 8. BMI, body fat percent, WC, visceral-subcutaneous fat ratio(VSR), waist-hip ratio(WHR) are criteria of abdominal obesity clincal trial in domestic study. WC, BMI, abdominal fat mass, body weight are measured at end point of abdominal obesity clincal trial in domestic study. Conclusions : To improve abdominal obesity study in traditional korean medicine, it is need to activate clinical trial, meta analysis, develope of clinical practice guidelines, co-works with conventional medicine and etc.

• 한국안광학회지
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• 제18권4호
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• pp.405-411
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• 2013

목적: 검안렌즈에서 렌즈마운트에 대한 렌즈의 장착상태를 알아보고자 하였다. 방법: 국내에서 유통되고 있는 임의의 검안렌즈에 대해 렌즈마운트의 기하중심과 렌즈의 광학중심사이 거리, 축 표시마크와 실제 축사이 각도의 차이를 조사하고 국제규격과 비교하였다. 결과: 일부 렌즈에서 렌즈마운트의 기하중심에서 발생되는 프리즘 굴절력, 원주렌즈의 축 표시마크와 실제 축사이 각도 차이가 국제규격의 허용오차를 초과하는 경우가 있었다. 결론: 정확한 시력검사를 위해 검안렌즈는 좀 더 정밀한 제조가 요구되며, 이를 위해 철저한 품질관리가 필요할 것으로 생각된다.

• Journal of Periodontal and Implant Science
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• 제51권1호
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• pp.63-74
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• 2021

Purpose: This study investigated the effects of hyaluronic acid (HA) on peri-implant clinical variables and crevicular concentrations of the proinflammatory biomarkers interleukin (IL)-1β and tumor necrosis factor (TNF)-α in patients with peri-implantitis. Methods: A randomized controlled trial was conducted in peri-implantitis patients. Patients were randomized to receive a 0.8% HA gel (test group), an excipient-based gel (control group 1), or no gel (control group 2). Clinical periodontal variables and marginal bone loss after 0, 45, and 90 days of treatment were assessed. IL-1β and TNF-α levels in crevicular fluid were measured by enzyme-linked immunosorbent assays at baseline and after 45 days of treatment. Clustering analysis was performed, considering the possibility of multiple implants in a single patient. Results: Sixty-one patients with 100 dental implants were assigned to the test group, control group 1, or control group 2. Probing pocket depth (PPD) was significantly lower in the test group than in both control groups at 45 days (control 1: 95% CI, -1.66, -0.40 mm; control 2: 95% CI, -1.07, -0.01 mm) and 90 days (control 1: 95% CI, -1.72, -0.54 mm; control 2: 95% CI, -1.13, -0.15 mm). There was a trend towards less bleeding on probing in the test group than in control group 2 at 90 days (P=0.07). Implants with a PPD ≥5 mm showed higher levels of IL-1β in the control group 2 at 45 days than in the test group (P=0.04). Conclusions: This study demonstrates for the first time that the topical application of a HA gel in the peri-implant pocket and around implants with peri-implantitis may reduce inflammation and crevicular fluid IL-1β levels.

• 수산해양기술연구
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• 제51권1호
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• pp.61-70
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• 2015

In an attempt to improve the maneuvering character of hull form renovated tuna purse seiner. A renovation was carried out on the 3 tuna purse seiner fishing vessel. To grasp the progress of maneuvering and resistance on ship B (730 ton class), new bulbous bow was only attached. The ship A (740 ton class) and C (600 ton class) were modified for new bulbous bow, enlarged slipway and rudder. And then the zigzag and the turning test were carried out. According to the turning test, the advance and the tactical diameter were improved very much for the modified ship. The sea trial was carried out for the original and modified ship A. It is showed that the results of sea trial corresponded with that of the tank test on the whole. In the result of the zigzag test on ship B, the turning ability was improved very much, but the yaw checking ability was deteriorated in just some degree. In the result of the zigzag test on ship C, the turning ability and yaw checking ability were remarkably improved. Ship C was greatly improved among the three ships for the maneuvering character of modified hull form.

• Journal of Advanced Marine Engineering and Technology
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• 제37권6호
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• pp.623-630
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• 2013

본 연구는 기 개발된 인플래터블 카약(RPO-2)과 새롭게 개발된 인플래터블 카약(RD-FK-11, RD-FK-12)의 유체역학적인 성능평가를 위하여 경사시험과 선회시험은 해양공학수조에서 저항시험은 축소된 모형선을 제작하여 회류수조에서 수행되었다. 결론적으로 각각의 카약에 대한 다양한 성능시험결과 복원성 측면에서는 KONA가 유리하고, 선회력과 무게중심 측면에서는 RD-FK-12가 우수하고, 저항성능 측면에서는 RD-FK-11이 KONA와 RPO-2에 비해 우수하였다.