• Ocean and Polar Research
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• 제27권1호
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• pp.75-86
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• 2005

Acoustic survey for density and biomass estimate of Antarctic krill, Euphausia superba, was conducted in the large area between South Shetland Islands and South Orkney Islands, during November 30-December 30, 2002. Considering oceanographic and geographic properties, the study area was divided into six sub-regions. Acoustic system and frequency used in the survey were quantitative echo sounder (Simrad Ek 500) and 38, 120-kHz split beam transducers. In order to discriminate krill aggregations in all acoustic signal, difference of mean volume backscattering strength $({\Delta}MVBS)$ method of the two frequencies was introduced. Averaged krill density for the overall surveyed area was $23.5g/m^2$, and spatially averaged estimates of krill density were $44.9g/m^2$ (north of the South Shetland Islands), $30.3g/m^2$ (Bransfield Strait), $11.3g/m^2$ (near the Elephant Island), $13.6g/m^2$ (north of the Elephant Island), $18.1g/m^2$(between Elephant Island and South Orkney Islands) and $21.7g/m^2$(northwest of the South Orkney Islands) at each sub-area. In the two sub-regions with surveyed area, estimated krill biomass in the north of the Elephant Island was 0.315 million tones with a CV of 18.35% $(6,766mile^2)$, and between Elephant Island and South Orkey Islands was 1.26 million tones with a CV of 9.45% $(20,299mile^2)$. As a whole, the krill density in the early summer season was low level, comparing with that of January-February. This suggested that major krill swarms in the around South Shetland Islands were reached in the mid-summer seasons from western part of the Antarctic Peninsula, and the low krill density also affects the density variation of the krill between Elephant Island and South Orkney Islands.

• 동의생리병리학회지
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• 제23권5호
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• pp.986-992
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• 2009

Type I interferons (IFNs) are critical mediators of the innate immune system to defend viral infection. Interferon regulatory factor (IRF) and signal transducer and activator of transcription (STAT) play critical roles in type I IFN production in response to viral infection. Luteolin is natural polyphenolic compounds that have anti-inflammatory, cytoprotective and anti-carcinogenic effects. However, the mechanism of action and impact of luteolin on innate immunity is still unknown. In this study, we examined the effects of luteolin on the lipopolysacchride (LPS)-induced inflammatory responses. Luteolin inhibited Type I IFNs expression of mRNA and increased interleukin(IL)-10 expression of mRNA. Next, we examined the protective effects of IL-10 using IL-10 neutralizing antibody (IL-10NA). Blockade of IL-10 action didn't cause a significant reduction of Type I IFNs than LPS-induced luteolin pretreatment. Pretreatment of luteolin inhibited the level of IRF-1, and IRF-7 mRNA and the nuclear translocation of IRF-3. Also, luteolin reduced the activation of STAT - 1, 3. Theses results suggest that luteolin inhibits LPS-induced the production of Type I IFNS by both IRFs and STATs not IL-10 and may be a beneficial drug for the treatment of inflammatory disease.

• 한국방사선학회논문지
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• 제6권5호
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• pp.351-356
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• 2012

초음파 캐비테이션 현상이란 강한 초음파 조사 조건에서 매질(주로 유체) 내에서 미세기포를 발생시키고, 천이시키는 물리적 현상을 의미한다. 본 연구에서는 초음파 캐비테이션 발생량의 정량적 평가를 위하여 초음파 조사조건에 따른 기포군의 초음파 음향 특성변화를 관찰하였다. 중심 주파수가 500 kHz. 1.1 MHz인 곡면형 단일 초음파 변환기를 이용하여 캐비테이션 현상을 발생시켰으며, 형성되는 기포군을 가로지르는 2.25 MHz 간섭 초음파를 송/수신하여 분석하였다. 본 연구에서는 캐비테이션 발생량 평가를 위한 파라미터로 투과하는 파의 중심주파수 변화 및 감쇠 특성, 전파시간을 제시하였으며, 캐비테이션 발생 조건(조사 강도 및 여기 신호, 중심주파수)에 따른 변화를 관찰하였다. 획득된 간섭 초음파 수신신호를 분석한 결과, 중심 주파수의 변화의 경우 상관계수는 낮지만 조사 강도에 따른 상관관계를 확인할 수 있었으며, 특정 조사 조건에서 주목할 만한 급격한 중심 주파수 변화가 관찰되었다. 조사조건에 따른 간섭 초음파의 감쇠 추세는 모든 조건에서 높은 상관관계를 보였으며, 캐비테이션 발생형태에 영향을 받지 않는 것으로 확인되었다. 조사조건에 따른 전파 시간의 변화는 관찰되지 않았다. 차후 다양한 조사조건에 대한 평가를 통하여 보다 정량적인 캐비테이션 발생량 평가가 가능할 것으로 판단되며, 이러한 정량적 평가는 고강도 초음파 치료에서 발생할 수 있는 현상에 대한 기초 연구로서 활용 가능할 것으로 사료된다.

• 전기전자학회논문지
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• 제24권2호
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• pp.638-648
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• 2020

현재 지능화 된 협동로봇의 사용자 추종 방법은 비젼 시스템 기반 및 라이다를 이용한 사례가 일반적이고 성능도 우수하다. 그러나 2020년 전세계로 확산된 코로나19 사태에 폐쇄된 공간에서 의료진과 협동을 위한 로봇의 활약은 미흡한 실정이였다. 그 이유는 의료진들은 바이러스 감염 방지를 위하여 모두 방호복을 입고 있어 기존 연구된 기술로는 적용이 쉽지 않기 때문이다. 따라서 본 논문에서는 이러한 문제점을 해결하기 위하여 초음파 센서를 송신부와 수신부로 분리하여 이를 바탕으로 사용자의 위치를 추정하고 능동적으로 모바일 플랫폼이 사람을 따라다니며 협동 할 수 있는 기법을 제안하였다. 그러나 초음파센서는 경면반사 및 수, 발신 간 통신 단락으로 인한 불규칙 오차가 발생하고, 오차를 줄이기 위해 메디안 필터 일부 개선하여 적용하였으며 협소한 공간에서 원활한 작업 수행을 위해 곡률궤적을 적용해 주행기술을 향상시켰다. 실험 결과 메디안 필터 전, 후 거리, 각도의 오차는 약 70% 감소하였으며 'S', '8'자 코스 주행을 통해 주행 안정성을 확인하였다.

• 비파괴검사학회지
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• 제33권2호
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• pp.193-197
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• 2013

본 연구에서는 열처리된 알루미늄 합금의 초음파 비선형 특성을 평가하였다. 초음파의 비선형성은 재료를 전파한 초음파의 2차고조파와 기본주파수 성분의 진폭비에 의존하는 비선형 파라미터 ${\beta}$로 측정하였다. 비선형 파라미터 ${\beta}$의 측정은 접촉식 탐촉자를 이용하여 동일 평면상에서 시편저면에서 반사된 신호로부터 구하였다. 열처리(시효)는 $300^{\circ}C$에서 1시간부터 50시간까지 다양한 유지시간동안 수행하였다. 인장시험으로부터 인장강도와 연신율을 구하고 비선형 파라미터와 비교하였다. 비선형 파라미터 ${\beta}$는 시효시간 5시간에서 피크를 나타내고 이후는 감소하였다. 이는 인장강도와 연신율의 변화와 밀접한 관련이 있는 것으로 나타났다. 또한 비선형 파라미터가 피크를 나타낸 열처리 시간과 인장곡선에서 최대변화가 나타난 열처리 시간이 일치하였다. 이 같은 결과는 알루미늄합금의 시효처리로 인한 강도 변화를 모니터링 하는데 초음파의 비선형성이 유용할 수 있음을 보여준다.

• 대한한방내과학회지
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• 제19권1호
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• pp.385-408
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• 1998

Pyeongpaesan (平肺散) has been used in Korea for many centuries as a treatment for respiratory disease. The effect of Pyeongpaesan (平肺散) on tracheal smooth muscle is not known. The purpose of the present study is to determine the effect of Pyeongpaesan (平肺散) on histamine and acetylcholine induced tracheal smooth muscle contraction in rats and guinea pigs. Guinea pig (500 g, male) and Sprague Dawley rats (200 g, male) were killed by $CO_2$ exposure and a segment (8-10 mm) of the thoracic trachea from each rat and guinea pig was cut into equal segments and mounted 'in pairs' in a tissue bath. Contractile force was measured with force displacement transducers under 0.5 g loading tension. The dose of histamine (His) and acetylcholine (Ach) which evoked 50% of maximal response ($ED_{50}$) was obtained from cumulative dose response curves for histamine and acetylcholine $(10^{-7}{\sim}10^{-4}M)$. Contractions evoked by His $(ED_{50})$ and Ach $(ED_{50})$ were inhibited significantly by Pyeongpaesan (平肺散). In guinea pig tracheal smooth muscle, the mean percent inhibition of acetylcholine induced contraction was 13.5% (p<0.05) after $10{\mu}l/ml$ Pyeongpaesan (平肺散), $64.6\(p<0.01)\;after\;30{\mu}l/ml$ Pyeongpaesan (平肺散), and $92.8\(p<0.01)\;after\;100{\mu}l/ml$ Pyeongpaesan (平肺散). In rat tracheal smooth muscle, the mean percent inhibition of acetylcholine induced contraction was $60.9\(p<0.01)\;after\;30{\mu}l/ml$ Pyeongpaesan (平肺散), and $91.2\(p<0.01)\;after\;100{\mu}l/ml$ Pyeongpaesan (平肺散). Also, in guinea pig tracheal smooth muscle, the mean percent inhibition of histamine induced contraction was $104.8\(p<0.01)\;after\;30{\mu}l/ml$ Pyeongpaesan (平肺散) and $142.3\(p<0.01)\;after\;100{\mu}l/ml$ Pyeongpaesan (平肺散). In rat tracheal smooth muscle, the mean percent inhibition of histamine induced contraction was $63.7\(p<0.01)\;after\;30{\mu}l/ml$ Pyeongpaesan (平肺散), and $107.5\(p<0.01)\;after\;100{\mu}l/ml$ Pyeongpaesan (平肺散). Propranolol $(10^{-7}M)$ slightly but significantly attenuated the inhibitory effects of Pyeongpaesan (平肺散). Following treatment with propranolol, the mean percent inhibition caused by $100{\mu}l/ml$ Pyeongpaesan (平肺散) fell to 15.7% (p<0.05) in guinea pig induced by acetylcholine contraction and the mean percent inhibition caused by $100{\mu}l/ml$ Pyeongpaesan (平肺散) fell to 22.3% (p<0.05) in guinea pig induced by histamine contraction and by $100{\mu}l/ml$ Pyeongpaesan (平肺散) fell to 28.7% (p<0.01) in rat induced by histamine contraction. Indomethacin and methylene blue $(10^{-7}\;M)$ did not significantly alter the inhibitory effect of Pyeongpaesan (平肺散). Also, I could find the effects of Pyeongpaesan (平肺散) and Pyeongpaesanga (平肺散加) morphine on the tracheal smooth muscle in guinea pig and rat did not change significantly. These results indicate that Pyeongpaesan. (平肺散) can relax histamine and acetylcholine-induced contraction of guinea pig and rat tracheal smooth muscle, and that this inhibition involves sympathetic effects and the release of cyclooxygenase products.

• Asian Pacific Journal of Cancer Prevention
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• 제16권8호
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• pp.3117-3120
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• 2015

Objective: Interferon-${\gamma}$ (IFN-${\gamma}$) and signal transducers and activators of transcription (STATs) each play an important role in carcinogenesis associated with viral infection. Cervical cancer is almost invariably associated with infection by human papillomavirus (HPV), and previous studies suggested that dysregulation of the signal pathway involved in IFN-${\gamma}$ and STATs is associated. Our objective was to evaluate the association of SNPs in STAT2, STAT3, and IFN-${\gamma}$ with cervical cancer susceptibility in Chinese Han women in Hunan province. Materials and Methods: Genomic DNA was extracted from peripheral blood samples of 234 cervical cancer patients and 216 healthy female controls. STAT2 and STAT3 genotyping was performed using polymerase chain reaction-restriction enzyme (PCR-RE) analysis. IFN-${\gamma}$ genotyping was detected by PCR-amplification of specific allele (PASA). Results: For STAT2 rs2066807 polymorphisms, there was no significant difference of genotype distribution (P=0.827) and allele frequencies (P=0.830, OR=1.09, 95% CI: 0.51-2.31) between cases and controls. For STAT3 rs957970 polymorphisms, there was no significant difference of genotype distribution (P=0.455) and allele frequencies (P=0.560, OR=0.92, 95% CI: 0.71-1.20) between cases and controls. For IFN-${\gamma}$ +874A/T polymorphisms, there was no significant difference of genotype distribution (P=0.652) and allele frequencies (P=0.527, OR=1.12, 95% CI: 0.79-1.59) between cases and controls. Conclusion: These results suggest that polymorphisms in STAT2, STAT3 and IFN-${\gamma}$ genes are not likely to be strong predictors of cervical cancer in Han women in southern China.

• The Korean Journal of Physiology
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• 제4권1호
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• pp.19-28
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• 1970

In order to investigate the changes in the temperature regulation mechanism following ingestion of red pepper, twenty healthy man were given 2 gms of powdered red pepper each in 100 ml of water at room temperature, $20^{\circ}C$, Simultaneous recordings of temperature and electrical resistance of the skin of forehead were taken by means of Physiograph, using appropriate transducers. Temperature of various spots such as the cheek, upper tack and the forearm was also measured by the telethermometer at interval of two minutes. The results obtained were as follows: 1. Seventeen out of 20 subjects showed immediate rise in the skin temperature of the forehead, and 11 of them manifested the oscillating pattern of the skin temperature. The average of the largest peak amplitude was $0.58{\pm}0.355^{\circ}C$. 2. Even those who failed to show the immediate rise in the temperature did not keep the quiescence over 9 minutes, and delayed responses were revealed. 3. The rise in tile skin temperature is the favourable sign for the heat discipating mechanism only because the sweat glands are activated with the concomittant rise in the temperature of the skin. 4. There was a preceding or coincide fall in the electrical resistance of the skin, and it was also attributed to the glandular activity. 5. At rather cool room temperature, $20^{\circ}C$, no visible sweat was seen during the period of observation. Nevertheless it was obvious that latent activation of the sweat glands was triggered and the. threshold was lowered. This situation imitates the acclimatized condition in the hot environment, and it is likely to increase the tolerance in tropical climate from the view point of temperature regulation.

• 동의생리병리학회지
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• 제17권2호
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• pp.493-498
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• 2003

Paeoniae Radix, Glycyrrhizae Radix and Jakyakgamchotang have been used in Oriental Medicine for many centuries as a treatment for various disease. The purpose of the present study is to determine the effect of Paeoniae Radix, Glycyrrhizae Radix and Jakyakgamchotang on narepinephrine(NE) induced contraction of isolated rabbit femoral artery. Rabbits (2.0kg, female) were killed by CO₂ exposure and a segment (8-10mm) of the aortic ring from each rabbit was cut into equal segments and mounted 'in pairs' in a tissue bath. Contractile force was measured with force displacement transducers under 1.5g loading tension. The dose of NE which evoked 50% of maximal response (ED/sub 50/) was obtained from cumulative dose response curves for NE (10/sup -7/～10/sup -4/M). Contractions evoked by NE (ED/sub 50/) were inhibited significantly by Paeoniae Radix, Glycyrrhizae Radix and Jakyakgamcho-tang. The mean percent inhibition of NE induced contraction was 83.9% (p<0.01) after 150㎕/㎖ Paeoniae Radix, 101.1 %(p<0.01) after 150 ㎕/㎖, Glycyrrhizae Radix and 107.3%(p<0.01) after 150㎕/㎖ Jakyakgamcho-tang, Indomethacin slightly but significantly attenuated the inhibitory effects of Paeoniae Radix. Following treatment with indomethacin, the mean percent inhibition caused by 150㎕/㎖ Paeoniae Radix fell to 16.4% in femoral artery induced by NE contraction. Propranolol, ODQ, and L-NNA did not significantly alter the inhibitory effect of Paeoniae Radix. ODQ slightly but significantly attenuated the inhibitory effects of Glycyrrhizae Radix. Following treatment with ODQ, the mean percent inhibition caused by 150㎕/㎖ Glycyrrhizae Radix fell to 13.0% in femoral artery induced by NE contraction. Propranolol, indomethacin and L-NNA did not significantly alter the inhibitory effect of Glycyrrhizae Radix. L-NNA slightly but significantly attenuated the inhibitory effects of Jakyakgamchotang. Following treatment with L-NNA, the mean percent inhibition caused by 150㎕/㎖ Jakyakgamchotang fell to 13.8% in femoral artery induced by NE contraction. Propranolol, ODQ and indomethacin did not significantly alter the inhibitory effect of Jakyakgamcho-tang. These results indicate that Paeoniae Radix, Glycyrrhizae Radix and Jakyakgamcho-tang can relax NE induced contraction of the isolated rabbit femoral artery, and that this inhibition related to nitric oxide.

• 비파괴검사학회지
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• 제14권4호
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• pp.237-243
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• 1995

고체 시료를 대상으로 하여 silicon wafer에는 $90^{\circ}$ wedge형 진동자를 사용하고 압전재료인 $LiTaO_3$에는 interdigital transducer(IDT)를 사용하였으며, knife edge를 이용한 광학적 검지(optical probing)법을 써서 표면탄성파의 발생 및 측정하는 기법으로써 재료에서의 표면탄성파의 감쇠를 검출하는 방법을 연구하였다. IDT1 및 IDT2로는 20.8 MHz와 14.5 MHz를, $90^{\circ}$ wedge형 진동자로부터는 20.0 MHz의 표면탄성파를 발생시켰으며 표면탄성파로 생기는 표면의 굴곡을 검출하는데 He-Ne laser beam을 이용하였다. Optical chopper로 변조시킨 laser beam을 같은 주파수로 변조시킨 표면탄성파에 입사시켜 산란되는 광을 같은 주파수로 동조된 lock-in amplifier로 검출하였다. 이와 같이 함으로써 검출할 표면탄성파와 검출에 사용된 laser beam 및 측정기기인 위상감지기(Phase Sensitive Detector : PSD)를 같은 주파수로 변조하여 동기시킬 수 있었으며 측정계를 단순화하였다. IDT1, IDT2에서 발생된 표면탄성과의 감쇠계수는 각각 $0.62{\sim}0.75dB/mm,\;0.60{\sim}0.72dB/mm$였으며 wedge형 진동자에서는 $0.83{\sim}1.28dB/mm$인 값을 얻었다.