• Korean Journal of Acupuncture
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• 제38권3호
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• pp.122-132
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• 2021

Objectives : This systematic review aims to assess the effectiveness of thread embedding therapy on animal model for rheumatoid arthritis. Methods : Search was conducted in the Cochrane library, MEDLINE (PubMed), EMBASE, the Chinese National Knowledge Infrastructure, Wan-Fang Database, Technology Journal Database, the Korean Studies Information Service System, the Oriental Medicine Advanced Searching Integrated System, the Research Information Sharing Service, the National Digital Science Library, the Korean Traditional Knowledge Portal and the Korea Citation Index. Data were extracted concerning animal model, intervention and rheumatoid arthritis indicator by two independent reviewers. Reporting quality was also evaluated by the ARRIVE (Animal Research: Reporting In Vivo Experiments) guidelines 2.0. Results : One thousand thirty six studies were primarily selected. After screening, 10 studies met the inclusion criteria. 1 study was published 2005, 1 study was published 2010, 1 study was published 2012, 1 study was published 2015, 2 studies were published 2016, 3 studies were published 2017, 1 study was published 2018. The most frequently used acupoints were ST36 and BL23, and were used with an average frequency of 11.8 days. All of these thread embedding therapy studies were effective on behavioral, morphological, immunohistological and hematological indicators to treat of rheumatoid arthritis model. Conclusions : These results demonstrated the effectiveness of thread embedding therapy and suggested the putative mechanism. However, considering the small number of included studies, low reporting quality and differences in study design, further studies with rigorous designs and high reporting quality need to be conducted.

• Journal of Microbiology and Biotechnology
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• 제31권7호
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• pp.1011-1021
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• 2021

The root bark of Ulmus davidiana var. japonica (Japanese elm) is used in Korea and other East Asian countries as a traditional herbal remedy to treat a variety of inflammatory diseases and ailments such as edema, gastric cancer and mastitis. For this study, we investigated the lipid metabolism and anti-obesity efficacy of ethyl alcohol extract of Ulmus davidiana var. japonica root bark (UDE). First, HPLC was performed to quantify the level of (+)-catechin, the active ingredient of UDE. In the following experiments, cultured 3T3-L1 pre-adipocytes and high-fat diet (HFD)-fed murine model were studied for anti-obesity efficacy by testing the lipid metabolism effects of UDE and (+)-catechin. In the test using 3T3-L1 pre-adipocytes, treatment with UDE inhibited adipocyte differentiation and significantly reduced the production of adipogenic genes and transcription factors PPARγ, C/EBPα and SREBP-1c. HFD-fed, obese mice were administered with UDE (200 mg/kg per day) and (+)-catechin (30 mg/kg per day) by oral gavage for 4 weeks. Weight gain, epididymal and abdominal adipose tissue mass were significantly reduced, and a change in adipocyte size was observed in the UDE and (+)-catechin treatment groups compared to the untreated control group (^***p < 0.001). Significantly lower total cholesterol and triglyceride levels were detected in UDE-treated HFD mice compared to the control, revealing the efficacy of UDE. In addition, it was found that lipid accumulation in hepatocytes was also significantly reduced after administration of UDE. These results suggest that UDE has significant anti-obesity and lipid metabolism effects through inhibition of adipocyte differentiation and adipogenesis.

• 한국컴퓨터정보학회논문지
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• 제26권5호
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• pp.47-53
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• 2021

희소한 평가 데이터는 사용자들 간의 신뢰할만한 유사도 산출을 저해하기 때문에 추천 시스템을 위한 메모리 기반의 협력 필터링 기법의 성능을 저하시킨다. 기존 연구의 많은 결과물은 이 데이터 희소성 문제를 해결하기 위해 개발되었으며, 가장 단순하고 대표적인 업적은 자카드 계수를 활용하는 방법들이다. 이 계수는 두 사용자의 공통 평가 항목수를 반영하며, 그들 간의 유사도를 보다 정확하게 계산하기 위해 전통적인 유사도 척도와 통합된다. 그러나, 그러한 통합은 데이터 희소성의 정도를 고려하지 않은 매우 단순한 방법이다. 본 연구는 두 사용자의 자카드 계수값에 의거하여 다른 유사도 척도를 적용하는 새로운 아이디어를 제시한다. 제안 방법에서 사용하는 파라미터의 최적값을 구하기 위하여 성능 실험을 진행하였고, 다른 관련된 방법들과 비교 평가하였다. 결과로서, 제안 방법은 예측 정확도와 추천 정확도에 있어서 가장 우수하거나 대등한 성능을 보였다.

• Journal of Ginseng Research
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• 제43권4호
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• pp.539-549
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• 2019

Background: 20(S)-Protopanaxadiol (PPD), the aglycone part of 20(S)-protopanaxadiol ginsenosides, possesses antidepressant activity among many other pharmacological activities. It is currently undergoing clinical trial in China as an antidepressant. Methods: In this study, an ultra-performance liquid chromatography coupled with triple quadrupole time-of-flight mass tandem mass spectrometry method was established to identify the metabolites of PPD in human plasma and urine following oral administration in phase IIa clinical trial. Results: A total of 40 metabolites in human plasma and urine were identified using this method. Four metabolites identified were isolated from rat feces, and two of them were analyzed by NMR to elucidate the exact structures. The structures of isolated compounds were confirmed as (20S,24S)-epoxydammarane-12,23,25-triol-3-one and (20S,24S)-epoxydammarane-3,12,23,25-tetrol. Both compounds were found as metabolites in human for the first time. Upon comparing our findings with the findings of the in vitro study of PPD metabolism in human liver microsomes and human hepatocytes, metabolites with m/z 475.3783 and phase II metabolites were not found in our study whereas metabolites with m/z 505.3530, 523.3641, and 525.3788 were exclusively detected in our experiments. Conclusion: The metabolites identified using ultra-performance liquid chromatography coupled with triple quadrupole time-of-flight mass spectrometry in our study were mostly hydroxylated metabolites. This indicated that PPD was metabolized in human body mainly through phase I hepatic metabolism. The main metabolites are in 20,24-oxide form with multiple hydroxylation sites. Finally, the metabolic pathways of PPD in vivo (human) were proposed based on structural analysis.

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2019년도 추계학술대회
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• pp.86-86
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• 2019

Scutellaria baicalensis Georgi (SB) has been widely studied to treat inflammatory diseases in east Asia. In the recent years, many studies have focused on modifying herbs to increase the pharmacological effects. Roasting alcohol absorbed SB is one of the traditional methods to increase the therapeutic effects. Currently there are no reports on the pharmacological effects of roasted SB. This study investigated the anti-inflammatory effects of roasted 30% ethyl alcohol absorbed SB extract (SR) on mice ear edema. After intra-gastric injection of dexamethasone (for positive control, 2 mg/kg) and SR (50, 100, 400 mg/kg), ear edema was provoked by croton oil (5% v/v in acetone, 10 ul/ear). Ear thickness was measured with a digital caliper to quantify the change in swelling. For histological study, we made paraffin sections and performed Phloxine-Tartrazine staining and Masson's trichrome staining to observe epidermis, dermis and subcutaneous region and collagen fiber of mice ear tissues. Ear thickness decreased dose-dependent manner in SR treated groups. Histological analysis compared with dexamethasone treated group, SR treated groups demonstrated a similar reduction in hypoplasia of epidermis and influx of inflammatory cells. Increase of subcutaneous layer and decrease of collagen fibers were significantly recovered in SR treated group (400 mg/kg) and dexamethasone treated group. In conclusion, treatment with SR ameliorates auricular inflammation induced with croton oil in mice. Experiments are now underway to understand the molecular mechanisms underlying anti-inflammatory activities of SR.

• 한국약용작물학회지
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• 제28권6호
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• pp.471-480
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• 2020

Background: The roots of Cirsium japonicum var. ussuriense (RCJ) have been used as traditional medicine in Korea for hematuria and hematemesis. These extracts exert anti-oxidative and anti-inflammatory effects by scavenging for free radical and regulating the inflammatory response. However, the effect of RCJ on rheumatoid arthritis (RA) has not been elucidated. Thus, we evaluated the water extract of RCJ (WRCJ) using type II collagen-induced RA models. Methods and Results: RA was induced by immunization with type II collagen. All experimental materials were orally administered daily for three weeks. The positive control group was administered with 0.2 mg/kg methotrexate (n = 7), while the experimental group was administered with WRCJ (100 or 500 mg/kg, n = 7). Serum levels of TNF-alpha, Interleukin 6 (IL-6), and type II collagen IgG (CII) were measured using ELISA. Administration of 500 mg/kg WRCJ decreased the levels of TNF-alpha, IL-6, and CII. Moreover, WRCJ treatment diminished swelling of hind legs and infiltration of inflammatory cells in RA models' synovial membrane. Conclusions: These results indicate that WRCJ could improve RA, reduce inflammatory indicators and synovial inflammation. However, further experiments are required to determine how WRCJ can influence the signal transduction pathway in RA.

• Journal of Information Science Theory and Practice
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• 제9권2호
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• pp.1-17
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• 2021

Pseudo relevance feedback (PRF) is a powerful query expansion (QE) technique that prepares queries using the top k pseudorelevant documents and choosing expansion elements. Traditional PRF frameworks have robustly handled vocabulary mismatch corresponding to user queries and pertinent documents; nevertheless, expansion elements are chosen, disregarding similarity to the original query's elements. Word embedding (WE) schemes comprise techniques of significant interest concerning QE, that falls within the information retrieval domain. Deep averaging networks (DANs) defines a framework relying on average word presence passed through multiple linear layers. The complete query is understandably represented using the average vector comprising the query terms. The vector may be employed for determining expansion elements pertinent to the entire query. In this study, we suggest a DANs-based technique that augments PRF frameworks by integrating WE similarities to facilitate Arabic information retrieval. The technique is based on the fundamental that the top pseudo-relevant document set is assessed to determine candidate element distribution and select expansion terms appropriately, considering their similarity to the average vector representing the initial query elements. The Word2Vec model is selected for executing the experiments on a standard Arabic TREC 2001/2002 set. The majority of the evaluations indicate that the PRF implementation in the present study offers a significant performance improvement compared to that of the baseline PRF frameworks.

• 대한건축학회논문집:구조계
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• 제35권2호
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• pp.21-28
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• 2019

Handmade hydrated lime has been used for preservation and repair of architectural heritage in Korea. However, the effect of the amount of water used for slaking quicklime on the physical and chemical properties of the hydrated lime, which is the result of the slaking process, has not been clearly understood. In this study, particle size distribution, chemical composition and crystalline phases of the hydrated lime are investigated by varying the amount of water used for the slaking. In addition, temperature history during the slaking process is examined. For this, various experiments, such as laser diffraction analysis, X-ray fluorescence, X-ray diffraction, thermogravimetric analysis, and temperature recording using a thermocouple, were performed. When the quicklime came into contact with water, its temperature reached $100^{\circ}C$ within 10 min due to sudden exothermic reaction of calcium oxide, and this temperature was maintained for about 30 min. The water to lime ratio influenced the cooling rate during the slaking process; that is, the more water was used, the longer it took to reach an ambient temperature. The amount of water for the slaking did not have a noticeable effect on the contents of major components of the hydrated lime such as calcium hydroxide and calcium carbonate, but when slaked with more amount of water, average particle size of the lime tended to decrease. The experimental results in this study can be used as references for developing guidelines on the safety or appropriate amount of water in the lime slaking process.

• 한국컴퓨터정보학회논문지
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• 제25권12호
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• pp.203-210
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• 2020

메모리 기반의 협력 필터링은 추천 시스템의 대표적인 타입이지만 데이터 희소성이라는 본질적인 문제를 갖고 있다. 이 문제를 해결하기 위해 많은 연구 업적들이 이루어졌으나, 보다 체계적인 접근 방법은 여전히 요구된다. 본 연구는 사용자 간의 유사도를 산출하기 위하여 항목들에 대한 사용자 평가치 분포를 활용한다. 따라서 제안 방법은 사용자의 모든 평가치를 이용하므로, 공통 항목에 대한 평가치만을 이용하는 기존 방법들과 대비된다. 더욱이, 각 항목에 대한 다른 사용자들의 평가치들을 유사도 계산에 반영함으로써 항목 평가치의 광역적인 관점을 취한다. 제안 방법의 성능은 실험을 통하여 평가하였고, 연관된 다른 방법들과 비교하였다. 그 결과, 제안 방법은 예측과 순위 정확도 측면에서 우수한 성능을 보였다. 이러한 예측 정확도의 향상은 전통적인 유사도 척도에 비해 최근의 방법으로 달성한 것보다 최고 2.6배 더 높다.

• 한국정보통신학회논문지
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• 제24권12호
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• pp.1574-1580
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• 2020

기존의 신체 인식 방법은 특수한 기기를 사용하거나 이미지로부터 영상처리를 통해 검출하는 방법들이 있다. 특수 기기를 사용할 경우 기기를 사용할 수 있는 환경이 제약되고 기기의 비용이 많이 든다는 단점이 있다. 카메라와 영상처리를 사용할 경우 환경의 제약과 비용이 낮아지는 장점이 있지만, 성능이 떨어진다. 이런 단점을 해결하기 위해 카메라와 합성 곱 심층 신경망을 사용한 신체 인식 방법들이 연구되었다. 합성 곱 심층 신경망의 성능을 올리기 위해 다양한 기법들이 제안되었다. 본 논문에서는 합성 곱 심층 신경망의 성능을 올리기 위한 기법 중 스킵 연결을 다양한 형태로 사용하여 스킵 연결이 손 검출 망에 끼치는 영향을 실험하였다. 실험을 통해 기본 스킵 연결 이외 추가적인 스킵 연결의 존재가 성능에 나은 영향을 끼치고 하향 스킵 연결만 추가된 망이 가장 나은 성능을 보임을 확인하였다.