• Asian Pacific Journal of Cancer Prevention
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• v.14 no.4
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• pp.2181-2184
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• 2013

Prostate cancer is the most common malignancy in men in the United States. Surgery or radiation are sometimes unsatisfactory treatments because of the complications such as incontinence or erectile dysfunction. Selenium was found to be effective to preven prostate cancer in the Nutritional Prevention of Cancer Trial (NPC), which motivated two other clinical trials: the Selenium and Vitamin E Cancer Prevention Trial (SELECT) and a Phase III trial of selenium to prevent prostate cancer in men with high-grade prostatic intraepithelial neoplasia. However, these two trials failed to confirm the results of the NPC trial and indicated that the selenium may not be preventive of prostate cancer. In this article we review the three clinical trials and discuss some different points which might be potential factors underlying variation in results obtained.

• Korean Journal of Biological Psychiatry
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• v.19 no.4
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• pp.153-158
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• 2012

Understanding of a clinical trial is essential in developing clinical guideline and adopting evidence based practice. In designing and executing clinical trials, following ethical requirements should be considered : social value, scientific validity, fair subject selection, informed consent, favorable risk-benefit ratio, institutional review board, and respect for human subjects. According to the stage of drug development, purpose of trials, accumulated scientific data, clinical trials for drug development are classified as phase 1, 2, 3, and 4. Phases of clinical trials can be overlapped and the judgment of entering into the next phase should be considered highly strategically. In reading, evaluating and interpreting clinical trial reports, various skills and challenges exist. Patient sample composition, trial duration, selection of endpoints, responders and non-responders, placebo effect, patient recruitment, and extrapolation to the real world are the examples of those challenges. Treatment success will come from the well balanced approach of evidence based decision making and consideration of specific single case.

• Journal of Navigation and Port Research
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• v.40 no.5
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• pp.231-239
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• 2016

In general, the attitude of a high-speed planning boat changes following a speed change. Since the hydrodynamic forces acting on a ship differ according to the change of its underwater shape, it is difficult to estimate its hydrodynamic force compared to that of a large commercial ship. In this paper, 6 Degrees Of Freedom (DOF) equations of motion that express the maneuvering motion of a planning boat are modeled by analyzing its motion characteristics based on various sea trial tests. Finally, a maneuvering simulation is carried out and a validation of the equations of motion is confirmed with the results of sea trial tests.

• 대한예방의학회:학술대회논문집
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• 2001.10a
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• pp.305-307
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• 2001

• Journal of Korea Multimedia Society
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• v.20 no.10
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• pp.1637-1645
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• 2017

Target/Nontarget classification can be divided into the study of shape estimation of the target analysing reflected echo signal and of type classification of the target using acoustical features. In active sonar system, the feature vectors are extracted from the signal reflected from the target, and an classification algorithm is applied to determine whether the received signal is a target or not. However, received sonar signals can be distorted in the underwater environments, and the spatio-temporal characteristics of active sonar signals change according to the aspect of the target. In addition, it is very difficult to collect real sea-trial data for research. In this paper, target/non-target classification were performed using real sea-trial data. Feature vectors are extracted using MFCC(Mel-Frequency Cepstral Coefficients), filterbank energy in the Fourier spectrum and wavelet domain. For the performance verification, classification experiments were performed using backpropagation neural network classifiers.

• Journal of the Korean Data and Information Science Society
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• v.22 no.3
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• pp.605-612
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• 2011

In multi-center randomized clinical trial the treatment eect may be changed over centers. It is thus important to investigate the heterogeneity in treatment eect between centers. For this, uncorrelated random-eect models assuming independence between random-eect terms have been often used, which may be a strong assumption. In this paper we propose a correlated frailty modelling approach of investigating such heterogeneity using the hierarchical-likelihood method when the outcome is time-to-event. In particular, we show how to construct a proper prediction interval for frailty, which explores graphically the potential heterogeneity for a treatment-by-center interaction term. The proposed method is illustrated via numerical studies based on data from the design of a multi-center clinical trial.

• Proceedings of the KIEE Conference
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• 2002.11b
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• pp.29-31
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• 2002

Purpose of the 765kV trial operation conducted for the first time in our country are performance verification of domestic developed equipment(765kV M.Tr, GIS,etc) and extraction of problem in advance to commercial operation and cultivation of operation ability. The trial operation of 765kV substation was finished successfully under the positive supports of institutes. manufactures. and constructers. It is expected that extraction of problems in advance and accumulation of operation techniques through the trial operation of 765kV substation will be contributed largly to the realization of the without a hitch operation of 765kV system.

• Journal of the Optical Society of Korea
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• v.11 no.3
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• pp.101-107
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• 2007

In this paper, we have presented the results of Wavelength Division Multiplexing-Passive Optical Network (WDM-PON) based fiber-to-the-home (FTTH) field trial test which was held in the city of Gwangju. We have implemented an injection locked Fabry-Perot Laser Diode (FP-LD) based WDM-PON system and reliably delivered Internet Protocol TV (IP-TV), networked Personal Video Recorder (N-PVR), High-Definition Video on Demand (HD-VoD), Education on Demand (EoD) and Internet service as FTTH service through the system during the field trial test. We have also verified that the WDM-PON system worked well to provide quality of service (QoS) guaranteed 100Mbps bandwidth per subscriber. Furthermore, we have presented network designing issues in Outside Plant (OSP) and Customer Premises Network (CPN) that should be overcome to efficiently deploy FTTH service. Finally, based on the field trial test results, we proposed FTTH service deployment strategies.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 1998.06a
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• pp.25-32
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• 1998

This study suggested the practical method which can reduce the lead time of the field trial and design of the dies. The virtual manufacturing, with the die design is evaluated by computer analysis, reveals the impropriety of a design before making dies. Three methods for reducing the die making process occupying over 60% of the automotive development are like fellows : First, the crack virtually adjusting the blank holding force and draw bead force with a computer simulation. Second, the parts which can not remove the forming defects in spite of the adjustment of forming process parameters need to modify the part geometry or punch temporary shape. Third, the simulation before trial, field trial, and field trial simulation can be used effectively in the die design.

• Journal of Ocean Engineering and Technology
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• v.27 no.6
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• pp.112-118
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• 2013

This paper reports the results of a comparative study on rudder performance between the steel rudders that have been used in coastal angling fishing boats in the 20-GT class and the newly developed FRP composite material rudders. In order to compare the rudder performances of these two types, a sea trial test was carried out to investigate the speed performance, fuel consumption, and ship's turning ability. The results showed that the sea trial performance of the FRP composite rudder was better than that of the steel rudder type in terms of the sea speed, fuel consumption rate, and turning ability.