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Effect of Hovenia dulcis Thunb. Ethanol Extract on the Melanogenesis in B16F10 Melanoma Cell  

Kim, Jun-Ho (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Moon, Dea-Won (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Choi, Mi-Eun (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Lim, Gyu-Sang (Research Center of Traditional Korean Medicine, WonkWang University)
Mun, Yeun-Ja (Research Center of Traditional Korean Medicine, WonkWang University)
Woo, Won-Hong (Research Center of Traditional Korean Medicine, WonkWang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.23, no.2, 2009 , pp. 337-342 More about this Journal
Abstract
Acquired pigmentary skin diseases such as abnormal melanogenesis, vitiligo, chloasma and inflammatory pigmentation are related to regulate the melanin production, In this study, an ethanol extract of Hovenia dulcis Thunb.(EHD) makedly inhibited melanin biosynthesis and suppressed, the protein expression of tyrosinase, tyrosinase-related protein 1(TRP-1), and tyrosinase-related protein 2(TRP-2) in B16F10 cells. On the other hand, EHD did not inhibit mushroom tyrosinase activity. These results indicate that EHD may contribute to the inhibition of melanin biosynthesis through regulating tyrosinase activity and expression, and serve as a new candidate in the design of new skin-whitening or therapeutic agents.
Keywords
Hovenia dulcis Thunb.; melanin content; tyrosinase activity; TRP-1; TRP-2;
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