• Journal of Microbiology and Biotechnology
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• 제32권4호
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• pp.405-418
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• 2022

Simotang oral liquid (SMT) is a traditional Chinese medicine (TCM) consisting of four natural plants and is used to alleviate gastrointestinal side effects after chemotherapy and functional dyspepsia (FD). However, the mechanism by which SMT helps cure these gastrointestinal diseases is still unknown. Here, we discovered that SMT could alleviate gastrointestinal side effects after chemotherapy by altering gut microbiota. C57BL/6J mice were treated with cisplatin (DDP) and SMT, and biological samples were collected. Pathological changes in the small intestine were observed, and the intestinal injury score was assessed. The expression levels of the inflammatory factors IL-1β and IL-6 and the adhesive factors Occludin and ZO-1 in mouse blood or small intestine tissue were also detected. Moreover, the gut microbiota was analyzed by high-throughput sequencing of 16S rRNA amplicons. SMT was found to effectively reduce gastrointestinal mucositis after DDP injection, which lowered inflammation and tightened the intestinal epithelial cells. Gut microbiota analysis showed that the abundance of the anti-inflammatory microbiota was downregulated and that the inflammatory microbiota was upregulated in DDP-treated mice. SMT upregulated anti-inflammatory and anticancer microbiota abundance, while the inflammatory microbiota was downregulated. An antibiotic cocktail (ABX) was also used to delete mice gut microbiota to test the importance of gut microbiota, and we found that SMT could not alleviate gastrointestinal mucositis after DDP injection, showing that gut microbiota might be an important mediator of SMT treatment. Our study provides evidence that SMT might moderate gastrointestinal mucositis after chemotherapy by altering gut microbiota.

• 대한한방소아과학회지
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• 제32권2호
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• pp.11-25
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• 2018

Objectives The purpose of this study is to provide evidence of pathogenesis, pattern differentiation, treatment principle, formula of traditional Chinese medicine for autism spectrum disorder by reviewing journal articles published in China. Methods We searched literatures dated up to 8 January, 2018 in China National Knowledge Infrastructure (CNKI), and evaluated pathogenesis, pattern differentiation, treatment principle, formula of traditional Chinese medicine for autism spectrum disorder. Results Thirty four studies were selected for analysis. These studies included pathogenesis, pattern differentiation, treatment principle, formula of traditional Chinese medicine for autism spectrum disorder. The most common pattern differentiations were the pattern of kidney essence depletion, pattern of phlegm confounding the orifices of the heart, pattern of dual vacuity of the heart and spleen, pattern of effulgent heart-liver fire, pattern of liver failing to course freely. The most common treatment principles were supplementing the kidney, transquilizing, fortifying the spleen, transforming phlegm, opening the orifices, and calming the liver. The most commonly-used formulas were Yukmijihwangtang (六味地黃湯), Modified Ondamtang (加味溫膽湯), Guibitang (歸脾湯), Yangsimtang (養心湯), Jwaguihwan (左歸丸), Cheonmagudeungeum (天麻鉤藤飮), and Danchisoyosan (丹梔逍遙散). Conclusions This study shows the latest trend of pathogenesis, pattern differentiation, treatment principle, formula of traditional Chinese medicine for autism spectrum disorder. Further study is needed to solidify these findings.

• 대한한의학방제학회지
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• 제21권2호
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• pp.13-28
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• 2013

Objectives : Term standardization is the most important for knowledge information in every study. There are several tries to make terminology standards in Korean Traditional Medicine(KTM). We, authors took a review on romanized prescription nomenclature of main titles in Herbal Formula Science to criticize the ways of romanized prescription nomenclature. Methods : We extract romanized prescription name from Vol. 11, No. 1 to latest Issue Vol. 21, No. 1, Herbal Formula Science. Results : The Korean Academy of Oriental Medicine Prescription has guideline for romanized prescription nomenclature. However, only 6 out of 147 romanized prescription name are confirmed with guideline. In addition, 58 out of 142 names are italicized without guideline. Also there are several ways of marking for prescription names. Conclusions : For making knowledge information and easy searching for terms, we need normative regulations for romanized prescription nomenclature by the Society of Korean Medicine level.

• 대한한의학방제학회지
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• 제28권4호
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• pp.351-363
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• 2020

Objectives : The purpose of this paper is to describe how Wu Kun(吳昆) understood Huangdineijing 『黃帝內經』 and implemented his understanding when writting Yifangkao 『醫方考』. Methods : From Yifangkao 『醫方考』, we collected all paragraphs including "經曰", "內經曰" while excluding the ones with "論曰" to filter out Sanghanlun 『傷寒論』's perspective. The contents of Huangdineijing·Suwen 『黃帝內經·素問』 and Huangdineijing·Lingshu 『黃帝內經·靈樞』, cited in Wu Kun's Yifangkao 『醫方考』 were extracted, identified from which part it comes and sorted into headings under RyuPyeon Huangjenaegyung 『類編黃帝內經』. Results : The most cited traditional chinese medical classic in Yifangkao 『醫方考』 was Huangdineijing·Suwen 『黃帝內經·素問』 Yinyangyingxiangdalun 「陰陽應象大論篇」 which was cited 41 times. Zhizhenyaodalun 「至眞要大論篇」 had a total of 39 citations followed by Shengqitongtianlun 「生氣通天論篇」 and Liuyuanzhengjidalun 「六元正紀大論篇」 which were cited 13 times and 11 times each. In addition, it was confirmed that other 28 chapters from Huangdineijing·Suwen 『黃帝內經· 素問』, 3 chapters from Huangdineijing·Lingshu 『黃帝內經·靈樞』, 3 chapters from Nanjing 『難經』 and one chapter from Zhenjiujiayijing 『鍼灸甲乙經』 were also cited. Also the analysis of the classification of the Huangdineijing·Suwen 『黃帝內 經·素問』 showed that 57 citations were classified as 'treatment', 41 citations were classified as 'Yin and Yang and Five phases', 39 citations were calssified as 'Cause and Mechanism of Disease'. Conclusion : 1. Yifangkao 『醫方考』 have explained prescriptions by implementing principles from 5 kinds of traditional chinese medical classic including Huangdineijing·Suwen 『黃帝內經·素問』, Huangdineijing·Lingshu 『黃帝內經·靈樞』 etc. 2. According to table 3, Yifangkao 『醫方考』 have cited Huangdineijing·Suwen 『』 to explain how each compounds were used and how the Korean medical principle of Yin and Yang was applied in the prescriptions. 3. It can be suggested in formula study there is utility to understand principles of traditional chinese medical classic to comprehend prescriptions.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 2001년도 봄 학술발표회 논문집
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• pp.315-322
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• 2001

Underground flexible pipes for electric cables are subject to external loads and surrounding soil pressure. Particularly, strain of flexible pipes is of great concern in terms of safety and maintenance for electric cables. In this paper, stress and strain of flexible pipes with various depth are calculated using traditional formula and FEM analysis. The results show that theoretical values are more conservative in strain whereas FEM analysis gives larger stress. Considering the strain criteria - 3.5 %, maximum, flexible pipes can be buried at the range of 50cm to 5m in depth without additional soil improvement.

• 복식문화연구
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• 제7권2호
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• pp.275-288
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• 1999

The purpose of this is providing a simple, relatively errorless body surface area calculation. Subjects were 10 married women and 10 singles women whose age was 20 to 29 years old. The Gypsum method has applied for the sampling of body surface. The Weight method has been used to measure body surface by means of transferring gypsum shape on uniform plane polypropylene films. In this study, compare analyzed errors between the traditional formulas for measuring body surface area and measuring data in this experiment. More than all, it has been to induce a regression equation for measuring body surface area, which is so simple to calculate with less errors, with variable factors as weight and height. The results of this experiment as follows : 1. In the traditional formulas, weight formula was shown high average error : Niya\`s height formula. which was modified K value as 0.62 in the height formula (S = KH) is shown lower average error than Lassabliere\`s Height formula. 2. In the weight-height formula (S=K √WH), it was shown high average error according to the increasing of K value. Kawanami\`s formula, which 5.378 as K value, was shown low average error both the singles and the married women. 3. Dubois weight-heingt formula (S=W/sup a/·H/sub b/·K) was shown low average error than the weight, height, weight-height (S=K√WH) formula. 4. The regression equations with variable factors as weight and height are 156.74W + 86.05H - 660.25 (Single women) and 136.02W + 90.57H - 6241.32 (Married women) the average error and absolute average error to the singles are 0.09%, 0.94% and resoectively -0.13%, 1.16% for the married women.

• 대한한의학방제학회지
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• 제21권2호
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• pp.72-80
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• 2013

Objectives : Ontology is a good tool to represent the knowledge and has developed for Traditional Korean Medicine(TKM) in Korea Institute of Oriental Medicine. There are a lot of TKM terms, which have a complex meaning, especially major indication terms of medicinal treatment and terms of symptom and disease. These complex meaning terms result in the low linkage between major indication terms of medicinal treatment and terms of symptom and disease in TKM ontology. We studied to enhance the percentage of the linkage among those data in TKM ontology. Methods : We disassembled major indication terms of medicinal treatment into minimum meaning units and then linked them to enhance the percentage of the linkage among medicinal material, formula and disease ontology based on Traditional Korean Medicine. To retain objectivity, several experts of Korean Medicine used a web-based tool that supports users in refining terms and disassembling them into the minimum meaning efficiently. Results : The outcome shows that the percentage of the linkage among medicinal material, formula and disease ontology increased. By linking disassembled major indication terms to symptoms and diseases, the amount of information for medicinal materials and formulas also increased quantitatively in comparison with given formula for diseases in disease ontology. Conclusions : By this study, disassembled data increases the percentage of linkage between diseases and medicinal treatments. And the applicability of TKM ontology is also increased.

• 한국한의학연구원논문집
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• 제14권2호
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• pp.131-146
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• 2008

Treasured Mirror of Eastern Medicine was written by Heo Joon in 1610 and published in 1613, it was stored in the Library of Seoul University. It quotes more than 190 ancient Chinese books including mostly those of medicine. The author discusses mainly the theory of herbal formulas and its numbers comparing formulas between quotation and original text in Zhu Zhongjing's formula. Prescriptions from the Great Peace Imperial Grace Pharmacy, Effective Formulas Handed Down for Generations and Recovery from All Ailments. Through comparison it's found that there are five correlations between quotation and original. That shows a affinity relation in traditional medicine between China and Korea and a historical visage that Korean doctors followed Chinese medicine and tried to further development from it.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2002년도 추계학술대회 논문집
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• pp.443-446
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• 2002

A vehicle oversteered or cornering at excessive speed leaves tire yaw mark on the road surface. A yaw mark is a sign that the tire was sideslipping and exceeded its frictional limit because of centrifugal force. Problems exist with the traditional equation, “critical speed formula (CSF)”, that limits its practical use in traffic accident reconstruction. A major problem is that the equation dose not account for vehicle dynamics and interface between tire and road. The literature refers to that the accuracy of the critical speed formula varies with several factors. New equations that account for vehicle dynamics are introduced in this paper. A comparison of the accuracy of the new method and the traditional method in the calculation of speed is conducted.

• Journal of Preventive Medicine and Public Health
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• 제56권4호
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• pp.338-347
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• 2023

Objectives: Young children's feeding characteristics can play an important role in eating habits and health during later childhood. This study was conducted to examine the associations of feeding characteristics with dietary patterns and obesity in children. Methods: This study utilized data from the Korea National Health and Nutrition Examination Survey conducted between 2013 and 2017. In total, 802 toddlers were included, with information on their demographic characteristics, feeding practices and duration, and 24-hour recall obtained from their parents. Feeding characteristics were categorized into feeding type, duration of total breastfeeding, duration of total formula feeding, duration of exclusive breastfeeding, and age when starting formula feeding. Dietary patterns were identified based on factor loadings for the food groups for 3 major factors, with "vegetables & traditional," "fish & carbohydrates," and "sweet & fat" patterns. Overweight/obesity was defined as ≥85th percentile in body mass index based on the 2017 Korean National Growth charts for children and adolescents. Multiple regression analysis was conducted to examine associations between feeding characteristics and dietary patterns. The association between dietary patterns and obesity was analyzed using multivariable logistic regression analysis. Results: The early introduction of formula feeding was inversely associated with the "vegetables & traditional" pattern (β=-0.18; 95% confidence interval [CI], -0.34 to -0.02). A higher "vegetables & traditional" intake was associated with a lower risk of obesity (odds ratio, 0.48; 95% CI, 0.24 to 0.95). Conclusions: Feeding characteristics are associated with dietary patterns in later childhood, and dietary patterns were shown to have a potential protective association against obesity.