Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Water-Soluble Fraction of Rheum Undulatum Attenuates $Amyloid-\beta-induced$ Neuronal Death and Microglial Activation in Vitro

  • Jung Bo Mi (Department of Medical Science, Graduate School of East-West Medical Science, Kyung Hee University) ;
  • Kim Sung Ok (Department of Medical Science, Graduate School of East-West Medical Science, Kyung Hee University) ;
  • Yun Su Jin (Department of Medical Science, Graduate School of East-West Medical Science, Kyung Hee University) ;
  • Hwang Eun Joo (Department of Medical Science, Graduate School of East-West Medical Science, Kyung Hee University)
  • Published : 2005.08.01
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Abstract

Oxidative stressand glia-associated chronic inflammation have been linked to the pathophysiology of Alzheimer's disease. Rhei rhizoma has been commonly used as a purgative and a haemostatic agent in traditional oriental medicine. Recently, the methanol extract from a dried root of Rheum undulatumhas been shown to have anti-allergic and anti-inflammatory effects. In this study, we tested the potential of the extract of Rheum undulatum for neuroprotective agent. The aqueous extract of Rheum undulatum reduced cell death and p53 phosphorylation in neuronal cells and attenuated levels of cyclooxygenase-2 and inducible nitric oxide synthase mRNAs in BV2 microglial cells treated with $amyloid-\beta$

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References

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