• Journal of the Korean Society of Physical Medicine
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• v.18 no.2
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• pp.41-48
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• 2023

PURPOSE: Falls are caused by a decline in physical and cognitive function. A quantitative evaluation tool that can comprehensively evaluate motor and cognitive functions for elderly people with an impaired physical function. This study assessed the clinical application potential by confirming the correlation between the physical function tests, cognitive and the stepping trail-making test (S-TMT). METHODS: Fourteen community-dwelling older patients (65-75 years) were recruited. The study conducted cognitive function tests with the trail-making test (TMT-A, B), and physical function tests (6-minute walking test (6MWT), short physical performance battery (SPPB), and timed up and go (TUG)). The results of were analyzed using SPSS version 21.0. Descriptive statistics were used for the general characteristics of the study subjects, and the correlations between S-TMT, other functional tests were examined through Pearson's correlation analysis. The statistical significance was set to .05. RESULTS: S-TMT had a significant positive correlation with the TUG (r = .588^*) and trail-making test-B (TMT-B) (r = .689^*, p < .05). Furthermore, S-TMT showed a negative correlation between SPPB (r = -.397) and 6MWT (r = -.422), but it was not statistically significant. CONCLUSION: S-TMT is a cognitive-gait dual-task performance evaluation tool that can be performed safely. A significant correlation was confirmed between the TUG test and the TMT-B. S-TMT is a dual-task screening tool that can evaluate both physical and cognitive functions simultaneously.

• Korean Journal of Occupational Therapy
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• v.26 no.4
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• pp.127-143
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• 2018

Objective : The purpose of this study was to compare with the effects of driving simulator and Dynavision training after stroke through the test of cognitive ability and driving performance. Methods : Twenty-one stroke patients were randomly classified to the driving simulator training group (N=11) and Dynavision training group (N=10), and were carried out respectively training for 15 times. The driving performances was measured by the driving simulator test, and cognitive-perceptive abilities was measured by the DriveABLE Cognitive Assessment Tool, Trail Making Test-A, Trail Making Test-B and Mini Mental State Examination-K. Results : The driving simulator training group showed significant changes in all cognitive tests and most of driving performances. The Dynavision training group also showed significant changes in all cognitive tests except for Trail Making Test-A and some driving performances. The significant differences on both groups were found regarding the estimated degree of results on the on-road evaluation, the number of off road accidents and collisions. In addition, the causal influence of the two training methods on these variables was analyzed to be more than 20%. Conclusion : The driving simulator and Dynavision training were found to be effective intervention in the driving rehabilitation after stroke. In particular, it was confirmed that the driving simulator is an effective training to improve overall driving ability of stroke patients. In addition, the difference in training effect between the two training methods was found to be more than 20%.

• Tuberculosis and Respiratory Diseases
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• v.65 no.6
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• pp.476-486
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• 2008

Background: TRAIL (TNF-related apoptosis inducing ligand) is a newly identified member of the TNF gene family which appears to have tumor-selective cytotoxicity due to the distinct decoy receptor system. TRAIL has direct access to caspase machinery and induces apoptosis regardless of p53 phenotype. Therefore, TRAIL has a therapeutic potential in lung cancer which frequently harbors p53 mutation in more than 50% of cases. However, it was shown that TRAIL also could activates $NF-{\kappa}B$ in some cell lines which might inhibit TRAIL-induced apoptosis. This study was designed to investigate whether TRAIL can activate $NF-{\kappa}B$ in lung cancer cell lines relatively resistant to TRAIL-induced apoptosis and inhibition of $NF-{\kappa}B$ activation using proteasome inhibitor MG132 which blocks $I{\kappa}B{\alpha}$ degradation can sensitize lung cancer cells to TRAIL-induced apoptosis. Methods: A549 (wt p53) and NCI-H1299 (null p53) lung cancer cells were used and cell viability test was done by MTT assay. Apoptosis was confirmed with Annexin V assay followed by FACS analysis. To study $NF-{\kappa}B$-dependent transcriptional activation, a luciferase reporter gene assay was used after making A549 and NCI-H1299 cells stably transfected with IgG ${\kappa}-NF-{\kappa}B$ luciferase construct. To investigate DNA binding of $NF-{\kappa}B$ activated by TRAIL, electromobility shift assay was used and supershift assay was done using anti-p65 antibody. Western blot was done for the study of $I{\kappa}B{\alpha}$ degradation. Results: A549 and NCI-H1299 cells were relatively resistant to TRAIL-induced apoptosis showing only 20~30% cell death even at the concentration 100 ng/ml, but MG132 ($3{\mu}M$) pre-treatment 1 hour prior to TRAIL addition greatly increased cell death more than 80%. Luciferase assay showed TRAIL-induced $NF-{\kappa}B$ transcriptional activity in both cell lines. Electromobility shift assay demonstrated DNA binding complex of $NF-{\kappa}B$ activated by TRAIL and supershift with p65 antibody. $I{\kappa}B{\alpha}$ degradation was proven by western blot. MG132 completely blocked both TRAIL-induced $NF-{\kappa}B$ dependent luciferase activity and DNA binding of $NF-{\kappa}B$. Conclusion: This results suggest that inhibition of $NF-{\kappa}B$ can be a potentially useful strategy to enhance TRAIL-induced tumor cell killing in lung cancer.

• Journal of the Korean Institute of Landscape Architecture
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• v.29 no.1
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• pp.11-21
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• 2001

This study investigates how motivations, preferences, and past experiences vary by each hikers trail choice at the Mt.Keyryong National Park. The purpose of this study is to find out the factors influencing behavioral choice in the recreation areas, and establish the fundamental theory for the efficient management of the resource and visitors. For this study, we have collected 472 respondents by on-site self-administrated questionnaire from the hikers in the park. The collected data were analyzed by the descriptive statistics and the discriminant analysis. The motivations variable of hiking participation on mountain trail were categorized three types; close-nature, escapism, and physical improvement. The preferences for trail environment were classified as four categories by factor analysis; preference for nature, safety, use density, and facilities. In descriptive statistics, the study showed that the experienced hikers prefer natural trials and hikers who have preference for close-nature select longer and deeper forest trails. The results of discriminant analysis indicate that the level of past experience is the most affectable in classification of trail choice. Such variables as motivation for close-nature and preference for nature were also appeared as affecting factors on classification of trail choice. Two discriminant functions were available, and 90.5 percent of analysis sample were correctly classified. In the validity analysis, 89 percent of holdout sample were correctly classified. These hit ratios ensures an accuracy by Press Q test. The result of this study is to be useful knowledge of the choice of detailed use environments in the same recreation areas.

• Korean Journal of Biological Psychiatry
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• v.12 no.2
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• pp.173-180
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• 2005

Purpose:We investigated the effect of menopausal duration on cognitive function using adjunctive hormone replacement therapy(HRT) in postmenopausal women with depression. Method:Twelve postmenopausal women with depressive disorder were enrolled. Six patients having menopausal duration of less than 3 years was assigned to the short duration group and six patients of more than 3 years to the long duration group. Each patient was treated with conjugated equine estrogen(1.25mg) plus medroxyprogesterone(5mg) for 8 weeks. Cognitive performance was measured by the Verbal Memory Test, Visual Memory Test, Trail Making Test, Digit Symbol Test, and Attention Shift Test. The Beck Depression Inventory was used for evaluation of depressed mood. The reproductive hormone levels were also measured. Results:The long duration group showed the lower performance only in Trail Making Test B compared with the short duration group at baseline. After 8 weeks, the long duration group performed significantly better in the Trail Making Test B compared with the short duration group. The differences in change of depressive mood and gonadal hormone level between two groups were not significant. Conclusion:Menopausal duration before HRT may influence the effect of estrogen on cognition in some cognitive domains. This might be related with estrogen receptor hypersensitivity which induced by the longer estrogen deficiency.

• Journal of Korea Entertainment Industry Association
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• v.13 no.8
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• pp.505-514
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• 2019

The purpose of this study is to analyze the difference of the visual perception and attention of the people with intellectual disability from the application of the assessment applying an electronic media and traditional paper material. The study subjects were 12 people with intellectual disability, To assess the visual perception, the motor free visual perception test-3 was used and the trail making test was used to assess the visual attention. After the assessment of the visual perception and attention applying the traditional paper material, the assessment applying the electronic media. The results of the visual perception and attention showed the difference of the visual perception and attention, and the scores of the visual perception and attention applying the assessment of the electronic media showed the more higher than the assessment of the traditional paper material. The electronic media could be worked as a factor to increase the visual perception and attention of the people with intellectual disability. Thus, the difference should be considered to apply the electronic media for them.

• Journal of the Korean Institute of Landscape Architecture
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• v.21 no.4
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• pp.83-99
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• 1994

To compare basic information and to inspect impacts situations between 1987 and 1992, this study was executed in Chongnung valley of Mt. Puk'an. And to provide basic informations through the change of plant species diversity, some methods were applied and analyzed such as the degree of environmental impacts and belt-transect method. The results were summarized as follows; 1. In order to find environmental impacts by visitor, the degree of environmental impacts class that was proposed by Kwon(1991) was implicated. In 4 sites, total area of over impact class 2 is 86,692$m^2$ and area of impacts class 4-6 that is impossible to recover naturally is 36,856$m^2$. Totally, the impacted area was profounded qualitatively and quantitatively against 1987's. 2. In the vegetation change by visitor's impacts, species diversity was rapidly decreased as nearer the campsite and trail. And in the basal area and coverage, lower layer species was sensitively changed. Trampling-resistent species is as following; Robinia pseudoacacia, Lespedeza cyrtobotrya, Staphylea bumalda, Clerdendron trichotomum, Stephanandra incisa, Rubus crataegifolius, Lespedeza maximowiczii, Weigela subsessilis, Rosa multiflora, Zanthoxylum schinifolium, Lindera obtusiloba, Callicarpa japonica, Sorbus alnifolia, Symplocos mongolica and so on. In the results of soil hardness test, that was decreased as far away from campsite and trail. 3. In the 4 sites selected in Chongnung valley of Puk'ansan Natioal Park, management plans was largely divided 4 category, such as trail improvement, facilities setting, ecotone vegetation establishment, and vegetation rehabilitation. And a suggestion was provided to each site.

• Korean Journal of Adult Nursing
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• v.16 no.2
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• pp.245-255
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• 2004

Purpose: this study was to evaluate Cognitive Function Test for the Korean population. Digit Forward (DF), Digit Backward (DB) and Trail Making Test-A(TMT-A) and the translated version of the Trail Making Test-B (TMT-B) were used. The study examined the performance of Korean normal adult population whose age ranged from 20 to over 80. It was predicted that performances of the Korean population would be different from that of the United States population due primarily to their differences in language, and education. Method: Normal Korean adults at the Daejeon Metropolitan City and Chungchung Province (N=298) participated in this study. Seven age scores were evaluated; 20~29, 30~39, 40~49, 50~59, 60~69, 70~79, & >80s. The effects of age, gender, and years of education was examined, which yielded significant age and education effects. The scores were further specified accordingly in terms of years of education (0, 1~6, 7~12, 13~16, & >17), and gender. Result: As the age increased cognitive function score decreased. As the years of education increased, cognitive function scores increased. There was no difference in cognitive function scores according to gender. Age and year of education had significant effects on cognitive function and explained 52-58% of variants of each test. Conclusion: The data of the cognitive function tests are expected to be utilized for research purposes such as basic and clinical studies, as well as practical purpose such as cognitive assessment for traumatic brain injury, stroke, and elderly and nursing education for assessment tools.

• Journal of Oriental Neuropsychiatry
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• v.24 no.1
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• pp.27-44
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• 2013

Objectives : This study was designed to investigate the effects of Gastrodia elata Blume on the improvement of memory. Methods : This study was a 12 week, double blind, comparative clinical study. There were eligible who worked with a group of healthy seniors, all 60 years of age or older. 50 subjects were randomized either to Gastrodia elata Blume in powder form and steep in hot water or placebo. We measured the faculty of memory by using K-DRS, MMSE-K, Digit Span, Letter Fluency Test, Word List Memory Test, and the Trail Making Test, and after 12 weeks we measured the faculty of memory again using the same methods. Results : Gastrodia elata Blume steeps in the hot water group significantly increased. Initiation, perseveration level, and Memory level of K-DRS and MMSE-K score. There were no considerable differences between three groups in Digit Span and Trail Making Test score. Gastrodia elata Blume group showed significant advances in Letter Fluency Test and recognition of Word List Memory Test. Conclusions : The results suggest that Gastrodia elata Blume may have positive effects on memory improvement and function of the frontal lobe activation.

• Proceeding of Spring/Autumn Annual Conference of KHA
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• 2009.04a
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• pp.199-203
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• 2009

The purpose of this research is to investigate how the indoor temperature has influence on occupants' attention abilities as a basis of productivity. To achieve the purpose, the experiment in chamber was conducted. In the experiment, temperature was controlled according to two levels ($20^{\circ}C$ or $23^{\circ}C$) and other of factors were controlled uniformly. Subjects were exposed to those two different thermal environments. Each participant was asked to mark their answers on the state of attention measurement sheets (FAIR and Trail making test), in two conditions. Total 60 times of experiments were conducted. The main results are as follows. First, subjects showed the better attention abilities in relation to Q score at $20^{\circ}C$. But on the other hand attention abilities in relation to C score were better at $23^{\circ}C$. Second, subjects showed the better attention abilities in relation to concentrate on one task at $20^{\circ}C$.