Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Flavonoid Luteolin Inhibits LPS-induced Type I Interferon in Primary Macrophages

플라보노이드 루테올린의 lippopolysacharide로 유도한 type 1 interferon 억제 효과

  • Jung, Won-Seok (Jeonnam Development Institute for Korean Traditional Medicine) ;
  • Bae, Gi-Sang (Department of Herbology, School of Oriental Medicine, Wonkwang University) ;
  • Cho, Chang-Re (Department of Herbology, School of Oriental Medicine, Wonkwang University) ;
  • Park, Kyoung-Chel (Department of Herbology, School of Oriental Medicine, Wonkwang University) ;
  • Koo, Bon-Soon (Department of Herbology, School of Oriental Medicine, Wonkwang University) ;
  • Kim, Min-Sun (Department of Herbology, School of Oriental Medicine, Wonkwang University) ;
  • Ham, Kyung-Wan (Department of Herbology, School of Oriental Medicine, Wonkwang University) ;
  • Jo, Beom-Yeon (Department of Herbology, School of Oriental Medicine, Wonkwang University) ;
  • Cho, Gil-Hwan (Department of Herbology, School of Oriental Medicine, Wonkwang University) ;
  • Seo, Sang-Wan (ChungBuk Oriental Medicine Center) ;
  • Lee, Si-Woo (Division of Constitutional Medicine Research, Korea Institute of Oriental Medicine) ;
  • Song, Ho-Joon (Department of Herbology, School of Oriental Medicine, Wonkwang University) ;
  • Park, Sung-Joo (Department of Herbology, School of Oriental Medicine, Wonkwang University)
  • 정원석 (전남 한방 산업 진흥원) ;
  • 배기상 (원광대학교 한의과대학 본초학교실) ;
  • 조창래 (원광대학교 한의과대학 본초학교실) ;
  • 박경철 (원광대학교 한의과대학 본초학교실) ;
  • 구본순 (원광대학교 한의과대학 본초학교실) ;
  • 김민선 (원광대학교 한의과대학 본초학교실) ;
  • 함경완 (원광대학교 한의과대학 본초학교실) ;
  • 조범연 (원광대학교 한의과대학 본초학교실) ;
  • 조길환 (원광대학교 한의과대학 본초학교실) ;
  • 서상완 (충북 제천 전통의약 산업센터) ;
  • 이시우 (한국 한의학 연구원) ;
  • 송호준 (원광대학교 한의과대학 본초학교실) ;
  • 박성주 (원광대학교 한의과대학 본초학교실)
  • Published : 2009.10.25
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Abstract

Type I interferons (IFNs) are critical mediators of the innate immune system to defend viral infection. Interferon regulatory factor (IRF) and signal transducer and activator of transcription (STAT) play critical roles in type I IFN production in response to viral infection. Luteolin is natural polyphenolic compounds that have anti-inflammatory, cytoprotective and anti-carcinogenic effects. However, the mechanism of action and impact of luteolin on innate immunity is still unknown. In this study, we examined the effects of luteolin on the lipopolysacchride (LPS)-induced inflammatory responses. Luteolin inhibited Type I IFNs expression of mRNA and increased interleukin(IL)-10 expression of mRNA. Next, we examined the protective effects of IL-10 using IL-10 neutralizing antibody (IL-10NA). Blockade of IL-10 action didn't cause a significant reduction of Type I IFNs than LPS-induced luteolin pretreatment. Pretreatment of luteolin inhibited the level of IRF-1, and IRF-7 mRNA and the nuclear translocation of IRF-3. Also, luteolin reduced the activation of STAT - 1, 3. Theses results suggest that luteolin inhibits LPS-induced the production of Type I IFNS by both IRFs and STATs not IL-10 and may be a beneficial drug for the treatment of inflammatory disease.

Keywords

References

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