• Journal of Physiology & Pathology in Korean Medicine
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• v.32 no.5
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• pp.321-327
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• 2018

The purpose of this study was to investigate the effects of Cuscuta chinensis Lamark ethanol extract (CL) on wrinkle improvement. Cuscuta chinensis Lamark is known to contain dried saccharide, alkaloids, flavonoids, lignans and rein glycoside as major components of dried mature seeds of Cuscuta japonica Choisy. In this study, we evaluated the anti-wrinkle effects of CL and investigated bio-markers (e.g ; MMP-1, MMP-3, MMP-9, TIMP-1, type I procollagen) associated with skin wrinkle improvement. We tested the anti-wrinkle effect of CL using human fibroblast called CCD-986Sk cell. We observed an increase in MMPs, TIMP-1, and type 1 pro-collagen CL in CCD-986Sk cells irradiated with UVB at an intensity of $2mJ/cm^2$ for 60 seconds. As a result, CL decreased UVB-induced MMPs levels and mRNA expressions in CCD-986Sk cell. The levels and mRNA expressions of type I procollagen and TIMP-1 were increased by CL. These results suggest that CL has activities on improvement of skin wrinkle, which is induced by UVB radiation. Taken together, this study proposed the possibility of developing herbal medicine and functional herbal cosmetic materials with wrinkle-improving effects of Cuscuta chinensis Lamark.

• Journal of Physiology & Pathology in Korean Medicine
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• v.21 no.2
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• pp.485-490
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• 2007

Zingiberis rhizoma(ZB) has been used to treat a various condition and disease in many traditional preparation. The present study was conducted to investigate the immunomodulatory effect on cyclophosphamide(CY)-induced immunotoxicity of aqueous-extracted ZB(ZBE) using in vitro and in vivo experiment. In vitro experiment, the mouse spleen cells proliferation and nitric oxide(NO) production in RAW 264.7 mouse macrophage cells were investigated. ZBE enhanced mitogenic activity in mouse spleen cells. The suppression of CY-induced mouse speen cell proliferation was significantly restored by ZBE treatment. ZBE inhibited NO production, iNOS mRNA and protein levels in LPS-stimulated RAW 264.7 cells. In vivo experiment, ZBE was orally administrated(single dose of 150mg/kg for 12 days) and CY i.p(150mg/kg) injected to SD rats. In CY alone injected group, body weights and spleen weights, and a various hematological parameters were reduced when compared with control group, whereas those values were increased by concomitant treatment of CY and ZBE when compared with CY alone injected group. These results indicated that ZBE can modulate CY-induced immune suppression through immune cell proliferation, the regulation of NO production and the inhibition of CY-induced immunotoxicity.

• Journal of Physiology & Pathology in Korean Medicine
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• v.18 no.4
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• pp.1098-1101
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• 2004

This study was carried out to investigate the solubility of the ingredients of the kidney stone in the solution of the traditional oriental medicines. Calcium hydroxide, apatite and uric acid were chosen as the ingredients of the kidney stone. Plantaginis Semen, Lysimachiae Herba, Saururi Herba seu Rhizoma, Imperatae Rhizoma, Allium tuberosum Rottler were studied as the oriental medicines for the kidney stone. Calcium hydroxide had showed the very good solubility in the solution of Imperatae Rhizoma, the apatite had showed the good solubility in the solutions of Saururi Herba seu Rhizoma and Allium tuberosum Rottler. Uric acid had showed the mild solubility in the solution of Lysimachiae Herba and Saururi Herba seu Rhizoma.

• Proceedings of the Korean Society of Veterinary Pathology Conference
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• 2000.09a
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• pp.21-21
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• 2000

We performed this study to determine the effect of Bu-Zhong-Yi-Qi-Tang, as a prescription of traditional Oriental medicine, and its major ingredients on jejunal crypt survival, endogenous spleen colony formation, and apoptosis in jejunal crypt cells of mice irradiated with high and low dose of r-radiation. Bu-Zhong-Yi-Qi-Tang administration before irradiation protected the jejunal crypts (p<0.0001), increased the formation of endogenous spleen colony (p<0.05) and reduced the frequency of radiation-induced apoptosis (p<0.05). (omitted)

• Journal of Physiology & Pathology in Korean Medicine
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• v.20 no.3
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• pp.634-637
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• 2006

The GC pictures were taken to investigate the difference of the Samul-tang and Sakunja-tang, each prepared by the different boiling methods, which were the traditional method(using cover), using the condenser, and using no cover. For Samul-tang, there was not much difference in the GC pictures, but the one pick(rt about 7 min.) of the picture by the method using the condenser had the higher intensity than those in the pictures by other methods. For Sakunja-tang, the GC pictures of the method using the condenser had shown a lot of the peaks and the very high intensity, which were much better than those of the picture by the traditional method. However, the GC pictures of the method by using no cover had shown almost nothing.

• Journal of Physiology & Pathology in Korean Medicine
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• v.16 no.5
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• pp.888-892
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• 2002

Nae-Kyung says the puberty is corresponded to the age of 16～24(male) and 14～21 (female). And that time they are promoted the growth. However, Kidney qi doesn't make average situation during that time. So, the function of five viscera and six entrails fails to be perfect and symptoms appear. I came to the conclusion through the survey of about 200 high school students(male and female) and the theory of oriental medicine the distinctive features (like migraine, amnesia, depression, dysphoria, inappetence, irregular menstruation) came out that time. I defined this distinctive symptoms in boys and girls at puberty ‘synthetic symptoms of puberty’. For the medical cure and prevention I prescribed ‘Sachun-Nyung’ and that has medical benefits for ‘Replenishing qi and relieving the spleen, Soothing the liver and promoting blood circulation’

• Journal of Physiology & Pathology in Korean Medicine
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• v.25 no.5
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• pp.894-899
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• 2011

Traditional Korean Medicine (TKM) has been actively researched through various approaches, including computational methods. This paper aims at providing an overview of domestic studies using the computational techniques in TKM field. A literature search was conducted in Korean publications using OASIS system, and major studies of data mining in TKM were identified. A review was presented in six diagnosis fields, including sasang constitution diagnosis, eight constitution diagnosis, tongue diagnosis, pattern diagnosis for stroke, diagnosis based on ontology, diagnosis for cause of disease. They collect clinical data themselves for experiments and primarily applied a algorithm of decision tree, SVM, neural network, case-based reasoning, ontology reasoning, discriminant analysis. In the future, there needs to identify which algorithm is suitable to diagnosis or other fields of TKM.

• Journal of Physiology & Pathology in Korean Medicine
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• v.27 no.5
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• pp.594-601
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• 2013

The aim of this study was to analyze the differences between Qigong and Daoyin as a therapeutic exercise of traditional Korean medicine. We searched Pubmed and Chinese Academic Journals(CAJ) over time periods from their inception to August 13th, 2013. We analyzed the systematic reviews of Qigong and clinical trials of Daoyin. Total 12 Qigong and 16 Daoyin(11 Baduanjin, 4 Wuqinxi, 1 unspecified type of Daoyin) articles were met our inclusion criteria. As the results of our analyzation, Qigong was dominant in chronic or incurable disease. On the other hand, Daoyin was dominant in internal diseases or functional improving of internal organs. As using "Qi" is in common between Qigong and Daoyin, they have not been differentiated in world of traditional Korean medicine. However, it could be better to use the Qigong and Daoyin according to their effectual difference.

• Journal of Physiology & Pathology in Korean Medicine
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• v.18 no.2
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• pp.359-370
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• 2004

Before the current western medicine was spreaded out in the world as the main stream, each country had treated diseases with the medicine of their own and the traditional medical books, which are so characteristic, are handed down. Considering the earnest assignment to do in Korean medical of this age and one of the tendencies of medical circles in the world is putting together the current medicine with the traditional medicine, the production and spread of the classification system for the technical books which is contained the characteristic of traditional chinese medicine, the present condition of modern chinese medicine, and the future of it, must be settled without delay. The classification system for oriental medicine section developed in the range of the simple system before the time of flowering, since then the western medicine had grew as the main current in medicine in Korea. But until now the rational and realistic classification system based on the changeable time isn't be established, so setting up one of the classification systems for medicine section, it is classified according to the principle of classification system for medicine section. Hereupon, the result was made after researching the changes of modern classification system for korean and studying on the changes of classification system for oriental medicine section of the Korean decimal classification.

• Journal of Physiology & Pathology in Korean Medicine
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• v.23 no.2
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• pp.337-342
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• 2009

Acquired pigmentary skin diseases such as abnormal melanogenesis, vitiligo, chloasma and inflammatory pigmentation are related to regulate the melanin production, In this study, an ethanol extract of Hovenia dulcis Thunb.(EHD) makedly inhibited melanin biosynthesis and suppressed, the protein expression of tyrosinase, tyrosinase-related protein 1(TRP-1), and tyrosinase-related protein 2(TRP-2) in B16F10 cells. On the other hand, EHD did not inhibit mushroom tyrosinase activity. These results indicate that EHD may contribute to the inhibition of melanin biosynthesis through regulating tyrosinase activity and expression, and serve as a new candidate in the design of new skin-whitening or therapeutic agents.