Korean Journal of Medicinal Crop Science (한국약용작물학회지)

The Korean Society of Medicinal Crop Science (한국약용작물학회)
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Improvement Effect of the Water Extract from the Root of Cirsium japonicum var. ussuriense on Type II Collagen-induced Rheumatoid Arthritis Animal Models

엉겅퀴 뿌리 물 추출물의 류마티스 관절염 동물 모델에 대한 개선 효과

  • Nho, Jong Hyun (National Development Institute of Korean Medicine) ;
  • Lee, Hyeun Joo (National Development Institute of Korean Medicine) ;
  • Lee, E Na (National Development Institute of Korean Medicine) ;
  • Woo, Kyeong Wan (National Development Institute of Korean Medicine) ;
  • Jang, Ji Hun (National Development Institute of Korean Medicine) ;
  • Kim, Sun Ra (National Development Institute of Korean Medicine) ;
  • Cho, Hyun Woo (National Development Institute of Korean Medicine) ;
  • Noh, Se Eung (Department of Rehabilitation Medicine, Jangheung Intergrative Medicine Center, Wonkwang University College of Medicine) ;
  • Jung, Ho Kyung (National Development Institute of Korean Medicine)
  • Received : 2020.08.10
  • Accepted : 2020.10.30
  • Published : 2020.12.30
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Abstract

Background: The roots of Cirsium japonicum var. ussuriense (RCJ) have been used as traditional medicine in Korea for hematuria and hematemesis. These extracts exert anti-oxidative and anti-inflammatory effects by scavenging for free radical and regulating the inflammatory response. However, the effect of RCJ on rheumatoid arthritis (RA) has not been elucidated. Thus, we evaluated the water extract of RCJ (WRCJ) using type II collagen-induced RA models. Methods and Results: RA was induced by immunization with type II collagen. All experimental materials were orally administered daily for three weeks. The positive control group was administered with 0.2 mg/kg methotrexate (n = 7), while the experimental group was administered with WRCJ (100 or 500 mg/kg, n = 7). Serum levels of TNF-alpha, Interleukin 6 (IL-6), and type II collagen IgG (CII) were measured using ELISA. Administration of 500 mg/kg WRCJ decreased the levels of TNF-alpha, IL-6, and CII. Moreover, WRCJ treatment diminished swelling of hind legs and infiltration of inflammatory cells in RA models' synovial membrane. Conclusions: These results indicate that WRCJ could improve RA, reduce inflammatory indicators and synovial inflammation. However, further experiments are required to determine how WRCJ can influence the signal transduction pathway in RA.

Keywords

References

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