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Flavonoid Luteolin Inhibits LPS-induced Type I Interferon in Primary Macrophages  

Jung, Won-Seok (Jeonnam Development Institute for Korean Traditional Medicine)
Bae, Gi-Sang (Department of Herbology, School of Oriental Medicine, Wonkwang University)
Cho, Chang-Re (Department of Herbology, School of Oriental Medicine, Wonkwang University)
Park, Kyoung-Chel (Department of Herbology, School of Oriental Medicine, Wonkwang University)
Koo, Bon-Soon (Department of Herbology, School of Oriental Medicine, Wonkwang University)
Kim, Min-Sun (Department of Herbology, School of Oriental Medicine, Wonkwang University)
Ham, Kyung-Wan (Department of Herbology, School of Oriental Medicine, Wonkwang University)
Jo, Beom-Yeon (Department of Herbology, School of Oriental Medicine, Wonkwang University)
Cho, Gil-Hwan (Department of Herbology, School of Oriental Medicine, Wonkwang University)
Seo, Sang-Wan (ChungBuk Oriental Medicine Center)
Lee, Si-Woo (Division of Constitutional Medicine Research, Korea Institute of Oriental Medicine)
Song, Ho-Joon (Department of Herbology, School of Oriental Medicine, Wonkwang University)
Park, Sung-Joo (Department of Herbology, School of Oriental Medicine, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.23, no.5, 2009 , pp. 986-992 More about this Journal
Abstract
Type I interferons (IFNs) are critical mediators of the innate immune system to defend viral infection. Interferon regulatory factor (IRF) and signal transducer and activator of transcription (STAT) play critical roles in type I IFN production in response to viral infection. Luteolin is natural polyphenolic compounds that have anti-inflammatory, cytoprotective and anti-carcinogenic effects. However, the mechanism of action and impact of luteolin on innate immunity is still unknown. In this study, we examined the effects of luteolin on the lipopolysacchride (LPS)-induced inflammatory responses. Luteolin inhibited Type I IFNs expression of mRNA and increased interleukin(IL)-10 expression of mRNA. Next, we examined the protective effects of IL-10 using IL-10 neutralizing antibody (IL-10NA). Blockade of IL-10 action didn't cause a significant reduction of Type I IFNs than LPS-induced luteolin pretreatment. Pretreatment of luteolin inhibited the level of IRF-1, and IRF-7 mRNA and the nuclear translocation of IRF-3. Also, luteolin reduced the activation of STAT - 1, 3. Theses results suggest that luteolin inhibits LPS-induced the production of Type I IFNS by both IRFs and STATs not IL-10 and may be a beneficial drug for the treatment of inflammatory disease.
Keywords
luteolin type I interferon(IFN); lipopolysacchride(LPS); interferon regulatory factor(IRF); signal transducers and activators of transcription(STAT);
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1 Platanias, L.C. Nat Rev Immunol 5: 375-386, 2005   DOI   PUBMED   ScienceOn
2 Takeda, K., Akira, S. Int Immunol 17: 1-14, 2005   DOI   PUBMED   ScienceOn
3 Nguyen, H., Hiscott, J., Pitha, P.M. Cytokine Growth Factor Rev 8: 293-312, 1997   DOI   ScienceOn
4 Xagorari, A., Papapetropoulos, A., Mauromatis, A., Economou, M., Fotsis, T., Roussos, C. J Pharmacol Exp Ther 296(1):181-187, 2001
5 Chen, C.Y., Peng, W.H., Tsai, K.D., Hsu, S.L. Life Sciences 81: 1602-1614, 2007   DOI   PUBMED   ScienceOn
6 Kawai, T., Takeuchi, O., Fujita, T., Inoue, J., Muhlradt, P.F., Sato, S., Hoshino, K., Akira, S. J Immunol 167(10):5887-5894, 2001   DOI
7 Yamamoto, M., Sato, S., Hemmi, H., Uematsu, S., Hoshino, K., Kaisho, T., Takeuchi, O., Takeda, K., Akira, S. Nat Immunol 4(11):1144-1150, 2003   DOI   ScienceOn
8 Guo, B., Chang, E.Y., Cheng, G. J Clin Invest 118: 1680-1690, 2008   DOI   ScienceOn
9 Taniguchi, T., Takaoka, A. Nat Rev Mol Cell Biol 2: 378-386, 2001   DOI   ScienceOn
10 Takaoka, A., Hayakawa, S., Yanai, H., Stoiber, D., Negishi, H., Kikuchi, H., Sasaki, S., Imai, K., Shibue, T., Honda, K., Taniguchi, T. Nature 424: 516-523, 2003   DOI   PUBMED   ScienceOn
11 Sakaguchi, S., Negishi, H., Asagiri, M., Nakajima, C., Mizutani, T., Takaoka, A., Honda, K., Taniguchi, T. Biochem Biophys Res Commun 306: 860-866, 2003   DOI   PUBMED   ScienceOn
12 Barnes, B.J., Moore, P.A., Pitha, P.M. J Biol Chem 276: 23382-23390, 2001   DOI   ScienceOn
13 Alexopoulou, L., Holt, A.C., Medzhitov, R., Flavell, R.A. Nature 413: 732-738, 2001   DOI   ScienceOn
14 Rice-Evans, C.A., Miller, N.J. Biochem Soc Trans 24(3):790-795, 1996   DOI   PUBMED
15 Middleton, Jr. E., Kandaswami, C., Theoharides, T.C. Pharmacol Rev 52: 673-751, 2002
16 Taniguchi, T., Mantei, N., Schwarzstein, M., Nagata, S., Muramatsu, M., Weissmann, C. Nature 285: 547-549, 1980   DOI   ScienceOn
17 Kurt-Jones, E.A., Popova, L., Kwinn, L., Haynes, L.M., Jones, L.P., Tripp, R.A., Walsh, E.E., Freeman, M.W., Golenbock, D.T., Anderson, L.J., Finberg, R.W. Nat Immunol 1: 398-401, 2000   DOI   ScienceOn
18 Katze, M.G., He, Y., Gale, M. Jr. Nat Rev Immunol 2: 675-687, 2002   DOI   ScienceOn
19 Pestka, S., Langer, J.A., Zoon, K.C., Samuel, C.E. Annu Rev Biochem 56: 727-777, 1987   DOI   ScienceOn
20 Iwasaki, A., Medzhitov, R. Nat Immunol 5: 987-995, 2004   DOI   ScienceOn
21 Honda, K., Takaoka, A., Taniguchi, T. Immunity 25: 349-360, 2006   DOI   ScienceOn
22 Vilcek, J., Sen, G.S. 'Interferons and other cytokines', Virology, 3rd edn, eds by Fields, D.M., Knipe, P.M., Howley, P.M. Lippincott-Raven, Philadelphia, PA, p 395, 1996
23 Samuel, C.E. Clin Microbiol Rev 14: 778-809, 2001   DOI   PUBMED   ScienceOn
24 Toshchakov, V., Jones, B.W., Perera, P.Y., Thomas, K., Cody, M.J., Zhang, S., Williams, B.R., Major, J., Hamilton, T.A., Fenton, M.J., Vogel, S.N. Nat Immunol 3: 392-398, 2002   DOI   ScienceOn
25 Biron, C.A. Immunity 14: 661-664, 2001   DOI   PUBMED   ScienceOn
26 Moore, K.W., de Waal Malefyt, R., Coffman, R.L., O'Garra, A. Annu Rev Immunol 19: 683-765, 2001   DOI   ScienceOn
27 Taniguchi, T. Annu Rev Immunol 6: 439-464, 1988   DOI   ScienceOn
28 Monica, C., Isabel, B., Elvira, B., Saleta, S., Jordi, Z., Julio, G., Fermin, S.M., Antonio, Z. Biochem Pharm 72: 1010-1021, 2006   DOI   ScienceOn
29 Stark, G.R., Kerr, I.M., Williams, B.R., Silverman, R.H., Schreiber, R.D. Annu Rev Biochem 67: 227-264, 1998   DOI   ScienceOn
30 Gallucci, S., Lolkema, M., Matzinger, P. Nat Med 5: 1249-1255, 1999   DOI   ScienceOn
31 Xaus, J., Comalada, M., Valledor, A.F., Cardo, M., Herrero, C., Soler, C., Lloberas, J., Celada, A. Immunobiology 204: 534-550, 2001   DOI   ScienceOn
32 Karaghiosoff, M., Steinborn, R., Kovarik, P., Kriegshauser, G., Baccarini, M., Donabauer, B., Reichart, U., Kolbe, T., Bogdan, C., Leanderson, T., Levy, D., Decker, T., Müller, M. Nat Immunol 4: 471-477, 2003   DOI   ScienceOn
33 Takayanagi, H., Kim, S., Matsuo, K., Suzuki, H., Suzuki, T., Sato, K., Yokochi, T., Oda, H., Nakamura, K., Ida, N., Wagner, E.F., Taniguchi, T. Nature 416: 744-749, 2002   DOI   ScienceOn
34 Taniguchi, T., Ogasawara, K., Takaoka, A., Tanaka, N. Annu Rev Immunol 19: 623-655, 2001   DOI   ScienceOn
35 Honda, K., Yanai, H., Negishi, H., Asagiri, M., Sato, M., Mizutani, T., Shimada, N., Ohba, Y., Takaoka, A., Yoshida, N., Taniguchi, T. Nature 434: 772-777, 2005   DOI   ScienceOn
36 Levy, D.E., Marie, I., Prakash, A. Curr Opin Immunol 15: 52-58, 2003   DOI   ScienceOn
37 Theofilopoulos, A.N., Baccala, R., Beutler, B., Kono, D.H. Annu Rev Immunol 23: 307-336, 2005   DOI   ScienceOn
38 Hoshino, K., Kaisho, T., Iwabe, T., Takeuchi, O., Akira, S. Int Immunol 14: 1225-1231, 2002   DOI   ScienceOn
39 Jung, M., Sabat, R., Kratzschmar, J., Seidel, H., Wolk, K., Shonbein, C., Schutt, S., Friedrich, M., Docke, W.D., Asadullah, K., Volk, H.D., Grütz, G. Eur J Immunol 34: 481-493, 2004   DOI   ScienceOn
40 Haynes, L.M., Moore, D.D., Kurt-Jones, E.A., Fingberg, R.W., Anderson, L.J., Tripp, R.A. J Virol 75: 10730-10737, 2001   DOI   ScienceOn
41 Mamane, Y., Heylbroeck, C., Genin, P., Algarte, M., Servant, M.J., LePage, C., DeLuca, C., Kwon, H., Lin, R., Hiscott, J. Gene 237: 1-14, 1999   DOI   ScienceOn
42 Weissmann, C., Weber, H. Prog Nucleic Acid Res Mol Biol 33: 251-300, 1986   DOI   PUBMED
43 Levy, D.E., Garcia-Sastre, A. Cytokine Growth Factor Rev 12: 143-156, 2001   DOI   ScienceOn
44 Shinohara, M.L., Kim, J.H., Garcia, V.A., Cantor, H. Immunity 29: 68-78, 2008   DOI   ScienceOn
45 Miyamoto, M., Fujita, T., Kimura, Y., Maruyama, M., Harada, H., Sudo, Y., Miyata, T., Taniguchi, T. Cell 54: 903-913, 1988   DOI   PUBMED   ScienceOn
46 Lin, Q., Dong, C., Cooper, M.D. J Exp Med 187: 79-87, 1998   DOI   ScienceOn
47 Hertzog, P.J., O'Neill, L.A., Hamilton, J.A. Trends Immunol 24: 534-539, 2003   DOI   ScienceOn
48 Pestka, S., Krause, C.D., Walter, M.R. Immunol Rev 202: 8-32, 2004   DOI   ScienceOn
49 Takaoka, A., Taniguchi, T. Cancer Sci 94: 405-411, 2003   DOI   ScienceOn
50 Le Bon, A., Tough, D.F. Curr Opin Immunol 14: 432-436, 2002   DOI   ScienceOn
51 Sato, M., Suemori, H., Hata, N., Asagiri, M., Ogasawara, K., Nakao, K., Nakaya, T., Katsuki, M., Noguchi, S., Tanaka, N., Taniguchi, T. Immunity 13: 539-548, 2000   DOI   ScienceOn