• 대한한의학원전학회지
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• 제24권1호
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• pp.35-45
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• 2011

The concepts of Yeongwi(營衛) were made from "Hwangjenaegyeong(黃帝內經)" the most ancient and important book in East Asian Traditional Medicine, that have been used basic theories for the purpose of explaining physiology and pathology of The Oriental Medicine. In this article, through comparing with concepts of Yeongwi(營衛) in Onbyeonghak(溫病學) of Qing[淸] dynasty, some problems were investigated, through what process of thinking the unique pattern identification[辨證] of Wigiyeonghyeol(衛氣營血) had been made although there could be another inductive way, and what is the difference of concepts of Yeongwi(營衛) between "Hwangjenaegyeong(黃帝內經)" and Onbyeonghak(溫病學).

• 동의생리병리학회지
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• 제27권1호
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• pp.11-19
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• 2013

The aim of this study is to analyze the research trend focusing on Yangseng(養生) studies in Korea. Through this study, the researchers attempt to explore the research trends of the Yangseng(養生) in Traditional Korean Medicine. Yangseng(養生) as a key word was searched on representative domestic databases of articles and the researchers and collected the articles of journals published from 1980 to 2012. Finally 350 articles of Yangseng(養生) were selected. After mid-2000s, Yangseng(養生) studies has been increased with the great interest in quality of life. Taoism and Traditional Korean Medicine were closely related with Yangseng(養生). Most of the Yangseng(養生) Studies in Medicine have been carried out by Traditional Korean Medicine and primarily focused in the literature. Yangseng(養生) has been defined as a sort of health-promoting behaviors. Therefore, Yangseng(養生) studies that mainly analyzed the variables associated with health-related quality of life and Yangseng(養生) and the main subjects were elderly and workers in this study. But every measuring instrument except Yangseng(養生) was adapted from western tools. In order to handle the new wave of society and medicine, new health concept and measuring instrument of Traditional Korean Medicine should be developed through Korean unique ideas of Yangseng(養生).

• 동의생리병리학회지
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• 제22권6호
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• pp.1410-1415
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• 2008

Acupuncture and herbal treatment are based on diagnosis of cold and heat pattern in Traditional Korean Medicine. This diagnosis is accomplished through pulse, tongue and question examination, which are not objective. Quantification and objectification of this diagnosis process are required for efficacious treatment and traditional medicine development. In this study, we developed the cold-heat pattern questionnaire for this purpose. Seventy nine patients who visited oriental medical hospital were included in this study. The cold-heat pattern questionnaire was composed of many questions about patient's physical condition, which were derived from The Traditional Oriental Medical Literature with Delphi Technique. Patients filled out the cold-heat pattern questionnaire by themselves. Diagnosis of cold and heat pattern are conducted separately by oriental medical doctors with more than 5 years' clinical experience. Various physical condition factors were derived for the cold-heat pattern questionnaire. (Preference temperature, Body temperature, Pain type, Face color, Urine, Stool and secretion features) Each cold and heat symptoms group acquired internal consistency. (Cronbach's ${\alpha}$ : Cold - 0.605, Heat - 0.722) There were significant associations between doctor's diagnosis and cold symptoms in 'Aversion to cold', 'Desire for heat', 'Pale face', 'Loose stools'. (p-value < 0.05) There were significant associations between doctor's diagnosis and heat symptoms in 'Desire for cold', 'Body feverishness', 'Thirst'. (p-value < 0.05) The internal consistency results suggest that the cold-heat pattern questionnaire assured reliability. Besides, these results showed that cold-heat symptoms are apt to appear together with, and this can be indirect evidence that diagnosis of cold-heat pattern is valuable for comprehension about disease pattern. Moreover, respective symptoms of cold-heat pattern showed different significance with doctor's diagnosis. Consequently these significant symptoms can be more considered for comprehension of cold-heat pattern.

• 동의생리병리학회지
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• 제27권6호
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• pp.689-697
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• 2013

Yosimasu Nangai (吉益南涯) is son of Yoshimasu Todo (吉益東洞), an eminent figure of traditional Japanese medicine. He wrote many medical books including Ihan(醫範) and Kigetusuiyakucho(氣血水藥徵), which contain core thoughts of Nangai. This study analyzed Ihan(醫範) and Kigetusuiyakucho(氣血水藥徵) to figure out Nangai's explanation in depth. Conclusion is as follows. He was influenced by his father's theory that all diseases come from one toxin but there were many differences in his theory. Also influences of qi-blood-phlegm stasis theory(氣血痰鬱論) established by Zhudanxi(朱丹溪) are apparent in several aspects. Consequently he established his own body fluid pathology called qi-blood-fluid theory(氣血水論).

• 동의생리병리학회지
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• 제19권4호
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• pp.1073-1077
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• 2005

Oxidative stressand glia-associated chronic inflammation have been linked to the pathophysiology of Alzheimer's disease. Rhei rhizoma has been commonly used as a purgative and a haemostatic agent in traditional oriental medicine. Recently, the methanol extract from a dried root of Rheum undulatumhas been shown to have anti-allergic and anti-inflammatory effects. In this study, we tested the potential of the extract of Rheum undulatum for neuroprotective agent. The aqueous extract of Rheum undulatum reduced cell death and p53 phosphorylation in neuronal cells and attenuated levels of cyclooxygenase-2 and inducible nitric oxide synthase mRNAs in BV2 microglial cells treated with $amyloid-\beta$

• 동의생리병리학회지
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• 제25권3호
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• pp.389-397
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• 2011

This study tried to integrate the traditional oriental medical theories and results of experimental studies of herbaceous plants on anti-diabetes. And I tried to analyze recent experimental study trend on the anti-diabetic herb. I searched anti-diabetic herb studies on 4 korean databases and 10 korean journals by keywords, 'diabetes', 'blood glucose', 'glycometabolism', 'pancreatic ${\beta}$-cell', etc. In order to see detail review, searching was performed from 2000 to 2010. And I searched 125 study cases concerning anti-diabetic herb and 72 varieties herbaceous plants used in study of anti-diabetes. and I analyzed the choice motives of each herb for anti-diabetic study, the extract methods and anti-diabetic evaluation contents. And I analyzed anti-diabetic herbs from a traditional oriental medical point of view. When the researchers chose herb for anti-diabetic experiment, just 8.8% of the choice was based on the oriental medical evidences. I found that 60.6% of the herb shown to be effective in diabetes experimentally had oriental medical theory-based Properties(性). There were studies with whole plants(16.8%), aqueous extract(45.6%), methanol extract(8.0%), ethanol extract(8.0%) and comparative studies of more than 2 types of extracts or various fractions(18.4%). The most frequent experimental diabetic models was diabetic mouse induced by streptozotocin(STZ)(87.8%). And there were db/db mouse(6.7%), ob/ob mouse(1.1%), etc. 33.6% of all studies just measured hematological indices of diabetes, and 66.4% researches analyzed details. To improve herbaceous plants study on diabetes, we oriental medical scientists have to integrate the oriental medical theories and results of experimental studies.

• 대한예방한의학회지
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• 제14권3호
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• pp.117-127
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• 2010

Objectives : The purpose of this study was to find out the characteristics of patients who admitted due to industrial accident and to promote the superiority of oriental medical treatment on the sequelae of industrial accident. Methods : We analyzed the medical charts of 51 inpatients in a local oriental medicine hospital. The patients had been hospitalized from May 1, 2003 to October 31, 2010. Results : 1. By gender, males accounted for 78.4%, while females 21.6%. By age, most incidences occurred in the forties(29.4%), fifties(23.5%) and thirties(19.6%) in order. 2. Most causes of accident was carelessness(27.5%) and fall down(21.6%) was the next. 3. With regard to the interval from occurrence of accidents to hospitalization, 20 cases(39.2%) were found to be hospitalized 31～90 days after the accidents, followed by 11 cases(21.6%) in 91～180 days and 7 cases(13.7%) in 181～360 days. 4. Most cases turned out to be injuries with 40 patients from Sequelae of intracerebral hemorrhage (23.5%) and Lumbar and other intervertebral disc disorders with radiculopathy(13.7%). The mean duration of hospitalization was $209.03{\pm}346.04$ days. Inpatients of Organic brain syndrome NOS numbered the longest stay($676{\pm}86.26$days), Sequelae of intracerebral hemorrhage recorded $541.91{\pm}541.83$ days hospitalized. 5. Most of inpatients were treated with acupuncture(100%), herbal medication(98.0%), oriental physiological therapy(82.3%), and moxibustion(76.4%). Conclusions : This article will help the researchers related to Oriental medicine establish basic source of Oriental medicine approach for inpatients due to industrial accident.

• 동의생리병리학회지
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• 제18권2호
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• pp.468-473
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• 2004

Psoriasis is a chronic inflammatory disease of the skin characterized by epidermal hyperplasia, dermal angiogenesis, infiltration of activated T cells, and increased cytokine levels, and affects 1-3% of the world-wide population. Although many immunological and clinical reports indicate a role for the immune system in the pathogenesis of psoriasis, puzzling questions about psoriasis remain unsolved. During the several decade, immunosuppressor and PUVA treatment are ubiquitously used to psoriasis therapy. But recently, to promote terminal differentiation of keratinocytes, block either NK-Tcell or T-cell activation, and interrupting the angiogenic switch represent another therapeutic opportunity in psoriasis. To keep face with immunological therapy, the needs of newly designed prescription on the psoriasis treatments were demanded. With the object of understand the psoriasis from an orient medical point of view, patients were administrated the GY during several weeks. We investigated the changes of gene expression in involved and uninvolved skin samples during the oriental remedy. Microarray data showed several important results. First, Gene expression profiling is similar to each patient. Second, precursor proteins that organize cornified envelops are decreased at the end of remedy. But genes which related to apoptosis, G-protein signalling, and lipid metabolism are increased. Third, 68.5% of clustering genes localized on the psoriasis susceptibility locus. In our results indicated that GY influence on the keratinocytes hyperproliferation by regulating the gene, which located on the psoriasis susceptibility locus.

• 동의생리병리학회지
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• 제18권4호
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• pp.1098-1101
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• 2004

This study was carried out to investigate the solubility of the ingredients of the kidney stone in the solution of the traditional oriental medicines. Calcium hydroxide, apatite and uric acid were chosen as the ingredients of the kidney stone. Plantaginis Semen, Lysimachiae Herba, Saururi Herba seu Rhizoma, Imperatae Rhizoma, Allium tuberosum Rottler were studied as the oriental medicines for the kidney stone. Calcium hydroxide had showed the very good solubility in the solution of Imperatae Rhizoma, the apatite had showed the good solubility in the solutions of Saururi Herba seu Rhizoma and Allium tuberosum Rottler. Uric acid had showed the mild solubility in the solution of Lysimachiae Herba and Saururi Herba seu Rhizoma.

• 동의생리병리학회지
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• 제20권3호
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• pp.634-637
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• 2006

The GC pictures were taken to investigate the difference of the Samul-tang and Sakunja-tang, each prepared by the different boiling methods, which were the traditional method(using cover), using the condenser, and using no cover. For Samul-tang, there was not much difference in the GC pictures, but the one pick(rt about 7 min.) of the picture by the method using the condenser had the higher intensity than those in the pictures by other methods. For Sakunja-tang, the GC pictures of the method using the condenser had shown a lot of the peaks and the very high intensity, which were much better than those of the picture by the traditional method. However, the GC pictures of the method by using no cover had shown almost nothing.