• 대한한의학원전학회지
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• 제22권4호
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• pp.15-28
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• 2009

Traditional korean medicine which has long history and many clinical experiments stands out in bold relief because the medicine's point of view has been changed from medical treatment to disease protection and the wellbeing life through health care and complementary alternative medicine has been emerged for the incurable disease. Many traditional korean medical research has been conducted in the fields of preventive medical application, leading material drawing and medical service upgrade through eastern and western medical treatment and the more advanced project are being studied as time goes by. But because we have the hardship of manifesting traditional korean medicine's knowledge into detailed data and information in the field of analytical science and we don't have well arranged research trend data of it, researchers are using much time to survey the preceding research and planners needing more accurate research trend data to protect duplication and raise efficiency. So we have studied the traditional korean medicine's research trend to solve this problems by the method of bibliography applied for the preceding project results. Through the analysis of traditional korean medicine's 370 project reports we came to a conclusion that the R&D investment is concentrated on the university and research institute, the utilization projects are lower than basic and applied research, regional snobbism is excessive than the whole nation's R&D and advanced project has been started since 2006.

• 대한한방소아과학회지
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• 제30권4호
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• pp.99-110
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• 2016

Introduction Jaundice is one of the most common conditions found in neonatal period. Phototherapy is one of the main treatments for neonatal jaundice. However, several adverse effects of the phototherapy have been reported, including DNA damage recently. Therefore, a variety of treatments have been conducted to shorten the duration of phototherapy. Meanwhile, it has been hardly tried to prevent neonatal jaundice, but diverse approaches have been tried in traditional Chinese medicine (TCM) for many years. Therefore, this study aims to analyze the studies for the treatments to prevent neonatal jaundice based on TCM. Materials and Methods Various literatures have been searched via CNKI, and PubMed using the terms "neonatal jaundice" (新生儿黄疸, 胎黃, 胎疸) in category of 'Traditional Chinese Medicine', 'Traditional Chinese Medicinal Herbs' and 'Combination of Traditional Chinese Medicine With Western Medicine'. The search range included randomized controlled trials (RCTs), controlled clinical trials (CCTs), case reports, reviews and animal experiments published from 2013 to 2015. Results A total of 104 studies were found. 93 articles were excluded by reviewing the titles and abstracts. Out of the remaining 11 studies, 9 articles were RCTs, 2 articles were CCTs. The treatment used in neonatal babies in the studies were, using herbal remedies (meditation 5, bath 3 and retention enema 1) and the acupressure. All treatments were initiated within the first 24-48 hours after their birth. Then, there was a study that the subjects taken the herbal medicine were women during pregnancy. The outcome assessments used were the serum total bilirubin (TB), transcutaneous bilirubin measurement (TCB), the incidence of the hyperbilirubinemia, the duration time of the jaundice. Especially, TB, TCB and the incidence of the hyperbilirubinemia have decreased significantly more than that of the control group in the most of the results. No severe adverse events were reported in all articles reviewed. Conclusions Conventional treatment such as, herbal medicine in TCM, seems to be the effective way to prevent neonatal jaundice or hyperbilirubinemia. Therefore, the conventional treatment may be favorable choice for preventive treatment for neonatal jaundice.

• The Korean Journal of Physiology and Pharmacology
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• 제27권4호
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• pp.333-344
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• 2023

Hepatocellular carcinoma (HCC) is a prevalent malignant tumor with high fatality. It has yet to be reported whether circ-SNX27 can affect the progression of HCC. This study attempted to analyze circ-SNX27's precise role and underlying mechanisms in HCC. HCC cell lines and tumor specimens from HCC patients were analyzed using quantitative real-time PCR and Western blotting to quantify the expressions of circ-SNX27, miR-375, and ribophorin I (RPN1). Cell invasion and cell counting kit 8 experiments were conducted for the evaluation of HCC cell invasion and proliferation. Caspase-3 Activity Assay Kit was utilized to gauge the caspase-3 activity. Luciferase reporter and RNA immunoprecipitation assays were executed to ascertain the relationships among miR-375, circ-SNX27, and RPN1. To determine how circ-SNX27 knockdown affects the growth of HCC xenografts in vivo, tumor-bearing mouse models were constructed. Elevated expressions of circ-SNX27 and RPN1 as well as a reduced miR-375 expression were observed among HCC cells and HCC patient tumor specimens. Knocking-down circ-SNX27 in HCC cells abated their proliferative and invasive abilities but raised their caspase-3 activity. Moreover, the poor levels of circ-SNX27 inhibited HCC tumor growth among the mice. Circ-SNX27 enhanced RPN1 by competitively binding with miR-375. Silencing miR-375 in HCC cells promoted their malignant phenotypes. Nonetheless, the promotive effect of miR375 silencing was reversible via the knockdown of circ-SNX27 or RPN1. This research demonstrated that circ-SNX27 accelerated the progression of HCC by modulating the miR-375/RPN1 axis. This is indicative of circ-SNX27's potential as a target for the treatment of HCC.

• Journal of the Korean Society for Industrial and Applied Mathematics
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• 제9권2호
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• pp.83-89
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• 2005

In this paper a new algorithm of learning and evolving artificial neural networks using gene expression programming (GEP) is presented. Compared with other traditional algorithms, this new algorithm has more advantages in self-learning and self-organizing, and can find optimal solutions of artificial neural networks more efficiently and elegantly. Simulation experiments show that the algorithm of evolving weights or thresholds can easily find the perfect architecture of artificial neural networks, and obviously improves previous traditional evolving methods of artificial neural networks because the GEP algorithm imitates the evolution of the natural neural system of biology according to genotype schemes of biology to crossover and mutate the genes or chromosomes to generate the next generation, and the optimal architecture of artificial neural networks with evolved weights or thresholds is finally achieved.

• 대한한의학방제학회지
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• 제16권1호
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• pp.55-64
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• 2008

The span of life of human beings has lengthened because of medical progress and so on. Consequently, the old have begun to remark that quality of life (QOL) is as important as extension of the life expectancy. However, some diseases such as stroke, cancer induce decrease of QOL. In case of the stroke, it is followed by chronic headache and dementia as an aftereffect, causing serious decrease of QOL. Jodeungsan, traditional medicine, have been prescribed for headache and hypertension. Many clinical trials and laboratory experiments about pharmacological effects of Jodeungsan have been reported. Jodeungsan ameliorated chronic headache and improved recognitive deficit. Moreover, Jodeungsan lowered blood pressure in hypertensive condition which is one of a major cause of stroke. These effects of Jodeungsan on several diseases are partly attributed to antioxidant effect. This report reviews the pharmacological effect of Jodeungsan in the view of stroke-related diseases.

• 한국해안해양공학회지
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• 제8권4호
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• pp.269-273
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• 1996

계단식 호안 축조에 사용할 수 있는 신형 유공블록이 제시되었다. 또한, 2차원 수리모형실험을 통하여 신형 블록을 사용한 유공 계단식 호안에서의 월파량 면화를 파악하였다. 신형 유공 계단식 호안은 재래식 무공 계단식 호안에서보다 월파량이 작아 향후 친수성 호안의 한 대안이 될 수 있음이 입증되었다.

• The Journal of the Acoustical Society of Korea
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• 제28권3E호
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• pp.118-135
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• 2009

The level set based approach is one of active methods for contour extraction in image segmentation. Since Osher and Sethian introduced the level set framework in 1988, the method has made the great impact on image segmentation. However, there are some problems to be solved; such as multi-objects segmentation, noise filtering and much calculation amount. In this paper we address the drawbacks of the previous level set methods and propose an extension of the traditional fast level set to cope with the limitations. We introduce a relationship matrix, a new split-and-merge criterion, a modified Chan-Vese criterion and a novel filtering criterion into the traditional fast level set approach. With the segmentation experiments we evaluate the proposed method and show the promising results of the proposed method.

• 한국자동차공학회논문집
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• 제21권4호
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• pp.43-53
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• 2013

Lane marking detection based on a mono camera sensor provides a low cost solution to both ITS (intelligent transportation systems) and DAS (driver assistant systems). A number of methods and implementations have been reported in the literature. However, reliable detection is still an issue. Traditional approaches are mostly based on statistics or Hough transforms. However, the former approaches usually include many irrelevant detection areas, and the latter are not practical because actual lanes are not usually suitable for the approximation with linear or polynomial equations. In this paper, we focus on increasing the reliability of detection by reducing the detection of irrelevant areas while improving the detection of actual lane marking areas, which is usually a tradeoff for most conventional approaches. We use scale-space for that. Through experiments with real images obtained from various environments, we could achieve a significant improvement over traditional approaches.

• 한국미생물·생명공학회지
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• 제24권4호
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• pp.439-444
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• 1996

Microorganisms were collected to isolate the microbes producing Kochujang flavor from 3 kinds of traditional Kochujang. The strain B7 and Y20 which scored the highest sensory evaluation value among 400 microorganisms were finally selected. Also, they showed the most similar flavor pattern to the traditional Kochujang's by comparison of GC chromatogram after sniffing test. As the result of the result of the morphological and physiological experiments, the bacterial strain B7 could be identified Bacillus licheniformis and the yeast strain Y20 Saccaromyces dairensis. Especially, the bacterial strain B7 could grow in anaerobic condition and was able to hydrolysis the starch that was the major component in Kochujang.

• 한국시뮬레이션학회논문지
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• 제3권2호
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• pp.49-56
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• 1994

Performance measurement and analysis for computer systems has been studied for a long time. However, little attention has been focused on how to distribute a given budget to each part of a computer system for enhancing system performance maximally. In traditional approaches, performance enhancement is achieved by identifying a dominant system bottleneck and enhancing the bottleneck's performance. These approaches, however, often bring problems since the removal of a bottleneck may result in other bottlenecks. This paper proposes an approximated method for such budget distribution problem. For budget distribution, a critical set is defined. The set contains the servers of which performance changes affect the overall system performance significantly. Then, the given budget is distributed properly to every server in the critical set. To verify the proposed method, two benchmark experiments are carried out I SLAM environments. The experimental results show that the proposed method provides better results than the traditional method does in many cases.