• Title/Summary/Keyword: treatment plans

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Comparison of Histopathological Changes on the Three Drugs of Carbon Tetrachloride, Dimethylnitrosamine, Thioacetamide, and Bile Duct Ligation used for Induction of Liver Fibrosis in Rat

  • Kim, Jung-Hun;Park, Mi-Jung;Kim, Yo-El;Kim, Jin-Yeong;Sin, Jin-Hee;Park, Su-Young;Jekal, Seung-Joo
    • Korean Journal of Clinical Laboratory Science
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    • v.43 no.4
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    • pp.194-204
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    • 2011
  • This study was carried out to compare the histopathological differences of liver lesions in carbon tetrachloride ($CCI_4$), dimethylnitrosamine (DMN), thioacetamide (TAA) and bile duct ligation (BDL)-induced rats. $CCl_4$, DMN and TAA were administered intraperitoneally and conducted bile duct ligation for 4 weeks to induce hepatic fibrosis. Indices of liver cell injury (steatosis, hydropic degeneration, bile duct hyperplasia, hemorrhage & hemosiderin deposition), the extent of liver fibrosis (fibrotic area) and the rate of regeneration (number of PCNA-positive cells) were investigated in each group. Liver tissues were stained with hematoxylin-eosin (HE), sirius red, prussian blue and immunostained with ${\alpha}$-smooth muscle actin (${\alpha}$-SMA), transforming growth factor-${\beta}1$ (TGF-${\beta}1$), proliferative cell nuclear antigen (PCNA), and quantified using a computerized image analysis system. Liver cell steatosis was significantly increased in $CCl_4$ and TAA groups, and hydropic degeneration and bile duct hyperplasia were significantly increased in TAA and BDL groups when compared with that in normal control, respectively. Fibrosis area was significantly increased in all four groups, especially in $CCl_4$ group. Correlation between ${\alpha}$-SMA and TGF-${\beta}1$ expressions in four groups was good. Hemorrhage area in liver parenchyma was significantly increased in DMN group only when compared with that in normal control, while hemosiderin deposition area was significantly increased in TAA and BDL groups as well as DMN group. The Number of PCNA-positive cells was significantly increased in all four groups, especially in TAA group. These results indicate that the duration and methods of hepatotoxic drug treatment are very important factors to make plans for animal experimentation on the induction of hepatic fibrogenesis in rats.

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The Comparison of Dose Distribution on Radiation Therapy between IMRT and VMAT in Modified Radical Mastectomy Patients (전유방절제술 환자에서 IMRT와 VMAT을 이용한 방사선치료시 선량 분포의 비교)

  • Ko, Hye-Jin;Kim, Young-Jae;Jang, Seong-Joo
    • The Journal of the Korea Contents Association
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    • v.14 no.8
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    • pp.225-232
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    • 2014
  • Underwent on modified radical mastectomy(MRM) and radiation therapy, it affects increasing rates of chronic morbidity, because of including chest wall and internal mammary nodes(IMNs). It causes the high absorbed dose on heart and ipsilateral lung. Thus in this study, we compared dose distributions through utilizing the intensity modulated radiation therapy(IMRT) and the volumetric modulated arc therapy(VMAT). We selected 10 breast cancer patients at random who took MRM and radiation therapy. Treatment plannings were done by using IMRT and VMAT from each patient ranging supraclavicular lymphnodes(SCL) and IMNs. After that we analysed the planning target volume(PTV)'s conformity and absorbed doses on heart and lungs. As a results, PTV conformities were indicated the same patten(p<0.05) in both plans. In case of Lt breast cancer patients, the dose maximum regions of the heart were more lesser in VMAT technique rather than the IMRT(p<0.05). Also, the maximum dose areas of lungs were lesser in VMAT technique rather than the IMRT(p<0.05). Therefore, it would be safe to say that it is more effective way to adapt the VMAT technique than IMRT in such cases like involve IMNs in breast cancer patients.

Water Quality Improvement Plans based on the Analysis of Pollutant Discharge Characteristics and Water Quality Modelling of Seokmun Reservoir Watershed (석문호 유역 오염물질 배출특성 분석 및 수질모델링에 기초한 수질개선방안 연구)

  • Choi, Moojin;Jung, Woohyeuk;Choi, Jaehun;Kim, Youngil
    • Journal of Korean Society of Environmental Engineers
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    • v.39 no.10
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    • pp.581-590
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    • 2017
  • For effective improvement of water quality in Seokmun reservoir, this study implemented various analyses including the tributary water quality and flowrate monitoring, contamination of sediment, investigation of pollution source, selection of priority management target tributary by stream grouping method. The COD concentration of the majority of tributaries in Seokmun reservoir watershed was relatively higher than BOD concentration. The concentration of water pollutants regardless of water quality parameters in Yeokcheon, Dangjincheon, Sigokcheon, Baekseokcheon, small stream in Jinkwanri and Janghangri were higher than the other tributaries. The pollution sources in the Seokmun reservoir watershed were mostly distributed in the population, livestock, and industry. The pollutants, which located in Yeokcheon, Dangjincheon, Baekseokcheon, and small stream in Janghangri selected as priority management target tributary, should be preferentially reduced for improving the water quality in Seokmun reservoir. As the evaluation results of water quality in Seokmun reservoir for the effect of water quality improvement according to various scenarios using water quality model, it was found that the water quality in Seokmun reservoir due to the construction of a wastewater treatment plant for management of pollutants in the watershed would be satisfied the class V of water environment standard in reservoir.

A Study on Local Economic Resilience after Disasters through Time Series Analysis -Focusing on the Sewol Ferry Disaster- (시계열자료 분석을 통한 재난발생 이후 지역경제 회복력(resilience)에 관한 연구 -세월호 참사를 중심으로-)

  • Kwon, Seol A
    • The Journal of the Korea Contents Association
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    • v.18 no.5
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    • pp.456-463
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    • 2018
  • Increases in disasters and damage caused by the disasters in modern society, have a negative impact on local economy. In particular, a local economic downturn leads to a deterioration in quality of life of local residents and causes mental and material damage. Therefore, in order to achieve stable and sustainable local economic development, it is necessary to strengthen the resilience of the local economy. This study aims to estimate indicators of local economic resilience of Jindo County after the Sewol Ferry disaster, analyze a trend of the economic level after the disaster through time series data and suggest improvement plans of the local crisis management and restoration policy that considers future economic resilience. Results of this study showed that a decrease in the number of tourists and of workers in related industries hit tourism industry, causing a loss to the local economy and that an increase in a drinking rate of and stress awareness rate of local residents was a stress factor due to disaster impacts. These findings provides policy implications that it is necessary to make efforts for improving the depressed local image by utilizing local resources in the area, to build a sustainable long-term economic recovery policy and to provide psychological treatment and the relevant government and local government's support for relieving the stress of local residents due to the disaster impacts.

Study on the Realities in Seoul Subway Crimes: Criminal Psychology (서울지하철 범죄 실태에 대한 범죄심리학적 연구)

  • Rim, Sang-Gon
    • Korean Security Journal
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    • no.7
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    • pp.233-285
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    • 2004
  • ‘Defined legally as a violation of law' (Sutherland, E. H. Principles of Criminology, Lippincott, Chicago, 1939) Crime within the group is essentially and primarily antisocial in that the criminal who is welfare of his group acts instead against it and breaks the principles of social solidarity not merely by not doing what these principles prescribe, but by doing something exactly opposites. Any program set up to attack crime and delinquent behavior at their sources. A program of his nature needs the constant and comprehensive collaboration of psychiatrists, social works, educations, lawmakers, and public officials, since crime is a social problem and it should be treated as such. Some crime preventives which should be mentioned are as follows, (1) The insurance that every child will be decently born and that his home life be socially and economically adequate; without socially mature parents the chid is handicapped at the start; thus parental education, integrated with the public school system, should be developed now. (2) A more meaningful educational program which would emphasize ideals of citizenship, moral integrity, and respect for the law and the police. (3) A periodic check made for potential delinquents throughout the public schools and treatment provided if possible; and if not, proper segregation in institutions. (4) Careful attention paid to press, movies, and radio so that crime may no longer appear to be glamorous. This can be done by women's clubs, civic bodies, and other educational groups exerting pressure on the movie syndicates and broadcasting companies to free their productions of the tawdry and lurid characteristics of crime and criminals. Aggression associated with the phallic stage of development, The child ordinarily comprehends sexual intercourse as an aggressive and sadistic act on the part of the male, and specifically on the part of the penis. Evidence that the penis is phantasied as a weapon of violence and destruction come from unconscious productions of normal adults. Limerick, for instance, often refer to the penis as square, or too large, etc., so that intercourse is dangerous and painful for the partner, This may wall be a projection of the male's own fear of coitus. A certain portion of the death-instinct always remains within the person; it is called 'primal sadism' and according to Freud is identical with masochism. 'After the chief part of it(the death instinct) has been directed outwards towards objects, there remains as a residuum within the organism the true erotogenic masochism, which on the one hand becomes a component of the libido and on the other still has the subject itself for a object.' Criminalism, compulsive-neurotic frequent repetition of criminal acts in a compulsive manner. Like most symptoms of the compulsive-neurotic, such antisocial act are closely rated to feelings of hostility and aggression, often against the father. Because these acts are symptomatic, they afford only temporary relief and are therefore repeated. One patient with compulsive-neurotic criminalism was apprehended after breaking into hardware store and stealing money. He later confessed to many similar incidents over the preceding two years. At the same time it was apparent that he stole only for the sake of stealing. He did not need the money he thus obtained and had no special plans for using it.

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Morphological and hematological analysis of and angered Eurasian eagle owl (Bubo bubo kiautschensis) (멸종위기종 수리부엉이의 형태학적 및 혈액학적 분석)

  • Jung, Bae-Dong;Park, In-Chul;Kim, Jung-Nam;Kim, Hyeon-Cheol;Cheong, Ki-Soo;Kim, Jong-Taek
    • Korean Journal of Veterinary Service
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    • v.32 no.4
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    • pp.391-397
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    • 2009
  • Eurasian eagle owl (Bubo bubo kiautschensis) is a natural monument (No. 324) and is also classified as an endangered wildlife grade II the Ministry of Environment of Korea. Eurasian eagle owl is threatened by the human being. But the efficient rescue and treatment for Eurasian eagle owl are still problematic, due to lack of basic data. In this study, to obtain basic resources for establishing more efficient rescue system, we held a physical examination and measured size physical part. In addition, we analyzed blood sample and feces samples and autopsy. We conduct the physical examination with measuring tapes and scales for 16 live features and 11 dead features. After inhalation anesthesia take the blood samples from wing vein. Blood samples are analyzed in hematologic and chemistric methods. We collected the feces through individual floor of cages from 12 live features and conducted the feces analysis. Autopsy was conducted for 11 dead samples. In physical examination, the mean body weight and total length of live features was 2.26${\pm}$0.35kg, 61${\pm}$2.38cm, the mean body weight and total length of dead features was 1.57${\pm}$0.51kg, 59.31${\pm}$3.51cm. Mean PCV was 46.57${\pm}$4.97%, while mean TPP was 3.49${\pm}$0.57g/dL. In feces sample analysis, 9 of 12 owls(75%) were infested by gastrointestinal helminths. The infection rates were: Trematoda (41.7%), Capilaria sp.(66.7%), acanthocephalans (25%). In autopsy, we confirmed 11 features were infested by duplicated infection of more than 2 helminths. Result of this study will be used for establishing reference range for physical features, blood analysis in Eurasian eagle owl. Therefore, to obtain basic resources for establishing more efficient rescue system, we have to make long-term conservation plans for Eurasian eagle owl.

A Comparative Analysis on Generated Construction Waste Quantities in a Case Study for Deconstruction of an Apartment (공동주택의 분별해체 시험시공을 통한 건설폐기물 발생량 비교 분석)

  • Kim, Hyojin;Kang, Leenseok;Kim, Changhak
    • Korean Journal of Construction Engineering and Management
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    • v.15 no.6
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    • pp.63-70
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    • 2014
  • Deconstruction of the building must be applied firstly in order to improve recycling and reuse of construction wastes. In this study have done a case study for deconstruction of an apartment. All construction waste(CW) which will be generated during deconstruction was examined in each part of the building. Because drawing did not exist in most of the old building, we drew up floor plans of buildings. After analyzing these drawings, estimated quantities of CW. It was measured working time of labor and equipments for deconstruction and general demolition on each building of the apartment. In addition, it was proposed in the volume and weight per unit after analyzing detailed measurement of CW which was generated in the process of deconstruction and traditional demolition. It suggested recovery rate at a site, volume and weight conversion factors, and waste basic unit per area that based on the results of comparative analysis on the amount of CW which is calculated from drawing and generated at a site. These factors will be used fundamental materials for estimating quantities and treatment cost of CW, and scheduling of works.

A Case of Lung Cancer with Metastasis to the Right Fifth Toe (제 5 우족지의 전이를 동반한 폐암 1예)

  • Lee, Hong-Lyeol;Kim, Se-Kyu;Lee, Hwan-Mo;Shin, Dong-Hwan;Chang, Jung-Hyun;Kwak, Seung-Min;Chang, Joon;Kim, Sung-Kyu;Lee, Won-Young
    • Tuberculosis and Respiratory Diseases
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    • v.40 no.1
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    • pp.72-78
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    • 1993
  • Background: In malignancies, detection of metastatic foci is of value in making therapeutic plans for treatment of disease and prevention of life-threatening complications. Common sites for metastasis of bronchogenic cancer include lymph nodes, liver, brain, adrenals and bone. Skull, vertebrae, ribs and long bones are common sites for bone metastasis. But in epidermoid carcinoma, the incidence of bone metastasis is relatively low and especially to the distal phalangeal bone is rare. Methods: We experienced a case of epidermoid carcinoma with the first distant metastasis to the fifth distal phalangeal bone, right toe. Results: The initial stage in the diagnosis of epidermoid carcinoma was T4N3MO. During the third round of anticancer chemotherapy, we recognized the distant metastasis to the fifth distal phalangeal bone for the first time. Localized abnormal findings were noted by bone X-ray and scanning. By a histopathologic examination of the amputated toe, we confirmed the metastasis of epidrmoid bronchogenic carcinoma. Conclusion: If localized abnormal finding is discovered at an unusual site for metastasis, we recommend physicians to consider the possibility of metastasis even though it is very low.

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A Study on the Status of Utilization of Health Care Institution by Geriatric Patients -Focus on the Utilization of Physical Therapy- (노인환자 보건의료기관 이용실태 분석)

  • Lee, Jong-Sub;Song, Myung-Soo
    • Journal of agricultural medicine and community health
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    • v.22 no.2
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    • pp.277-293
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    • 1997
  • This study was conducted to provide basic materials required to enforce and develop welfare policies, as well as the health system, for the aged, by surveying the status of health care utilized by the daily increasing old population and the importance of receiving physical therapy. Data that need in this research was gathered from over ages of 65, during the period from Jan 4, 1996 to Jan 31, using the inquiries previously made by geriatric researchers and through literatures investigator by this writer. The data were analyzed by $X^2$, Z-test, Likert scale. The findings were as follows : 1) General characteristics of subjects. People in the age group between 65 and 69 were 55.6% and the highest number, while male were 37% and female 63%. Analysis of income group disclosed 60.6% whose monthly income, including the pocket money given by children, was less than 200,000 won. 91.1% of the elderly people surveyed owned houses; only 36.4% live with spouses; while 15.6% live alone. 2) Characteristics with respect to utilization of health care institution. 56% of the total medical institutions used by the elderly people were clinics and the rates of chronic disease and musculoskeletal disease were 73.2%. 3) Characteristics with respect to approach of health care institution. 45.1% of the respondent stated it took 20 minutes to arrive at hospital, and bus accounted for 48.6% of all transportation means used to go to hospital. 4) Degree of cognition with respect to the rights of geriatric patients. (1) There is no financial support from the government for geriatric patients(71.4%). (2) Government financial support is needed for geriatric patients(95.3%). (3) Have never been regionally surveyed or called upon for interviews with respect to treatment desire and problems relating to geriatric patients(87.2%). (4) Health and medical policies for geriatric patients must be established rapidly(98.4). (5) Expansion and construction of specialized medical facilities for geriatric patients such as elderly hospital and medical center are needed(90.2%). (6) Government's welfare policies for the elderly people is insufficient(82.0%) 5) Degree of cognition on importance of physical therapy with respect to geriatric patient. (1) Physical therapy is considered most effective in treating geriatric patients(82.9%). (2) Physical therapists specializing in only elderly people must be need of separately(76.2%). (3) It is desirable for medical specialists to visit geriatric patients at home to provide physical therapy(82.9%). (4) Hospitals specializing in physical therapy for geriatric patient are required(85.6%). Based on the result for this research, the following suggestions are presented to facilitate the utilization of health care institution for the welfare of geriatric patients. Medical facilities such as elderly hospital and geriatric patient's medical center specializing in elderly people must be constructed as early as possible; and home-visiting physical therapist system must be important to treat chronic geriatric patients; our government must establish policies to provide the old ages with means for the health care and curing chronic diseases, and carry out the plans of reasonable distribution and effective untilization of medical resources.

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Prevalence and Distribution of Congenitally Missing Teeth in Patients Visiting the Department of Pediatric Dentistry of Chonbuk National University Hospita (전북대학교병원 소아치과에 내원한 어린이에서 선천적으로 결손된 치아의 유병률 및 분포)

  • Jeon, Hyunsoon;Yang, Yeonmi;Baik, Byeongju;Kim, Jaegon
    • Journal of the korean academy of Pediatric Dentistry
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    • v.40 no.4
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    • pp.274-282
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    • 2013
  • The goal of this study was to analyze prevalence and distribution of congenitally missing teeth in 3302 patients from 7 to 15 years old, who had visited and taken panoramic radiographs at the Department of Pediatric Dentistry, from January 2008 to December 2012. The prevalence of hypodontia in the males (5.9%) was slightly higher than in the females (4.7%). In the affected patients, the mean number of congenitally missing teeth in the mandible was statistically higher than in the maxilla (p < 0.05). However, there was no significant difference in the number of congenitally missing teeth between left and right dentitions (p > 0.05). Excluding the Mn. third molars, the most frequent congenitally missing teeth site was the Mn. second premolars. In contrast, the most infrequent congenitally missing teeth sites were the Mx. and Mn. first premolars, and Mx. central incisors. The bilateral combination or antagonistic quadrants combination of congenitally missing teeth in hypodontia patients was 80.3%. The result of this study will contribute to clinicians to make accurate diagnosis and establish favorable treatment plans, by offering invaluable data about the number and distribution of congenitally missing teeth.